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2016 Macmillan Publishers Limited. All rights reserved
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| 12
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)ngeo2791 (2016
(
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J. Anthropol. Archaeol. http://
doi.org/bn82 (2016); Sci. Rep.
)6, 31279 (2016
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.
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( 6.6 )
( 9.9 12.7
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| 14
| 2016
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.
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(
"") .
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)(2016
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)(2016
%40
.
"" .
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.
Cell Metab. http://
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.1993
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)(2016
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Cell http://dx.doi.org/10.1016/j.
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SOURCE: GWEC
1.8 .
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nuTonomy
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19 | 2 0 1 6
1 .1990
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- 3
.4
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.
" :
" .
- .
"
" .
2012
.
1. Steinhauer, J. Nature Phys. http://dx.doi.
org/10.1038/nphys3863 (2016).
2. Unruh, W. G. Phys. Rev. Lett. 46, 13511353
(1981).
3. Steinhauer, J. Nature Phys. 10, 864869
(2014).
4. Weinfurtner, S. et al. Phys. Rev. Lett. 106, 021302
(2011).
KAMIOKA OBSERVATORY, ICRR (INST. FOR COSMIC RAY RESEARCH), UNIV. TOKYO
.
:
.
( )ICHEP
.
" :
" . ..
.
(;Y. Fukuda et al. Phys. Rev. Lett. 81, 1562
.)1998
NOvA
()
.
" :
"
.
.
kaons B mesons
.
.
.
2016 Macmillan Publishers Limited. All rights reserved
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( Tokai to Kamioka )T2K
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.
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" :
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. 20 (
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2021
13
.
2025 .
810
.
.2017
3
.2020
( 5)
.
.:
"
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|
25 | 2 0 1 6
.NgAgo
- 9.
NgAgo
Nature
.
Nature Biotechnology .
. 8
- 9
. 9
Cpf1
. Staphylococcus aureus
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RNA
NgAgo
.
9
- 9 .
.)go.Nature.com/2bbgxwb :
DNA
.
- 9
.
- 9
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| 26
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| 2016
DAVID CYRANOSKI
NgAge .
Addgene
.
.
- 9
( :
).
.
:
.
- 9
DNA .
Nature
Biotechnology
)Ago( Argonaute
(F. Gao et al. Nature Biotechnol. 34,
.)768773; 2016
- 9 .
- 9
.
.
42
JCSMR/ANU
.
Nature
" .
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.
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5,000.
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" . .
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" "
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. ..
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|
27 | 2 0 1 6
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.
3.18
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Australopithecus afarensis
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;Nature http://dx.doi.org/10.1038/nature19332
.)2016
.
" :
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:
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" :
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8
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.
. 100 1,500
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2013
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.2008
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.
.
. :
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Thrones
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%22
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29 | 2 0 1 6
11,600
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.2018
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2019
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| 30
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. ..
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. " :
" .
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10 ( )
. 25 30
.1988
100
.
..
100 .
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..
9
.
.
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150
7,400
.
200 .
FASTER
60 .
100 100
MAREA
6,600
. 2017
160 .
..
.
( .)E. Temprana et al. Science 348, 14451448; 2015
"
.
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.
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.
.
200
86
.
8,600
1 20
90
31 | 2 0 1 6
.
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39,000
2.3
2000
39
.
92
.
.
.
.
.
.
110 502
.
.
21
(W. Liu
.)et al. Nature Photon. 10, 190195; 2016
.
" :
".
.
.
35
" .
" :
.
.
| 32
| 2016
SOURCE: TELEGEOGRAPHY
.
.
10
.
.
( : ).
. " :
" .
.
%85
. Amazon Web Services
.2011
2017
3 .FASTER
2016
.
.
BOB DAEMMRICH/POLARIS/EYEVINE
.
.. .
.
2011
%30 1 .
.
.
. 50
%80 .
" :
.
".
" "
.
:
.
.
" :
" . .
( )UNEP
"
".
2014
33 | 2 0 1 6
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11
.
. 2
"" %10
640 .
300
.
.
.
2014
%87 4.75 .3
( : )
%7 .
.
2004
5) .
18
.4
) 1 0.33(
100
10
1,000
" " .
.
" " "
"
. 2001 334.271
7
.
32014 5 250 .
.
" " .
) 4.75 1.01(
10,000
.
.
.5
500
4.8 12.7
.
.
.
.6
11.854
" " .
2014 15 51
93 236 .
" : ".
Marine Debris Tracker
.
) 200 4.76(
) 200(
1,000,000 100,000
= 10
9
1,830
7.04
3,020
| 34
28.5
| 2016
380
30.6
202.8
.
.
.
.8
.
"" . 2014
.9 " :
" "
".
100 .
" : ..
.
"
10
RealRiskNano
.
" :
".
.
.
.
%90
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.
%41
.10
.
".
" :
"
"
. 24
%34
%46 .11
" :
.
".
80-10
" :
".
. :
The Ocean Cleanup
2020 100
.
.
.
.
." :
. ".
12
. " :
. " .
" :
".
.
.
.13
. " :
" .
Nature .
1. Carson, H. S., Colbert, S. L., Kaylor, M. J. & McDermid, K. J. Mar. Pollut. Bull. 62,
17081713 (2011).
2. Macfadyen, G., Huntington, T. & Cappell, R. Abandoned, Lost or Otherwise
Discarded Fishing Gear (UNEP, 2009).
3. Eriksen, M. et al. PLoS ONE 9, e111913 (2014).
4. Thompson, R. C. et al. Science 304, 838 (2004).
5. Jambeck, J. R. et al. Science 347, 768771 (2015).
6. van Sebille, E. et al. Environ. Res. Lett. 10, 124006 (2015).
7. Moore, C. J., Moore, S. L., Leecaster, M. K. & Weisberg, S. B. Mar. Pollut. Bull. 42,
12971300 (2001).
8. Woodall, L. C. et al. R. Soc. Open Sci. 1, 140317 (2014).
9. Obbard, R. W., Sadri, S., Wong, Y. Q., Khitun, A. A., Baker, I. & Thompson, R. C.
Earths Future 2, 315320 (2014).
10. Sussarellu, R. et al. Proc. Natl Acad. Sci. USA 113, 24302435 (2016).
11. Lnnstedt, O. M. & Eklv, P. Science 352, 12131216 (2016).
12. Sherman, P. & van Sebille, E. Environ. Res. Lett. 11, 041001 (2016).
13. van Franeker, J. A. & Law, K. L. Environ. Pollut. 203, 8996 (2015).
35 | 2 0 1 6
41 .
40 .
42 .
43 .
KEVIN FRAYER/GETTY
. .
.
30
EPA
.
REACH
37 | 2 0 1 6
-
- .
.
.
2015
glyphosate
2
"
" .
. ..
()BPA
.
( )CFCs
4
.CFC
| 38
| 2016
.5
.
.
.
1 ( 10
1
)
10
. ..
.
.
.
.
" "
.
2016 Macmillan Publishers Limited. All rights reserved
.
.
.
.
.
Green Chemistry Gordon
.
john.warner@warnerbabcock.com :
jennifer.ludwig@warnerbabcock.com
1. Anastas, P. T. & Warner, J. C. Green Chemistry:
Theory and Practice (Oxford Univ. Press, 1998).
2. Guyton, K. Z. et al. Lancet Oncol. 16, 490491
(2015).
3. Rochester, J. R. & Bolden, A. L. Environ. Health
Perspect. 123, 643650 (2015).
4. UNEP. HFCs: A Critical Link in Protecting Climate
and the Ozone Layer 36 (UNEP, 2011).
5. Schug, T. T. et al. Green Chem. 15, 181198
(2013).
6. Bengtstrm, L. et al. Food Addit. Contam. Part A
33, 10801093 (2016).
()
(J. T. Wilbanks & E. J. Topol
)Nature 535, 345348; 2016
Enlite
.
23andMe 115
.
150
The Ethics
.of Invention
.
.
| 40
| 2016
..
2016 :
2016 Macmillan Publishers Limited. All rights reserved
UNIVERSAL IMA/REX/SHUTTERSTOCK
iCub .
.
2010
"
"
.
.
"
".
1984
"
"
.
.
.
.
( .)J. Kuzma Nature 531, 165167; 2016
"
" .
1995
"
"
"
".
" :
" .
..
(R. McKinlay Nature 531, 573
.)575; 2016
saftergood@fas.org :
:
)(2016
.
(
)
.
..
Tetrao tetrix Athene cunicularia
.
. :.
)(2016
1953
..
.
)(2016
1500 .
.
( ) .
..
.
:
)(2016
..
)(2016
( )
Ornithorhynchus anatinus 83
Varanus komodoensis
.
" "
..
.
41 | 2 0 1 6
| 42
| 2016
.2016 :
.2016 :
.2016 :
:
.2016 :
Lactobacillus
Firmicutes
Bacteroides
2013
muciniphila
.Akkermansia
(A. Everard et al. Proc. Natl Acad. Sci. USA 110,
.)90669071; 2013
.
Euprymna scolopes
Vibrio
fischeri
The Human
Superorganism
Homo sapiens
.
"
"
"
"
CRISPR
SPL
.
2001
.
microRNA
I Contain Multitudes
30
39
20,000
10
.
metagenomics
.
.
Aphids
Buchnera
1927
. :
SELMUR/CINEMA REL. CIRO./THE KOBAL COLLECTION
This Is Your Brain on
Parasites
.
Toxoplasma gondii
The
Mind-Gut Connection
noradrenaline
endorphins
serotonin
.
(--)
.probiotics
PD-L1
CTLA4
.Life Without Genes
adrianwoolfson@yahoo.com :
.
1968
2014
.1966 :
DNA
Flowers for
Algernon
.
1946 1953
.Quaker oats
"
"
1994
43 | 2 0 1 6
facebook google+
Research highlights
Science events
Job search
nature.com/nmiddleeast
Sponsored by
1932 1972
1959
32
(
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.
.
.
.
5
Charly
1968
.
.
.Marvel Comics
NATURE.COM
:
go.nature.com/
booksandarts
| 44
| 2016
" :
" .
.
"
" .
20
30
( .)Nature http://doi.org/bnh7; 2013 :
.
(.)Nature 464, 19; 2010
100
(;Nature 534, 163
.)2016
HeLa
1951
.
2013
.
.
The Economist .
:
ananyobhattacharya@economist.com
360
46 .
48 .
50 .
| 1
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. . 10 :.
"" .. . ""
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.
""
1
.
.
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.
.
.
2016 Macmillan Publishers Limited. All rights reserved
4
5
.
2011 6
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.
45 | 2 0 1 6
.
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.
.
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.
7 8
9
.
.
.
)
(
.
..
.
.
.10
| 46
| 2016
.
.
11
.12
7. Heckele, M. & Schomburg, W. K. J. Micromech.
)Microeng. 14, R1R14 (2004
8. Qin, D., Xia, Y. & Whitesides, G. M. Nature Protocols
5, 491502 (2010).
9. Wu, W., DeConinck, A. & Lewis, J. A. Adv. Mater. 23,
H178H183 (2011).
10. Paul, C. Robot. Auton. Syst. 54, 619630 (2006).
11. Ranzani, T., Gerboni, G., Cianchetti, M. & Menciassi, A.
Bioinspir. Biomim. 10, 035008 (2015).
12. Park, Y.-L. et al. Bioinspir. Biomim. 9, 016007 (2014).
56025
.
barbara.mazzolai@iit.it :
1. Pfeifer, R., Lungarella, M. & Iida, F. Science 318,
10881093 (2007).
2. Rus, D. & Tolley, M. T. Nature 521, 467475
(2015).
3. Wehner, M. et al. Nature 536, 451455 (2016).
& 4. Mazzolai, B., Margheri, L., Cianchetti, M., Dario, P.
Lasch, C. Bioinspir. Biomim. 7, 025005 (2012).
5. Lin, H.-T., Leisk, G. G. & Trimmer, B. Bioinspir.
Biomim. 6, 026007 (2011).
6. Shepherd, R. F. et al. Proc. Natl Acad. Sci. USA 108,
2040020403 (2011).
.
. . .
.
2
.
( )MRI
( )1
" "Human Connectome Project
2016 Macmillan Publishers Limited. All rights reserved
.3
.
(
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.
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.
.
3 3 (
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.
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| 1 . 1
.54
.
.
.
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10,000
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.
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"" .
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.
360
.
.
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.
. .
117456 .
.
40225
( )INM-I .
s.eickhoff@fz-juelich.de :
thomas.yeo@nus.edu.sg
1. Glasser, M. F. et al. Nature 536, 171178 (2016).
2. Brodmann, K. Vergleichende Lokalisationslehre
der Grohirnrinde: in ihren Prinzipien dargestellt
;)auf Grund des Zellenbaues (J. A. Barth, 1909
English transl. available in Garey, L.J. Brodmanns
Localization in the Cerebral Cortex (Smith Gordon,
1994).
3. WU-Minn HCP Consortium. NeuroImage 80, 6279
(2013).
4. Buckner, R. L., Krienen, F. M. & Yeo, B. T. T. Nature
Neurosci. 16, 832837 (2013).
5. Gordon, E. M. et al. Cereb. Cortex 26, 288303
(2014).
6. Hopf, A. J.Hirnforsch. 2, 311333 (1956).
7. Yeo, B. T. T. et al. Cereb. Cortex 25, 36543672
(2015).
8. Eickhoff, S. B., Thirion, B., Varoquaux, G. & Bzdok, D.
Hum. Brain Mapp. 36, 47714792 (2015).
9. Amunts, K. PLoS Biol. 8, e1000489 (2010).
10. Wang, D. et al. Nature Neurosci. 18, 18531860
(2015).
|
47 | 2 0 1 6
1
.1
()
.
:
(
)
( )
.
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AT1
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.
.
.
.
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| 1
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.
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| 48
| 2016
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.
.
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.
.
3,4
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.
6
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.
.
.
.
.
.
.7
.
.8
(
:
).
.
1
.
.
60590
60596.
arkan@med.uni-frankfurt.de :
1. Giovannucci, E. & Michaud, D. Gastroenterology
132, 22082225 (2007).
2. Incio, J. et al. Cancer Discov. http://dx.doi.
org/10.1158/2159-8290.CD-15-1177 (2016).
3. Rhim, A. D. et al. Cancer Cell 25, 735747 (2014).
4. zdemir, B. C. et al. Cancer Cell 25, 719734 (2014).
5. DuFort, C. C., Paszek, M. J. & Weaver, V. M. Nature
Rev. Mol. Cell Biol. 12, 308319 (2011).
6. Provenzano, P. P. & Hingorani, S. R. Br. J. Cancer
108, 18 (2013).
7. Shook, B. et al. Annu. Rev. Cell Dev. Biol.
http://dx.doi.org/10.1146/annurevcellbio-111315-125426 (2016).
8. Guilak, F. et al. Cell Stem Cell 5, 1726
(2009).
..
.
.
.
.
.
.
.
(.)MMOs
2016 Macmillan Publishers Limited. All rights reserved
1997
2
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.
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.
.
.7
( 200 )
.
.
91125
.
jal@caltech.edu :
1. Snyder, B. E. R. et al. Nature 536, 317321 (2016).
2. Panov, G. I. et al. React. Kinet. Catal. Lett. 61,
251258 (1997).
3. Shu, L. et al. Science 275, 515518 (1997).
4. Dubkov, K. A., Ovanesyan, N. S., Shteinman, A. A.,
Starokon, E. V. & Panov, G. I. J. Catal. 207, 341352
(2002).
5. Xia, H. et al. J. Phys. Chem. C 112, 90019005 (2008).
6. Vallee, B. L. & Williams, R. J. Proc. Natl Acad. Sci.
USA 59, 498505 (1968).
7. Labinger, J. A. J. Mol. Catal. A 220, 2735 (2004).
& 8. Parfenov, M. V., Starokon, E. V., Pirutko, L. V.
Panov, G. I. J. Catal. 318, 1421 (2014).
"
"
:
.
%80 .
.
( -Fe)II
| 50
| 2016
.
1
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2016 Macmillan Publishers Limited. All rights reserved
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"".
.
2016 Macmillan Publishers Limited. All rights reserved
"" 11
.
""
. 11
RA 2300 .
jan@lorentz.leidenuniv.nl :
1. Tinkham, M. Introduction to Superconductivity
(Dover, 2004).
2. Bardeen, J., Cooper, L. N. & Schrieffer, J. R. Phys.
Rev. 106, 162164 (1957).
3. Bednorz, J. G. & Mller, K. A. Z. Phys. B 64, 189193
(1986).
4. Keimer, B., Kivelson, S. A., Norman, M. R., Uchida, S.
& Zaanen, J. Nature 518, 179186 (2015).
5. Boovi, I., He, X., Wu, J. & Bollinger, A. T. Nature
536, 309311 (2016).
6. Zaanen, J. Science 315, 13721373 (2007).
7. Mott, N. F. Proc. Phys. Soc. A 62, 416422 (1949).
8. Vignolle, B. et al. Nature 455, 952955 (2008).
9. Chatterjee, U. et al. Proc. Natl Acad. Sci. USA 108,
93469349 (2011).
10. Leggett, A. J. J. Stat. Phys. 93, 927941 (1998).
11. Uemura, Y. J. et al. Phys. Rev. Lett. 62, 23172320
(1989).
|
51 | 2 0 1 6
T H E I N T E R N AT I O N A L W E E K LY J O U R N A L O F S C I E N C E
NATURE.COM/NATURE
11 August 2016 10
Vol. 536, No. 7615
PLANETARY SCIENCE
JUPITERS
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OLD ENEMIES
Overexploitation and
agriculture still main threats
PAGE 143
INFORMATION TECHNOLOGY
GIVE US MORE
!BANDWIDTH
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Internet up to speed
PAGE 139
11 2016
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doi: 10.1038/nature18593
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doi: 10.1038/nature18592
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doi: 10.1038/nature19075
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18 August 2016 10
Vol. 536, No. 7616
STRUCTURAL BIOLOGY
SEEING IS
BELIEVING
NEUROSCIENCE
TOXICOLOGY
THROW THE
SLEEP SWITCH
GIVE CHEMISTS
A CHANCE
18 2016
18
" "Nature.
.
.
p53
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doi: 10.1038/nature19069
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.
.7q11.23
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doi: 10.1038/nature19067
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H Tsai et al
doi: 10.1038/nature18306
T H E I N T E R N AT I O N A L W E E K LY J O U R N A L O F S C I E N C E
NEAR HORIZON
A warm terrestrial planet in orbit around
Proxima Centauri, closest star to the Sun PAGES 408 & 437
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B Snyder et al
doi: 10.1038/nature19059
| 56
| 2016
-.
D Paez-Espino et al
doi: 10.1038/nature19094
NATURE.COM/NATURE
25 August 2016 10
Vol. 536, No. 7617
ROBOTICS
THE SOFT
MACHINE
Self-powered octobot
breaks new ground
PAGES 400 & 451
SUSTAINABILITY
PHARMACEUTICALS
CITIES COOK
CARBON BOOKS
VITAL DRUGS
MADE CHEAPER
PAGE 391
PAGE 388
Overhaul urban
emissions accounts
Non-profit initiative
targets neglected diseases
25 2016
25
" "Nature.
5
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.
125
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doi: 10.1038/nature19312
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"" ()prM-Env
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doi: 10.1038/nature19082
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economies
T H E I N T E R N AT I O N A L W E E K LY J O U R N A L O F S C I E N C E
TARGETING AMYLOID
Antibody aducanumab reduces Alzheimers
disease-associated amyloid in human brain PAGES 36 & 50
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1 September 2016 10
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ATOMIC THEORY
SPHERES OF
INFLUENCE
RESEARCH MISCONDUCT
CHEATING
HAPPENS
COMPUTING
DNA
MEMORIES
Genomic technology
tackles big data
PAGE 22
1 2016
1
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57 | 2 0 1 6
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C Marcinkiewcz et al
doi: 10.1038/nature19318
-
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doi: 10.1038/nature18604
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.
| 58
| 2016
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.Mini Mental State Examination
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doi: 10.1038/nature19323
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doi: 10.1038/nature18619
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doi: 10.1038/nature18641
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.
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J Doppler et al
doi: 10.1038/nature18605
.
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" :
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.2012
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2016 Macmillan Publishers Limited. All rights reserved
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.4" :
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| 2016
." :
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.
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.
." :
".
. " :
".
.
.7
(
)1962
.
8
"
:
.
" .
.
1. Chamberlin, T. C. Science 15, 9296 (1890).
2. Smaldino, P. E. & McElreath, R. Preprint at
https://arxiv.org/abs/1605.09511 (2016).
3. Elliott, L. P. & Brook, B. W. BioScience 57,
608614 (2007).
& 4. Pardon, L. G., Brook, B. W., Griffiths, A. D.
Braithwaite, R. W. J. Animal Ecol. 72, 106115
(2003).
5. Wegener, A. Petermanns Geogr. Mitt. 58, 185185,
253256, 305309 (1912).
6. MacCoun, R. & Perlmutter, S. Nature 526,
187189 (2015).
7. Branch, T. A. Fisheries 40, 373375 (2015).
8. Symes, L. B., Serrell, N. & Ayres, M. P. Bull. Ecol.
Soc. Am. 96, 352367 (2015).
JAXA
Akatsuki
7 .2015
.2010
.
.
.
20
.
.
2010
.
.
.
.
.
... 15 " :
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.
.
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.
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180
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.
.
.
.
|
63 | 2 0 1 6
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.
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.
.
.
.
.K'Dasewh
.
.
.
.
.
.
.
.
.
NATURE.COM
:
@NatureFutures
go.nature.com/mtoodm
| 64
| 2016
.
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