DADAMO
NAP PROFESSIONAL SERVICES
Gastro-D Complex (Mastic -DGL - Bismuth Complex)
90 Veggiecaps per bottle.
Suggested retail price: $39.95
Gastro-D Complex is comprised of seven
synergistic ingredients, including Mastic
Gum, which may help to protect the gastric
mucosa; Safflower Tops may help to provide
additional support against H. Pylori infestation,
especially for blood group nonsecretors;
Bentonite Clay assists in attracting and soaking
up environmental toxins; the inner bark rind of
Slippery Elm protects the GI tract from excess
acidity; and Bismuth helps protect the lining of the stomach from
stomach acid.
Product History
Gastro-D Complex was originally NAP product Gastroguard,
which was introduced in 2005 for use in the DAdamo Clinic. It
was renamed in 2006 for trademark purposes. It was reformulated
in 2008 to include deglycyrrhizinated licorice (DGL).
Description/Background
Gastro-D Complex comprises seven synergistic ingredients.
Mastic Gum (from Pistacia lentiscus)
The applicable part of mastic is the resin. Mastic tree contains resins
including the triterpenes mastic acid, isomastic acid, oleanlic acid,
and tirucallol. It also contains a volatile oil containing alpha-pinene
as a constituent. The volatile oil and the resin are both thought to
have astringent and aromatic effects (1). For prevention of gastric
and duodenal ulcers, some researchers think mastic might have
antisecretory and possibly cytoprotective effects. Animal models
show that it seems to help protect the gastric mucosa during
aspirin, phenylbutazone, or reserpine therapy (2). This effect has
not yet been found in humans. There is some in vitro evidence that
mastic extract has antimicrobial and antifungal activity (3). There
is also preliminary evidence that mastic might have hypotensive
and antioxidant effects (4).
Safflower (Carthamus tinctorios) Tops
Five interesting abstracts from the National Library of
Medicines PubMed, when taken in total, present intriguing
information on the components of safflower tops and the
effects of these components. Safflower tops also provide one
of the very few natural sources of free Lewis A type antigen
for anti-adhesive effects against H. pylori.
Bentonite Clay
Bentonite, also referred to as Montmorillonite, is one of
the most effective and powerful healing clays used to treat
both internal and external maladies. Bentonite can be used
externally as a clay poultice, mud pack or in the bath and, in
skin care recipes. Internally it can be added to water, dietary
supplements or glazed upon food to help those with sensitive
palates.
Bentonite clay is sedimentary clay composed of weathered
and aged volcanic ash. The largest and most active deposits
in the US come from Wyoming and Montana. Bentonite is
usually quarry mined from deposits that can range anywhere
from 100 feet to several thousand feet. This depends on the
health and vitality of the land it is processed from and how
far a producer will go to find the right clay with the proper
characteristics and consistency.
From here it is mined from the earth and brought out into
the sun to remove excess water and moisture and, to make
it easier to work with. After the initial drying begins the
final transformation. It gets processed (ground) with huge
hydraulic crushers and it then goes through the final process
of micronization, or fine granulating. This is usually done
with the assistance of sophisticated and expensive granulators.
Upon completion of this final process it gets inspected by a
quality control team and is sent off for consumer use.
Bentonite is very unusual in the fact that once it becomes
hydrated, the electrical and molecular components of the clay
rapidly change and produce an electrical charge. Its highest
power lies in the ability to absorb toxins, impurities, heavy
metals and other internal contaminants. Bentonite clays
structure assists it in attracting and soaking up poisons on its
exterior wall and then slowly drawing them into the interior
center of the clay where it is held in a sort of repository.
Bentonite is a swelling clay. When it becomes mixed with
water it rapidly swells open like a highly porous sponge. From
here the toxins are drawn into the sponge through electrical
attraction and once there, they are bound.
Licorice
Licorice has a long and highly varied record of uses. It was
and remains one of the most important herbs in Traditional
Chinese Medicine. Among its most consistent and important
uses are as a demulcent (soothing, coating agent) in the
digestive and urinary tracts, to help with coughs, to soothe
sore throats, and as a flavoring. It has also been used in
Traditional Chinese Medicine to treat conditions ranging
from diabetes to tuberculosis.
There are two types of licorice, standard licorice and
deglycyrrhizinated licorice (DGL). Each type is suitable
for different conditions.
 DGL is prepared without the glycyrrhizin in order to
circumvent potential safety problems, and is used for
conditions of the digestive tract, such as ulcers.
Slippery Elm (Ulmus fulva) bark
The applicable part of slippery elm is the inner bark rind.
The mucilages are considered the principal constituent. They
are responsible for slippery elms demulcent and emollient
effects (5,1). Used internally, slippery elm preparations cause
reflex stimulation of nerve endings in the GI tract, leading to
mucous secretion (6). This induced mucous may protect the
GI tract against ulcers, excess acidity, etc. Tannin constituents
have astringent properties (5). Oleoresins of some species are
responsible for contact dermatitis (6).
Bismuth (as Bismuth Citrate)
This is a combination of bismuth, a heavy reddish-white
crystalline metallic element and citric acid. RxMed
Pharmaceutical Information PYLORID states that in vitro,
bismuth-containing compounds have bactericidal activity
against the microorganism H. pylori. In vivo, growth is
inhibited and the bactericidal effects of antibiotics (e.g.,
clarithromycin) greatly enhanced. Bismuth acts at the site
of the ulcer by coating the ulcer and protecting it from the
stomach acid.
Cranesbill (Geranium maculatum) Root
Cranesbill is an effective astringent used in diarrhea, dysentery
and hemorrhoids. When bleeding accompanies duodenal
or gastric ulceration, this remedy is used in combination
with other relevant herbs. Where blood is lost in the feces,
this herb will help, though careful diagnosis is vital. It may
be used where excessive blood loss during menstruation
(menorrhagia) or a uterine hemorrhage (metrorrhagia) occur.
As a douche it can be used in leucorrhoea.
Bladderwrack (Fucus vesiculosis) Whole Plant
The applicable part of bladderwrack is the entire plant.
Bladderwrack is a brown alga (seaweed).
Bladderwrack contains high concentrations of iodine, which
is present in varying amounts. Bladderwrack is also a source
of nutrients such as fiber, minerals such as iron, and vitamin
B12 (7).
Preliminary clinical research suggests bladderwrack might
extend the menstrual cycle and have anti-estrogenic effects
in premenopausal women. It may also increase progesterone
levels (8). Preliminary research suggests that extracts of
bladderwrack also might have antibacterial, anti-HIV, and
antioxidant activity (9,10,11).
Fucoidan, a sulfated polysaccharide derivative of
bladderwrack, seems to be active against a variety of viruses
including the herpes virus, HIV, and cytomegalovirus (12).
Fucoidan also seems to stimulate the activity of transforming
growth actor (TGF)-beta to increase fibroblast proliferation,
which suggests it might be useful for treatment of wound
healing (13). Preliminary research also suggests that fucoidan
also has anticoagulant, fibrinolytic, and antiplatelet adhesion
effects (14). Other preliminary research suggests that it
might have antiangiogenic and antitumor activity (15).
Preliminary clinical research suggests topical administration
of bladderwrack extract might reduce skin thickness and
other signs of aging (16).
Actions and Indications
Gastric distress, dyspepsia
Mastic gum helps support the prevention and healing of
gastric and duodenal ulcers
The lentiscus resin in mastic gum has been shown to
induce blebbing, morphological abnormalities and cellular
fragmentation in H. pylori cells.
Safflower tops help provide additional support for
nonsecretors (particularly O blood type nonsecretors)
against H. pylori infestation, to which they are typically
more sensitive than are secretors.
Bentonite clays structure assists it in attracting and
soaking up poisons on its exterior wall and then slowly
drawing them into the interior center of the clay where it
is held in a sort of repository. When used internally, the
poisons are then excreted with the clay.
Slippery elm preparations cause reflex stimulation of
nerve endings in the GI tract, leading to mucous secretion
(7). This induced mucous may protect the GI tract against
ulcers and excess acidity.
In vitro, bismuth-containing compounds have bactericidal
activity against the microorganism H. pylori. In vivo,
growth is inhibited and the bactericidal effects of antibiotics
(e.g., clarithromycin) greatly enhanced. Bismuth acts at
the site of the ulcer by coating the ulcer and protecting it
from the stomach acid.
Cranesbill has traditionally been used in combination
with other relevant herbs, when bleeding accompanies
duodenal or gastric ulceration.
Bladderwrack contains the sugar fucose, which acts as
a decoy mechanism for H. pylori. The polysaccharide
fucoidin in bladderwrack also serves to inhibit the growth
of many unfriendly viruses and bacteria including H.
pylori.
Synergistic Products
Fucus Plus (anti-adhesion therapy)
Polyflora (for additional support during bacterial
overgrowth)
Dosage
Typical dose is 1-2 capsules twice daily for one-two months or
on the advice of a physician. The bismuth in the formula will
often tinge the stool a grey-green color and the patient should
be advised of this possibility.
See Also
15. Koyanagi S, Tanigawa N, Nakagawa H, et al. Oversulfation of fucoidan
Adhesins enhances its anti-angiogenic and antitumor activities. Biochem Pharmacol
Diet, Helicobacter pylori, and p53 mutations in gastric cancer. 2003;65:173-9.
A molecular epidemiology study in Italy 16. Fujimura T, Tsukahara K, Moriwaki S, et al. Treatment of human skin with an
extract of Fucus vesiculosus changes its thickness and mechanical properties.
FUT3 J Cosmet Sci 2002;53:1-9.
Fucus vesiculosis (Bladderwrack) 17. Whorwood CB, Shepard MC, Stewart PM. Licorice inhibits
11-hydroxysteroid dehydrogenase messenger ribonucleic acid levels and
Genetic polymorphism of interleukin-8 (IL-8) is associated potentiates glucocorticoid hormone action. Endocrinology 1993;132:2287
with Helicobacter pylori-induced duodenal ulcer 92.
18. Soma R, Ikeda M, Morise T, et al. Effect of glycyrrhizin on cortisol
Helicobacter pylori infection, ABO and secretor blood groups metabolism in humans. Endocrin Regulations 1994;28:314.
Interleukin-8 (IL-8) 19. Beil W, Birkholz C, Sewing KF. Effects of flavonoids on parietal cell acid
secretion, gastric mucosal prostaglandin production and Helicobacter pylori
Lewis Blood Group growth. Arzneim Forsch 1995;45:697700.
Lewis antigens 20. Morgan AG, McAdam WAF, Pacsoo C, Darnborough A. Comparison
between cimetidine and Caved-S in the treatment of gastric ulceration, and
Secretor Status subsequent maintenance therapy. Gut 1982;23:54551.
T Helper Lymphocyte 21. Kassir ZA. Endoscopic controlled trial of four drug regimens in the treatment
of chronic duodenal ulceration. Irish Med J 1985;78:1536.
Tumor Necrosis Factor alpha (TNFa)
22. Bardhan KD, Cumberland DC, Dixon RA, Holdsworth CD. Clinical trial of
p53 deglycyrrhizinised liquorice in gastric ulcer. Gut 1978;19:77982.
23. Das SK, Das V, Gulati AD, Singh VP. Deglycyrrhizinated licorice in aphthous
References ulcers. J Assoc Physicians India 1989;37:647.
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2. Al-Said MS, Ageel AM, Parmar NS, Tariq M. Evaluation of mastic, a crude
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Model: NP042
7. Phaneuf D, Cote I, Dumas P, et al. Evaluation of the contamination of marine
algae (Seaweed) from the St. Lawrence River and likely to be consumed by
* Manufactured by: Genoma Nutritionals
humans. Environ Res 1999;80:S175-S182.
8. Skibola CF. The effect of Fucus vesiculosus, an edible brown seaweed, upon
menstrual cycle length and hormonal status in three pre-menopausal women:
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10. Beress A, Wassermann O, Tahhan S, et al. A new procedure for the isolation
of anti-HIV compounds (polysaccharides and polyphenols) from the marine
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12. Baba M, Snoeck R, Pauwels R, de Clercq E. Sulfated polysaccharides are
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