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  • Cardiac Enzymes and Biomarkers Review - Troponin, CK and Myoglobin - Learntheheart

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    Tisha Patricia Oedoy
    18 Ansichten2 Seiten
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    Cardiac Enzymes and Biomarkers Review - Troponin, CK and Myoglobin _ Learntheheart

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    18 Ansichten2 Seiten

    Cardiac Enzymes and Biomarkers Review - Troponin, CK and Myoglobin - Learntheheart

    Hochgeladen von

    Tisha Patricia Oedoy
    Enzim jantung

    Copyright:

    © All Rights Reserved
    Als PDF, TXT herunterladen oder online auf Scribd lesen
    Markieren Sie unangemessene Inhalte
    von 2

    31/10/2016

    CardiacEnzymesandBiomarkersReviewTroponin,CKandmyoglobin|Learntheheart.com

    CardiacEnzymesReview
    Cardiacenzymes(a.k.a.cardiacbiomarkers)includemyoglobin,troponinandcreatinekinase.
    Historically,LDH(lactatedehydrogenase)wasusedaswellhoweverisnonspecific.Cardiac
    enzymesarereleasedintothecirculationwhenmyocardialnecrosisoccursasseeninmyocardial
    infarction.
    Myoglobin:Myoglobinisreleasedintocirculationwithanydamagetomuscletissue,including
    myocardialnecrosis.Sinceskeletalmusclecontainsmyoglobin,thismeasurementinquitenon
    specificformyocardialinfarctions.Thebenefitlaysinthefactthatadetectableincreaseisseenonly
    30minutesafterinjuryoccurs,unliketroponinandcreatinekinasewhichcantake34hours.
    Troponin:TheenzymestroponinIandtroponinTarenormalproteinsimportantinthecontractile
    apparatusofthecardiacmyocyte.Theyarereleasedintothecirculationabout34hoursafter
    myocardialinfarctionandarestilldetectablefor10daysafterwards.Thelonghalflifeallowsforthe
    latediagnosisofmyocardialinfarction,howevermakesitdifficulttodetectreinfarctionascanoccur
    inacutestentthrombosisafterpercutaneouscoronaryintervention.Thereareanumbercausesof
    troponinelevationnotrelatedtomyocardialinfarction,howevertroponinelevationismuchmore
    sensitivethanmyoglobinandevenCK.
    Creatinekinase(CK):Creatinekinase(a.k.a.creatinephosphokinaseorCPK)isamuscle
    enzymewhichexistsasisoenzymes.TheMBtypeisspecifictomyocardialcellswhileMMandBB
    arespecifictoskeletalmuscleandbraintissuerespectively.TheCKlevelwillincrease
    approximately34hoursafteramyocardialinfarctionandstayselevatedfor34days.Thismakesit
    usefulforthedetectionofreinfarctioninthe410daytimewindowaftertheinitialinsultsince
    troponinremainselevatedfor10daysmakingitlessusefulforthispurpose.

    RelatedLinks:
    TopicReview:STEMI
    http://www.healio.com/cardiology/learntheheart/cardiologyreview/cardiacenzymes

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    31/10/2016

    CardiacEnzymesandBiomarkersReviewTroponin,CKandmyoglobin|Learntheheart.com

    TopicReview:STEMI
    TopicReview:UnstableAnginaandNSTEMI

    References:
    1.Braunwald'sHeartDisease:ATextbookofCardiovascularMedicine
    2.Hurst'stheHeart,13thEdition
    ByStevenLome

    http://www.healio.com/cardiology/learntheheart/cardiologyreview/cardiacenzymes

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