Beruflich Dokumente
Kultur Dokumente
John Mathers
Human Nutrition Research Centre
Institute for Ageing and Health
Newcastle University
John Mathers
Diet, genes and health: towards
effective personalised nutrition advice
Presenter Disclosure Information:
Conflicts of interest/
This speaker has no conflicts of interest
Nutrition
interacts with
genotype to
influence
health
Diet
Personalised lifestyle-based
interventions .1
Personalised lifestyle-based
interventions .2
MARK GABRENYA/ISTOCKPHOTO.COM
Views of
genotypic
analysis
among
readers of
Nature
Systematic
review of
effectiveness of
DNA-based
advice in
changing
behaviour .1
2.
3.
4.
5.
6.
7.
Coordinated by Newcastle
University
Study Design
Randomised Controlled Trial
Adults
Recruitment target (1540)
220
4 Treatment groups
220
220
220
220
220
Internet-based format
Study Design
Is PN advice more effective than general healthy
eating guidelines?
Level 0: Non-Personalised dietary advice (Control group)
Total Participants
Level 0 n=385
Study Design
Is PN advice more effective than general healthy
eating guidelines?
Level 1: Personalised DIETARY Advice
Total Participants
Level 1 n=385
Study Design
Is PN advice more effective than general healthy
eating guidelines?
Level 2: Personalised DIETARY + PHENOTYPE Advice
Total Participants
Level 2 n=385
Study Design
Is PN advice more effective than general healthy
eating guidelines?
Level 3: Personal DIETARY + PHENOTYPE + GENOMIC advice
Total Participants
Level 3 n=385
Validation
Novel aspects of
food4me PoP Study:
Internet-based
Remote collection of
data and biological
samples
Validation
Two major issues:
Validation
10% validation sample:
1. Identity
+
2. Measurements
Personalised nutrition?
Promising
Too early for implementation
Outcomes of Food4Me Proof
of Principle Study awaited
Kevin Clarke (1989) Self portrait in Ixuatio
Acknowledgements
Carlos Celis
Jose Lara
Marianne Walsh
Mike Gibney