Beruflich Dokumente
Kultur Dokumente
HISTORY
OF
MALARIA
Parasite
Plasmodium falciparum
Plasmodium vivax
Plasmodium malariae
D E A T H
Plasmodium knowlesi
(Protozoan Infection)
Chronic Complications
Splenomegally
Anemia
Acute Complications
Neurological Symptoms:
Generalized seizure
Coma
Vectors
Anopheles minimus flavirostris
Anopheles litoralis
Anopheles dirus
Anopheles gambiae
Anopheles minimus
Host
Cerebral malaria:
At risk: pregnant women and lactating mothers, infants, young children, elderly
Genetics
- Seizure, Opisthothonus
Malaria paroxysms
Pulmonary Symptoms:
Blood Transfusion
(hypothermia, mild shivering, feeling of apprehension, violent teeth chattering, vomiting, febrile convulsion in children
Acquired Immunity
Non-immune traveller
Clinical Horizon
Migration
Socioeconomic status: People living in remote area & Lacking access to medical services
Human activities:
Going out at night, Night time occupation, Agricultural works, & Raising domestic animals
Immunosuppression
Environmental
Living in endemic area
People living in remote area
Lacking access to medical services
People living in tropical and sub-tropical regions
Shaded margins of clear fresh water stream
Foot hills and mountainous areas
Rainy season
Rural areas
Water resources development
Irrigations
Dams
Creeks
Malarial endotoxin
Parasite antigen
Macrophage
Pyrogenic cytokines
Thrombocytopenia, Shock
Hypoglycemia:
- Decerebrate and Decorticate, Metabolic Acidosis
Urinary Symptoms:
- ARF, Hemoglobinuria (Blackwater disease)
TNF
IL-6
IFN y
Hepato-billary Symptoms:
- Jaundice
Infects RBC via expression of Reticulocyte-binding protein homologue 5 that binds to CD147 of red blood cells
Inoculation of sporozoite in
the blood stream
Recovery
PREPATHOGENESIS PERIOD
HEALTH PROMOTION
S P E C I F I C
Genetics
Jaymee B. Quindara
EARLY DIAGNOSIS
Chemoprophylaxis
Zooprophylaxis
PROMPT TREATMENT
D I S A B I L I T Y
Case finding
AND
PRIMARY PREVENTION
Lindfonn Eunice F. Querubin
P R O T E C T I O N
P E R I O D
First Line
Gametocidal
Primaquine (15mg)
P R E V E N E T I O N
P A T H O G E N E S I S
L I M IT A T I O N
Schizontocides
R E H A B I L I T A T I O N
Special Cases:
Hypnozonticidal (Anti-relapse)
S E C O N D A R Y
O F
Primaquine
Trainings for Medical Technologist and other allied healthcare providers for proper detection of new cases
Multi-Drug Resistant
Artesunate-Mefloquine (25/50mg)
P R E V E N T I O N
Nelia P. Salazar Ph.D.