PHARMACEUTICS-VI [PHARMACEUTICAL TECHNOLOGY-I] T 3.5.2.

SECTION I
1. Preformulation
a. Two marks question:
1. Enlist physicochemical properties of drug to be studied in preformulation.
2. Comment on pka to enhance the Bioavailability of the product.
3. Give the physicochemical properties to be studied during preformulation
studies.
4. Define Preformulation and give its objectives.
5. Define excipients and granules.
b. Five marks question:
1.
Give the importance of preformulation with respect to stability & bioavailability.
2.
Elaborate stability and bioavailability aspects of preformution.
2. Hard gelatin & soft gelatin capsules
a. Two marks question:
1. What is acid bone and green bone ?
2. Enlist the methods for the manufacturing of soft gelatin capsules.
3. What are container dosage forms?
4. Give the various steps in manufacturing of capsule shell.
5. What are the IPQC tests for capsules?
6. Give composition of empty hard gelatin capsule shell.
7. Write a note on size and shape of soft gelatin capsule.
8. Enlist the IPQC test for capsule.
9.
Define capsules. Give the various sizes of capsules.
10. Give any four difference between Hard gelatin capsules and soft gelatin capsules
b. Five marks question:
1. Explain in detail about IPQC tests for capsules.
2. What are the various tests recommended by I.P. for the evaluation of capsules?
3. Explain in detail environmental control for the manufacturing of capsules.
4. Discuss an environment control in manufacturing of capsule shells.
5. Write a brief note on capsule filling machines.
6. Elaborate manufacturing of gelatin.
7. Enlist in detail formation of empty hard gelatin capsule shell.
8. Explain in detail various method of capsule filling.
9. Explain the rotary die process of soft gelatin capsule preparation.
c. seven marks question:
1. What are container dosage forms? Discuss in detail formulation aspects of hard
gelatin capsules.
2. What are container dosage forms? How the empty hard gelatin capsules are
manufactured? Explain in detail filing of hard gelatin capsules.
3. Explain in detail manufacturing of Hard gelatin capsule shell. Discuss evaluation
of Hard gelatin capsule as per LP.

3. Suppositories:
Two marks question:
1. Give ideal requirement of suppositories bases.
2. Give the advantage and disadvantage of suppositories.
3. Give ideal properties/requirements of suppository base.
4. Define stabilizer and suppository.
5. Give various theories of emulsification.
6. Write the ideal properties of suppositories base.
7. Enlist the various additives used in suppositories.
8. Why it is necessary to calibrate moulds?
b. Five marks question:
1. Explain in detail quality control aspects of suppositories.
2. Discuss in detail evaluation of suppositories.
3. Explain in detail quality control aspects of suppositories.
c. Seven marks question:
1. Define suppositories. Discuss in detail formulation of suppositories.
2. Explain in detail methods used in manufacturing of suppositories.
3. Give theories of emulsification and give evaluation of emulsions.
4. Define suppositories and displacement value. Discuss in detail formulation of
suppositories.
5. Explain in detail various theories of emulsifications.
6. Discuss in detail formulation of the suppositories.
SECTION-II
4. Disperse system
a. Two marks question:
1. Give classification of disperse system with suitable examples.
2. What are microemulsion? Give example.
3. What is the significance of suspending agent in suspension?
4. What is the significance of wetting agent in suspension?
5. Define emulsion, suspension, proplellant.
6. Enlist the quality control of aerosols.
7. What are microemulasions? Give its examples.
8. Enlist the theories of emulsification.
9. What are disperse systems? Give their classification.
10. Describe in brief HLB scale.
11. Give the difference between flocculated and deflocculted systems.
12. Give the classification of emulsifying agent with suitable examples.
13. What are emulsions? Give their type.
14. Write a note on phase inversion temperature.
15. What are group responsibilities?
16. Give classification of disperse system with suitable examples.
17. Explain hydrophilic colloids with examples.
18. Enlist various detection techniques for types of emulsions.
19. Define suspensions and HLB scale.

20. Enlist type and identification test for emulsion.

21. Enlist various additives used in disperse systems.
22. Define emulsion and suspension.
23. Add a note on microemulsion.
24. Define wetting agent and flocculating agent.
25.State Schuz and Hardly rule.
26.Write a note on phase inversion temperature.
b. Five marks question:
1. Give the quality control aspects of pharmaceutical suspensions.
2. Explain in detail manufacturing of the suspension.
3. Write a note on DLVO theory.
4. Give methods for determination of HLB scales.
5. Give the identification test for type of emulsion.
6. Dicuss in detail evaluation of suspensions.
7. Comment on stability of emulsion.
8. Describe in brief selection of emulsifying agents.
9. Explain DLVO theory in detail.
10. Explain in detail methods used in preparations of emulsion.
11. Discuss in detail stability of emulsion.
12.Give the various methods of emulsification with special emphasis on low energy
emulsification.
13.What is HLB value? How it is to be determined?
14.Discuss in detail evaluation of suspensions.
15.Describe in brief selection of emulsifying agents.
16.Explain in detail formulation of disperse system.
17.Explain various theories of emulsification.
c. Seven marks question:
1. Explain in detail theories of emulsification.
2. Explain in detail formation of suspensions.
3. Comment on stability of emulsions.
4. Give theories of emulsification and give evaluation of emulsions.
5. Pilot plant scale up
a. Two marks question:
1. What are group responsibilities?
2. Explain pilot plant scale up for tablet dosage form.
3. Explain pilot plant scale up for capsules.
b. Five marks question:
1. Explain in brief pilot plant scale up for capsules
2. Explain in detail pilot plant scale up techniques for tablets.
3. Explain in detail pilot plant scale up techniques for the suspension.
c. Seven marks question:
1. Discuss in detail pilot plant scale up technique for manufacturing of tablets.
2. Discuss in detail pilot-plant-scale up techniques for capsules.
3. Explain in detail formulation of pharmaceutical aerosols.
4. Discuss in detail group responsibilities in pilot-plant scale up.

5.

Discuss in detail pilot plant scale-up techniques for pharmaceutical dosage forms.