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Habitat
Paris polyphylla prefers to grow in forests, bamboo forests, thickets, grassy or rocky slopes and stream
sides.[10] It likes moist, damp, and shady places (such as under deciduous trees). It is said to grow at
altitudes up to 3300 meters and thrives well in places with moist and humus rich soil under canopy of
forest in full shade to partial shade.[11]
Soil nutrients like organic matter, nitrogen and phosphorus were found in higher levels in areas where the
plant was absent.[11] However, the levels of phosphorus tended to be found in higher levels in areas were the
plant grew.[11]
Paris polyphylla is considered to be a traded plant and it might have become less abundant in the past
decade and this could be due to deforestation.[12]
Paris polyphylla plants are supposed to be planted with the pointy shoot at one end of the rhizome facing
upwards.[2] The rhiome is then supposed to be covered with around 5 cm (2 in) of humus-rich soil which
should not be allowed to dry out during the summer months.[2] In the autumn, a generous layer of mulch
should be added and the plants should be left undisturbed after that so that they can increase in number
year after year.[2] Caution should be taken since if eaten raw, the leaves of P. polyphylla could be toxic, even
though it can be used in many medicinal remedies.
Reproduction
In the different varieties of Paris polyphylla, there are as many stamens (usually eight) as there are outer
tepals, or there could be more.[10] Stamens have short filaments. The filaments are about 10 mm in size,
while the anthers are about 12 mm.[10] The ovary is subglobose, ribbed, one-loculed and sometimes
tuberculate.[10] The style is short with an enlarged base and purple to white in color.[10] The capsule, which is
a kind of dry fruit produced by many flowering plants, is globose and sometimes tuberculate.[10] The plant
was found to reproduce mainly by vegetative propagation in the field.[11]
It has been observed that Paris polyphylla seeds produce primary root about seven months after sowing and
then leaves about four months later in the second year.[11] The seeds of this plant can remain dormant and
this is thought to be because of changes of several endohormones, development of inhibiting substances,
and the increase in material accumulation during the embryo's physiological ripening period.[11] A single
offspring is grown from a single mother plant and this led to a rapid decline in its numbers.[11]
Morphology
Plants of Paris polyphylla usually grow about 10100 cm tall from a rhizome 12.5 cm thick.[10] The
leaves, which are in a whorl at the top of the stem are sessile, petiolate, lanceolate, to ovate or elliptic. The
ovary is in the superior position, with numerous ovules.[13] The fruit is a berry or berrylike capsule, in
which the seeds are enclosed in a red succulent aril when ripe.[10] The species is extremely polymorphic.[13]
A table of some characteristics of some varieties of Paris polyphylla follows.[10]
Taxonomy
The genus Paris has in the past been placed in a number of different families, including a broadly defined
Liliaceae and the former family Trilliaceae. In the APG III system, it is placed in the family Melanthiaceae,
where it is related to the genus Trillium.[8]
As of May 2012 the World Checklist of Selected Plant Families (WCSP) recognizes several varieties:[9][10]
Paris polyphylla var. chinensis - Anhui, Fujian, Guangdong, Guangxi, Guizhou, Hubei, Hunan,
Jiangsu, Jiangxi, Sichuan, Taiwan, Yunnan, Laos, Myanmar, Thailand, Vietnam
Paris polyphylla var. latifolia - Anhui, Henan, Hubei, Jiangxi, Shaanxi, Shanxi
Paris polyphylla var. stenophyla - China, Bhutan, Assam, Myanmar, Nepal, Sikkim
Paris polyphylla var. yunnanensis - Guizhou, Sichuan, Tibet, Yunnan, Assam, Myanmar
The Flora of China recognizes five additional varieties,[10] three of which are placed in different species by
the WCSP:[9]
Profile:
The members of the genus Paris impart supreme beauty to the garden and have an beautiful
inflorescence. The genus name Paris is derived from pars, referring to the symmetry of the plant.
Paris polyphylla is a clump forming plant growing 45 cm tall and characterized by its distinctive
flowers. It has long, yellow, radiating anthers and a blue-black center. Due to over harvesting, the wild
populations of this herb have fragmentized and declined greatly.
Habitat and ecology: The species is found naturally in broad-leaved forests and mixed woodlands up
to a height of 3000 m in the Himalayas. It occurs commonly in bamboo forests, thickets, grassy or
rocky slopes and streamsides. It enjoys a moist, well-drained soil and dappled shade. This species is
globally distributed in the Himalayan range across Pakistan, India, Nepal, Bhutan, Burma and
southwest China between the altitudinal ranges of 2000-3000 m. Within India, it has been
recorded in Jammu and Kashmir, Himachal Pradesh, Uttar Pradesh, Sikkim and Arunachal
Pradesh.
Morphology: The flowers are solitary, terminal, short-stalked, greenish and relatively inconspicuous,
with 4-6 lanceolate long-pointed green leaf-like perianth segments that are 5-10 cm long and with an
inner whorl of thread-like yellow or purple segments, as long or shorter than the outer. This species has
10 short stamens and lobed stigmas. The leaves are 4-9 in number and present in a whorl. The plant is
elliptic, short-stalked, with the stalk up to 10 cm and the plant up to 40 cm high. The rhizome is stout
and creeping. The fruits are globular and seeds are scarlet in colour. The plant shows wide variation in
different parts of its range.
Uses:
The plant finds its use in Ayurveda. The roots are analgesic, anti-phlogistic, antipyretic,
antispasmodic, anthelmintic, anti-tussive, depurative, febrifuge and narcotic. A decoction of
the roots is used in the treatment of poisonous snakebites, boils and ulcers, diphtheria and
epidemic Japanese B encephalitis. A paste of the roots is used as a poultice to treat cuts and
wounds. The juice of the roots has been used as an anthelmintic. The whole plant is a
febrifuge. The roots have shown antibacterial action against Bacillus dysenteriae, B. typhi, B.
paratyphi, Escherichia coli, Staphylococcus aureus, Haemolytic streptococci, Meningococci
etc.
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Uses in China
"P. polyphylla is a folk medicinal plant in the Indian Himalayan Region, traditionally used against
analgesic, antibacterial, antiphlogistic , antispasmodic, antitussive, any poisonous bites, burn, cut or
injury, depurative, detoxification, diarrhoea, dressing, dysentery, febrifuge, fever, gastric, gastritis,
intestinal wounds, narcotic, poisoning, rashes or itching, scabies, skin diseases, sleeplessness, snake
bite, stomach pain, typhoid, ulcer and wounds (Farooquee et al. 2004; Maity et al. 2004; Tiwari et al.
2010; Jamir et al. 2012; Lalsangluaii et al. 2013; Pfoze et al. 2013; Mir et al. 2014; Sharma and Samant
2014). Further Shah et al. (2012) reviewed the various medicinal properties of the P. polyphylla and
categorized the species as the 'jack of all trades'. Several pharmacological properties including antibacterial
, anticancer/anti-tumour, antimicrobial, antiviral, antifungal, antioxidant, cytotoxic, steroid saponin etc.
(Khanna et al. 1975; Ravikumar et al. 1979; Singh et al. 1980; 1982; Zhou 1991; Yu and Yang 1999;
Mimaki et al. 2000; Lee et al. 2005; Wang et al. 2006; Yun et al. 2007; Zhang et al. 2007; Guo et al. 2008;
Yan et al. 2009; Xuan et al. 2010; Zhao et al. 2010; Chan et al. 2011; Wang et al. 2011; Zhu et al. 2011;
Kang et al. 2012; Li et al. 2012; Zhao et al. 2012; Shen et al. 2014) have been reported from the rhizomes
of many species of the genus Paris. "
Botanical Name: Paris polyphylla
Description: Glabrous herb, leaves 4-9, shortly stalked, lanceolate, 7.5-15 cm long, pointed, petioled. Flowers stalked, in the
centre yellow-green perianth.
Uses: Rhizome acts as depressant on carotid pressure, myocardium and respiratory movements. It produces
vasoconstriction in kidney, but vasodilation in spleen and limbs ad stimulates isolated intestines.Rhizome is
anthelmintic and its powder is used as tonic.
References: A compendium of Medicinal Plants in Nepal by Sushim Ranjan Baral and Puran Prasad Kurmi (October' 2006)
ys
The herb comes also with the names Rhizoma Paridis , Paris Polyphylla Smith var. chinensis (French) Hare (chin.:
hua chong lou ), Paris polyphylla Smith (chin.: qi ye yi zhi hua ). It belongs to trilliaceae family.
Polyphylla is broad-leaved translates to many leaves many(poly) leaves(phyla) and is justified by its shape. It is
a perennial plant that has a preference to woodlands, forests, bamboo forests, thickets, grassy or rocky slopes
and streamside. The altitude ranges from 100 to 3500meters in western China. It is met in East Asia, China and
Himalayas. The plant can reach up to 1m height. It brings hermaphrodite flowers (both male and female) but it is
not self fertile. They bloom from July to August.
It is bitter, cold and slightly toxic.
Nanjing University in corporation with the oncology department of Drum Tower Hospital
(China), conducted an in-vitro anticancer research to investigate the activity of aqueous
extracts and ethanol extracts of fifteen traditional Chinese medicines on human digestive
tumor cell lines. The outcome of this study suggested that traditional Chinese medicine, and Paris
polyphylla Smith in particular, might have potential anticancer activity on digestive cancer and its mechanism
needs further study.
Another study has justified the traditional use of the herb for insect bites, as it has proven the existence of
tyrosinase inhibitory effect and antileishmanial constituents from the roots of the herb. Those are attributed
mostly
to
diosgenin
saponins.
A number of diosgenyl saponins of Paris polyphylla were explored in another research, which was found to
possess immuno-stimulating properties. There was a significant enhancement in phagocytic activity for certain
saponin concentration.
A different study shows how effective can be a synergy between Paris polyphylla and Panax ginseng. Two isolated
oligosaccharides of the former herb presented stimulation in the saponin production of the other herb, enhancing
thus its therapeutic value. The result also suggested that those two oligosaccharides could have plant growthregulatory
activity
in
plant
tissue
cultures.
time
dependent
manner.
Researchers from Japan presented that the methanolic extract from the rhizomes of Paris polyphylla SM. var.
yunnanensis (FR.) H-M. was found to potently inhibit ethanol(and/indomethacin )-induced gastric lesions in rats.
A research carried out by the Naujing Pharmaceutical University in China reported the analgesic and sedative
actions of Rhizoma Paridis. All of the 6 experimented species and varieties in common use were effective. Among
them Paris polyphylla var. chinensis, P. polyphylla var. yunnanensis had more potent analgesic action. Sedative
action of P. fargesii, P. polyphylla var. chinensis, P. thibetica is also strong. In addition, pariphyllin A and gracillin
were also used in the experiment.
In China a biochemistry research has exploited the antimutagenic activity of 36 herbal extracts from anticancer
drugs in Chinese medicine. This work presented that along with other four herbs (Actinidia chinensis P., Artemisia
lavendulaefolia DC., Prunella vulgaris L.,. and Ampelopsis brevipedunculata T), Paris polyphylla , contains
antimutagenic factors against both picrolonic acid- and benzo[a]pyrene-induced mutation.
are
10
main
saponins
and
non
saponin
ingredients
extracted
from
Paris
Polyphylla.
Glycosides are the bioactive components of many famous Chinese medicines. C27-steroid Hemostatic
saponins were found in Paris polyphylla.
Mechanistically, polyphyllin D dissipates the mitochondrial membrane potential, induces a down regulation of
anti-apoptotic Bcl-2 expression and an up-regulation of pro-apoptotic Bax expression, and activates caspase-9.
These results suggest that polyphyllin D elicits apoptosis through mitochondria dysfunction. This action
provides novel insights that polyphyllin D could serve as a candidate in breast cancer treatment. Paris Pollyphylla
is being used in hospitals along with other herbs in conjunction with conventional drugs for the treatment
of lung and breast cancers.
Dosage
If used internally use from 4.5 to 9grams daily in decoction form.
For external use, appropriate quantity to be ground into powder with water or apply mixed powder with vinegar
and then apply to affected parts.
Warnings contraindications - reactions
Paris Polyphylla is generally safe. However, Pregnant or lactating women should refrain from using the herb
unless otherwise stated by their GP.
As with all herbs and nutritional supplements, you should not try any of the above if you are on medical
treatment unless you are told so by a professional healthcare provider.
Paris polyphylla is an important medicinal plant and its rhizome is used mainly for
medicinal purpose for treatment of different diseases. The plant contains saponin
steroids polyphyllin D, dioscin and balanitin. The rhizome is used as antihelmintic,
antispasmodic, expectorant, scabies, rashes, or itching problems, to treat liver
cancer.
RESULTS:
PPSS exerted growth inhibitory effects on A549 cells, and effectively inhibited A549 cell adhesion, migration and
invasion in a concentration-dependent manner. Western blotting and gelatin zymography analysis revealed that
PPSS inhibited the expression and secretion of MMP-2 and MMP-9 in A549 cells.
CONCLUSIONS:
PPSS has the potential to suppress the migration, adhesion and invasion of A549 cells. PPSS could be a potential
candidate for interventions against lung cancer metastases.
Seed - best sown as soon as it is ripe in a cold frame. The seed can
be stratified and sown in spring but will then be slow to germinate. When large enough to
handle, prick the seedlings out into individual pots and grow them on in a cold frame for
their first winter. Plant them out in late spring or early summer. Division - best done in
spring but it can also be done in autumn. Another report says that division is best carried out
in the autumn or late winter because the plants come into growth very early in the year.
Cultivation of the herb:
Crowfoot
Latin name: Aconitum bisma (Buch. Ham.) Rapaics (Ranunculaceae), A.
palmatum D. Don
Sanskrit/Indian name: Prativisha, Bakhma
General information:
Crowfoot is a bitter herb, found in Sikkim, Nepal, and across the Himalayan terrain.
Used in conjunction with Long Black Pepper, it is a potent remedy for bowel spasms,
diarrhea and vomiting. It is regarded as a valuable tonic and a digestive.
Therapeutic constituents:
Crowfoot contains the alkaloids vakognavine, palmatisine, vakatisine, vakatisinine and
vakatidine, which render the herb its therapeutic properties (Indian Medicinal PlantsAn Illustrated
Dictionary, C.P.Khare. 24. 2007).
A herbal concoction of Crowfoot and Long Black Pepper is effective in treating gastrointestinal
disorders.