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Gangrene is the death of tissue, often resulting from an obstruction in the blood supply to

the tissue. The blood that feeds your tissues provides oxygen, nutrients that feed your
cells and immune system, without a proper blood supply, your cells can't survive.
Gangrene most commonly affects the extremities, including your toes, fingers and limbs,
but can also occur in the muscles and in internal organs.

Types of Gangrene and Its Treatments

Three Major Types of Gangrene:

a. Dry gangrene is a condition that results when one or more arteries become obstructed,
in this type of gangrene, the tissue slowly dies because of inadequate or no blood supply.
This occurs mostly in the extremities and it may develop in people with diabetes or
advanced hardening and narrowing of the arteries. It may also develop after prolonged
exposure to freezing temperatures.

Symptoms: In dry gangrene, the tissue first becomes bluish and they feel cold to
the touch. As time progresses, a line of demarcation appears between the healthy
and devitalized tissue, which becomes dry and black. Eventually, there may be a
separation of the dead tissue from the living tissue, with spontaneous amputation
of the involved extremity. If the gangrene does not affect an entire extremity, the
gangrenous area may separate and slough off, leaving an ulcer in the skin.
Treatment: Treatment of this type of gangrene is aimed at improving circulation
to the affected area. This may be accomplished with drugs or through the surgical
removal of the obstruction.

b. Moist, or wet, gangrene is caused by certain bacterial infection. It can develop

following a severe burn, frostbite or injury. When blood flow stops, bacteria begin to
invade the muscle and thrive, multiplying quickly without interference from the body's
immune system. It often occurs in people with diabetes who unknowingly injure a toe or

Symptoms of Moist or Wet Gangrene: The affected area becomes swollen,

discolored, and often foul smelling.
Treatment: Administration of antibiotics and sometimes the surgical removal of
the dead tissue to keep the infection from spreading.

c. Gas gangrene is an infection caused by certain bacteria of the genus Clostridium.

These bacteria live in the soil and thrive in an atmosphere that is low in oxygen. The huge
majority of gas gangrene cases occur as complications of bad wounds, particularly ones
that are contaminated with dirt.

Symptoms: After an incubation period of one to four or five days, the affected
tissue is swollen, painful and cold. A watery, brownish, foul-smelling fluid drains
from the wound, and little bubbles of gas develop in the tissues.
Treatments: Gas gangrene is often treated with the antitoxin for clostridium. In a
number of cases, amputation may have to be used to keep the infection under
control. Severe cases have been treated by keeping the patient in an oxygen-rich
atmosphere, as in a hyperbaric chamber. In hyperbaric oxygen (HBO) therapy the
patient is placed in a pressurized chamber and receives 100% pure oxygen to
breathe. This has been shown useful in inhibiting the production of toxins in gas
gangrene and for getting oxygen quickly to tissues.