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Fleurette Soliven

Simulated Diffusion
Phis 309; Fall 2014
Quantitative Physiology

Fleurette Soliven

Section One
Flow is comparable to the current in Ohms law because both concepts have three
integral factors that dictate how it is measured. Flow can be represented by an electric
current: both are measurements of some particle moving per unit of time. The equation
governing electric current is as follows: I = (1/R) V(Current is equal to the inverse of
resistance multiplied by the difference in voltage). This bears a resemblance to the
equation for flow which states Q = PC (Flow is equal to the permeability multiplied by
the difference in concentration. In both equations, there is some factor hindering the
movement of electrons, which in Ohms law is the resistance, and in flow is causing an
imperfect permeability. There is also some concentration of particles causing flow to
occur in the first place, or voltage in electrical settings and concentration in diffusion.
Figure 1: SPICE Voltage Graph Two Compartment Model

Figure 2: SPICE Voltage Graph Two Compartment Model 1000 Csource

Graph Analysis:
From the resulting SPICE simulations, Figure 1 shows the graph reaching a 50V
equilibrium at approximately 1.75s. When the initial condition for the capacitance is
changed from 100 to 1000, neither the voltage nor the time were affected. From this it
can be assumed that the current was affected, increasing by a factor of 10 like the
capacitance.

Fleurette Soliven

Figure 3: Ten Compartment Model (Ca)


(see attached sheet)
Calculating the resistance for Protein:
Area
= 7.85E-5 cm
Thickness
= 2.5 m
Diffusion Coefficient = .15E-5 cm/s
1/R = A/x
R = x/DA
R = 2.5 m / (.15E-5 cm/s)( 7.85E-5 cm)
R = 2.12E7
Figure 4: Ten Compartment Model (K)

Figure 5: Table lnC for Ca at 4s, 6s, 8s, and K at 4s



1
2
3
4
5
6
7
8
9
10
11

Ca 4s
Ca 6s
Ca 10s
K 4s
3.103105762
2.938367956
2.712772367
3.425467141
2.904767638
2.920739295
2.633901202
2.469793012
2.609996261
2.60984918
2.515435855
1.207167695
2.220724067
2.348609531
2.357262654
-0.296779327
1.741167683
2.024193067
2.158599242
-1.9975077
1.174646975
1.637053079
1.91706966
-3.862899563
0.52532007
1.187538498
1.626884826
-5.868892995
-0.205188217
0.670390193
1.272285445
-7.997025342
-1.025229865
0.05921186
0.810040932
-10.2601625
-2.031680478
-0.780013114
0.077886539
-12.56991608
-17.51230122
-21.83853761
-13.84701774
-23.34990657

Fleurette Soliven

The Equation:
Js = D (CL CR)
x
This states that the diffusion coefficient is equal to the flux (denoted by Js) times the
change in distance divided by the slope of ln(C).
Figure 6: Plot ln(C) vs x for Ca
5
y = -0.2735x + 3.3125
0
1

16

25

36

49

64

81

100
y = -0.4064x + 3.7971

y = -0.5664x + 4.2168

-5

4s2
-10

6s3
8s4

-15

-20

-25

The slopes are as follows:


4s: -.274
6s: -.406
8s: -.566
Figure 7: Plot ln(C) vs x for K
10
5
0
-5

16

25

36

49

64

81

-20
-25

121
K 4s

-10
-15

100

y = -1.8041x + 6.3473

Fleurette Soliven

Discuss:
If the radius of the muscle cell was halved, x would be half as large, thereby doubling
the flux, unless either the diffusion coefficient or the change in concentration was halved
as well.