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BIOLOGY
Central Dogma of Molecular Biology?
The central dogma of molecular biology
deals with the detailed residue-byresidue
transfer
of
sequential
information.
It
states
that
such
information cannot be transferred back
from protein to either protein or nucleic
acid. Francis Crick, 1970
tRNA non-coding RNA but extremely related with the central dogma
rRNA non-coding RNA but extremely related with the central dogma
snRNA small nuclear RNA
<200bp length.
Five important members: U1, U2, U4, U5 and U6.
Together with some peptides they form the spliceosome, a RNP directly
responsible for mRNA processing through mRNA splicing.
Self-splicing introns
They are guide RNA for the modification of others RNA molecules.
Hundreds of different snoRNAs.
Responsible for rRNA, tRNA and snRNA chemical modifications.
These modifications include methylation and pseudouridylation.
miRNA microRNA
These ncRNA are not directly related with the central dogma. They are
related with regulation (sRNA(asRNA) and miRNA) and defense (siRNA)
Enzymes:
Ribozymes