Case 1 Craniopharyngioma

1. Explain definition, general concept of classification, MoA, general

pathophysiology of hormone disorder
2. Explain the hierarchy of hormone and regulation of hormone secretion
(physiology)
3. Describe endocrine disorder in general (physiology)
4. Explain the origin (embryology) of hypophysis and hypothalamus
(Biomedical)
5. Describe anatomy, topography, and pathway of hypophysis and
hypothalamus (anatomy)
6. Describe histological part and cell type of hypophysis, hypothalamus
hypophyseal system (histology)
7. Explain the physiology of growth hormone (Physiology)
8. Explain the physiology of normal growth and puberty (pediatric)
9. Explain how non-endocrine factor (genetic, socioeconomic, psychologic
factor and chronic disease) influence growth (pediatric)
10. Explain how endocrine factor and hormone such as GH, insulin, growth
factor,IGF-1, steroid, and thyroid hormone and other growth factor
influence growth and puberty (physiology)
11. Explain the regulation of growth hormone secretion (HPT tissue axis)
12. Explain regulation of the steroid secretion (HPG axis)
13. Explain growth disorder / diorder of growth
14. Describe the progree of puberty: development of secondary sexual
maturation (Tanners stage), measurement of phallus and testicular
volume (Pediatric)
15. Describe disorder of puberty (precocious puberty, delay puberty,
hypogonadism (pediatric)
16. Making differential diagnosis of short stature: define diagnosis of
growth hormone deficiency and gonadotropin deficiency and identify
the etiology
17. Describe how hormonal substitution could overcome the problem
(pharmacology)
18. Describe the etchical issue of this case (BHP)
19. Explain the autonomy of teenager patient in medical decision making
(BHP)
20. PHOP, CRP, BMP
Case 2 Graves disease

1. Explain the origin (embryology of thyroid gland (BioMed)

2. Describe anatomy, topography and vasculature of Thyroid Gland
(Anatomy)
3. Describe histological part and cells type of the Thyroid Gland
(Histology)
4. Explain the physiology of Thyroid Gland (Physiology)
5. Classification of anti thyroid agent (Pharmacology)
6. MOA related to pharmacological intervention of Propylthiouracil
(pharmacology)
7. Pharmacology of PTU related to clinical aspect (DOA, Half life, drug
administration) (Pharmacology)
8. Adverse effect of PTU (Pharmacology)
9. Contraindication of PTU (Pharmacology)
10. Dosage of PTU (Pharmacology)
11. Select and prescribe the appropriate drug of antithyroid
(Pharmacology)
12. Patient education in prescribing PTU (Pharmacology)
13. The role of propanolol in the management of thyrotoxicosis
(Pharmacology)
14. The difference between Propylthiouracil and Carbimazole
(Pharmacology)
15. Evaluate the duty of a doctor to explain the risk of honestly (BHP)
Case 3 Hypoparathyroiditis and hypocalcemia
1. The anatomy and histology of parathyroid gland
2. The structure of parathyroid hormone (PTH)
3. The synthesis, regulatory mechanism and secretion of PTH
4. Transport in circulation, action and metabolism of PTH
5. The biologic effect of PTH on calcium and phosphate metabolism
6. The mechanism of action of PTH
7. Factor contribute to calcium metabolism
8. The various parathyroid disorder
9. Hypoparathyroidism and hypocalcemia: causes and pathogenesis;
clinical pictures, lab finding, and principles of management
10. Hyperparathyroidism and hypercalcemia: causes and pathogenesis;
clinical pictures, lab finding, and principles of management

11. The role of calcium supplementation in hypoparathyroid patient

(pharmacology)
12. Pharmacokinetic of calcium preparation in related to clinical aspect
(DOA, Half life, drug administration
13. Adverse effect of calcium supplementation
14. Contraindication of calcium supplementation
15. Dosage of calcium supplementation
16. Select the appropriate form of calcium supplementation
17. Proscribe calcium supplementation
18. Patient education in prescribing calcium
19. Explain the difference between the occurrence of foreseen risk,
unforeseen risk, and malpractice case
Case 4 Cushings syndrome
1. Describe the embryology, anatomy, and physiology of adrenal Gland
2. Explain steroidogenesis: biosynthesis of cortisol and adrenal
androgens: effect of ACTH on adrenal cortex and steroidogenesis
3. Explain the HPA axis
4. Describe transport of cortex adrenal hormone
5. Explain the steroid signal transduction
6. Explain the biologic effect of glucocorticoid, mineralcorticoid, and
adrenal androgen
7. Explain the general concept of endocrine system / hormone disorder
and disorder of adrenocortical insufficiency (primary and secondary)
8. Describe the evaluation and basic principle of adrenocortical
insufficiency
9. Describe the definition, classification and epidemiology of Cushings
syndrome
10. Describe the main cause of Cushings syndrome
11. Describe the pathogenesis and pathophysiology of Cushings syndrome
12. Explain the clinical characteristic (including psychiatric sign and
symptoms) of Cuschings syndrome
13. Explain diagnostic tools of diagnose Cushings syndrome
14. Give treatment of Cushings syndrome
15. Explain the advantages and disadvantages for long term usage of
corticosteroid
16. Classification of corticosteroid

17. MOA related to pharmacological intervention of corticosteroid

18. Pharmacokinetic of corticosteroid related to clinical aspect (DOA, Half
life, drug administration)
19. Adverse effect of corticosteroid and its mechanism
20. Contraindication of corticosteroid
21. Dosage of corticosteroid
22. Select the appropriate drug in Cushings disease and adrenal crisis
23. Prescribe corticosteroid
24. The importance of tapering off corticosteroid
25. The role of antihypertention in Cushings syndrome patient
26. Evaluate doctors duty to be able to communicate properly with patient
from various social and educational background
LO CASE 5
1. Describe anatomy and histology of pancreas gland

2. Explain insulin : synthesis, secretion, action, physiologic action of

insulin on carbohydrate, fat, and protein metabolism
3. Describe the principle of carbohydrate metabolism and its relation to
lipid and protein metabolism
4. Differentiate gluconeogenesis from glycolysis; process and
regulation of glycogenesis & glycogenolysi; and control of blood
glucose
5. Describe the lipid transport; disorder of lipoprotein metabolism;
atherosclerosis process and principle management of disorder
lipoprotein metabolism
6. Explain the secretion and action of glucagon
7. Know and define type 2 diabetes (TD2DM) and epidemiology of
TD2DM
8. Understand and explain the etiology, pathophysiology, and clinical
signs of TD2DM and its chronic complications
9. Explain the metabolic abnormalities in the development of TD2DM
10. Explain the prevention strategies of TD2DM
11. Explain the principles of the management of TD2DM
12. Explain the pharmacological properties of OAD
13. Explain the pathophysiology of chronic complications in TD2DM:
macroangiopathy, microangiopathy and dislipidemia
14. Explain and summarize the prognosis of TD2DM and its chronic
complications
15. Understand the definition of gestational diabetes
16. Understand the effect of diabetes on intrauterine development, and
effect of pregnancy on the diabetic mother, diabetes complications,
and on fetus

17. Define and explain the pathogenesis of gestational diabetes

18. Explain the principles in management od diabetes in pregnanacy
LO Case 6 Diabetes Mellitus Type 1
1. Understand the definition and pathogenesis of Type 1 DM
2. Explain the pathophysiology of Type 1 DM
3. Describe the clinical manifestation of patient with Type 1 DM
4. Explain the principle management of patient with Type 1 DM
5. Understand the influence intercurrent illness and stress hormone in
Type 1 DM patient
6. Understand the pathophysiology of DKA
7. Understand the principle management of DKA
8. Understand insulin induce hypoglycemia
9. Describe the clinical manifestation and principle management of
hypoglycemia
10. Explain the prevention of acute complications of Type 1 DM