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immediately available.
4. Check BP repeatedly when epinephrine is administered IV during first 5 min, then
q35min until stabilized.
5. Advise patient to report to physician if symptoms are not relieved in 20 min or if they
become worse following inhalation.
6. Advise patient to report bronchial irritation, nervousness, or sleeplessness. Dosage
should be reduced.
7. Monitor blood glucose & HbA1c for loss of glycemic control if diabetic
Atropine
Generic name: atropine.
Trade name: Sal-tropine.
Class: anticholinergic or parasympatholytic agents
Mechanism:
blocks the bradycardia associated with some drugs used in anesthesia such as
halothane.
Indication:
To restore cardiac rate and arterial pressure during anesthesia, when vagal stimulation
produced by intra-abdominal surgical traction causes a sudden decrease in pulse rate
and cardiac action.
Contraindication:
Atropine is contraindicated in patients with narrow-angle glaucoma, hypersensitivity to
anticholinergic drugs, cardiac insufficiency, myocardial ischemia, unstable cardiac status
during acute hemorrhage, GI obstructive disease.
Side effect
Dryness of the mouth, blurred vision, photophobia and tachycardia commonly occur
with chronic administration of therapeutic doses.
Nursing Implication and intervention:
1. Assess for allergies, presence of BPH, glaucoma, tachycardia, MI, CHF, hiatal
hernia,and GI or GU obstruction.
2. Perform baseline assessment of VS and systems overview .
3. Medications should be taken exactly as prescribed to have the maximum therapeutic
effect.
4. Overdosing can cause life-threatening problems.
5. Check with physician before taking any other medication, including OTC medications.
6. Patients should report the following to their physician: urinary hesitancy and/or
retention, constipation, palpitations, confusion, excessive dry mouth or fever.
7. Teach patients to limit physical exertion, and avoid high temperatures and strenuous
exercise.
8. Monitor for therapeutic effects.
Dopamine (Inatropin)
Class
Sympathomimetic
Dopamine is chemically related to epinephrine and norepinephrine. It acts primarily on
alph1- and beta1- adrenergic receptors, increasing systemic vascular resistance and
exerting a positive inotropic effect on the heart. In addition, the actions of this drug on
dopaminergic receptors dilate renal and splanchnic vasculature, maintaining blood flow.
Dopamine is commonly used to treat hypotension associated with cardiogenic shock.
Onset & Duration
Onset:
2-4 min
Duration:
10-15 min
Indications
Hypotension
Low cardiac output states
Contraindications
Tachydysrhythmias
Ventricular fibrillation
Patients with pheochromocytoma
Side effect
Nausea, vomiting, headache, chest pain; dizziness; irregular heartbeat; pain, redness,
or swelling at the injection site.
Digitalis Toxicity
Neurological
Visual Disturbances
Flashing lights
Altered color vision
GI Disturbances
Cardiac Rhythm Disturbances
Hyperkalemia
K and Digoxin both bind to the same site on the sdoium/K pump
Isoproteronol (Isuprel)
Class
Sympathomimetic
Isoproterenol is a synthetic catecholamine that stimulates both beta1- and beta2adrenergic receptors (no alpha-receptor capabilities). The drug affects the heart by
increasing inotropic and chronotropic activity. In addition, isoproterenol causes arterial
and bronchial dilation and is sometimes administered via aerosolization as a
bronchodilator to treat bronchial asthma and bronchospasm. (Because of the
undesirable beta2 cardiac effects, the use of this drug as a bronchodilator is uncommon
in the pre-hospital setting.)
Onset & Duration
Onset:
1-5 min
Duration:
15-30 min
Indications
Hemodynamically stable bradycardias that are resistant to atropine.
Heart blocks with palpable pulse
Contraindications
Ventricular tachycardia
Ventricular fibrillation
Hypotension
Pulseless idioventricular rhythm
Ischemic heart disease
Cardiac arrest
Dobutamine (Dobutrex)
Class
Sympathomimetic
Mechanism : The effects of this drug include positive inotropic effects with minimal
changes in chronotropic activities or systemic vascular resistance. For these reasons,
dobutamine is useful in managing congestive heart failure when an increase in heart
rate is not desired.
Onset:
1-2 min; peak after 10 min
Duration:
10-15 min
Indications
Inotropic support for patients with left ventricular dysfunction
Contraindications
Tachydsrhythmias
Severe hypotension
Side effect:
Headache, nausea or vomiting and restlessness, hypertension, allergic reaction, muscle
cramps or weakness, chest pain, trouble breathing, dizziness.
Nursing implication:
1. Correct hypovolemia by administration of appropriate volume expanders prior to
initiation of therapy.
2. Monitor therapeutic effectiveness. At any given dosage level, drug takes 1020 min to
produce peak effects.
3. Monitor ECG and BP continuously during administration
4. Note: Marked increases in blood pressure (systolic pressure is the most likely to be
affected) and heart rate,or the appearance of arrhythmias or other adverse cardiac
effects are usually reversed promptly by reduction in dosage.
5. Monitor I&O ratio and pattern. Urine output and sodium excretion generally increase
because of improved cardiac output and renal perfusion.
NORADRENALIN
Generic name: Ephedrine sulfate.
Brand name: Levophed.
Class: ACLS ( Advanced Cardiac Life Support)
Mechanism:
Noradrenaline functions as a peripheral pressor and as an inotropic stimulator of the
heart and dilator of coronary arteries.
Indication:
For blood pressure control in certain acute hypotensive states ; myocardial infarction
septicemia ,blood transfusion, and drug reactions.
As in the treatment of cardiac arrest and profound hypotension.
Contraindication:
1. vascular thrombosis
2. hypoxia,
3. hypercapnia
4. volume depletion
5. caution if TCA use ( Tricyclic Antidepressants )
6. caution if MAO-inhibitor use (Monoamine oxidase inhibitor )
Side effect:
Bradycardia, rise in blood pressure, arrhythmias,Anxiety, headache, Respiratory
difficulty.
Assessment & Drug Effects
Monitor constantly while patient is receiving norepinephrine. Take baseline BP and
pulse before start of therapy, then q2min from initiation of drug until stabilization occurs