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CLOXACILLIN
Apo-Cloxi, Cloxapen, Cloxilean,
Novocloxin ,Tegopen
Drug class: Antibiotic
FDA Pregnancy Category: B
Route: Oral
Adult: 250-500 mg 4 times daily.
Child: 50-100 mg/kg in divided
doses every 6 hr.
Parenteral: 500 mg/vial, 1 g/vial,
and 2 g/vial injectable solutions.
USE
Mechanism of action
-Inhibits cell wall
synthesis and causes call
lysis o rdeath in bacteria
that make rigid,crosslinked call wall in several
steps.
CNS: Headache
Therapeutic use:
-Treatment of mild
respiratory tract infections
or localized skin and softtissue infection cause by
penicillinase-producing
staphylococci.
Pharmacokinetics:
Absorption: 3760% absorbed
from GI tract.
Peak: 0.52 h.
Duration: 46 h.
Distribution: Distributed
throughout body with highest
SIDE EFFECTS/
ADVERSE
EFFECTS
NURSING
CONSIDERATIONS
DRUG
CARBENICILLIN INDANYL
Geocillin, Geopen Oral
Drug class: Antibiotic
FDA Pregnancy Category: B
Route: Oral
Adult: PO 382 mg q6h for 10 days
USE
Therapeutic Use:
-Treatment of prostatitis and acute
and chronic infections of upper
and lower urinary tract caused by
susceptible strains of Escherichia
coli, Enterobacter, Enterococcus,
Proteus, and Pseudomonas
species.
SIDE EFFECTS/
ADVERSE EFFECTS
EENT: dry mouth, furry tongue,
and glossitis.
NURSING
CONSIDERATIONS
Gastrointestinal: Nausea,
vomiting, diarrhea, flatulence,
heartburn, abdominal cramps,
rectal bleeding, anorexia, loose
stools, and epigastric distress.
Assess for
drug hypersensitivity, history
of allergy/asthma, severe
illness, N/V, gastric dilatation,
intestinal hypermotility, renal
impairment,
pregnancy/nursing status,
and possible drug interactions.
Pharmacokinetics
Absorption: Incompletely
absorbed , 3040% of an oral dose
absorbed from GI tract
Hematologic: Anemia,
thrombocytopenia, leukopenia,
neutropenia, and eosinophilia.
Peak: 0.51 h.
Metabolic: hypokalemia.
Hepatic: Mild elevations of liver
transaminases.
Genitourinary: Vaginitis.
Elimination: Urine
Other: Hyperthermia, itchy eyes,