Beruflich Dokumente
Kultur Dokumente
Original Article
Abstract Background Erythroderma may result from different causes and is a rare skin disorder.
Objective Our objective has been to determine the frequency of erythroderma in our
environment, its causes and patient evolution.
Patients and methods We reviewed the clinical features and laboratory profile of 102
patients diagnosed with erythroderma who were treated in our department over a 10 years
period (1993-2003).
Results The mean age at diagnosis was 48.6 years with male to female ratio of 1.9:1. The
most common causative factors were dermatoses (55.9%), followed by drug reactions
(29.4%), idiopathic cause (11.8%) and malignancies (2.9%). Apart from erythema that was
present in all patients, itching was the most common complaint (64.7%), followed by
generalized scaling (56.8%) and chills (30.3%). Most common physical findings were
generalized scaling, onychopathy, pitting edema and lymphadenopathy. Skin biopsy was
performed in 54 cases with clinical correlation in 36 patients (66.4%).
Conclusions As in other series, preexisting dermatoses were the most common cause of
erythroderma. Many of skin biopsies of idiopathic erythrodermic patients showed drug
reactions without any history of drug consumption, showing that drugs were suspected as the
cause in many patients that were overlooked by them. Drug-related erythroderma had the best
prognosis.
Key words
Erthroderma, psoriasis, eczema, drugs.
Introduction
Erythroderma or exfoliative dermatitis, first
described by Hebra in 1868, is an
inflammatory disorder in which erythema
and scaling occur in a generalized
distribution involving more than 90% of the
body surface.1 It doesnt have age or sex
Address for correspondence
Dr. Farideh Jowkar, Assistant Professor,
Department of Dermatology,
Faghihi Hospital, Zand Street, Shiraz, Iran
Ph # +987112300049
E-mail: jowkarf @sums.ac.i
130
Malignancy
3
1
Druginduced
2
9
Total
number
21
30
2
_
8
_
28
6
Drug
eruption
Pityriasis
lichenoid
Non
specific
Total
23
10
9
Table
4
Diagnostic
erythroderma (n=102).
entities
n
Preexisting
dermatoses
Psoriasis
Seborrheic
dermatitis
Contact dermatitis
Pityriasis
rubra
pilaris
Atopic dermatitis
Scabies
Drug reaction
Allopurinol
Carbamazepin
Penicillin
Phenytoin
Phenobarbital
Ceftriaxone
Cefixime
Amitryptyline
Unknown drug
Malignancy
Cutaneous
lymphoma
Szary syndrome
Idiopathic
causing
Total
57 (55.9%)
20
3
6
1
26
1
30 (29.4%)
1
17
4
1
1
1
1
2
2
3 (2.9%)
2
1
12
12 (11.8%)
132
Akhyani et al.
(2005)
Present
study
59.8
55.9
16
21.6
29.4
12.5
9
11.3
7.2
2.9
12
6.
9.
7.
8.
10.
References
1.
2.
3.
4.
5.
11.
12.
13.
14.
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134