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CHAPTER

Brandon G. Rocque

122 Sharad Rajpal


Daniel K. Resnick

Postlaminectomy Deformities in the


Thoracic and Lumbar Spine

INTRODUCTION dinal ligament, vertebral body, intervertebral disc, and annu-


lus. Everything dorsal to this, the laminae, facet joints, spinous
Posterior spinal laminectomy is a commonly used approach for processes, supraspinous and interspinous ligaments, ligamen-
the treatment of cervical, thoracic, and lumbar spinal pathol- tum flavum, and facet capsules, is considered the posterior
ogy. Common indications for laminectomy in adults include column.
herniated intervertebral disc, spinal stenosis, and intradural Although the osseous and ligamentous components of the
tumor. In children, laminectomies are often performed for the spine dictate the final position of the spine, the muscles con-
diagnosis and treatment of spinal cord tumors as well as for tribute to the instantaneous spatial arrangement of the verte-
other conditions such as neurofibromatosis and syringomy- brae. In the thoracic spine, the kyphotic curve is determined
elia.11 Although laminectomies are generally considered to be mainly by the osseous structures; in the lumbar spine, the lor-
a safe procedure with few associated complications, they do dotic curvature is determined more by the ligamentous struc-
involve the interruption or removal of stabilizing anatomical tures. At any particular time, the effect of gravity on the spine
elements. The changes associated with laminectomy have been will depend upon the overall sagittal alignment and the loca-
shown by several studies to alter the motion, load-bearing prop- tion of the center of gravity relative to the spine. When stand-
erties, and biomechanical interaction of various spinal compo- ing in a biomechanically neutral position, the anterior and pos-
nents. This leads to the risk of development of a postlaminectomy terior elements are under counter forces to maintain balance.
deformity. In general, the anterior elements are under compression while
Deformity development after laminectomy has long been the posterior elements are under tension. When either one or
recognized as a potential complication following pediatric spi- both of these elements are disrupted, there is potential for
nal tumor removal,7 and therefore much of the literature has development of a kyphotic deformity.15 Gravity tends to accen-
focused on the pediatric population. In adults, the develop- tuate the kyphosis of the thoracic spine and cause a kyphosis of
ment or progression of a spinal deformity has been noted after the lumbar spine because it places a flexion moment on the
decompressive operations for spondylolisthesis in the absence spine. The actual development of an angular deformity is not
of spinal fusion,2 a topic covered elsewhere in this textbook. this simplistic, however, and other contributing factors such as
Cervical postlaminectomy kyphosis is seen in adults with some facet arthropathy, skeletal deficiencies, and neuromuscular
frequency and is also discussed elsewhere in the text. imbalance must be considered. Segmental and regional ana-
Postlaminectomy deformities in the thoracic and lumbar spine tomical structures, such as the rib cage in the thoracic spine,
in adults are rare; these will be discussed in conjunction with the ligamentum flavum, and intervertebral discs are also impor-
pediatric disease. tant. In summary, the spinal column is a three-dimensional
structure under the influence of multiple loading forces that
can, under certain circumstances, result in the development
and progression of a spinal deformity.
ANATOMIC, BIOMECHANICAL, AND The effect of laminectomies on the thoracic spine has not
SURGICAL CONSIDERATIONS been studied as extensively as for the lumbar or cervical spine
likely because laminectomies are less often performed in this
One common biomechanical model of the spine is the three- region and because the rib cage is thought to mitigate the
column model of Denis.5 Although an analysis of the spinal destabilizing effect of the removal of posterior structures.
column in this fashion is relevant for traumatic injuries to the Yoganandan et al, however, did evaluate the effects of a lamine-
spine, it is less helpful for nontraumatic spinal deformities. For ctomy on thoracic spine biomechanics.28 In their experiment,
this purpose, the spinal column is conceptually divided into intact thoracic specimens were compared to specimens with a
two columns: anterior and posterior (Table 122.1). The ante- midthoracic two-level laminectomy. The specimens, it should
rior column consists of all the anatomic elements ventral to the be noted, did not include the rib cage. The ligamentum fla-
posterior longitudinal ligament, including the anterior longitu- vum and spinous processes of the laminae were resected in the

1326

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Chapter 122 Postlaminectomy Deformities in the Thoracic and Lumbar Spine 1327

Two-Column Model for CLINICAL IATROGENIC DEFORMITY


TABLE 122.1 PRODUCTION
Spinal Deformity
Anterior column In 1959, Haft et al published their experience after resection of
Anterior longitudinal ligament spinal cord tumors in children.7 In this series, 10 of the
Vertebral body
30 patients who underwent laminectomy for tumor removal
Intervertebral disc and annulus
Posterior column
developed kyphoscoliosis. Although their manuscript did not
Laminae specify the exact levels of the laminectomy, the majority of
Facet joints tumors were located between the cervicothoracic and the thora-
Facet capsules columbar junctions. A confounding factor was a high mortality
Spinous processes rate related to the primary disease process that lead to limited
Supraspinous and intraspinous ligaments follow-up. As the surgical treatment of children with spinal
Ligamentum flavum tumors progressed over time to more aggressive approaches
with better microsurgical techniques and better postoperative
therapeutic options, the risk of postoperative deformity was
laminectomy spines, but the integrity of the facet joints was noted to be quite significant. In 1965, Tachdjian and Matson
maintained. The specimens with laminectomy defects were reviewed a series of 115 children who underwent spinal tumor
relatively more flexible, had a lower load carrying capacity, resection followed, in some cases, by radiation. Ninety-one of
and failed at a significantly lower level of applied force. The these tumors were located at or below the cervicothoracic junc-
degree of deformation at failure was similar in the laminecto- tion and 31 patients (34%) developed postoperative scoliosis
mized group and the intact group, however, indicating a com- while 30 patients (33%) developed postoperative kyphosis.23
mon mode of failure among the groups but a lower threshold Factors that the authors provided in explanation for the devel-
in the laminectomized specimens. The authors furthermore opment of postoperative deformity included spinal instability
found that the laminectomized spines failed one or two levels after laminectomy, muscle weakness, tumor recurrence, lack of
rostral to the level of the laminectomy, suggesting a local postoperative spinal support, and postoperative radiotherapy.
increase in stress at that end of the decompression. Their Combining the cases from earlier reports, Lonstein con-
results suggest that two-level laminectomy in the thoracic spine cluded that the incidence of spinal deformity in children after
decreases the strength and stability throughout the loading laminectomy is approximately 49%.11 He postulated that the
range. These results have to be considered in light of the clini- most important factor in deformity development is the loss of
cal situation, where the sternum and rib cage contribute addi- the posterior ligamentous complex, including the supraspinous
tional stability. ligaments, ligamentum flavum, interspinous ligaments, and
Interruption of other spinal elements, in addition to the facet joint capsules. In addition, he hypothesized that the
lamina, can also contribute to deformity development. During paraspinal musculature is often weakened by either the tumor
posterior decompressive laminectomies, it is not uncommon to or operation, and therefore muscle tone is decreased. This in
include a partial or complete facetectomy to help relieve neu- turn leads to poor maintenance of posture and spinal align-
ral compression. Several studies have assessed the contribution ment. He identified two different types of postlaminectomy
of the facet complex to spinal stability, especially in the lumbar kyphotic deformities: a sharp-angled kyphosis and a gentle
spine.1,8,10,18,24 These authors have utilized several biomechani- sloping kyphosis. Lonstein hypothesized that the key factor to
cal models of the lumbar spine to assess the impact of varying differentiating these two is the integrity of the facet joint.
degrees of lamina and facet disruption on the spines response The pathogenesis of postoperative deformity development
to several different loading forces. in children is unique from adults and is thought to result from
The conclusion drawn from these biomechanical and wedging of the ventral part of the vertebral body. Prior to adult-
experimental studies has been that while there is some decrease hood, the vertebral bodies are incompletely ossified. After
in the overall stiffness and strength of the spinal column from laminectomy, axial loading forces lead to higher stress on the
laminectomy, the risk of postoperative deformities is greater incompletely ossified anterior portion of the vertebral body.
with facet destruction. Increasing facet interruption from par- This places increased strain on the remaining posterior liga-
tial unilateral removal to total bilateral removal also results in mentous elements, including the intervertebral ligaments. In
an increase in the motion of the studied segment. Increasing children, these ligaments have higher viscoelasticity and there-
compromise of the facet and facet capsule leads to an increased fore stretching can occur, thereby increasing the stress on the
risk of postoperative deformity. In an experimental model of vertebral body and leading to a vicious cycle.26 Eventually, the
the adult spine, laminectomy without facet removal has only a growth of the anterior portion of the vertebrae is slowed accord-
minor effect on the biomechanical properties of the tested ing to the HueterVolkmann principle resulting in progressive
segments. wedging of the vertebrae. Factors believed to predispose chil-
Skeletal deficiencies other than of the facet joints that can dren to instability include increasing numbers of levels involved
also produce deformity include compromise of the anterior in the laminectomy and cervical or high thoracic involvement.
column by tumor or surgical resection. This can add to the risk In children, a deformity may develop suddenly or gradually
of instability following laminectomy and contribute to the after laminectomy, and it may progress significantly during the
development of a deformity. Other potential factors that may adolescent growth spurt.25 Although scoliosis can also occur
contribute to spinal instability at the time of laminectomy either as the primary deformity or in association with kyphosis,
include a concomitant discectomy or performing the decom- kyphosis is the most common deformity following laminec-
pression adjacent to a prior fusion.6 tomy.25 Peterson describes three types of postlaminectomy

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1328 Section XI Kyphosis and Postlaminectomy Deformities

kyphosis: (1) instability after facetectomy, (2) hypermobility


Factors that Increase Risk of
between vertebral bodies associated with gradual rounding of
TABLE 122.2 Postlaminectomy Spinal
the spine, and (3) wedging of vertebral bodies caused by growth
disturbances.17 Similar to the kyphus described by Lonstein, Deformity
kyphosis due to instability after facetectomy will tend to be Facet joint disruption
angular and sharp, usually occurs in the immediate or early Spinal cord tumor
postoperative period, and can be associated with loss of neuro- Radiation exposure
logical function. When the facet complex has been preserved, Involvement of cervical or high thoracic spine
the kyphosis tends to be round and gradual and increases slowly Preoperative kyphosis or scoliosis
over time as a result of the ongoing stress to the remaining pos- Age less than 15 years
Increasing number of laminectomies
terior elements with the development of wedging of the verte-
bral bodies.
In concordance with biomechanical principles and the
investigational findings detailed above, facet injury is thought Because of the high incidence of deformity following thoracic
to produce the greatest predisposition to deformity in adults. laminectomy in children, however, efforts to prevent deformity
In a retrospective study comparing children and adults all in these patients may be warranted. Similarly, adults with preex-
under the age of 30 years, 33% of the children suffered postop- isting or potential iatrogenic biomechanical instability or defor-
erative deformity compared with only 8% of the adults.16 It is mity may benefit from concomitant stabilization at the time of
important to note that deformities may develop in a delayed decompression. Considerations for determining preoperative
fashion, mandating long-term follow-up of patients after a mul- biomechanical instability include careful analysis of the intrin-
tilevel laminectomy. In one series, the time to development of sic elements of the spine as well as the anterior and posterior
first signs of kyphosis was 2 to 74 months, with several first stabilizing elements. This may include evaluating the adequacy
noted as late as 6 years following surgery.27 of anterior bone quality (osteoporosis) and the presence of
The risk for postlaminectomy kyphosis is dependent on the preoperative deformity.
patients age and the level of the laminectomy. A retrospective Initial attempts at bracing at the first sign of deformity were
study of 58 patients who underwent multilevel laminectomy marginally successful, and the kyphosis often progressed. Once
over a 10-year period compared patients younger than 15 years the deformity has occurred and progressed, bracing becomes
with patients between 15 and 25 years of age.27 Forty-six percent ineffective in preventing further progression.11 In 1976,
of patients younger than 15 years developed a deformity in Raimondi et al introduced the concept of the osteoplastic lami-
comparison to 6% of those aged 15 to 25 years. In the thoracic notomy in an attempt to decrease the incidence of postopera-
spine, 36% of young patients developed a deformity, while in tive spinal deformity in children.21 This technique has since
the lumbar spine no patient developed deformity. No patient been widely adopted in the pediatric population. The tech-
in either group underwent facetectomy or postoperative radia- nique involves either the replacement of the laminae after their
tion therapy. A significant number of patients from both groups removal or hinging them to the side, top, or bottom like a
were lost to follow-up. door to expose the spinal cord. The laminae are either sutured
Ofluoglu et al recently published their retrospective analysis into place in children or fixed into place in adults using a
of the effects of laminectomy on spinal stability in the manage- screwplate system. Several different techniques for osteoplas-
ment of adults with degenerative lumbar stenosis.13 The aver- tic laminotomy have been described in the literature but are
age patient age was 58 years, and the average follow-up time was beyond the scope of this chapter.
23 months. In all cases, laminectomy was completed with pres- The rate of deformity following such procedures has recently
ervation of the facet joints bilaterally. Seven patients underwent been described in a large cohort study.20 In a retrospective
single-level laminectomy, 20 patients underwent two-level review of 70 pediatric patients treated with osteoplastic lamino-
laminectomy, and 10 patients underwent three-level laminec- tomy, results were compared with the cumulative results of pre-
tomy. Of the 34 patients with stand-alone laminectomy, only viously published series involving more than 10 patients (the
one patient (3%) developed segmental instability, following a details of several having already been noted above). Laminotomy
two-level laminectomy. Postacchini et al, in a retrospective study varied from 2 to 13 levels, and all but 6 patients involved the
designed to compare multiple-level laminotomy to laminec- thoracic, thoracolumbar, or lumbar spine. Good results were
tomy, noted the development of marked segmental instability defined as no deformity development or a lack of progression
in 3 out of 32 patients following laminectomy versus none with of a previous deformity. Twenty-seven percent of patients fol-
laminotomy.19 They note, however, that these three patients lowing laminotomy were found to have a new or progressive
had either preoperative lumbar scoliosis or spondylolisthesis, deformity. This is compared with 46% of the 330 cases reported
both known risk factors for deformity development. Please see in the literature, many of which excluded malignant tumors,
Table 122.2 for a summary of factors that may increase risk of and operation on the cervical spine, factors that would likely
postlaminectomy spinal deformity. increase the incidence of deformity. It has now become com-
mon practice to perform osteoplastic laminotomy rather than
laminectomy in patients younger than 15 years.
PREVENTION In their guidelines for performance of fusion procedures in
adult patients with degenerative disease of the lumbar spine for
The adult patient without spondylolisthesis or preoperative stenosis without spondylolisthesis, Resnick et al acknowledged
deformity is at little risk for developing kyphosis following that there is no treatment standard.22 However, they were able
single- or double-level laminectomy if the facets remain intact. to recommend the use of posterolateral fusion for patients with

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Chapter 122 Postlaminectomy Deformities in the Thoracic and Lumbar Spine 1329

Operative Candidate

Patients Age >15 Preexisting Spinal Instability or Deformity

15 y Yes No

Laminoplasty Possible? No Consider Fusion Yes Aggressive Facetectomy


or 5 Levels
Figure 122.1. Algorithm for selection of operative
Yes
patients in whom concomitant fusion procedure should
No
be considered. Each patient should be considered on
an individual basis, however, with the following algo- Fusion
rithm provided only as a general guideline. Not Necessary

spinal instability or deformity (scoliosis or kyphosis) undergo- kyphosis from 84 to 49 using posterior instrumented fusion
ing decompression for lumbar stenosis. Fusion was also recom- with anterior grafting. There were no cases of pseudarthrosis
mended as an option in cases where aggressive facetectomy was and an average progression of kyphosis of 5 in the follow-up
anticipated. In patients with lumbar stenosis in whom there is period (mean 5 years). Combining posterior instrumentation
no evidence of preexisting spinal instability and low likelihood to provide corrective force and anterior bone graft to provide
of iatrogenic instability from aggressive facetectomy, posterolat- a better environment for bone healing therefore appears to be
eral fusion is not recommended. one effective strategy.
As noted above, several authors have already demonstrated
that removal of the interspinous ligament and facetectomy of
greater than 50% affect the motion of the intervertebral joint
and induce additional stress at the other spinal components.1,8,18
Therefore, in general, it is important to preserve as much facet
joint and pars interarticularis as possible at the time of surgery
because destruction of these structures will lead to an increased
rate of spondylolisthesis postoperatively.9 Figure 122.1 illus-
trates an algorithm for selection of patients who would likely
benefit from osteoplastic laminotomy rather than laminectomy,
and for patients in whom concomitant fusion procedure should
be considered.

TREATMENT
Treatment of postlaminectomy deformity is not trivial and thus
it is best to prevent its development. Details of operative correc-
tion of spinal deformities are covered extensively elsewhere
and will only be covered briefly in this chapter. Options for cor-
rection of a postoperative deformity depend on the extent of
the previous bony removal. Early studies, prior to pedicle screw
availability, focused on anterior fusion using a variety of tech-
niques.3,7,12 However, posterior instrumentation and fusion
techniques have improved tremendously to become the cur-
rent treatment of choice in many situations. When a posterior
fusion construct is used in isolation, the instrumentation is sub-
ject to three-point bending and distraction forces. These forces
are disadvantageous for graft healing. The suboptimal environ-
ment for bone healing is thought to contribute to a rate of A B
pseudarthrosis as high as 57% and failure to maintain correc-
tion.11 In a retrospective review of 12 patients treated for post- Figure 122.2. (A and B) A 25-year-old woman underwent a T7-10
laminectomy for resection of an intramedullary low-grade astrocy-
laminectomy kyphotic deformity, Otsuka et al found posterior
toma. A few years later, she developed gradually worsening low back
instrumentation alone to be an effective treatment.14 All and thoracolumbar pain relieved with recumbency and a progressive
patients had previously undergone laminectomy of three to clinical deformity consisting of thoracolumbar kyphosis and lumbar
seven levels, and all had progressed at least 20 from the point hyperlordosis. Nonoperative management failed to ameliorate her
when kyphosis was identified as a potential problem. Staged symptoms and she subsequently underwent posterior instrumented
anterior and posterior approach was used, but without anterior fusion with posterior column osteotomies for correction of her defor-
instrumentation. The group reports a correction of the mean mity. (Courtesy of P. Angevine.)

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1330 Section XI Kyphosis and Postlaminectomy Deformities

Figure 122.3. (A and B) A 42-year-old man underwent


L2-5 laminectomies for lumbar spinal stenosis. Over a 5-year
period, he developed progressive low back pain and an
inability to stand erect. After failure of nonoperative manage-
ment, he underwent a T10 to pelvis posterior instrumenta-
tion with an L2 pedicle subtraction osteotomy and posterior
fusion. Six weeks later, he underwent a minimally invasive
transpsoas approach for L2-3 interbody fusion. (Courtesy of
A B
P. Angevine.)

Another approach to kyphosis correction is posterior osteot- disrupted in adult patients and at all times in patients younger
omy. Either Smith-Peterson osteotomy (SPO) or pedicle sub- than 15 years.
traction osteotomy (PSO) may be used. Decision as to which
technique to use must be individualized based on the degree of
kyphosis and of sagittal imbalance. One might expect up to
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