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Faculty of Pharmacy
Course Description: This course deals with the study of the intrinsic, formulation, physiologic, and pathologic factors affecting
bioavailability of drugs from drug products. It focuses on drug absorption, distribution, metabolism and excretion and how these
processes are modified by the different factors affecting the presence and action of the drug in the biologic system. Students are
expected to be able to rationalize the design of drug delivery systems in relation to dose, dosage form and clinical efficacy. They are
also expected to explain the construction of a dosing regimen in relation to optimizing therapeutic outcomes.
Leadership and Teamwork Assume leadership roles as appropriate 2.Lead the health care team as
Demonstrate capacity for leadership and teamwork to the work profession and society a specialist in rationalizing
including the ability to motivate others, to be effectively and harmoniously as dosage forms and drug
responsible and reliable members of healthcare teams. delivery systems in clinical
settings
Critical Thinking, Research and Problem Solving Demonstrate critical application of 3. Analyze drug absorption,
Skills principles, theories and processes in distribution, metabolism and
Initiate innovative ideas and methods through pharmacy using logical and systematic excretion through physiologic
research responsive to the changing needs of the methods to provide practical solutions to and mathematical models.
society real-life professional situations. Appraise factors that influence
drug product design and justify
the criteria for drug product
selection in clinical practice.
Productivity and Accountability Generate insights and new knowledge in 4. Design a drug product that is
Develop new knowledge and understanding that pharmacy that will contribute to nation- safe and effective; optimize
will contribute to nation-building and sustainable building and sustainable development patient therapy through
development through the processes of inquiry, through drug designs and development appropriate drug product
research and innovation for the prevention, diagnosis, mitigation selection and customizing
and treatment of diseases of man and disease treatment based on
animals. drug pharmacokinetics
Social and Ethical Responsibility Exhibit Catholic values and moral 5. Integrate Catholic values
Uphold Catholic values and moral principles principles reflective of the Thomasian and moral principles in drug
reflective of a competent, committed and identity as health care professionals in selection and use that
compassionate Thomasian in the formation of the formation of humanely progressive strengthen the therapeutic
humanely progressive and healthy society and healthy society. relationship of patient and
pharmacist.
A. Pharmacokinetic
parameters
Explain the complex systems 1. Drug absorption, distribution, Lecture forum Whats the principle
and events or sequences of metabolism and excretion Reflective lecturing Illustrating concepts and
events and pathways for drug Concept mapping principles
disposition (CILO 3) Work along Activities Categorizing grid
Problem solving learning Defining features matrix
Analyze the LADMERT system 2. Pharmacokinetic Modelling Lecture forum Whats the principle
using applicable physiologic a. Mathematical models Reflective lecturing Illustrating concepts and
and mathematical models b. Physiologic models Concept mapping principles
(CILO 3) Work along Activities Problem sets
Problem solving learning Problem recognition tasks
B. Biopharmaceutic
Consideration
Defend the biological and 1. Mechanism of drug absorption Lecture forum Whats the principle
pharmaceutical consideration 2. Anatomy and physiology of Reflective lecturing Illustrating concepts and
on drug product design and the gastrointestinal tract Concept mapping principles
manufacture (CILO 4) 3. Factors affecting drug Categorizing grid
absorption Defining features matrix
Compare and contrast chart
Unit III: Drug Design and
Bioavailability
A. Drug Product Design
Compare the factors to be 1. Effect of drug product design Lecture forum Whats the Principle
considered in bioavailability and manufacture on drug Reflective lecturing Illustrating concepts and
testing and drug product availability Concept mapping principles
selection (CILO 4) 2. Drug delivery systems Work along Activities Categorizing grid
3. Bioavailability Problem solving learning Defining features matrix
Compare and contrast chart
Problem sets
Problem recognition tasks
Basic Readings
Boroujerdi, Mehdi. Pharmacokinetics: Principles and Applications. New York: McGraw-Hill, 2002.
Cadwallader, Donald E. Biopharmaceutics and Drug Interaction. USA. Raven Press 1983.
Ritschel, W. A. Handbook of Basic Pharmacokinetics: Including Clinical Applications 7th ed. Singapore: Info Access &
Distribution Pte Ltd, 2009.
Rowland, Malcolm. Clinical Pharmacokinetics: Concepts and Application. Baltimore: Williams and Wilkins, 1995.
Shargel, Leon. Applied Biopharmaceutics & Pharmacokinetics. Stanford, CT: Appleton and Lange, 2012.
Extended Readings
Allen, Ansel, Popovich. Pharmaceutical Dosage Forms and Drug Delivery Systems. Philadelphia: Lipincott, 2010
Web Researches
GRADING SYSTEM:
Quizzes, seatworks, assignments - 40% Quizzes, seatworks, assignments - 40% Quizzes, seatworks, assignments - 40%
Monthly Examination - 60% Prelim Examination - 60% Final Examination - 60%
TENTATIVE COURSE CALENDAR:
WEEK CONTENT
1 Definition and evolution of biopharmaceutics, relevance of biopharmaceutics & pharmacokinetics
2 Drug absorption, distribution, metabolism & excretion
3 Drug absorption, distribution, metabolism & excretion
4 Mathematical models
5 Mathematical models, physiologic models
6 MOTHLY EXAMINATION
7 Mechanisms of drug absorption
8 Mechanisms of drug absorption
9 Anatomy and physiology of the gastrointestinal tract
10 Factors affecting drug absorption
11 Factors affecting drug absorption
12 PRELIMINARY EXAMINATION
13 Effect of drug product design and manufacture on drug availability
14 Effect of drug product design and manufacture on drug availability, drug delivery systems
15 Bioavailability, bioequivalence
16 Pharmacologic effect or clinical efficacy
17 Dosing regimen
18 FINAL EXAMINATION