DRUG STUDY

Name of Patient:_________________________________________________________________________________________________________ Ward No.: _______ Bed No.: _______

Medical
Diagnosis:_______________________________________________________________________________________________________________________________________
Drug Name: CAPTOPRIL
Indication for Patient:

USUAL DOSAGE/ PHARMACOLOGIC CONTRAINDICATIONS INTERACTION ADVERSE EFFECTS

AVAILABILITY ACTION OF DRUG
Tablets: 12.5mg, 25mg, Inhibits ACE, Contraindicated in Drug-drug. Antacids: May decrease captopril effect. Separate CNS: dizziness, fainting,
50mg, 100mg preventing conversion patients hypersensitive to dosage times. headache, malaise, fatigue,
of angiotensin I to drug or other ACE Diuretics, other hypertensives: May cause excessive fever.
angiotensin II, a inhibitors. hypotension. May need to stop diuretic or reduce captopril CV: tachycardia, hypotension,
potent Use during pregnancy dosage. angina pectoris
vasoconstrictor. Less can cause injury and Insulin, oral antidiabetics: May cause hypoglycemia when GI: abdominal pain, anorexia,
angiotensin II death in the developing captopril therapy is started. Monitor patient closely. constipation, diarrhea, dry
decreases peripheral fetus. When pregnancy Lithium: May increase lithium level; symptoms of toxicity mouth, dysgeusia, nausea,
arterial resistance, of detected, stop drug as possible. Monitor lithium level and patient closely. vomiting
decreasing soon as possible. NSAIDs: May reduce antihypertensive effect. Monitor blood Hematologic: leukopenia,
aldosterone secretion, Use cautiously in pressure. agranulocytosis,
which reduces sodium patients with impaired Potassium-sparing diuretics, potassium supplements: May thrombocytopenia,
and water retention renal function or serious cause hyperkalemia. Avoid using together unless pancytopenia, anemia.
and lowers blood autoimmune disease, hyperkalemia is confirmed. Metabolic: hyperkalemia
pressure especially systemic lupus Drug-herb. Black catechu: May cause additional hypotensive Respiratory: dry, persistent,
erythematosus, and in effect. Discourage use together. nonproductive cough;
those who have been Capsaicin: May worsen cough. Discourage use together. dyspnea.
exposed to other drugs Drug-food. Salt substitutes containing potassium: May cause Skin: urticarial rash,
that affect WBC counts hyperkalemia. Monitor patient closely. maculopapular rash, pruritus,
or immune response. alopecia.
OverdoseS&Sx: Other: angioedema.
Hypotension.

DANICA PAULINE G. RAMOS|2012-63528

 NURSING RESPONSIBILITIES
o Black patients who take ACE inhibitors as monotherapy for hypertension have a smaller reduction in blood pressure than nonblacks.
o Black patients taking ACE inhibitors have a higher incidence of angioedema than nonblacks.
o Monitor patients blood pressure and pulse rate frequently.
o Elderly patients may be more sensitive to drugs hypotensive effects
o Assess patient for signs of angioedema
o Drug causes the most frequent occurrence of cough, compared with other ACE inhibitors
o In patients with impaired renal function or collagen vascular disease, monitor WBC and differential counts before starting treatment, every 2 weeks for the first 3 months of
therapy, and periodically thereafter.

DANICA PAULINE G. RAMOS|2012-63528