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In this question, one
mark is available for the quality of spelling, punctuation and grammar.
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OCR 2009
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[Total: 15]
6 ) Insulin-dependent diabetes most often appears during childhood. It is caused by the
autoimmune destruction of cells in the pancreas. In this autoimmune response, specific
white blood cells respond to proteins on the surface of the cells.
(a) (i) Name the hormone that will become deficient due to the autoimmune destruction of
the cells.
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(ii) Name the pancreatic tissue in which the cells are found.
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(iii) Suggest what happens to the proteins on the cell surface membranes of the cells to
stimulate the autoimmune response.
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(i) Describe the changes in blood glucose concentration in the diabetic individual for the 120
minutes following the meal.
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ii) Explain the changes in blood glucose concentration in the healthy individual for the 120
minutes following the meal.
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[Total: 12]
1 (a) The pancreas is a gland that plays an important role in the digestion of food.
(i) Name A.
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(ii) The exocrine cells in Fig. 1.1 produce enzymes that are in an inactive form.
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(b) A study was carried out on a group of people to measure the concentration of the
hormone, cholecystokinin (CCK) in the blood.
(ii) Calculate the rate of increase of mean blood CCK concentration, in arbitrary units per
minute, between 30 and 60 minutes.
(iii) After the meal is eaten, the blood CCK concentration increases rapidly.
Describe the stimulus that leads to an increased production of CCK and explain why more
CCK is needed after the meal is eaten.
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(c) The same study also measured the concentrations of glucose and insulin in the blood.
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[Total: 16]
(7+1)