Hematology/Hemostasis Reference Intervals

Unless otherwise noted, data for reference interval tables were compiled from multiple sources and may vary slightly from
intervals listed within chapters. Each laboratory must establish its particular intervals based on its instrumentation, meth-
odology and demographics of the population it serves.

COMPLETE BLOOD COUNT REFERENCE INTERVALS (ADULT)

Assay Units Reference Intervals Assay Units Reference Intervals
RBC, male 106/L ( 1012/L) 4.206.00 RETIC % 0.52.5
RBC, female 106/L ( 1012/L) 3.805.20 NRBC /100 WBC 0
HGB, male g/dL (g/L) 13.518.0 WBC 103/L ( 109/L) 3.610.6
(135180) NEUT % 5070
HGB, female g/dL (g/L) 12.015.0 NEUT (ANC) 103/L ( 109/L) 1.77.5
(120150) LYMPH % 1842
HCT, male % (L/L) 4054 LYMPH 103/L ( 109/L) 1.03.2

i. r
(0.400.54) MONO % 211
HCT, female % (L/L) 3549 MONO 103/L ( 109/L) 0.11.3
(0.350.49) EO % 13

s
MCV fL 80100 EO 103/L ( 109/L) 00.3

s
MCH pg 2634 BASO % 02
MCHC g/dL 3236 BASO 103/L ( 109/L) 00.2

n
RDW % 11.514.5 PLT 103/L ( 109/L) 150450
RETIC 103/L ( 109/L) 20115 MPV fL 7.012.0

is a
r
REFERENCE INTERVALS FOR OTHER COMMONLY ORDERED TESTS (ADULTS)
Assay Units Reference Intervals Assay Units Reference Intervals

e
ESR, male (Westergren) mm 1 hour 015 (050 y) ESR, female mm 1 hour 020 (050 y)

p
020 (50 y) (Westergren) 030 (50 y)

.
Serum iron g/dL 50160 Serum vitamin B12 pg/mL 200900
Total iron-binding g/dL 250400 Serum folate ng/mL 4.0

iv p
capacity RBC folate ng/mL 120
Transferrin saturation % 2055 Haptoglobin mg/dL 30200
Serum ferritin, male ng/mL 40400 Free serum hemoglobin mg/dL 010
Serum ferritin, female ng/mL 12160

HEMOGLOBIN FRACTION REFERENCE INTERVALS

Fraction Adult Reference Intervals (%) Newborn Reference Intervals (%)
Hb A 95 1040
Hb F 02.0 6090
Hb A2 03.5
 BONE MARROW ASPIRATE REFERENCE INTERVALS (ADULT)
WBC Differential Reference Intervals (%) Erythrocyte Series Reference Intervals (%)
Blasts 03
Promyelocytes 15 Pronormoblasts 01
N. myelocytes 617 Basophilic NB 14
N. metamyelocytes 320 Polychromatophilic NB 1020
N. bands 932 Orthochromic NB 610
N. segmented (polymorphonuclear) 730
Eosinophils 03 Other
Basophils 01 M:E ratio 1.53.3:1
Lymphocytes 518 Megakaryocytes 210/lpf
Plasma cells 01
Monocytes 01
Histiocytes (macrophages) 01

COMPLETE BLOOD COUNT REFERENCE INTERVALS (PEDIATRIC)

i. r
s
Assay Units 01 d 24 d 57 d 814 d 1530 d 12 mo 35 mo 611 mo 13 y 47 y 813 y
RBC 106/L 4.106.10 4.365.96 4.205.80 4.005.60 3.205.00 3.405.00 3.655.05 3.605.20 3.405.20 4.005.20 4.005.40

s
( 1012/L)

n
HGB g/dL (g/L) 16.521.5 16.420.8 15.220.4 15.019.6 12.218.0 10.616.4 10.416.0 10.415.6 9.615.6 10.215.2 12.015.0
(165215) (164208) (152204) (150196) (122180) (106164) (104160) (104156) (96156) (102152) (120150)

is a
HCT % 4868 4868 5064 4662 3853 3250 3551 3551 3448 3646 3549
MCV fL 95125 98118 100120 95115 93113 83107 83107 78102 7692 7894 8094
MCH pg 3042 3042 3042 3042 2840 2737 2535 2331 2331 2331 2632

r
MCHC g/dL 3034 3034 3034 3034 3034 3137 3236 3236 3236 3236 3236
RDW % * * * * * * * 11.514.5 11.514.5 11.514.5 11.514.5

e
RETIC % 1.85.8 1.34.7 0.21.4 01.0 0.21.0 0.82.8 0.51.5 0.51.5 0.51.5 0.51.5 0.51.5
RETIC 103/L 73.8353.8 56.7280.1 8.481.2 0.056.0 6.450.0 27.2140.0 18.375.8 18.078.0 17.078.8 2078.0 20124.2

p
( 109/L)

.
NRBC /100 WBC 224 59 01 0 0 0 0 0 0 0 0
103/L

iv p
WBC 9.037.0 8.024.0 5.021.0 5.021.0 5.021.0 6.018.0 6.018.0 6.018.0 5.517.5 5.017.0 4.513.5
( 109/ L)
NEUT 103/L 3.730.0 2.617.0 1.512.6 1.211.6 1.09.5 1.28.1 1.17.7 1.28.1 1.28.9 1.511.0 1.69.5
(ANC) ( 109/L)
LYMPH 103/L 1.614.1 1.311.0 1.211.3 1.513.0 2.112.8 2.513.0 2.713.5 2.914.0 2.012.8 1.511.1 1.07.2
( 109/L)
MONO 103/L 0.14.4 0.23.4 0.23.6 0.23.6 0.13.2 0.22.5 0.12.0 0.12.0 0.11.9 0.11.9 0.11.5
( 109/L)
EO 103/L 0.01.5 0.01.2 0.01.3 0.01.1 0.01.1 0.00.7 0.00.7 0.00.7 0.00.7 0.00.7 0.00.5
( 109/L)
BASO 103/L 0.00.7 0.00.5 0.00.4 0.00.4 0.00.4 0.00.4 0.00.4 0.00.4 0.00.4 0.00.3 0.00.3
( 109/L)
PLT 103/L 150450 150450 150450 150450 150450 150450 150450 150450 150450 150450 150450
( 109/L)

*The RDW is markedly elevated in newborns, with a range of 14.2% to 19.9% in the rst few days of life, gradually decreasing until it reaches adult levels by 6 months of age.
Pediatric reference intervals are from Riley Hospital for Children, Indiana University Health, Indianapolis, IN.

Some reference intervals are listed in common units and in international system of units (SI units) in parenthesis.
ANC, absolute neutrophil count (includes segmented neutrophils and bands); BAND, neutrophil bands; BASO, basophils; d, days; EO, eosinophils; ESR, erythrocyte sedimentation rate;
Hb, hemoglobin fraction; HCT, hematocrit; HGB, hemoglobin; lpf, low power eld; LYMPH, lymphocytes; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; MCV,
mean cell volume; M:E, myeloid:erythroid; mo, month; MONO, monocytes; MPV, mean platelet volume; N, neutrophilic; NB, normoblast; NEUT, neutrophils; NRBC, nucleated red blood
cells; PLT, platelets; RBC, red blood cells; RDW, red blood cell distribution width; RETIC, reticulocytes; WBC, white blood cells; y, year.

Please see inside back cover for additional reference interval tables.