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Lesson 5 Genetics
Though essential in every other aspect, except the following five topics (very very
important), I personally expect no other question from this lesson in university exam. Not to
waste time in this lesson at the eleventh hour
Must know
1. Marfans syndrome
2. Ehlers Danlos syndromes (only the basics)
3. Downs syndrome (with diag)
4. Turner syndrome (with diag)
5. Barr body
Distinction questions
1. Transmission pattern and characteristics of
a. Autosomal dominant
b. Autosomal recessive
c. X- linked recessive disorders
2. Tay sachs disease
3. Hurlers and hunters syndrome
4. Von gierkes disease
5. Sex chromatin
6. Klinefelter
7. Fragile X syndrome
8. Genomic imprinting (only the basics)
Lesson 6 Immunity
Important lesson. Your knowledge of microbiology should help
Must know
1. T- lymphocytes and B-lymphocytes
2. Antigen presenting cells
3. NK cells
4. Type 1, type 2, type 3 and type4 hypersensitivity
5. SLE (Important -only the basics)
6. LE cell (Important -notes for 5 makrs)
7. Kidney manifestations in SLE
8. AIDS Full (pathogenesis, CRS involvement, natural history, aids defining conditions,
kaposi's sarcoma) can be asked as case (very important)
9. Amyloidosis (Prepare notes for 5 marks) - Again very important
10. Difference between sago spleen and lardaceous spleen
Distinction questions:
1. Cytokines: types and functions
2. HLA molecules (notes for 5 marks)
3. Arthus reaction for 5 marks
4. Types and morphology of graft rejection (prepare notes for 5 marks)
5. Anergy
6. Digeorge syndrome
Lesson 7 neoplasia
Except for p53 and RB (important), the whole of molecular level of cancer path can be
skipped exams, though you might need them for better understanding
Must know
1. Characteristics of benign and malignant tumors.
2. Diff between benign and malignant tumors (as table)
3. Metastasis: pathways of spread of tumor (very important)
4. P53-as guardian of human genome (With diag)
5. Retinoblastoma: two hig hypothesis of RB gene
6. Chemical carcinogenesis (etiology, pathogenesis)
7. Viral carcinogenesis (HPV-very important) - Important
8. Paraneoplatic syndromes - very important
9. Tumor markers (oncofetal antigens-very important)
Distinction questions:
1. Differences between anaplasia and dysplasia (prepare notes for 5 marks)
2. 5 occupational cancers with their etiologic agent
3. Oncogenes (notes for 5 marks)
4. Radiation carcinogenesis
5. Tumor antigens (notes for 5 marks)
6. Laboratory diagnosis of cancer (basic points only)
Lesson 8 Infectious diseases
Must Know:
Pathogenesis, morphology, c/f and complications of TB (very very important)
1. Other important questions in tuberculosis:
a. Ghons focus
b. Ghons complex or primary complex
c. Ranke complex
d. Progressive pulmonary tuberculosis
e. Military tuberculosis
f. Pots spine
g. Scrofula
2. Leprosy (types, pathogenesis and c/f) - important
3. Stages, pathogenesis and c/f of syphilis
4. Black water fever and cerebral malaria
5. Typhoid fever
6. Amoebic liver abscess
7. Hydatid cyst
8. Actinomycosis
9. Madura foot
10. Rhinosporidiosis
Distinction questions:
All other infectious diseases (I would advice not to waste time in this lesion at the last minute. Your
knowledge of micro is more than enough for handling this lesion. Tuberculosis and syphilis is all that is
needed in path)
Lesson 9 Environment and nutrition
Chances of getting a question from this chapter are near to nil. If at all, you might get
1. Rickets
Distinction questions:
1. Radiation injury
2. PEM
SYSTEMIC PATHOLOGY
Hematology
Please note that the whole of hematology account for nearly 40% of marks in paper 1.
Must study topics.
10 marks or LONG CASE
The pathogenesis, peripheral blood picture, bone marrow picture, other relevant morphology,
INVESTIGATIONS (for investigations, you might refer to Alagappan - manual of medicine
separately under each heading) , c/f of
1. Sickle cell disease
2. B- thallasemia
3. Megaloblastic anemia, esp. pernicious anemia
4. Iron deficiency anemia
5. Hemophilia A
6. ALL
7. CLL
8. Multiple myeloma
9. Hodgkin disease- types, pathogenesis, basic morphology of each type and their prognosis, clinical
features
10. AML (In addition to the general headings, you need to know atleast the basics of FAB
classification)
11. CML (pathophysiology, morphology and investigations)
12. Polycythemia vera
All these 12 questions are must read for all hematology exams
Important note:
Before diagnosing the case, please make sure that the age of the concerned patient coincides with
the age group affected, for that particular disease, as given in Robbins. Also look for
characteristic symptoms like lymphadenopathy, bone tenderness, abrupt onset, massive
splenomegaly, cancer cachexia, etc. These clue words in the case are directly picked from
Robbins. So dont miss the clinical features of any suspected long case. For all investigations for
any long case, refer to Alagappan- manual of medicine.
Again please note that more than 50% of previous paper 1 question papers have CML (massive
splenomegaly) as the long answer.
Short notes for Lesson 13 RBCs and platelets
Must know:
1. Classification of anemia, according to underlying pathology
2. Heriditary spherocytosis (pathogenesis and morphology)
3. Howell jolly bodies (prepare notes)
4. Heinz bodies (prepare notes)
5. Bone marrow picture in megaloblastic anemia
6. Pathophysiology of B-thalassemia
7. Aplastic anemia- very important 5 mark- prepare notes for 5 marks, incorporating all the
headings.
8. Von willebrand disease
9. Hemophilia A and B
10. DIC Very important. Prepare notes for 5 marks. For pathophysiology, the flow chart in Robbins
is enough.
Distinction questions in 5 marks:
1. -thallasemia (Just know the types, genetics of each condition and the outcome)
2. Immuno hemolytic anemia (only the table in Robbins is more than enough)
3. ITP
5 marks:
1. Mitral valve prolapse
2. Types of angina
3. Causes and types of pericarditis (rare)
Lesson 15 The Lung
10 mark cases:
1. Bronchiectais (very important)
2. Asthma
3. Emphysema
4. Ca lung Squamous cell Ca, AdenoCa, Small cell, Large cell gross pathology , histology and
prognosis. Local effects of tumor spread (very important. Local effects can be asked as short
notes also)
Must know in 5 marks:
1. Pathogenesis and types of emphysema (very important)
2. Asbestosis
3. Pneumoconiosis (prepare notes for 5 marks)
4. Pulmonary embolism
5. Etiology and morphology of community acquired pneumonia (Very important)
6. Lung abscess (important)
7. Pancoast tumors ( highly repeated)
Distinction questions in 5 marks:
1. Types and causes of atelectasis
2. Diffuse alveolar damage or ARDS
3. Goodpasture syndrome (rare)
4. Pananeoplastic syndromes, associated with lung Ca
All these 5 questions are essential must-read for all GIT exams
Please note that iron deficiency anemia in an elderly male is due to GIT cancer, unless proved
otherwise.
Must know in 5 marks:
1. Achalasia cardia
2. Barrett cosophagus very important
3. Types of gastritis and H. pylori as an etiological agent.
4. Celiac disease important
5. Adenoma colon and rectum (types, morphology, risk of malignancy, prognosis, clinical impact)
6. FAP syndrome
7. Staging of Colorectal carcinoma - Important
8. Carcinoid tumors (prepare notes for 5 marks under location, morphology, c/f of carcinoid
syndrome)
9. Pseudomyxoma peritonei
10. Intestinal polyps - types, morphology and prognosis - Important
Very rare:
1. Ca Esophagus (know only the basics)
2. Pseudomembranous colitis.
Viral and alcoholic hepatitis are must know topics in this lesson.
Distinction questions:
1. Pathogenesis of ascites
2. Indian childhood cirrhosis (refer any pediatrics book)
3. Wilsons disease (rare)
4. Primary biliary cirrhosis (rare)
Rare 5 marks:
1. Testicular lymphoma.
Must know:
1. Squamous cell carcinoma (prepare notes for 5 marks)
2. Basal cell carcinoma (5 marks)
3. Malignant melanoma
4. Pre malignant lesions of the skin (refer Sanjay Azad surgery)
5. Mycosis fungoides
Lesson 26 Bones
Very important. Not to be ignored
Must know:
1. Osteopetrosis
2. Osteoporosis (rare know only the basics)
3. Paget disease (Important)
4. Osteomyelitis pyogenic and TB (potts spine) - Very important
5. Osteosarcoma (prepare notes for both 10 and 5 marks) - Very important
6. Chondrosaroma (5 marks)
7. Ewing sarcoma (sure 5 marks) - Very important
8. Giant cell tumor or osteoclastoma - Very important.
Lesson 27 Peripheral nervous system can be conveniently skipped.
If your conscience still doesnt agree, read it after your exams!!!
Lesson 28 The CNS
Selected questions are very important. Dont waste time at the eleventh hour, however, reading
unnecessary details. You can go to exams confidently only with these questions in CNS. They
are very important.
1. CSF findings in different types of meningitis (Read Robbins and also prepare yourself a tabular
column referring to med books or applied micro notes)
2. Brain abscess.
3. TB menigitis Morphology, investigations and c/f
4. Berry aneurysm (5marks)
5. Astrocytoma
6. Meningioma (5 marks)
7. Schwannoma (5 marks)