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SpecialPathology:ImportantMCQsfromthewholebook
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Respiratorysystem
1.A25yearoldmalepatientpresentswithacuterenalfailure,
whichisnotamenabletodialysis.Hehashistoryofrecurrent
episodesofhemoptysisandchestradiographshowsfocallung
consolidation.Whattypeofantibodiescanberesponsibleforhis
pulmonaryandrenalsymptoms?
a.Antismoothmuscleantibodies
FOLLOWUS
b.Antineutrophilcytoplasmicantibodies
GetLatestarticlesdirectlytoyourmailbox c.Antinuclearantibodies
SignintoyourEmailandclickonthelinkto d.AutoantibodiestotypeIVcollage
completethesubscription
e.AutoantibodiestotypeIIIcollagen
Enteryouremailaddress: 2.A55yearoldhuqqasmokerpresentswithseveredyspneaand
slightdrycough.Hehasabarrelchestandexpirationis
prolonged.FEV1isdecreased.ChestXrayshowsvoluminous

Subscribe lungsovershadowingtheheart.Whatistheprinciple
pathogeneticmechanismforthispatientslungdisease?
DeliveredbyFeedBurner a.Productionofautoantibodiesagainstalveolarbasementmembrane
b.TypeIVHypersensitivity
c.Vasculitisofpulmonaryarterioles
d.Proteaseproductionbyneutrophilsandmacrophages
JoinusonFacebook e.Squamousmetaplasiaofbronchialepithelium
YoungDoctors'ResearchForum 3.Followingrenaltransplantationapatientdevelopshighgradefeverwithchillsandcoughproductive
ofmucopurulentsputum.Chestradiographshowsfociofconsolidation.Whichbacterialinfection
wouldyoumostsuspectinthispatient?
a.Staphylococcusaureus
b.Klebsiellapneumoniae
c.Pseudomonas
FEATUREDPOSTS d.Streptococcuspneumoniae
e.Legionellapneumophilia

FreeArticleSubmission:: 4.Aresidentinthesurgerydepartmentisconductingasurveytoidentifyriskfactorsforlungcancerin
GuidelineforAuthors thelocalpopulation.Inwhichsubsetofpatientsishelikelytoencounterthehighestfrequencyof
tobaccosmokers?
a.Squamouscellcarcinoma
b.Smallcellcarcinoma
InstrumentsusedInGynecology c.Adenocarcinoma
andObstetrics d.Largecellcarcinoma
e.Bronchoalveolarcarcinoma
5.APathologyresidentisreviewingslidesofcasesoflungcancerreportedduringthelasttwoyears.
WhyporkisHaraminIslam? Hefinds20casesofSquamouscellcarcinoma,12casesofadenocarcinoma,4casesofsmallcell
ScientificAnswers
carcinoma,and2eachofBronchoalveolarcarcinomaandlargecellcarcinoma.Ifheordersp53
stainingonallthesecaseswhichtumortypeislikelytobemostfrequentlypositive?
a.Adenocarcinoma
b.Squamouscellcarcinoma
SolvedMCQspaperDepartment c.Smallcellcarcinoma
OfEyeRawalpindiMedical
College2010 d.Bronchoalveolarcarcinoma
e.Largecellcarcinoma
6.A32yearoldfemalepresentswithsevererespiratorydistress.Shehasaprotractedhistoryof
dyspneaonmildexertionforthepastmanyyears.Chestradiographshowsrightventricular
OxfordHandbooksOfClinical
Medicine.pdfTorrentFree enlargement.Thereisnohistoryofcongenitalheartdisease,interstitiallungdiseaseorobstructive
Download pulmonarydisease.Serologicaltestsforautoimmuneconditionsarenegative.Alungbiopsyshows
markedmedialhypertrophyandintimalfibrosisofpulmonaryarterioles.Whatisthemostlikely
causeforthispatientssymptoms?
a.Rightsidedcardiacfailure
IdentificationofChestXraysof
CommonLungDiseases b.Emphysema
c.Goodpasturesyndrome
d.Primarypulmonaryhypertension
e.Secondarypulmonaryhypertension
PhysiologicalChangesin 7.A4yearoldchild,residentofIslamabadhasseasonalboutsofbreathingdifficultywithprolonged
Pregnancy coughproductiveofcopiousMucinoussecretions,eachspringseason.Peripheralsmearshows
eosinophliaduringanepisodeandsputumexamrevealcharcoatladencrystals.Whatisthemost
potentmediatorofbronchospasminthispatient?
a.TNF
SpecialPathologyMCQs:GIT, b.Leukotrienes
Liver,GallBladderAndBiliary
c.Interleukins
Tract,Kidneyanditscollecting
system d.Histamine
e.Prostaglandins
8.Whatisthecommonpathogeneticmechanismforallatypical(viralandMycoplasmal)pneumonias?
FunctionsofBloodInHuman a.Productionofcrossreactingantibodiestoalveolarbasementmembrane
BodyItsRoleAndSignificance
b.Directinvasionoflungparenchymabythecausativeorganism
c.Hypersensitivityreactiontomycoplasmal/viralantigens
d.Attachmentoforganismtoupperrespiratorytractepitheliumfollowedbynecrosisand
inflammation
Malaria:TypesOfMalaria,itsLife
e.Exotoxinproduction
Cycle,SignsandSymptoms,
preventionAndTreatmentOf 9.ACTHandADHproductionisassociatedwithwhichhistologicalsubtypeoflungcancer?
Malaria a.Squamouscellcarcinoma
b.Adenocarcinoma
c.Smallcellcarcinoma
d.Carcinoidtumor
SITECONTRIBUTORS
e.Largecellcarcinoma

Dr.M.AwaisZia
10.A56yearoldmalepatientoflungcancerdevelopshoarsenessofvoice.Thissymptomis
Dr.AbairulHaq attributabletotumorinvasionof:
Dr.AmerSaleem a.Larynx
Dr.ZebaUnnisa b.Trachea
c.Recurrentlaryngealnerve
Readytobeenlisted??
d.Vagusnerve
e.Sympatheticchain
YOUAREVISITORNO. 11.Followingbilateralhipreplacementsurgerya75yearoldfemaleexpiresonthetenthpostopday.
Theautopsypathologistrecoversasaddleemboluslyingastridethemainrightandleftpulmonary
2 3 5 6 9 6 8 arteries.Whatisthemostprobablesourceofthisembolus?
a.Pulmonaryveins
YoungDoctors'Forum.PoweredbyBlogger.
b.Inferiorvenacava
c.Renalveins
SEARCHENGINEOPTIMIZATION
d.Deepveinsoftheleg
SearchEngineSubmissionAddMePingBlog e.Mesentericveins
12.InpathogenesisofBronchiectasisthesusceptibilitytoinfectionsisdueto:

a.Progressivefibrosisoflungparenchyma
b.Accumulationofthickandviscidsecretionsobstructingtheairways
c.Chronicinflammationofairwaysleadingtoepithelialsloughing
d.Immunodeficientstatus
e.Repeatedhospitaladmissionsandexposuretonosocomialinfections
13.Apathologistperforminganautopsyona65yearoldmalewhodiedafteranacuterespiratorytract
illnessnoticesthatthelowerlobeofhisleftlungshowsappearsgrayishbrown,firmerthantherest
ofthelungandhasdrycutsurfaces.Histologicalsectionsfromthesameshowfibromyxoidmasses
infiltratedbymacrophagesandfibroblasts.Whatwillyoulabelthislesionas?
a.Lungabscess
b.Squamouscellcarcinoma
c.Grayhepatization
d.Redhepatization
e.Atelectasis
14.Whileexaminingabronchoscopicbiopsyapathologistnoticesatumorcomposedofcellssmaller
thanlymphocyteswithdeeplystainingnucleiandscantycytoplasm.Whatisthelikeliestdiagnosis?
a.Adenocarcinoma
b.Largecellcarcinoma
c.Squamouscellcarcinoma
d.Bronchoalveolrcarcinoma
e.Smallcellcarcinoma
15.Duringathoracotomyperformedforlungcancer,thesurgeonnoticesa3.5cmtumorinhilarregion
ofrightlunginvolvingthevisceralpleura.HowwillthistumorbestagedaccordingtotheInternational
SystemforStagingofLungcancer?
a.T1
b.TIS
c.T2
d.T3
e.T4

MaleGenitalSystem

16.A32yearoldmalepresentswithapainless,largetesticularmass.Orchidectomyspecimenreveals
slargepalefleshymass,12cmindiameter.Histologyconsistsofnestsofuniformcellsseparated
byfibrousbandsshowinglymphocyteinfiltration.ThetumorstainsnegativeforAFPandHCGand
positiveforplacentalalkalinephosphatase.Whatgermcelltumorarethesefeaturesmost
characteristicof?
a.Seminoma
b.Choriocarcinoma
c.Yolksactumor
d.Embryonalcarcinoma
e.Teratoma
17.A32yearoldmalepresentswithcahexiaandhemoptysis.ChestXrayrevealmultiplehemorrhagic
fociinthelungs.ColonoscopyandupperGIendoscopyareunremarkable.Notesticularmassis
palpable.SerumHCGlevelisraisedCEAandAFParewithinnormalrange.Lungbiopsyfromone
ofthelesionsshowsmassivehemorrhagewithfewcytotrophoblastandsyncitiotrophoblastlike
elements.Whatisthediagnosis?
a.Lymphoma
b.Squamouscellcarcinoma
c.MetastaticYolksactumor
d.MetastaticChoriocarcinoma
e.Metastaticadenocarcinoma
18.Inapatientwithmixedgermcelltumorofthetestis,whichserummarker/markersarebestusedto
monitorresponsetochemotherapy?
a.AFPandHCG
b.LDHandCEA
c.CEAandAFP
d.Ca125
e.CA199
19.A55yearoldpatientdiagnosedtohavenodularhyperplasiaofprostateisprescribeda5alpha
reductaseinhibitor.Whichtrophicfactorresponsibleforprostatichyperplasiawillthisagentinhibit?
a.Testosterone
b.Estrogen
c.Dihydrotestosterone
d.Epinephrine
e.Epidermalgrowthfactor
20.Whileexaminingaprostaticneedlebiopsyapathologistnoticesaclusterofsmallcrowded,closely
packedglandslackingthemyoepitheliallayerepithelialcellsshowprominentpinknucleoli.Adjacent
tothesearelargerglandslinedbyepitheliumandmyoepitheliumandshowingbranchingandtufting.
Howwillthesetwotypesofglandsdifferinbehavior?
a.Botharebenign
b.Botharemalignant
c.Thefirstclusterisbenign
d.Thesecondclusterisbenign
e.Thefirstclusterismorelikelytobemalignant
21.Ofthemajorspecificinflammatoryconditionsoftestis,whichinvariablyeffectstestisbefore
epididymus?
a.Gonorrhoea
b.Tuberculosis
c.Chlamydia
d.Syphilis
e.AllGramnegativebacterialinfections
22.Twomaleseachaged28yearsarediagnosedwithCryptorchidism.Onepatienthasabdominal
undescendedtestisandtheotherhasinguinalundescendedtestis,whatistheriskofboth
developingtesticularcancer?
a.Thepatientwithinguinaltestishasthehigherrisk
b.Thepatientwithabdominaltestishasthehigherrisk
c.Bothhaveequalrisk
d.Undescendedtestisisnotrelatedtotheriskoftesticularcancer
e.Undescendedtestisprotectsagainsttesticularcancer
23.A25yearoldmalepresentswitharapidlyenlargingpainlesstesticularmass.SerumHCGis
markedlyraised.AdiagnosisofmixedgermcelltumorismadeonHistopathologyofthe
orchidectomyspecimen.Whichcomponentofthemixedtumorismostresponsiblefortherisein
HCG?
a.Embryonalcarcinoma
b.Yolksactumor
c.Teratoma
d.Choriocarcinoma
e.Seminoma
24.A50yearoldmaledevelopsacuteurinaryretentionandiscatheterized.Theprostateisfound
moderatelyenlargedondigitalrectalexamination.LateronserumPSAlevelisfoundslightly
elevated(8ng/dL).Howbestwillyouinterpretthisresult?
a.Diagnosticforprostaticadenocarcinoma
b.Diagnosticfornodularhyperplasia
c.Mayhaveresultedfromcatheterizationanddigitalrectalexamination
d.Thevalueisfalselyhighduetoanalyticallaberror
e.Normallevelforthisage
25.Apatientwithdiagnosisofnodularprostatichyperplasiaisunresponsivetomedicaltherapyandis
anxiousabouthisriskofdevelopingcancer.Whatisthemostpertinentinformationyoucangivethis
patient?
a.Hehasan80%riskofdevelopingprostatecancerinthenext5years
b.Hehasa50%riskofdevelopingprostatecancerinthenext5years
c.Hehasa10%riskofdevelopingprostatecancerinthenext5years
d.Hehasa100%riskofdevelopingprostatecancerinthenext5years
e.Heisnotatriskforprostatecancersincenodularhyperplasiaisnotapremalignant
condition
26.A25yearoldmalepresentswithinfertilityandoligospermiaisfoundonsemenanalysis.Leftscrotal
sacisemptyandanundescendedtestisispalpableintheleftinguinalregion,whichisexcised.The
excisedtestiswillmostlikelyshow:
a.Activespermatogenesis
b.Atrophywithnospermatogenesis
c.Granulomatousorchitis
d.Hydrocele
e.Leydigcelltumor
27.A28yearoldmalepresentswitharapidlyenlargingpainlesstesticularmass.Serumalphafeto
proteinismarkedlyraised.AdiagnosisofmixedgermcelltumorismadeonHistopathologyofthe
orchidectomyspecimen.Whichcomponentofthemixedtumorismostresponsiblefortherisein
alphafetoprotein?
a.Embryonalcarcinoma
b.Yolksactumor
c.Teratoma
d.Choriocarcinoma
e.Seminoma
28.HandEsectionsfromtesticularmassofa24yearoldpatientrevealdisorganizedclustersof
glands,cartilage,smoothmuscle,bronchialandbronchiolarepithelium.Thejuniorresidentexamining
thecaseseeksthehelpofaseniorcolleagueaboutthepresenceorabsenceofimmatureelements
intheteratomatodetermineitsmalignantpotential.Heisadvisedthathedoesnotneedtosearch
fortheimmaturecomponentsinthistumorbecause:
a.Inpostpubertalmalesallteratomasareconsideredbenign
b.Allteratomasarebenignirrespectiveofpresenceorlackofimmaturecomponents
c.Allteratomasaremalignantirrespectiveofpresenceorlackofimmaturecomponents
d.Allteratomasareconsideredmalignantinpostpubertalmales
e.Excisioniscurativeforalltesticularteratomas
29.A55yearoldmalepresentswithlowbackpain,dysuriaandsuprapubicdiscomfort.Expressed
prostaticsecretionscontain15leukocytes/HPF.Bacterialculturesarenegative.Whatisthe
diagnosis?
a.Granulomatousprostatitis
b.Acuteprostatitis
c.Chronicbacterialprostatitis
d.Chronicabacterialprostatitis
e.Nodularhyperplasia
30.Forpredictingprognosisofprostaticadenocarcinoma,whatisthemostimportantfactorbesides
tumorstage?
a.Perineuralinvasion
b.Comorbidconditions
c.Tumorgrade
d.Immunestatus
e.SerumPSAlevels

FemalegenitalSystem

31.Colposcopicbiopsyofa48yearoldwomanrevealsdiffuseAtypiaofSquamousepitheliumwith
completelackofmaturationinalllayersandnosurfacematuration.Basementmembraneisintact.
Howwillyoulabelthislesion?
a.NormalSquamousmetaplasia
b.InvasiveSquamouscarcinoma
c.CINI
d.CINII
e.CINIII
32.A68yearoldobesepostmenopausalwomanisatagreaterriskofdevelopingendometrial
carcinomathana40yearoldpremenopausalwomanwithnormalweight.Howbestwouldyou
explainthis?
a.Advancingagerenderstheendometriumgeneticallyunstable
b.Postmenopausalwomenaremorelikelytobetakingexogenoushormones
c.Progesteronelevelsarehigherinpostmenopausalwomen
d.Inpostmenopausalwomenthereisagreatersynthesisofestrogenfrombodyfat
e.Estrogenlevelsarehigherinpremenopausalwomen
33.Endometrialhyperplasiaistheforerunnerof:
a.Poorlydifferentiatedendometrialcarcinoma
b.Moderatelydifferentiatedendometrialcarcinomas
c.Welldifferentiatedendometrialcarcinomas
d.AllEndometroidendometrialcarcinomas
e.Serousendometrialcarcinomas
34.HandEstainedsectionsfromallovariantumorsreportedinthepastoneyeararereviewedbya
pathologyresident.Whathistologicfeatureswouldfavoradiagnosisofserouscystadenoma?
a.Cystlinedbycolumnarepitheliumwithabundantcilia
b.Cystlinedbycolumnarepitheliumwithoutmucinorcilia
c.Cystlinedbytransitionalepithelium
d.Solidtumorcomposedofnestsoftransitionalcells
e.CystlinedbystratifiedSquamousepithelium
35.Acysticmassremovedfromtherightovaryofa28yearoldfemaleconsistsofacystwalllinedby
maturestratifiedSquamousepitheliumwithskinappendages.Maturegutandbronchialepithelium,
cartilageandthyroidtissuearealsopresent.Whatmalignanttransformationisthistumormostlikely
toundergo?
a.Immatureteratoma
b.Squamouscellcarcinoma
c.Thyroidfollicularcarcinoma
d.Adenocarcinoma
e.Chondrosarcoma
36.A45yearoldfemalehavinghistoryofmultiplesexualpartnersisdiagnosedasSquamouscell
carcinomaofcervix.Geneticmaterialofwhichvirusismostlikelytobedetectedinthetumor?
a.HPV16
b.HPV6
c.EBV
d.HSVtypeI
e.HSVtypeII
37.A28yearoldfemalepresentswithdysmenorrhea,pelvicpainandirregularvaginalbleeding.
Ultrasoundexaminationrevealsapartlycysticrightadnexalmass.Cystectomyspecimenisfilled
withthickchocolatecoloredfluidandhistologicsectionsrevealacystwalllinedshowingmarked
hemorrhage,withendometrialglandsandstromaalongwithhemosiderinladenmacrophages.What
isthediagnosis?
a.Mucinouscystadenoma
b.Serouscystadenoma
c.Endometrioticcyst
d.Hemangioma
e.Endometrialcarcinoma
38.Papillaryserousendometrialcarcinomaisgradedas:
a.G1
b.G2
c.G3
d.Gradingisnotapplicable
e.GradingwoulddependoncellularAtypia
39.A22yearoldfemaleisdiagnosedwithamalignantgermcelltumoroftheovarythatismetastaticto
liver,lungsandboneatthetimeofdiagnosis.Whatisthistumormostlikelytobe?
a.Yolksactumor
b.Dysgerminoma
c.Choriocarcinoma
d.Embryonalcarcinoma
e.Teratoma
40.Acysticmassremovedfromtherightovaryofa28yearoldfemaleconsistsofacystwalllinedby
maturestratifiedSquamousepitheliumwithskinappendages.Maturegutandbronchialepithelium
andcartilagearealsopresent.Whatistheexpectedkaryotypeofthistumor?
a.46XX
b.46XY
c.45Y
d.47XXY
e.45X
41.WhileworkinginagynecologydepartmentinaremotedistrictofsouthernPunjabyounoticeahigh
numberofpatientspresentingwithadvancedcervicalcancer.Inordertoscreenforcervicalcancer
sothatthesepatientscanbedetectedatanearlierstageofthediseasewhattestwouldyourequest
yourlaboratorytostartdoing?
a.HPVDNAbyPCR
b.HPVDNAbyhybridization
c.p53stainingonallcolposcopicbiopsies
d.p16stainingonallcolposcopicbiopsies
e.Papanecolaoucytologyforcervicalsmears
42.A58yearoldnulliparouswomanwithhistoryoffunctionalmenstrualabnormalitiesismostlikelyto
develop:
a.Endometroidendometrialcarcinoma
b.CervicalSquamouscellcarcinoma
c.Cervicaladenocarcinoma
d.Ovariancystadenocarcinoma
e.Endometrialstromaltumor

43.Anendometrialadenocarcinomagrosslyinvolvingtheuterinecorpusandextendingintocervix
hiostologicallyshowsawelldifferentiatedandeasyrecognizableglandularpattern.Whatisthe
tumorgradeandstage?
a.StageI,GradeI
b.StageII,GradeI
c.StageI,GradeII
d.StageII,GradeII
e.StageIII,GradeI
44.Strumaovariiisamonodermalteratomacomposedof:
a.Bone
b.Cartilage
c.Thyroidtissue
d.Skinandappendages
e.Skeletalmuscle
45.A45yearoldfemalepresentswithmassiveabdominaldistensioncausingrespiratorydistress.An
emergencylaparotomyrevealsmassiveMucinousascitesandadhesionswithalargeleftovarian
tumor,whichislater,reportedasaborderlineMucinousneoplasm.Whatisthisconditionknownas?
a.Meigssyndrome
b.Pseudomyxomaperitonei
c.Krukenbergtumor
d.Carcinomatosis
e.MullerianMucinouscystadenoma

Diseasesofthebreast

46.A32yearoldfemalepresentswithapainless,irregularfirmtohardmassinherrightbreast.She
hashistoryoftraumatothebreast.Excisedmassconsistsoffociofnecroticfatcellssurroundedby
macrophagesandintenseinflammatoryreaction.Whatisthediagnosis?
a.Acutemastitis
b.Invasivecarcinoma
c.Fatnecrosis
d.Fibroadenoma
e.Lipoma
47.Duringamastectomyforinvasivecarcinomaofbreast,thesurgeoninjectsdyeintothetumor,
localizesandresectsthefirstlymphnodetotakeupthedye.Thelymphnodeisreportednegative
formetastasesonfrozensectionexamination.Howwillthiseffectthemanagementofthispatient?
a.Thepatientmustundergocompleteaxillaryclearance
b.Lumpectomywillbecurativeinthispatient
c.Quardrantectomywillbecurativeinthispatient
d.Thepatientcanbesparedcompleteaxillaryclearance
e.Anegativeresultisofnosignificance
448.Twofemalepatientsofthesameagearediagnosedwithbreastcancer.Mastectomyspecimenofthefirst
patientrevealsDuctalcarcinomainsituwithoutinvasivecomponenttheotherpatienthasa2cminvasive
componentinhertumor.Botharenodenegativeandhavenodistantmetastases.Whatdoesthistellyouabout
theprognosisofthesepatients?
a.Prognosiswillbesimilarinbothpatients
b.PatientwithDCISislikelytohaveabetterprognosis
c.Patientwithinvasivecomponentislikelytohaveabetterprognosis
d.Prognosisisdeterminedbyresponsetochemotherapy
e.Prognosiswilldependonthehistologicaltypeofbothtumors
49.Asurgeonexaminestwopatientsofclinicallysuspectedbreastcarcinomathepalpabletumorsizeis2cmin

onepatientand4cminthesecondpatient.Whatcanhededuceaboutthelymphnodestatusofthesepatients?
a.Tumorsizedoesnotpredictlymphnodestatus
b.Firstpatientwillhaveinvolvedaxillarylymphnodes
c.Secondpatientwillhaveinvolvedaxillarylymphnodes
d.Bothwillhaveinvolvedaxillarylymphnodes
e.Bothwillhaveuninvolvedaxillarylymphnodes
550.Whichbreastlesioncarriesthegreatestriskofdevelopingintoaninvasivecarcinoma?
a.Fibroadenoma
b.Papilloma
c.Atypicalductalhyperplasia
d.LowgradeDCIS
e.HighgradeDCIS
51.Whatisthecommonestcausativeorganismforacutemastitis?
a.Streptococcusaureus
b.Staphylococcusaureus
c.Ecoli
d.Pseudomonas
e.Candidaalbicans
52.A35yearoldfemalepatientisdiagnosedtohaveInvasiveductalcarcinomaoftherightbreast.Her
grandmotherandtwomaternalauntshavehadbreastcancerbelow40yearsofage.Whatgenetic
mutationisshelikelytocarry?
a.cMyc
b.KRas
c.BRCA1or2
d.p53
e.INK4A
53.A55yearoldfemaleisfoundtohave3cmmammographicdensitywithirregularbordersand
calcificationinherleftbreast.Thereisa90%likelihoodthatthislesionisa:
a.Benignlesion
b.Invasivecarcinoma
c.Insitucarcinoma
d.Sclerosingcondition
e.Sarcoma
54.Thedesignationsductalandlobularwithreferencetocarcinomaofthebreastreferto:
a.Tumorgrowthpatterns
b.Celloforiginofthetumor
c.TumorGrade
d.Degreeofinvasiveness
e.Anatomicsiteoforiginoftumor
55.Examinationofamastectomyspecimeninthepathologylabrevealsaneczemalikeerythematous
eruptiononthenipplewithscalecrust.Underlyingthisisaninvasiveductalcarcinoma.H&E
sectionsfromthenippleshowpresenceoflargeatypicalcellsintheepidermiswithnobreechofthe
basementmembraneoftheskin.Whatisthisconditioncalled?
a.Dermatitis
b.Psoriasis
c.Inflammatorycarcinoma
d.Comedocarcinoma
e.Pagetsdisease
56.A30yearoldfemalesmokerpresentswithapainfulsubareolarmassinherleftbreast.On
examinationthenippleisfoundtobeinverted.Histologyofexcisedlesionshowssquamous
metaplasiaoflactiferousductwithabundantkeratintrappedinthelumen.Adjacenttissueshows
chronicinflammation.Whatisthediagnosis?
a.Pagetsdisease
b.Acutemastitis
c.Fatnecrosis
d.Periductalmastitis
e.Mammaryductectasia

57.Thehistoryofa35yearoldfemalepresentingwithmenorrhagiashowsthatshewasoperatedfora
fibroadenomainherleftbreastfiveyearsback.Whatisthislesion?
a.Inflammatorydisease
b.Malignantepithelialneoplasm
c.Benignepithelialneoplasm
d.Reactivefibrohistiocyticlesion
e.Sarcoma
58.Two60yearoldwomenarerecruitedintoascreeningprogramforbreastcancer.Thefirstwoman
(A)gavebirthtoherfirstchildat18yearsofagewhilethesecondwoman(B)hadherfirstissueat
34years.Ifallotherfactorsareconsideredequalwhichstatementismostaccurateregardingthe
relativeriskofthetwowomendevelopingbreastcancer?
a.Bothhaveequalrisk
b.Ahasthegreaterrisk
c.Bhasthegreaterrisk
d.Bothhavenorisksinceparitypreventsbreastcancer
e.Bothhavenorisksincebreastcancerisrareafter60yearsofage
59.FDAhasbannedhormonalreplacementtherapyfortreatmentofpostmenopausalsymptomssinceit
wasfoundtobeassociatedwithanincreasedriskofdevelopingbreastcancer.Howcanthisbe
bestexplained?
a.Prolongedexposuretoestrogenincreasestheriskofbreastcancer
b.Prolongedexposuretoprogesteroneincreasestheriskofbreastcancer
c.Allhormonesexogenouslyadministeredincreasetheriskofbreastcancer
d.Postmenopausalwomenareatincreasedriskofbreastcarcinomaregardlessof
hormonalstatus
e.Therelativeexcessofandrogensinpostmenopausalwomenisprotectiveagainst
breastcancer
60.Ofthehistologicalsubtypesofbreastcarcinoma,whichmetastasizesmostfrequentlyto
peritoneum,reteroperitoneumandleptomeninges?
a.Invasiveductalcarcinoma
b.Lobularcarcinoma
c.Mucinouscarcinoma
d.Medullarycarcinoma
e.Metaplasticcarcinoma

Musculoskeletal,Bonesandjoints

61.A55yearoldfemalepatientpresentswithdeepachingpainintherightkneejoint.Clinicalexam
revealosteophytes(Heberdonnodes)atdistalinterphalangealjointsofhands.Xrayshows
narrowingofjointspace,subchondralsclerosisandosteophyteslipping.SerumRAfactoris
negative.Thispathologicalprocessprimarilytargets:
a.Hyalinecartilage
b.Subchondralbone
c.Articularcartilage
d.Synovium
e.Periosteum
62.A30yearoldfemalepresentswithmorningstiffnesswithpainandswellingofmetacarpophalangeal
jointsandproximalinterphalangealjointsofherhands.SerumRAfactorispositive.Thiscondition
resultsfromanautoimmunereactionagainst:
a.Articularcartilage
b.Periosteumofbone
c.Hyalinecartilage
d.Synovium
e.Unknownarthritogenicantigen
63.Juvenilerheumatoidarthritisaffects:
a.Largerjointsmorefrequentlythansmallerjoints
b.Smallerjointsmorefrequentlythanlargerjoints
c.Bothlargeandsmalljointsequally
d.Onlykneejoint
e.Onlysmalljointsoffingers

64.Severaldaysafteranepisodeofurethritisa28yroldmandevelopsacutepainandswellingofthe
leftknee.Onphysicalexaminationthekneeisswollenandiswarmandtendertotouch.Noother
jointsappeartobeaffected.Labexamoffluidaspiratedfromtheleftkneejointshoesnumerous
neutrophils.Agramstainofthefluidshowsgramveintracellulardiplococcic.Nocrystalsareseen.
Whichisthemostlikelyorgasnism?
a.Borreliaburgdorferi
b.Treponemapallidum
c.Neisseriagonorrhoeae
d.Staphylococcusaureus
e.Haemophilusinfluenza
65.A47yroldmanseesthephysicianbecausehehashaddullconstantpaininthemidsectionofthe
rightthighforthepast4months.Onphysicalexamthereispainonpalpationopftheanteriorright
thighwhichworsensslightlywithmovement.Therightthighappearstohavealargercircumference
thantheleftthigh.Aradiogaraphoftherightupperlegandpelvisshowsnofracturebutthereisanill
definedsofttissuemassanteriortothefemur.MRIshowsa1087cmsolidmassdeeptothe
quadricepsbutitdoesnotinvolvethefemur.Whatisthemostlikelydiagnosis?
a.Nodularfasciitis
b.Liposarcoma
c.Osteosarcoma
d.Rhabdomysarcoma
e.Haemangioma
f.Chondrosarcoma

SEQsfromGIT,Liver,Kidney
MCQsfromGIT,Liver,GallBladderAndBiliaryTract,Kidneyanditscollecting
system
MCQsfromPathologyofCVSandHaematologyDiseases

Postedin:FourthYearMBBSpastpapers,PASTPAPERSMBBS

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