PEER-REVIEWED ARTICLES

1. G. B. Karlsson and F. M. Platt. Analysis and isolation of human transferrin receptor using the
OKT-9 monoclonal antibody covalently coupled to magnetic beads (1991) Analytical.
Biochem. 199; 219-222

2. F. M. Platt, G. B. Karlsson, and G. S. Jacob. Modulation of cell surface transferrin receptor by

iminosugar N-butyldeoxynojirmycin (1992) Eur. J. Biochem. 208; 187-193

3. G. B. Karlsson, T. D. Butters, R. A. Dwek, and F. M. Platt Effect of the imino-sugar N-

butyldeoxynojirimycin on the N-glycosylation of recombinant gp120 (1993) J. Biol. Chem.
268; 570-576

4. F. M. Platt, G. R. Neises, G. B. Karlsson, R. A. Dwek, and T. D. Butters. N-

butyldeoxygalactonojirimycin inhibits glycolipid biosynthesis but does not affect N-linked
oligosaccharide processing (1994) J. Biol. Chem. 269; 27108-27114

5. P. B. Fisher, M. Collin, G. B. Karlsson, W. James, T. D. Butters, S. J. Davis, S. Gordon, R. A.

Dwek, and F. M. Platt. The alpha-glucosidase inhibitor N-butyldeoxynojirimycin inhibits
human immunodeficiency virus entry at the level of post-CD4 binding (1995) J. Virol. 69;
5791-5797

6. F. Gao, S. G. Morrison, D. L. Robertson, C. L. Thornton, S. Craig, G. Karlsson, J. Sodroski, M.

Morgado, B. Galvao-Castro, H. von Briesen, S. Beddows, J. Weber, P. M. Sharp, G. M. Shaw,
B. H. Hahn, and the WHO and NIAID Networks for HIV isolation and characterization.
Molecular cloning and analysis of functional envelope genes from human immunodeficiency
virus type 1 sequence subtypes A through G (1995) J. Virol. 70; 1651-1667

7. G. B. Karlsson, F. Gao, J. Robinson, B. H. Hahn, and J. Sodroski. Increased envelope spike

density and stability are not required for the neutralization resistance of primary human
immunodeficiency viruses (1996) J. Virol. 70; 6136-6142

8. P. B. Fisher, G. B. Karlsson, T. D. Butters, R. A. Dwek, and F. M. Platt. N-

butyldeoxynojirimycin mediated inhibition of human immunodeficiency virus type 1 entry
correlates with changes in antibody recognition of the V1/V2 region of gp120 (1996) J. Virol.
70; 7143-7152

9. P. B. Fisher, G. B. Karlsson, R. A. Dwek, and F. M. Platt. N-butyldeoxynojirimycin mediated

inhibition of human immunodeficiency virus type 1 entry correlates with impairment of
gp120 shedding and gp41 exposure (1996) J. Virol. 70; 7153-7160

10. K. A. Reimann, J. T. Li, R. Veazey, M. Halloran, I-W. Park, G. B. Karlsson, J. Sodroski, and N. L.
Letvin. A chimeric simian/human immunodeficiency virus expressing a primary patient HIV-1
isolate env causing an AIDS-like disease after in vivo passage in Rhesus Monkeys (1996) J.
Virol. 70; 6922-6928

11. G. B. Karlsson, M. Halloran, J. Li, I-W. Park, R. Gomila, K. A. Reimann, M. K. Axthelm, S. A. Iliff,
N. L. Letvin, and J. Sodroski. (1997) Characterization of molecularly cloned simian-human
immunodeficiency viruses causing rapid CD4+ lymphocyte depletion in rhesus monkeys
(1997) J. Virol. 71; 4218-4225
12. M. Farzan, H. Choe, K. Martin, L. Marcon, W. Hofmann, G. Karlsson, Y. Sun, P. Barrett, N.
Marchand, N. Sullivan, N. Gerard, C. Gerard, and J. Sodroski. Two orphan seven-
transmembrane segment receptors that are expressed in CD4-positive cells support simian
immunodeficinecy virus infection (1997) J. Exp. Med. 186; 405-411

13. D. H. Margolin, K. A. Reimann, J. Sodroski, G. B. Karlsson, K. Tenner-Racz, P. Racz, and N. L.

Letvin. Immunoglobulin VH usage during primary infection of rhesus monkeys with simian-
human immunodeficiency viruses (1997) J. Virol. 71; 8582-8591

14. B. Etemad-Moghadam, G. B. Karlsson, M. Halloran, Y. Sun, D. Schenten, M. Fernandes, N.

Letvin, and J. Sodroski. Characterization of Simian-Human Immunodeficiency virus envelope
glycoprotein epitopes recognized by neutralizing antibodies from infected monkeys (1998) J.
Virol. 72; 8437-8445

15. G. B. Karlsson, M. Halloran, D. Schenten, J. Lee, P. Racz, K. Tenner-Racz, J. Manola, R.

Gelman, B. Etemad-Moghadam, E. Desjardins, R. Wyatt, N. P. Gerard, L. Marcon, D. Margolin,
J. Fanton, M. K. Axthelm, N. L. Letvin, and J. Sodroski. The envelope glycoprotein
ectodomains determine the efficiency of CD4+ T-lymphocyte depletion in simian-human
immunodeficiency virus-infected macaques (1998) J. Exp. Med. 188; 1159-1171

16. M. Cayabyab, G. B. Karlsson, B. Etemad-Moghadam, W. Hofmann, T. Steenbeke, M. Halloran,

J. W., Fanton, M. K. Axthelm, N. L. Letvin, and J. Sodroski. Changes in human
immunodeficiency virus type 1 envelope glycoproteins responsible for the pathogenicity of a
multiply passaged simian-human immunodeficiency virus (SHIV-HXBc2) (1999) J. Virol. 73;
976-984

17. D. Schenten, L. Marcon, G. B. Karlsson, C. Parolin, T. Kodama, N. Gerard, and J. Sodroski.

Effects of soluble CD4 on simian immunodeficiency virus infection of CD4-positive and CD4-
negative cells (1999) J. Virol. 73; 5373-5380

18. B. Etemad-Moghadam, Y. Sun, E. K. Nicholson, G. B. Karlsson, D. Schenten, and J. Sodroski

Determinants of neutralization resistance in the envelope glycoproteins of a simian-human
immunodeficiency virus (SHIV) passaged in vivo (1999) J. Virol. 73; 8873-8879

19. K. A. Reimann, A. Watson, P. J. Dailey, W. Lin, C. I. Lord, T. D. Steenbeke, M. K. Axthelm, and

G. B. Karlsson. Viral burden and disease progression in rhesus monkeys infected with
chimeric simian human immunodeficiency viruses (1999) Virology 256; 15-21

20. G. B. Karlsson, A. Jensen, L. F. Stevenson, Y. L. Wood, D. P. Lane, and M. Shandorf Srensen

Intracellular expression of p53-activating peptides: visualisation of reporter gene induction
at the single cell level (2004) Br. J. Cancer, 91:1488-94.

21. E. K. L. Nordstrm, M. N. E. Forsell, C. Barnfield, E. Bonin, M. Sundstrm, G. B. Karlsson, and

P. Liljestrm, Enhanced induction of HIV-1 specific T cell responses using alphavirus replicon
DNA vaccines (2005) J. Gen Virol 86; 349-354

22. . S. Hidmark, G. M. McInerney, E. K. L. Nordstrm, I. Douagi, K. M. Werner, P. Liljestrm,

and G. B. Karlsson Hedestam Early IFNalpha/beta production by myeloid dendritic cells in
response to UV-treated virus requires viral entry and IRF-3, but not MyD88 (2005) J. Virol.
79; 10376-10385
23. M. N. E. Forsell, Y. Li, M. Sundbck, K. Svehla, P. Liljestrm, J. Mascola, R. Wyatt and G. B.
Karlsson Hedestam Biochemical and immunogenic characterization of soluble HIV-1
envelope glycoprotein trimers expressed by Semliki Forest virus (2005) J. Virol. 79: 10902-
10914

24. M. Sundbck, I. Douagi, C. Dajaray, M. N. E. Forsell, E. L. Nordstrm, G. McInerney, K.

Spngberg, L. Tjder, E. Bonin, M. Sundstrm, P. Liljestrm and G. B. Karlsson Hedestam,
Efficient expansion of HIV-1 specific T cell responses by homologous immunization with
recombinant Semliki Forest virus particles (2005) Virology 341: 190-202

25. . S. Hidmark, E. K. L. Nordstrm, P. Dosenovic, M. Forsell, P. Liljestrm, and G. B. Karlsson

Hedestam Humoral immunity against co-immunized protein antigen but not against
alphavirus-encoded antigens require IFNalpha/beta signaling (2006) J. Virol. 80; 7100-7110

26. H. Sjlin, S. H. Robbins, . Hidmark, E. Tomasello, M. Johansson, G. Bessou, H. Hall, F. Charifi,

C. A. Biron, K. G. B. Karlsson Hedestam, Krre, P. Hglund, E. Vivier, M. Dalod Differential
regulation of Il-12 and IFNalpha production by endogenous DAP12 signalling in pDCs during
viral infection in vivo (2006) J. Immunol. 177; 2908-2916

27. Douagi, G. McInerney, . S. Hidmark, V. Miriallis, K. Johansen, L. Svensson and G. B. Karlsson

Hedestam Role of IRF-3 in Type I IFN Responses in Rotavirus Infected Dendritic cells and
Fibroblasts (2007) J. Virol. 81; 2758-2768

28. L. Breakwell, P. Dosenovic, G. B. Karlsson Hedestam, M. D'Amato, P. Liljestrm, J. Fazakerley,

and G. M. McInerney. Semliki Forest virus non-structural protein 2 is involved in the
suppression of the type I Interferon response (2007) J. Virol. 81; 8677-8684

29. M. Hgbom, R. Collins, S. van den Berg, R-M. Jenvert, T. Karlberg, T. Kotenyova, A. Flores, G.
B. Karlsson Hedestam and L. Holmberg Schiavone Crystal Structure of the conserved core of
the human DEAD-box helicase DDX3X in complex with the mononucleotide AMP (2007) J.
Mol. Biol.372; 150-159

30. M. N. E. Forsell, G. McInerney, P. Dosenovic, . S. Hidmark, C. Eriksson, P. Liljestrm, C.

Grundner and G. B. Karlsson Hedestam Increased HIV-1 Env expression and antibody
induction using an enhanced alphavirus vector (2007) J. Gen Virol 88:2774-2779

31. M. N. E. Forsell, B. Dey, A. Mrner, K. Svehla, S. Odell, C-M Hgerkorp, G. Voss, R.

Thorstensson, G. Shaw, J. Mascola, G. B. Karlsson Hedestam and R. T. Wyatt B cell
recognition of the conserved HIV-1 co-receptor binding site is altered by endogenous
primate CD4 (2008) PLoS Pathog. 2008 Oct 3;4(10):e1000171

32. C. Sundling, K. Schn, A. Mrner, M. N. E. Forsell, R Wyatt, R. Thorstensson, G. B. Karlsson

Hedestam and N. Lycke CTA1-DD adjuvant promotes strong immune responses against
human immunodeficiency virus type I envelope glycoproteins following mucosal
immunizations (2008) J Gen Virol; 89: 2954 - 2964

33. A. Mrner, I. Douagi, M. N. E. Forsell, C. Sundling, P. Dosenovic, S. Odell, B. Dey, P. Kwong, G.

Voss, R. Thorstensson, J. Mascola, R. Wyatt and G. B. Karlsson Hedestam HIV-1 Env-trimer
immunization of macaques and impact of priming with viral vector or stabilized core protein
(2009) J. Virol; 83: 540-551
34. I. Douagi, C. Gujer, C. Sundling, W. Adams, R. Seder, A. Smed-Srenssen, G. B. Karlsson
Hedestam and K. Lor, Human B cell responses to toll-like receptor ligands are differentially
modulated by myeloid and plasmacytoid dendritic cells (2009) J. Immunol. 182:1991-2001

35. W. C. Adams, E. Bond, M. Havenga, L. Holterman, J. Goudsmit, G. B. Karlsson Hedestam, R.

A. Koup and K. Lor Adenovirus Serotype 5 Infects Human Dendritic Cells via a CAR-
Independent Receptor Pathway Mediated by Lactoferrin and DC-SIGN. (2009) J Gen Virol;
90:1600-1610

36. P. Dosenovic, B. Chakrabarti, M. Soldemo, I. Douagi, M. N. E. Forsell, Y. Li, A. Phogat, S.

Paulie, J. Hoxie, R. T. Wyatt and G. B. Karlsson Hedestam Selective expansion of HIV-1 Env-
specific B cell subsets recognizing distinct structural elements following immunization
(2009). J. Immunol. 183; 3373-82

37. I. Douagi, M.N.E. Forsell, C. Sundling, S. ODell, Y. Feng, P. Dosenovic, Y. Li, J. Mascola, K. Lor,
R. Wyatt and G.B. Karlsson Hedestam Influence of Novel CD4 binding-defective HIV-1
Envelope Glycoprotein Immunogens on Neutralizing Antibody and T Cell Responses in
Nonhuman Primates (2010). J. Virol. 84; 1683-1695

38. O.M. Siggs, M. Berger, P. Krebs, C. Arnold, C. Eidenschenk, C. Huber, E. Pirie, N.G. Smart, K.
Khovananth, Y. Xia, G.M. McInerney, G.B. Karlsson Hedestam, D. Nemazee and B.A. Beutler
A mutation of Ikbkg causes immune deficiency without impairing degradation of IB
(2010) Proc. Nat. Acad. Sci. 107; 3046-51.

39. K. Eng, M. Panas, G. B. Karlsson Hedestam and G. M. McInerney. A novel quantitative flow
cytometry based assay for autophagy flux (2010) Autophagy, Jul 19;6(5).

40. C. Sundling, M.N.E. Forsell, S. ODell, Y. Feng, S. Rao, K. Lor, J. Mascola, R.T. Wyatt, I. Douagi
and G.B. Karlsson Hedestam. Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse
functional B cell responses in primates (2010). J Exp Med; 207: 2003-17

41. C. Sundling, S. ODell, I. Douagi, M.N.E. Forsell, A. Mrner, R.T. Wyatt, J. Mascola, and G.B.
Karlsson Hedestam. Immunization with wild-type or CD4 binding-defective HIV-1 Env
trimers reduces viremia equivalently following heterologous SHIV challenge (2010) J Virol;
84: 9086-95

42. J. Guenaga, P. Dosenovic, G. Ofek, D. Baker, W.R. Schief, P.D. Kwong, G.B Karlsson Hedestam
and R.T. Wyatt Heterologous epitope-scaffold prime:boosting immuno-focuses B cell
responses to the HIV-1 gp41 2F5 neutralization determinant (2011) PLoS One (2011) 6;
16074

43. C. Gujer, K.J. Sandgren, I. Douagi, W.C. Adams, C. Sundling, A Smed-Srensen, R.A. Seder,
G.B. Karlsson Hedestam, K. Lor. IFN produced by human plasmacytoid dendritic cells
enhances T cell dependent nave B cell activation (2011) Journal of Leukocyte Biology,
89(6):811-21

44. W.C. Adams, C. Gujer, G.M. McInerney, J.G.D. Gall, C. Petrovas, G.B. Karlsson Hedestam, R.A.
Koup and K. Lor Adenovirus type-35 vectors block human CD4+ T cell activation by CD46
ligation (2011) Proc. Nat. Acad. Sci. 108:7499-504
45. C. Gujer, C. Sundling, R.A. Seder, G.B. Karlsson Hedestam, K. Lor. Human and Rhesus
plasmacytoid dendritic cell and B cell responses to TLR stimulation (2011) Immunology
134:257-69

46. Y. Feng, K. McKee, S. ODell, S.D. Schmidt, A. Phogat A, E.A. Lybarger, M.N. Forsell, G.B.
Karlsson Hedestam, J.R. Mascola and R.T. Wyatt Biochemically defined HIV-1 Env variant
immunogens display differential binding and neutralizing specificities to the CD4 binding
(2012) J Biol Chem. Feb 17;287(8):5673-86

47. K. Eng, M. Panas, D. Murphy, G.B. Karlsson Hedestam and G.M. McInerney Accumulation of
autophagosomes in Semliki Forest virus infected cells is dependent on the expression of the
viral glycoproteins (2012) J Virol.; 86:5674-85

48. W.C. Adams, R.J. Berenson, G.B. Karlsson Hedestam, A. Lieber, R. A. Koup, and K. Lor
Attenuation of CD4+ T cell function by human adenovirus type-35 is mediated by the knob
protein J Gen Virol. (2012); 93:1339-44

49. P. Dosenovic, M. Soldemo, J. L. Scholz, M. C. Karlsson, R.T. Wyatt, M.P. Cancro, G.B. Karlsson
Hedestam BLyS-mediated modulation of nave B cell subsets impacts HIV Env-induced
antibody responses (2012) J. Immunol. 2012 Jun 15;188(12):6018-26

50. C. Sundling, Y. Li, N. Huynh, R. Wilson, S. ODell, C. Poulsen, J. R. Mascola, R. T. Wyatt, and
G.B. Karlsson Hedestam High-resolution genetic and functional definition of vaccine-elicited
B cell responses against the HIV primary receptor binding site (2012) Science Translational
Medicine 2012 Jul 11;4(142):142ra96

51. C. N. Arnold, E. Pirie, P. Dosenovic, G. McInerney, O. Siggs, Y. Xia, G. B. Karlsson Hedestam,

and B. Beutler A forward genetic screen reveals novel roles for Nfkbid, Zeb1, and Ruvbl2 in
humoral immune responses (2012) Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12286-93

52. C. Sundling, G. Phad, I. Douagi, M. Navis and G.B. Karlsson Hedestam Isolation of antibody
V(D)J sequences with from single cell sorted rhesus macaque B cells (2012) J. Immunol.
Methods 2012 Dec 14;386(1-2):85-93

53. M. D. Panas, M. Varjak, A. Lulla, K. Eng, A. Merits, G. B. Karlsson Hedestam and G. M.

McInerney Semliki Forest virus non-structural protein 3 sequesters G3BP into viral
replication complexes to inhibit stress granule assembly (2012) Mol. Biol. Cell. 2012
Dec;23(24):4701-12

54. C. Sundling, P. Martinez Murillo, M. Soldemo, M. Spngberg, K. Lvgren Bengtsson, L.

Stertman, M.N. Forsell, and G. B. Karlsson Hedestam Rapid contraction of circulating
antibody and memory B cells in macaques immunized with soluble HIV-1 and influenza virus
envelope glycoproteins (2013) J. Inf. Dis 2013 Feb 1;207(3):426-31

55. Kuri T, Smed-Srensen A, Karlsson Hedestam GB, Normark S, Henriques Normark B,

McInerney GM and Plant L: Influenza A virus-mediated priming enhances cytokine secretion
by human dendritic cells infected with Streptococcus pneumoniae. Cellular Microbiology
2013 Feb 20. doi: 10.1111/cmi.12122.

56. M. N. E., Forsell, M. Soldemo, P. Dosenovic, R.T. Wyatt, M.C. Karlsson and G. B. Karlsson
Hedestam Independent expansion of epitope-specific plasma cell responses upon HIV-1
envelope glycoprotein immunization (2013) Journal of Immunology; 191(1):44-51
57. Sandgren K, Smed-Srensen A,, Forsell M, Soldemo, M., Liang F, Perbeck L, Wyatt R, Karlsson
Hedestam G.B., Lor K. Human plasmacytoid dendritic cells efficiently capture HIV-1
envelope glycoproteins via CD4 for antigen presentation (2013) Journal of Immunology;
191(1):60-69

58. Y. Feng, M. N. E., Forsell, B. Flynn, W. Adams, K. Lor, R. Seder, R. Wyatt and G. B. Karlsson
Hedestam Functional analysis of HIV-1 envelope glycoproteins covalently linked to Toll-like
receptor ligands (2013) Virology; 446: 56-65

59. B. Chakrabarti, Y. Feng, S. Kumar, K. McKee, G.B. Karlsson Hedestam, C. Labranche, D. C

Montefiore, J.R. Mascola and R. T. Wyatt HIV-1 JRFL Envelope Glycoprotein Trimers Elicit
Robust Neutralizing Antibodies in Two Distinct Assays (2013) Journal of Virology; EPub
ahead of print Sept 25

60. K. Tran, J. Guenaga, C. Poulsen, N. de Val Alda, R. Wilson, C. Sundling, Y. Li, R. Stanfield, I.
Wilson, A. Ward, G. B. Karlsson Hedestam and R. Wyatt Vaccine-elicited primate antibodies
use a distinct approach to the HIV-1 primary receptor binding site informing vaccine
redesign (2014) Proc Natl Acad Sci U S A; Epub. February 4, 2014

61. Sundling, Z. Zhang, G. Phad, Z. Sheng, Y. Wang, J. Mascola, Y. Li, R.T. Wyatt, L. Shapiro, and
G.B. Karlsson Hedestam Single-cell and deep sequencing of macaque B cells reveal a diverse
IGHV repertoire following immunization (2014) Journal of Immunology; 192(8):3637-44

62. M. Spngberg, P. Martinez, H. Fredlund, G. B. Karlsson Hedestam and C. Sundling A simple

and safe technique for longitudinal bone marrow aspiration in cynomolgus and rhesus
macaques (2014) Journal of Immunological Methods: S0022-1759(14)00149-5

63. M. Navis, K. Tran, S. Bale, G. Phad, J. Guenaga, R. Wilson, M. Soldemo, K. McKee, C. Sundling,
J. Mascola, Y. Li, R.T. Wyatt and G. B. Karlsson Hedestam HIV-1 receptor binding site-
directed antibodies using a VH1-2 gene segment orthologue are activated by Env trimer
immunization (2014) PLOS Pathogens;10(8):e1004337

64. G. Pedersen, M. dori, S. Khoenkhoen, P. Dosenovic, B. Beutler and G. B. Karlsson Hedestam

B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IkBNS
(2014) Proc Natl Acad Sci U S A, 111(39):E4119-26

65. M. Soldemo, G. Pedersen and G. B. Karlsson Hedestam HIV-1 Env-specific memory and
germinal center B cells in C57BL/6 mice (2014) Viruses, 2014 Sep 5;6(9):3400-14

66. P. Dosenovic, M. dori, W. Adams, G. Pedersen, M. Soldemo, B. Beutler and G. B. Karlsson

Hedestam Slc15a4 function is required for intact class switch recombination to IgG2c in
response to TLR9 stimulation. (2014) Immunol Cell Biol. 2014 Oct 14. doi: 10.1038/icb

67. F. Klein, L. Nogueira, Y. Nishimura, G. Phad, A. P. West, A. Halper-Stromberg, J. A. Horwitz, A.

Gazumyan, C. Liu, T. Eisenreich, M. Martin, P. J. Bjorkman, G. Ftkenheuer, M. S. Seaman, S.
Zolla-Pazner, G. B. Karlsson Hedestam and M. C. Nussenzweig Enhanced HIV-1
immunotherapy by naturally arising antibodies targeting resistant variants (2014) J. Exp.
Med.; 211(12):2361-72

68. M. Zeng, Z. Hu, X. Shi, X. Li, X. Zhan, M. Tang, M. Fina, R. Deberardinis, E. M. Y. Moresco, G.
Pedersen, G. M. McInerney, G. B. Karlsson Hedestam, Z. J. Chen, B. Beutler Essential
 requirement for MAVS, cGAS, and endogenous retroviruses in T-independent B cell
responses (2014) Science. Online 18 December 2014, doi: 10.1126/science.1257780

69. T.Wang, X. Zhan, C. Bu, S. Lyon, D. Pratt, S. Hildebrand, J. Choi, Z. Zhang, M. Zeng, K. Wang, E.
Turer, Z. Chen, D. Zhang, T. Yue, Y. Wang, H. Shi, J. Wang, L. Sun, J. SoRelle, W. McAlpine, N.
Hutchins, X. Zhan, M. Fina, R. Gobert, J. Quan, M. Kreutzer, S. Arnett, K. Hawkins, A. Leach, C.
Tate, C. Daniels, C. Reyna, L. Prince, S. Davis, J. Purrington, R. Bearden, J. Weatherly, D.
White, J. Russell, Q. Sun, M. Tang, X. Li, L. Scott, E. Moresco, G. M. McInerney, G. B. Karlsson
Hedestam, Y. Xie, and B. Beutler Realtime resolution of point mutations that cause
phenovariance in mice (2015) Proc Natl Acad Sci U S A:10.1073/pnas.1423216112

70. P. Martinez, C. Sundling, S. ODell, J. R. Mascola, R. T. Wyatt, and G. B. Karlsson Hedestam

HIV-1 Env-specific primate immune responses induced by the saponin-based adjuvant
AbISCO-100 with or without TLR9 co-stimulation (2015) Scientific Reports 12;5:8925. doi:
10.1038/srep08925

71. F. Baharom, S. Thomas, A. Bieder, M. Hellmr, M. Volz, KJ Sandgren, G.M. McInerney, G.B.
Karlsson Hedestam, I. Mellman and A. Smed-Srensen Protection of human myeloid
dendritic cell subsets against influenza A virus infection is differentially regulated upon TLR
stimulation. (2015) Journal of Immunology, Mar 23. pii: 1402671

72. G. Phad, N. Vzquez Bernat, Y. Feng, I. Ingale, P. Martinez, S. ODell, Y. Li, J. R. Mascola, C.
Sundling, R. Wyatt and G. B. Karlsson Hedestam Diverse antibody genetic and recognition
properties revealed following HIV-1 Env immunization (2015) Journal of Immunology, May
11. pii: 1500122

73. J. M. Coquet, M. Schuijs, M. J. Smyth, K. Deswarte, R. Beyaert, H. Braun, L. Boon, G. B.

Karlsson Hedestam, S. L. Nutt, H. Hammad and B. N. Lambrecht IL-21 promotes type 2
immune responses and allergic airway inflammation(2015) Immunity 18;43(2):318-30

74. K. Dai, L. He, N. Khan, R. Wilson, K. Tran, Y. Li, C. Sundling, G. B. Karlsson Hedestam, R. T.
Wyatt, and J. Zhu Rhesus macaque B-cell responses to an HIV-1 trimer vaccine revealed by
unbiased longitudinal repertoire analysis (2015) mBio:e01375-15. doi: 10.1128/mBio.01375-
15.

75. K. Dai, S. Kahn, L. He, J. Guenaga, K. McKee, J. Ingale, C. Sundling, S. OOdell, K. McKee, G.
Phad, M. Corcoran, R. Wilson, Y. Li, J. Mascola, J. Zhu, G. B. Karlsson Hedestam, and R. T
Wyatt HIV-1 vaccine-elicited antibodies reverted to their inferred germline reveal
associations between in vitro binding affinity and in vivo activation (2016) Scientific Reports,
Feb 16;6:20987. doi: 10.1038/srep20987

76. N. Madani, A. M. Princiotto, D. Easterhoff, T. Bradley, K. Luo, H-X. Liao, A. Moody, G.E. Phad,
N. Vzquez Bernat, B. Melillo, A. B. Smith III, G. B. Karlsson Hedestam, B. Haynes and J.
Sodroski Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates
Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic
Compounds (2016) Journal of Virology, Mar 9. pii: JVI.03211-15

77. G. Pedersen, M. dori, J. Stark, S. Khoenkhoen, C. Arnold, B. Beutler and G. B. Karlsson

Hedestam Heterozygous mutation in IBNS leads to reduced levels of natural IgM
antibodies and impaired responses to T-independent type 2 antigens in mice (2016)
Frontiers in Immunology, Mar 1;7:65. doi: 10.3389/fimmu.2016.00065
 78. Wang Y., Sundling C., Wilson C., ODell S., Chen Y., Dai K, Phad G., Zhu J, Xiao X., Mascola J. R.,
Karlsson Hedestam G. B., Wyatt R. T., Li Y. High Resolution Longitudinal Study of HIV-1 Env
Vaccine-elicited B Cell Responses against the Virus Primary Receptor Binding Site Reveals
Affinity Maturation and Clonal Persistence (2016) Journal of Immunology Mar 21. pii:
1502543.

79. P. Martinez, L. Pramanik Sollerkvist, C. Sundling, K. Hultenby, P. Wretenberg and G. B.

Karlsson Hedestam Definition of primate bone marrow-resident plasma cells as CD138 and
CD31 double-positive antibody-secreting cells (2016) Front. Immunol., 242, Doi: 10.3389

80. M. Corcoran, G. Phad, N. Vzquez Bernat, C. Stahl-Hennig, N. Sumida, M. Persson, M.

Martin and G. B. Karlsson Hedestam Production of individualized V gene databases reveals
high levels of immunoglobulin genetic diversity (2016) Nature Communications 7:13642,
doi: 10.1038

81. T. Chen, C. Tibbitt, X. Feng, J. M. Stark, L. Rausch, K. Sedimbi, M. C. Karlsson, B. N.

Lambrecht, G. B. Karlsson Hedestam, R. Hendriks, B. Chambers, S. Nylen, J, M. Coquet
PPAR-g promotes type 2 immune responses in allergy and nematode infection (2017)
Science Immunology, In press March 10

PEER-REVIEWED REVIEW ARTICLES AND BOOK CHAPTERS

82. G.B. Karlsson and P. Liljestrm Live viral vectors-Semliki forest virus (2003) Methods in
Molecular Medicine 87:69-82

83. G.B. Karlsson and P. Liljestrm Delivery and expression of heterlogous genes in mammalian
cells using self-replicating alphavirus vectors (2004) Methods in Molecular Biology 246:543-
557

84. M. A. Liu, B. Wahren, and G.B. Karlsson Hedestam DNA vaccines: recent developments and
future possibilities (2006) Human Gene Therapy. 17; 1051-1061

85. S. Phogat, R.T. Wyatt and G. B. Karlsson Hedestam "Inhibition of HIV-1 entry by antibodies:
potential viral and cellular targets" (2007) J. Internal Medicine. 262; 26-43

86. G. B. Karlsson Hedestam, S. Phogat, D. Burton, J. Sodroski, R.T. Wyatt The challenges of
elicitation of neutralizing antibodies to HIV-1 and to influenza virus" (2008) Nature Reviews in
Microbiology 6, 143-155

87. Lor K and G. B. Karlsson Hedestam, Novel adjuvants for B cell immune responses (2009)
Current Opinion in HIV and AIDS, 4; 441-446

88. Gerald McInerney and G. B. Karlsson Hedestam, Direct cleavage, proteasomal degradation
and sequestration: three mechanisms of viral subversion of type I interferon responses"
(2009) Journal of Innate Immunity 6; 1-8

89. G. Pedersen, M. dori and G. B. Karlsson Hedestam NF-B signaling in B-1 cell
development (2015) Annals of the New York Academy of Sciences Jun 11. doi:
10.1111/nyas.12800
90. G. Karlsson Hedestam, J. Guenaga, M. Corcoran and R. Wyatt Evolution of B cell analysis
and Env trimer re-design Immunological Reviews 275; pp-pp