MED23

Medical Spa Expo & Conference

LED Systems and Light Therapy
Fact Vs Fiction
Unlocking the Truth

By Marcel Besse

Faculty Disclosure
Marcel Besse, shareholder Light Bio Science, LLC

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LEDs - Light Emitting Diodes

LED Categories

Yellow 580-600nm
Blue 410-417nm
Red 600-660nm
Mixture

2
 Red LEDs 630-660nm
NASA Studies on Wound Healing
Vasodilation
Blood Flow
Oxygenation
Reduce Pain
Skin Cancer - AKs

Blue LEDs 412-417nm

ACNE Suppression
FDA Cleared
15-20 Minutes Exposure
Multiple Treatments 12-20 3/week
Marginal Results

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 Yellow LEDs 590nm
LED Photomodulation
35 second Pulsed Technology
Light Activation of Fibroblasts
Collagen stimulation
Collagenase/MMP Suppression
FDA Cleared for wrinkle reduction and Skin
Rejuvenation
Dr. David McDaniel..5 Peer Review Studies

LED Photomodulation: Parameter Codes

Wavelength(s)
Bandwidth
Energy Density
Energy Fluence
Time
Continuous Wave vs Pulsed
Pulse Time: On Time & Off Time
# of Pulses
Time Interval of Treatment

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 FDA & Devices
FDA Approved
FDA Cleared
FDA Allowed Claims
FDA Classification Class I Class II
Medical or Non Medical Devices
Cosmetic????

Collagen I Expression In Cultured Human Skin Fibroblasts

24hrs Post LED Exposure (RT-PCR).

590/870nm (0.1 J/cm2 pulsed)

Relative Expression

-1

660nm (0.1 J/cm2 continuous)

-2

-3

-4

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LED Photomodulation 590 nm
visible Yellow
4.0 mW/cm20.1 J/cm

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7
 The Human Cell

The Factory

Human Fibroblast Cell

Mitochondria

The Power Plant

LED Photomodulation

LED Mechanisms of Action

Mitochondria O2

H+
Mitochondrial
cyst c FeCu Inner Membrane
Heme
Ligand
H+
ADP+Pi ATP

H2O

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 % Change in ATP Level
(After Exposure to a 590 nm LED Array)

60

40
% Change

20

Mitochondria photo
0
5

15

30

60

15

30

60
se

m
se

se

se

m
in

in
c

in

in

in
c

Post Exposure Time

LED illumination of fibroblast cells in culture well

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 LED Photomodulation

The exact formula of safe, non-thermal light necessary to

stimulate the formation of our own natural collagen.

LED Photomodulation can slow down the formation of degrading

enzymes that break down our skin.

LED Photomodulation reduces inflammation and thus helps in

the reduction of unsightly skin redness and evens out skin
pigment.

Collagen
Structural Support of the Skin
Adds to Elasticity of the Skin
Thicken & Strengthen Skin
Skin Fitness

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 LED Photomodulation
(57-year-old
(57-year-old photoaged
photoaged female)
female)

Pre
Pre treatment
treatment 11 month
month post
post 88 treatments
treatments

David H. McDaniel, M.D. David H. McDaniel, M.D.

High
High resolution
resolution ultrasound
ultrasound skin
skin imaging
imaging

LED Photomodulation
(LED
(LED device
device alone)
alone)

PRE

POST

New
New collagen
collagen formation
formation is
is blue
blue tissue
tissue

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 Primos Digital Surface Profilometry
(LED
(LED device
device alone)
alone)
PRE
PRE

POST
POST

Collagenase / MMPs
MMP Enzyme to Dissolve & Transport
Damaged Collagen
UV Sun Exposure will Trigger
Collagenase
Smoking will Trigger Collagenase
Non-Ablative Thermal Injury Stimulates
Collagen & Collagenase
GWs Decreases all MMPs
True Anti-Aging

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Environmental Damage/Aging
Identical 59-yo twins: one did not smoke

Smoker Non-Smoker
Photo credit: Dermatology Times (February 2000)

LED Photomodulation Protocol

8 to 10 treatments recommended
One or two treatments per week with
min 2 days rest
Clean dry Skin Critical
Exfoliation before allows better light
penetration
Monthly maintenance is good option

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When Will You See Improvement
4-8 Treatments:
Smoother, Softer, Better Looking Skin,
Decreased Erythema
2-3 months post 8-10 Treatments
Wrinkle Reduction
Pore Size Reduction
Collagen takes 60-90 days to remodel

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Progressive Improvement
1,
1, 8,
8, 16,
16, 24
24 weeks
weeks post
post tx
tx

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 Progressive Improvement
PRE
PRE POST
POST (6
(6 months)
months)

LED Photomodulation works on darker skin

types for pigmentation and smoothing

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 LED Photomodulation
(LED
(LED device
device alone)
alone)

PRE
PRE

POST
POST

Case LED
LED Photomodulation
Photomodulation Case
Case Study
Study
Case #5
#5
(56-year-old
(56-year-old photoaged
photoaged female)
female)

Pre
Pre treatment
treatment 44 months
months post
post 88 treatments
treatments

Robert A. Weiss, M.D. Robert A. Weiss, M.D.

Photos courtesy of Robert A. Weiss, M.D.

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LED Photomodulation Reverses Acute UV
Induced Matrix Enzyme Expression
Robert
Robert Weiss,
Weiss, MD
MD
David
David H.
H. McDaniel,
McDaniel, MD
MD
Roy
Roy Geronemus,
Geronemus, MD
MD
Margaret
Margaret Weiss,
Weiss, MD
MD
John Newman,
John Newman, MDMD

April
April 2004
2004
ASLMS
ASLMS
Annual
Annual Meeting-
Meeting- Dallas
Dallas

Sunburn
LED
LED Photomodulation
Photomodulation

Right side treated with LED Photomodulation

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 Histopathology Results
IL-6
IL-6 -- Marker
Marker showing
showing decreased
decreased inflammation
inflammation in
in the
the skin
skin
PRE
PRE POST
POST (4
(4 months)
months)

IPL Alone

IPL + LED Photomodulation

Courtesy of Mitchel Goldman, MD

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 Dr Tina Alster

LED Photomodulation offers superior

rejuvenation compared to applying
Retin-A, but without the potential
irritation.

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 Skin Fitness
Exercise for the Skin
Healthy Looking Skin
Collagen Thickens and Strengthens Skin
Suppression of Collagenase slows Skin
Breakdown
8 to 10 Treatments to Get your Skin in
Shape
Once a Month to Keep it in Shape

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 LED Photomodulation Benefits
Softer, Smoother Skin
Better Skin Appearance, Less Dull
Softens Skin Redness
Reduction of Fine Lines and Wrinkles
Better Skin Tone & Texture
Better Canvas = Better Results!!!

Why LED Photomodulation

Pain Free Risk Free Affordable
Safely & Effectively Treat All Skin Types
Repeat VisitsNew Revenues
Skin Health Skin Fitness Collagen Production
Best compliment to all Procedures!!!!!!
Rescue Device!!!!! Anti-Inflammatory ---Redness
Your Skin Looks Great!

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 Credentials
FDA Studied Device
FDA Cleared for Collagen Production
FDA Photos
Peer Review Published
Luminary Endorsed
Science First -- Proven Results
Strong Media Exposure

Thank you for attending!

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