BREX Pharmacy Review Center Phils. Co.
Additional Notes:
Module 5 -Pharmaceutics (17.5%)
Dosage Forms and Drug Delivery System and
Manufacturing Pharmacy
Prepared, Revised and Updated by:
Mr. Jerico Isaiah S. Dumbrique, RPh,
MCEM (on-going), Juris-Doctor (candidate)
References:
1) Ansel, Howard C, et. al., ed.
Pharmaceutical Dosage Forms and Drug
Delivery Systems. 7th ed. USA: Lippincott
Williams & Wilkins. 1999.
2) BREX Pharmacy Review Center Phils.
Co., 2016: BREX Manual, power point
presentations and lecture notes, compiled
previous BREX modular exams, mock
board exams, critical thinking and final
coaching materials.
3) Gennaro, Alfonso, ed. Remington: The
Science and Practice of Pharmacy. 20th
ed. Philadelphia. Mack Publishing Co.
2000
4) Katzung, Bertram G., ed. Basic and
Clinical Pharmacology. 9th ed.
Philadelphia. 2004.
5) Limuaco, Olivia M. and Emma G. Pena.
Pharmaceutical Jurisprudence. 1988.
Philippines: Centro Escolar Univeristy.
6) Martin, Alfred. Et al. Physical Pharmacy:
Physical Chemical Principles in the
Pharmaceutical Sciences 4th ed. 1993.
Lea & Febiger. USA
7) Mims, et. al. Medical Microbiology. 2nd ed.
1998. Mosby Published Ltd.
8) Philippine Association of Colleges of
Pharmacy (PACOP). The
Comprehensive PACOP Pharmacy
Reviewers. 1st and 2nd Editions, 2000 and
2005.
This review material was prepared, revised and updated by:
Mr. Jerico Isaiah S. Dumbrique, RPh, MCEM (on-going), Juris Doctor (Candidate)
Copy Rights Protected for BREXBabies2016
ALCOHOL, USP
Ethyl alcohol, Ethanol, C2H5OH
94.9 to 96% C2H5OH by volume when
determined at 15.56C
Primary solvent for organic compounds
Frequently used with other solvents like
glycols and glycerin to reduce the amount of
alcohol required
Pharmaceutically, a solvent and preservative
Recommended alcohol limit for OTC oral
products:
o Under 6 years of age 0.5 %
o 6-12 years old 5 %
o Over 12 years old 10 %
DILUTED ALCOHOL, NF
Prepared by mixing equal volumes of
Alcohol, USP, and Purified water, USP
Useful as hydroalcoholic solvent in various
pharmaceutical processes and preparations
RUBBING ALCOHOL
Alcohol rubbing compound
Contains 70% of ethyl alcohol by volume
Employed as a rubefacient externally and a
soothing rub for bedridden patients
A germicide for instruments and a skin
cleanser prior to injection
Also used as a vehicle for topical
preparations
GLYCERIN USP
Glycerol, CH2OH-CHOH-CH2OH
Clear syrupy liquid with a sweet taste
Miscible both in water and in alcohol
Has a preservative qualities
used as a stabilizer
auxiliary solvent in conjunction with water or
alcohol
ISOPROPYL RUBBING ALCOHOL
70 % by volume isopropyl alcohol
Externally as a rubefacient and soothing rub
as a vehicle for topical products
PROPYLENE GLYCOL, USP
CH3CH(OH)CH2OH BACTERIOSTATIC SODIUM CHLORIDE
Miscible with water and alcohol INJECTION, USP
Useful as a solvent and is frequently substituted Bacteriostatic Sodium Chloride Injection,
glycerin USP, 0.9% is a sterile, isotonic solution.
Frequently used as catheter or IV lines
WATER FOR INJECTION flush to maintain patency
Used by manufacturer To be labeled NOT FOR USE IN
Not sterilized but pyrogen free NEWBORNS
Should be used within 24 hours after
collection RINGERS INJECTION, USP
Sodium Chloride, Potassium Chloride,
STERILE WATER FOR INJECTION, USP Calcium Chloride
WFI that has been sterilized As a plasma expander, electrolyte
Packaged in single-dose containers of type I replenisher
or type II glass that do not exceed the
capacity of 1 liter
Intended to be used as a solvent, vehicle or LACTATED RINGERS INJECTION, USP
diluent for already-sterilized and packaged Sodium Chloride, Potassium Chloride, Calcium
injectable medications Chloride and sodium lactate
Electrolyte replenisher and systemic alkalinizer
BACTERIOSTATIC WATER FOR INJECTION,
USP Radiopharmaceutical Disease
SWFI that contains one or more suitable Diagnosed/Used
bacteriostatic agents Cyanocobalamin 57 Pernicious anemia
Packaged in pre-filled syringes or in vials capsules
containing NMT 30 mL 125 I Serum Albumin Blood Volume
Employed as a sterile vehicle in the Injection Determination
preparation of small volumes of injectable Iodohippurate 131 I Renal Function
preparations (in multiple-dose vials) Injection
which is also a 0.9% solution, Sodium Chromate 51 Blood Volume
intended solely for multiple reconstitutions. It Cr Injection Determination
contains an agent that inhibits bacterial Sodium Iodide 131 I Thyroid function,
growth (e.g., benzyl alcohol, propylparaben, Capsules / Solution thyroid inhibitor
methylparaben) , Sodium Pertechnetate Brain and thyroid
To be labeled NOT FOR USE IN 99mTc injection scanning
NEWBORNS Sodium Phosphate Ocular tumor
32P Solution localization,
SODIUM CHLORIDE INJECTION, USP antipolycythemic
Usually given as a 0.9% solution. 99mTc Albumin Lung scanning
Because it is isotonic with blood, this Aggregated Injection
solution is called normal saline solution 99mTc Sulfur Collid Imaging areas of
(NSS) . Injection functioning
Frequently used as catheter or IV lines reticuloendoethial
flush to maintain patency celss (liver, speen,
Used to reconstitute medication bone marrow)
This review material was prepared, revised and updated by:
Mr. Jerico Isaiah S. Dumbrique, RPh, MCEM (on-going), Juris Doctor (Candidate)
Copy Rights Protected for BREXBabies2016
99mTc Labelled RBC Cardiaci pooling
pump
99mTc Methylene Bone imaging
Diphosphonate
99mTc Pyrophosphate Cardiac infarct
imaging
99mTc Sestamibi Imaging of
myocardial
perfusion, breast
tumor
99mTc Sulfur Colloid Gastric emptying
cooked in scrambled imaging
eggs
Thallium Parathyroid and
tumor imaging

This review material was prepared, revised and updated by:

Mr. Jerico Isaiah S. Dumbrique, RPh, MCEM (on-going), Juris Doctor (Candidate)
Copy Rights Protected for BREXBabies2016