What is Alzheimers disease?

Alzheimers disease is the most commonly observed neurodegenerative disorder, associated with
memory loss and difficulty with cognitive functions of the body. It can be referred to, as an
adverse form of dementia that can progressively get worsen due to the death or degeneration of
neurons.

How prevalent is Alzheimers disease?

Alzheimer is the very common form of dementia i.e. the memory loss. In 2013, on an average 6
million people were affected by the disease only in US. The CDC, has estimated 50% rise with the
number of people affected by the disease over the age of 65years in every 5 years. In this regard,
the expected projection of 14 million people by the end of 2025 has been put forth by many health
institutions.

In the younger generations, Alzheimer is found but is of very less percentage. Males are more
prone to the diseased condition as compared to the females. Since the death rate of the disease is
increasing, it has been ranked as the 6th leading cause of the disease in US itself.

Factors responsible for Alzheimers Disease

Scientists all over the world are working hard to get the clarification about the Alzheimers
disease, known to undergo progressive brain cells failure. So far it has been cleared that the
disease develops due to the complex results of multiple factors rather than any one particular
cause. As of now, age and genetics play the major role in disease manifestations, although much
research is needed to understand many other factors as well, which are contributing to its
development.

The greatest risk factor for the disease is the growing age of the person. It has been suggested that
the risk of developing the disease increases or doubles up to be precise after every five years.
Another possible risk factor is the family history of the disease. It has been observed that if there
are Alzheimer patients in your family as brothers, sisters or parents then there is increased risk of
developing the disease, through either hereditary or environmental causative factors. The studies
have revealed the fact that both risk genes and deterministic genes can be present in the people
with family history of the disease.

There are many mentioned environmental risk factors which can be avoided such as factors that
can increase the blood vessel risk including diabetes, high blood pressure, stroke which can lead
to the disease.

Symptoms Associated with the Alzheimers Disease

In a progressive diseases like Alzheimers disease, initially mild version of the symptoms are
expressed, which are generally being ignored till the time they get worsen and interfere with the
daily life. It is as well necessary to understand that no two Alzheimer cases are the same; their
experiences with the symptoms can differ in a drastic way! Thus some of the common symptoms
can be noted down as a precaution. The most typical symptom of the disease is the memory lapses
with the regular intervals due to the early damage of the brain in hippocampus region, having a
central role in day to day memory.
The memory loss due to Alzheimers disease increasingly interferes with the daily life as the
condition progresses. The person may:

Lose items around the house.

Struggle to find out the right words in the conversation or forget somebodys name
Forget about the recent conversation, even, situation, etc.
Get lost in the familiar places or journeys.

Apart from the memory issues, some of the people with the disease may also face language
difficulties, difficulty in concentration, planning as well as execution, difficulty in the orientation
etc. The people with the disease may also become very moody, anxious, irritable or notably
depressed.

Stem Cell Treatment for Alzheimers

What goes wrong in Alzheimers disease?

Alzheimers disease is the neurodegenerative disorder named after the scientist Alois Alzheimer;
involving progressive death or damage of the neurons. The post mortem analysis of the brain with
the disease has revealed the fact that nerve tissue has many tiny inclusions of proteins known as
the Plaques and tangles, which interfere with the signalling mechanism of the brain leading to the
damage of brain cells. Plaques have been observed in between the dying cells of the brain from the
accumulation of protein known as the Beta Amyloid proteins. There is also reported
disintegration of another protein known as the tau protein, resulting in the deposition of tangles
between the axonal regions of the brain cells.

These depositions can delay or halt the signalling process of the brain between the brain cells. Due
to loss of work, neurons may become damaged or weak. The disease may thus progressively lead
to the loss of neurons leading to the shrinkage of the total brain.
How Stem Cells treatment can help!

Stem cells are the mother cells that are responsible for developing an entire human body from a
tiny two celled embryo; due to their unlimited divisions and strong power to differentiate into all
the cells of different lineage. This power of stem cells has been harnessed by the technology to
isolate them outside the human body, concentrate in the clean environment and implant back.

Thus, stem cells treatment involves administration of concentrated cells in the targeted area,
wherein they can colonize in the damaged area, adapt the properties of resident stem cells and
initiate some of the lost functions that have been compromised by the disease or injury.

The loads of data accumulated from different research suggested, an evidence based
differentiation of stem cells into neurons. The vasculogenetic properties of stem cells can as well
lead to formation of blood vessels to improve the paracrine effect, supply of growth factors and
immune cells leading to the faster recovery.

Treatment of Alzheimers disease at GIOSTAR

We have mastered the technology for isolating maximum number of viable stem cells from either
the autologous sources of your own body or allogeneically with the matched donor to treat
various children with ASD. We are the licensed, private organization with the excellent, well
equipped state of the art facility to isolate process and enrich the viable number of stem cells,
which can be re infused back into the patients body. Generally, these cells are administered
through any one of the below mentioned methods depending upon our experts advice:

Intrathecal Administration:-Through this mode, cell are infused in the cerebrospinal fluid
through the subarachnoid spaces of the spinal canal.

Intravenous Administration:- Through this mode, cells are infused through the veins
along with the mannitol to expand blood volumes in the central nervous system, to ensure
that the maximum number of cells are reaching to the targeted area.

Once infused back in the body, these cells can be repopulated at the damaged parts of the brain,
through their strong paracrine effects and differentiate into lost or damaged neurons or other
damaged supporting cells to improve motor functions of the brain.

Thus with our standardized, broad based and holistic approach, it is now possible to obtain
noticeable improvements in the patients with the Alzheimers Disease , in the symptoms as well as
their functional abilities.