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What Is Cirrhosis?
Cirrhosis (pronounced sur-o-sis) is a stage of liver disease that occurs when cells in the liver are
damaged and scar tissue forms. This scar tissue causes blood flow to be blocked and waste
products to build up in the body. In cirrhosis, normal areas of liver are surrounded by scarred areas
that do not function properly.
Cirrhosis in pediatric patients causes normal areas of the liver to be surrounded by scarred areas
that do not function properly.
People often think of cirrhosis as a disease caused by long-term alcohol abuse. While this is
sometimes a factor in adults, cirrhosis in children often stems from a wide variety of liver disorders,
including (but certainly not limited to):
Autoimmune hepatitis
Inherited diseases:
o Tyrosinemia
o Wilson disease
o Alpha1-antitrypsin deficiency
o Cystic fibrosis
o Biliary artresia
o Sclerosing cholangitis
o Choledochal cysts
o Isoniazid
o Methotrexate
o Excess vitamin A
Liver cirrhosis symptoms itself often causes no symptoms early in the disease process. Symptoms
start when there is portal hypertension and/or the liver begins to fail, as scar tissue replaces healthy
cells. Symptom severity may depend on the extent of liver damage.
A person in the early stages of cirrhosis may feel fatigued and weak. Sometimes he or she will
experience abdominal swelling that feels tender or painful. Family may notice the person has a poor
appetite or is losing weight.
As the disease progresses, bile flow is blocked or stopped, and jaundice (yellow skin or eyes)
appears. The same bile pigment, bilirubin, which is responsible for the yellow skin tones of jaundice
can turn urine dark. Bleeding and bruising can occur more easily and take longer to heal. Other later
symptoms, some due to complications, include:
Reddened palms
Enlarged liver
Enlarged spleen
Appearance of thin, purplish-red, spidery looking blood vessels on the skin, especially
around the navel
Vomiting blood
Itching
Abdominal infections
Forgetfulness or confusion
Tremors
Liver cancer
Cirrhosis Diagnosis
If your child's doctor suspects that your child has cirrhosis, he or she will perform tests to confirm or
rule out the diagnosis. Tests may include (but are not limited to):
Blood Tests to assess how well the liver is working and determine a cause
Liver Biopsy analyzing a sample of liver tissue removed via a thin needle inserted into the
liver
Cirrhosis Treatment
In general, cirrhosis cannot be cured or reversed, doctors treat it with the following goals:
Your child's doctor may prescribe drugs to treat the underlying cause of the liver disease. Other
medications may be used to control symptoms or fight infections. Some medications are prescribed
to get rid of excess fluid in the body or reduce the risk of a blood vessel breaking. Others help your
child's body cut down on its absorption of harmful waste products or toxins.
If the complications of cirrhosis can no longer be controlled, or if the liver is in danger of no longer
functioning, a liver transplant is often the best option.
Many of the liver disorders that cause cirrhosis in children are not preventable, but there are
precautions you can take. Make sure your child receives all recommended immunizations including
influenza and hepatitis vaccines at the times your pediatrician recommends. If your child needs to
take medications that may damage the liver, follow your doctor's recommendations about blood
tests.
Balanced nutritional intake is important for people who already have cirrhosis of the liver can prevent
or slow further liver damage by following their doctor's instructions regarding diet. Your child may
need extra calories to grow properly and to maintain adequate overall strength. If the cirrhosis is
more advanced and compromises the liver's ability to process protein properly, the doctor may
recommend limiting protein. The doctor may also recommend limiting salt in your child's diet,
because salt tends to make the body retain water. They may also advise avoiding raw seafood.
Make sure your child takes any vitamin supplements prescribed. Due to increased risk of infections,
doctors recommend vaccines against flu, pneumonia, and hepatitis for people with cirrhosis.
One of the dangerous complications that can arise in an individual with cirrhosis is variceal
hemorrhage. This occurs when an enlarged blood vessel in the esophagus and/or stomach breaks
open and causes bleeding. Typically if this occurs one may vomit blood (which could be bright red or
black like coffee grounds). Alternatively, blood might be noted in the stools it could be bright red or
black and tarry. This occurrence is a medical emergency. Immediate medical attention should be
sought, either by calling for an ambulance or by going to the nearest medical facility.
- See more at: http://www.chp.edu/our-services/transplant/liver/education/liver-
disease-states/cirrhosis#sthash.Lu8GFZTC.dpuf