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of Colloid Gelatin
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Gelofusine'
[mt]rOO
---..ea &-iofusincm (O) 4c*]
rcffiffiryil{#*
0123{56
Tine [hourl
Changts in blod volurrc and extravascular fluid tolume after lnfilsion of
t litrc of 0.9tlb sline (5), 4qt modified fluid gelatin {6) and 6oh HES 130 M
ovrr t hourr.
p values S vs G < 0.0@l ; Svs V< 0.0@l; 6 vsV= 0.70
Gelofusine'
[Albuminlb 40dr
{Gelatin urea-linkrdlb 3s s/l
l6datin sueeinylated]b ao s,l
IK'] 5.1 3
lca*1 r 2.5 5
[ilrt9r-1 o.8
[L-lactate] 28
[Glucose] 5-5
fOctanoattl 6.4
PTASMA + HEVNaO PTASMA + Gelofusine 0tla* t54 nrmoUL Cl- 120 mnrol&)
:B:
SID: 39 + 19 = risk hyperclorernic acidosis SID: 39 + 37 = No hypercloremic acidosis
compare other NaCl base
Safety Profile
,rckhrt
h$
Minimol anaphylwcis
unJ B lG{
a.&e
tlrta
tdir.ar
sl{*
ret
r$ol
F&6
e.l
Minimol anaphyloxis of
o, Gelofusine' com pa ra ble
with HES Et Albumin. (d
ct
6 Minimal
ll-
Q coagulation effrcf
C'
Gelafusine' minimal
coagulation effect
compare to HES. {7)
{&b Dihtim
D 6EL0FrJstr{F Et }tEs r30 Hs 200
Br @r GELCIRtSttE }tEs 130 I GElt REt}tpIHES zm
(ctr)
5{}.
Gelofusine';u
Fluid Loss
(Maintenance)
ICU Peri 0perative
I T
Tetraspa
J
n'f Venofu nd n'
Ringerfundin* Gelofusine' i
J
lf patients ore of risk far rensl
failure / coogulatian disarder
T
Gelofusine*
Concentration 40 [4q)]
7,4 r'0.3
Gcloturlnc!
&rlrldor Ilpnlcutlc ldhrtau sgcli.l xrtrf!3 rJ prtcrrtiorr for rrr
flm d rdrdon a!.ltala: Colloldrl plrmr rulum! lubstit tc h. ocldUrioc! lhould b..dnlnlsH with aution Aft er the sd iiiiaist'5lion otGrLlfiialntt infi5iort{
b p.ticoB dth . hlstory of rllcrgic dis.rs.s, .{. just a3.deni crdloldel'voluar.srs<thunt anr
Suctinylrhd glbtln - PmgMrb.rd t r.t ncnt ot rtliliw rsOrrn plrybetob rmctbrs of WyinS dlSru5 ol sarcrity
(- nodiftd f,uid grlrtinl ,10I)0 9 o, &oqrE hygsrlbcnb rd of drosh maY ocelr
- P4hyB of hypotr0do, {co.r,utiq iduction &lofirfipsbuld mly bc dminisEtrrt nith
lffohcub'$dght
It,ghl.r,rrE[x 3Om 0iloo
of oEurl or Cnrl enccsilril; crutbn s Tlr.ftqiidinigof undrsid!& fisctr of
- ?ntdu[ls invDlyi0q Crtra6iD0|tal ci'tublbn &lofurl.i*:rs,,! folla$r
,lrolarlb?nEnl lc{. hcrt.lung rrdline); - ddrdy pDtiolB Lr!: rnrlMtcbid cl(tian all tnd6
nurnbcraoae Armlhhon) - Agltc nonnoolicmh hrcatodiludon. - Fti.nB .t iirt duc to dltrr|.tory orlrlcd t{. liry r,c:Saert arphrlactoid mctio{6
FticnB f,ith coogtrtilt hcrn hiErt. right thcr.5rr: Inmitnt mild nel'aa or abdominal
Sodium rhloridc 70t 0 Catrhdlrrdor ortrt rt. Uiclrb? intullhicncL lrypcrtailion, paiclramicnt milil t*e of lodylqmrrat.uit .,
EdduCrlc. ilrtrt not be.dminiftGd iil cr* of: Fdmoftrry oldafiL or ,tnal inruffic'rcrq wittr
EGcroit olhe or mudr. t &a!|!l irrkrntcn l8
Sdium t5l nrrltul - ]ryI!|rsritiuiv to rnyotthr aomtitrlnts d lilll2 MrkunEnm Qemrnf
Chlor5. t2omtlb0 llndulhO h srch dtr! Gclofurin:r rhould ody tc giYtn
Ihco,ldt.lGmd$it : Z7a m0sn0
- irnrmbcmb, mdn (rcful monitqiae d tllG prthrf3
7.4r03
- hyD!.t?doflon. h-rodyrBmlc n'turtioL
9ll: - lrtrc ordhr ltEufici('rcr.
- **'G blo.d colgulrtio[ d!odc6.
Reference:
1. WilkesN)etal.,,AnesthAnalgg3(2Nl)Theeffectsofboloncedversussoline-bosedhetostorchandcrystalloidsolutionsonocid-bqseondelectrolytestotus
and gostric mucosal peffusion in elderly surgical patients
2. Webb A R et ol. lntensive Cdre Med 15 {1989) ln vitro calloid osmatic pressure of commonly used plasmo exponde rs (Aebfusine) ond substitutes: a study of the
di ffit sibil ity of col I o id molecu les
3. Lobo DN:, Crit Care Med" 2010, Effect af volume looding with 1 liter intravenous infusions of o"99b soline, 4% Gelofusine and 6ch HES (Voluven) on blood volume
and endocrine responses.' o rondamized, three-woy crossover study in heolthy volunteers.
4. Y WH George slide The effect of Fluid lheropy on ocid base balonced (Stewort oppraach) t penonal communicotion
5. TJ Margon, Critical Core April 2AOS The meoning of acid-bosc obnormolities in the ICU - effects of fluid sdministrotion
6. Laxenoire,M-'C.etol.AnnFrAesthReonimlS(1gg4)301-31Oand Lundsgoord-HonsenP.etot.DevBiolStond4S(1980)251-256
7. Fries D. et ol. Anesth Anotg 20a2, The Effect of the Combined Administrotion of Colloids (1etotusine t HES) on the Coogulotion System: An tn Wtro Study lJsing
Thrombela siagroph Coog u latian Analysis
8. Schartgen, F. et ol.: ly'.NCET, 2N? Mor 24 Effects of Hydroryethylstorch ond Gelotin an renol functian in severe sepsis: a multicenter rondarnised study
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