Answer key

MULTIPLE CHOICES :

B 1. The biological half- life of a

A. is a constant physical property of a drug
B. is the time of one-half of the therapeutic activity be lost
C. is constant chemical property of the drug
D. amount of the drug in the body.
A 2. An entity which can be describe by a definite volume & concentration
a drug contained in thar volume.
A. compartment C. receptor
B. serum level D. blood stream
C 3. Tmax means
A. Time of great solubility of drug
B. peak height concentration
C. time of peak concentration
D. AUC values
D 4. The term systemic circulation refers to
A. veins B. arteries C. hepatic vein D. A & B B 5. The term oftenly used to describe drug
distribution & elimination.
A. elimination only C. absorption
B. disposition D. metabolism,
B 6. The principal place for exchange & interchange of biological fluids
A. heart C. capillary network
B. lymphatic vessels D. body fluids
D 7. Absorption is not involved when a drug administered by w/c
of the ff/ route
A. IV B. intraarterial C. intracardiac D. all
C 8. W/c of the ff.poorly perfuse organs or tissues is a potential size
A. liver B. brain C. bone D. lungs
A 9. If drug A is more lipophiollic than Drug B, t
A. Drug A will be better distributed than drug B
B. drug B will be better distributed than drug A
C. drug A is an agonist
D. either A & B
C 10. The most common entry of drug into the cell is through
A. infusion C. diffusion
B. levigation D. dissolution

C 11. Clinical effectiveness often depends on:

A. time after the administration to reach the onset of action
B. minimum serum drug concentration
C. maximum serum drug concentration
D. All of the given
D 12. The onset time for a drug given orally is the time for
A. drug to reach the MTC
B. drug to reach the MEC
C. drug to begin elimination from the body
D. drug to reach the the peak plasma drug concentration

B 13. Biological half-life of a drug i

a constant physical property of a drug
B. the time for one-half of the therapeutic activity be Lost
C. a constant chemical property of a drug.
D. depends entirely on the route of administration

B 14. In which kinetic reactions the rate of reaction dependent on ?

A.. Zero order C. pseudo-first order
B. first-order D. second order

C 15. Tmax means

A. time of great solubility of drugs
B. peak height oncentratio
C. time of peak concentration
D. AUC values

A 16. The integral of drug level over time from zero to infinity is
A. area under curve C. bioavalability
B. biologic half life D. biopharmaceutics

A 17. An entity which can be described by a definite volume &

concentration of drug contained in that volume
A. compartment C. receptor
B. serum level D. blood stream
D 18. W/c of the ff. parameters can evaluate bioequivalency of
drugs?
I. time to reach peak concentration II. AUC
III. Concentration of drug at platau level.
A. I only B. I & II only C. II & III only D. I, II, III
C 19. Study of what the body does to the body.
A. biopharmaceutics C. pharmacokinetics
B pharmacodynamics D,. pharmacology
D 20. An absorption mechanism for Sabin polio vaccine
A. passive diffusion C. active transport
B. ion-pair transport D. vesicular diffusion
C 21. Compared to normal adults, infants have
I. slower absorption II. Smaller Vd
III slower metabolism IV. Shortened elimination time
A. I & II B. III & IV C. I & III D. I,II, & IV
C 22. The only metabolic process present in an infant is
A. REDOX C. sulfation
B. . acetylation D. glucorinidation
C 23. The ff. statements describe the pharmacokinetic profile of
geriatric patients
I.decreased absorption rate II. Increased Vd
III. Decreased metabolism IV. Decreased half life
A. I & II B III & IV C. I & III D.. I,II,& IV
C 24. The rate of zero order reaction
A. changes conctantly C. independent of concentration
B. independent of temp., D. holds only for light
D 25. To achieve the same steady state plasma concentration (for a drug
that is excreted by the kidney) in renal failure patients as in
patients w/ normal function, you should
A. increase the dosing intervals
B. decrease the dose
C. adjust both the dose & the dosing
 D. do any of the above depending upon the pharmacokinetic of
the drug
D 26. W/c of the ff. factors may make it necessary to give lower doses of
drugs to geriatric patients
A. reduced enzyme activity C. enhanced absorption
B. reduced kidney function D. A & B only
B 27. The AUC of a drug can be determined from a graph by using w/c of
the ff. method?
I. law of diminishing returns II.Rule of nine III.Trapezoidalrule
A. I only B. III only C. I & II only D. II & III only
B 28. Differences in bioavailability are most frequently
observed/ drug products administered by w/c route.
A. intravenous C. oral
B. subcutaneous D. sublingual
D 29. In w/c of the ff. sites may drug be metabolized?
I. skin II. Lungs III liver
A. I only B. III only C. I & II only D. all of the given
D 30 For two drugs to be considered pharmaceutical
equivalents includes
A. have the same active ingredient
B. consist of the same salt
C. contain the same excipients
D. both A & B
C 31. Gastric emptying is slowed by all of the ff., except
A. vigorous exercise C hunger
B. fatty food . D. hot meals
A 32. A rate limiting factor in the dissolution of tablet is
A. disintegration of the tablet C. content uniformity
B. thickness D. local effect

D 33. The pH value is calculated mathematically as the

A. log of the [OH - ] ion C. log of the hydrogen ion conc. B. - log of the OH ion conc. D. log [H + ]
B 34. What pH does weak acid greatly ionized?
A. high pH B. low pH C. neutral pH D. any of
the given
D 35. These are addition compounds of drug & water.
A. hydrates B. solvates C. polymorphs D. chelates
A 36. Ability of chemical compounds to exist as optically active
stereomers or enantiomers is known as
A. chirality C. chemical variation
B. polymorphism D. chelating
A 37. A portion of a prolonged release dosage form w/c liberate the
drugs from its form at a slower rate that is unrestricted absorption
rate
A. depot phase C. dissolve phase
B. release phase D. all of the given
B 38. The value of of particle size reduction to enhanced drug absoption
is limited to the situation in which the
A. absorption process occur by active transport
B. absorption processis rate limited by the dissolution of the drug
in the GIT
C. drug is very soluble
D. drug is very potent
B 39. In general, the form of a drug that can be absorbed faster is a/
A. ionized form B. unionized form C. bound form D. A & C A 40. The absorption of vit. A from the GIT
depends on
 A. the presence of bile in the intestine C. acid-base balance
B. which salts is used D. needs of the pati

B 41 In the oral administration of drug for aged people, the

possible consequence/s when the gastric emptying time
is increased is /are
A. reduced mixing of intestinal content C., A and B
B. delayed transfer to the small intestine D. A & D
D 42. A condition that may increase the time of gastric emptying is
A. depression C. lying on the left side
B. stressful D. A and C
D 43. Which of the ff. statement is the least that can increase
drug absorption?
A. increase blood flow to the site of administration
B. decreased particle size
C. increased surface area dedicated to absorption
D. decreased pH when the drug is a weak
D 44. In the diffusion controlled system, the initial rate of
dissolution is directly proportional to the
A. pKa C. quantity of free acids
B. pH D. solubility of a drug in the dissolution
medium
B 45. Sodium pump is a special type of
A. convective transport C. passive transport
B. active transport D. ion-pair transport
B 46. Arrange the mechanism of absorption of drugs in order of
their importance
A. active- passive- convective transport
B. passive diffusion convective active transport
C. convective- active- passive transport
D. active pinocytosis passive
B 47. The driving force for passive absorption of a drug is the
A. specific carrier proteins & show saturation kinetics
B. conc. gradient across a membrane separating body
compartment
C. both A & B
D. none of the given
A 48. If the extent & rate of absorption is similar to the standard drug, it
has achieved the
A. bioequivalence of a drug product C. pharmaceutical
alternative
B. pharmaceutical equivalence D. A & B
D 49. Possible approaches to measure the bioavailability
A. blood level data C. clinical data
B. urinary excretrion data D. all of the given
A 50. Clinical effectiveness often depends on
A. maximum serum drug conc.
B. minimum serum drug conc.
C. time after after the administration to reach the onset of conc.
D. all of the given

B 51. W/c of the ff. physiologic factor is the least influencing drug distribution?
A. osmotic pressure C. tissue perfusion
B. particle size D. diffusional barrier
B 52. A creatinine clearance of 40 is indicative of:
 A. normal kidney function C. moderate renal failure
B. mild renal failure D. severe renal failure
D 53. To achieve the same steady-state plasma concentration
(for a drug that is excreted by the kidney) in renal failure
as in patients with normal renal function, you should,
A. increase the dosing interval\
B. decrease the dose
C. adjust both the dose and the dosing interval
D. do any of the above, depending on the pharmaco-
dynamic properties of the drug
D 54. Which of the following factors may make it necessary to give lower doses of drugs to geriatric patients?
A. reduced enzyme activity
B. reduced kidney function
C. enhanced absorption
D. A and B only
A 55. The ability of chemical compound to exist as optically active stereoisomers or enantiomers is known as:
A. hygroscopicity C. chemical variation
B. micronization D. chelation
A 56. A portion of a prolonged release dosage from which
liberates the drug from the form at a slower rate that is
unrestricted absorption rate:
A. depot phase C. dissolve phase
B. release phase D. AOTA
B 57. The value of particle size reduction to enhance drug absorption is
limited to the situation in which the ________.
absorption process occurs by active transport
B. absorption process is rate limited by dissolution of the drug in the
GIT
C. drug is very solu
D. drug is very potent
D 58. In what part of GIT is where no absorption of food takes place but
large amount of water are absorbed?
A. rectum B. stomach C. small intestine D. large intestine
D 59. In general, the form of a drug that can be absorbed faste
A. pKa value of the drug and pH of the drug product
B. perfusion rate
C. osmotic pressure D. NOTA
C 60. Due to their anatomical structure, the organ that is considered as the
most important site of drug absorption is
A. large intestine C. small intestine
B. stomach D. mucous membrane of the mouth
B 61. In the oral administration of drugs for aged people, the possible
consequence/s when the gastric emptying time is increased is/are
A. reduce mixing of intestinal content
B. delayed transfer to small intestine
C. change in epithelial transfer D. A and C
D 62. Which of the following statements is the least that could increase drug
absorption?
A. increased blood flow to the site of administration
B. increased particle size
C. increased surface area dedicated to absorption
D. decreased pH when the drug is a weak base
A 63. Absorption of vitamin A from the GI tract depends on
A. the presence of bile in the intestine
B. which salt is used
C. acid-base balance
 D. needs of the patient
D 64. A condition that may increase the time of gastric emptying is
A. depression C. stressful
B. lying on the left side D. A and C
B 65. The rate of diffusion of drugs across biological membranes is:
A. independent on the concentration gradient
B. dependent on the availability of carrier substrate
C.directly proportional to the concentration gradient
D. dependent on the route of administration
C 66. The ratio of drug concentration in 2 phases separated by a
semipermeable membrane is called:
A. APC C. concentration gradient
B. pKa D. elimination half-life
D 67. The cell membrane is capable of forming vesicles which may engulf
drug substances outside the cell membrane to transport drug (via the
engulfed drug) into the compartment
A. Ion-pair C. convective transport
B. passive diffusion D. pinocytosis
A 68. The primary proof of drugs availability
A. production of its pharmacologic effect
B. production of high blood levels
C. production of high urine levels D. appearance of metabolites in urine
B 69. These conditions require immediate increase in the blood levels of
the drug except
A. hypertensive attack C. sudden increase in blood glucose B. chronic asthma D. none
C 70. In vitro dissolution rate studies for drug products are useful for
evaluating bioavailability only if they can be correlated with
A. disintegration rates
B. the chemical stability of the drug
C. in vivo studies in humans
D. in vivo studies in at least 3 species of animals
C 71. The relationship between the drug concentration at the site of action
and pharmacologic response
A. pharmacokinetics C. pharmacodynamics B. pharmacology D. none

D 72. In all quantitative work for bioavailability, the concentration

of the drug is measured in the
A. blood/plasma B. urine C. gastric fluid
E. a and b
D 73. Is the difference between the MEC and MTC
A. minimum effective concentration
B. minimum toxic concentration
C. minimum inhibitory concentration
D. therapeutic plasma concentration
A 74. In which kinetic reactions, the rate of reaction is
dependent on concentration??
A. first order C. pseudo first order
B. zero order D. second order
A 75. The onset time for a drug given orally is the time for
A. drug to reach the peak plasma drug concentration
B. drug to reach the MEC
C. drug to begin to be eliminated from the body
D. drug to reach the MTC

B 76. The term often used to describe drug distribution and elimination
 A. elimination only B. disposition C. absorption D. metabolism only
E. NOTA
D 77. The term systematic circulation refers primarily to
A. veins B. arteries C. hepatic portal vein D. a and b E. b and
c
E 78. Compartments of total body water include
A. vascular fluid B. extracellular fluid C. salivary fluid D.
intracellular fluid E. AOTA

A 1. The major plasma protein involved in the distribution of weak acids is

A. albumin B. glycoprotein C. glycine D. gelatin E.
ceruloplasma
A 2. All of the following may shorten the duration of drug effects except:
A. extensive plasma protein binding of the drug C. redistribution of the drug
E. NOTA
B. renal excretion of the drug D. metabolism of the drug
E 3. Which of the following statement is not about displacement of drug from plasma protein binding sites?
A. results in transient increased volume of distribution
B. makes more free drug available for glomerular filtration
C. displacement of a potent drug that is normally more than 95% bound may cause toxicity
D. increases tissue levels of the drug
E. generally has smaller VD compared with drugs that are highly bound to plasma proteins
A 4. The larger the volume of distribution
A. the more extensive the distribution C. the slower the distribution
B. the higher the physiological significance D. a and b only E. AOTA
C 5. A neonate is given drug A, a compound with high affinity for plasma proteins, in a dose that does not exceed the binding
capacity of
Albumin. Later, a second drug B that binds strongly to albumin is given in amounts that greatly exceed albumins binding
capacity.
Which of the following sentences is most likely to be true?
A. the free plasma concentration of drug A is decreased
B. the relative free drug concentration of both compounds is unchanged
C. the concentration of drug A in tissues is likely to be increased
D. the concentration of drug A in tissues is likely to be decreased
E. the free plasma concentration of drug B would likely be markedly increased if drug A were given second rather than first
C 6. To produce its characteristic pharmacologic action/s, a drug must always
A. reach high blood levels C. achieve adequate concentration at its site/s of action
B. be absorbed from the GIT D. be excreted unchanged in the urine
E. NOTA
A 7. Which of the following drugs do not bind to plasma protein to any significant extent
A. lithium B. digoxin C. amitriptyline D. diazepam E. AOTA
B 8. A study of drugs & what it can do to our body.
A. pharmacokinetic B. pharmacology C. pharmacodynamic D. pharmacy
B 9. Particles of drug that can reach the receptor site. A. free drug B. bound drug C. addictive drug D. both B
&C
D 10. Particles of drug ferried by proteins, enzymes etc. A. free drug B. bound drug C. unbound drug D. both A
&C

II. TRUE OR FALSE : A for true B for false

SET A SET B
. A 1. Drug interaction may occur if 2 or more drugs are given to a patient. A 1. pH wil tell if the drug is acidic or
alkaline
A 2. Free drug are agonist drugs B 2. The lower the pH the more basic
is the drug.
 A 3. Metabolism is one manner of elimination of drug. A 3. Drug clearance can be
determine in urine samples.
A 4. Infant dose should be lower than adult dose A 4. Drug volume can be determine
in plasma drug conc.
A 5 Thereason for # 4 their organs are not yet fully developed A 5. Membranes of the body are
barriers to drug .
A 6, IV drug do not undergo first pass effect. B 6. The lower the pOH the more
acidic is the drug.
A 7. First- pass effect is detoxification A 7. All drugs have adverse
reactions to the body.
B 7 Kidney is responsible for no.6 A 8. Fate of drug is LADMER
B 9. Compliance to dosage regimen, patient will be more sick. A 9. Drug performed well if the
patient get well.
A 10. Pharmacist should counsel patients regarding drugs B 10. Pharmacist is authorize to
diagnose a sick person.

III. IDENTIFICATION Identify by matching column A with column B

Column A Column B
1. Forensic medicine A. IV, IM, IT, IP, SUBCUTANEOUS
2. Time of onset of drug to elimination B. CIRCULATORY SYSTEM
3. Scheduling of drug intake C. LIBERATION
4. Amount of drug or potency of drug D. BUFFERS
5. Disintegration & dissolution E AUC CURVE
6. Body system involve in oral drug intake F. CRIME
7. Body system that distribute the drug G. PHARYN
8. Pharmacokinetic of parenteral preparation H. NOSE
9. Resistance to change in pH I. DOSE
10. Passage of air in the trachea J. LARYNX
K DIGESTIVE SYSTEM
L. DOSAGE REGIMEN