Name: LAU Aik Jiang

Present Appointment:
Assistant Professor, Department of Pharmacy, Faculty of Science, National University of
Singapore (primary)
Assistant Professor, Department of Pharmacology, Yong Loo Lin School of Medicine,
National University of Singapore (secondary)

Contact Information:
Department of Pharmacy
National University of Singapore
18 Science Drive 4
Singapore 117543
Email: aikjiang.lau@nus.edu.sg

Research Areas:
Drug metabolism
Drug transport
Receptor pharmacology

Teaching Areas:
Pharmaceutical analysis
Pharmacokinetics

Academic/Professsional Qualifications:
Ph.D. (Pharmaceutical Sciences), National University of Singapore, 2007
B.Sc. (Honours) (Pharmacy), National University of Singapore, 2000
Registered pharmacist, Singapore, 2001

Career History:
Postdoctoral Research Fellow, Drug Metabolism and Toxicology Laboratory, Molecular
and Cellular Pharmacology Group, Faculty of Pharmaceutical Sciences, The University
of British Columbia, Vancouver, British Columbia, Canada, 2007-2013
Instructor, Department of Pharmacy, National University of Singapore, 2007
Teaching assistant, Department of Pharmacy, National University of Singapore, 2005-
2007
Part-time lecturer, Certified Pharmacy Technician Course, Pharmaceutical Society of
Singapore, 2005-2007
Graduate assistant, Department of Pharmacy, National University of Singapore, 2001-
2005
Pre-registration pharmacist, National University Hospital, 2000-2001

Awards/Honours (Post-PhD):
Postdoctoral Scientist Award, Division of Drug Metabolism, American Society of
Pharmacology and Experimental Therapeutics (ASPET), U.S.A., 2012

Updated: July 8, 2013 1

 Young Scientist Travel Award, American Society of Pharmacology and Experimental
Therapeutics (ASPET), U.S.A., 2012
Emil A. Pfitzer Postdoctoral Award, Drug Discovery Toxicology Specialty Section
(DDTSS), Society of Toxicology (SOT), U.S.A, 2012
Best Presentation Award Postdoctoral category, International Society for the Study of
Xenobiotics (ISSX), Taiwan, 2011
Young Scientist Travel Award, American Society of Pharmacology and Experimental
Therapeutics (ASPET), U.S.A., 2010
Postdoctoral Fellow Travel Award, Regulatory and Safety Evaluation Specialty Section
(RSESS), Society of Toxicology (SOT), U.S.A., 2010

Updated: July 8, 2013 2

 LIST OF PUBLICATIONS

Peer-Reviewed Publications (published or in press)

18. Lau AJ, Chang TKH. Indirect activation of the SV23 and SV24 splice variants of human
constitutive androstane receptor: Analysis with 3-hydroxyflavone and its analogues. British
Journal of Pharmacology, 2013, in press.

17. Sharma D, Lau AJ, Sherman MA, Chang TKH. Agonism of human pregnane X receptor by
rilpivirine and etravirine: Comparison with first generation non-nucleoside reverse
transcriptase inhibitors. Biochemical Pharmacology, 2013, 85: 1700-1711.

16. Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TKH. Evaluation of Ginkgo biloba
extract as an activator of human glucocorticoid receptor. Journal of Ethnopharmacology,
2013, 145: 670-675.

15. Lau AJ, Yang G, Yap CW, Chang TKH. Selective agonism of human pregnane X receptor by
individual ginkgolides. Drug Metabolism and Disposition, 2012, 40: 1113-1121.

14. Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TKH. Species-dependent and receptor-
selective action of bilobalide on the function of constitutive androstane receptor and
pregnane X receptor. Drug Metabolism and Disposition, 2012, 40: 178-186.

13. Lau AJ, Yang G, Chang TKH. Isoform-selective activation of human constitutive androstane
receptor by Ginkgo biloba extract: Functional analysis of the SV23, SV24, and SV25 splice
variants. Journal of Pharmacology and Experimental Therapeutics, 2011, 339: 704-715.

12. Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TKH. Differential effect of meclizine on
the activity of human pregnane X receptor and constitutive androstane receptor. Journal of
Pharmacology and Experimental Therapeutics, 2011, 336: 816-826.

11. Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TKH. Human pregnane X receptor
agonism by Ginkgo biloba extract: Assessment of the role of individual ginkgolides. Journal
of Pharmacology and Experimental Therapeutics, 2010, 335: 771-780.

10. Lau AJ and Chang TKH. Inhibition of human CYP2B6-catalyzed bupropion hydroxylation
by Ginkgo biloba extract: Effect of terpene trilactones and flavonols. Drug Metabolism and
Disposition, 2009, 37: 1931-1937.

9. Ching J, Chua TK, Chin LC, Lau AJ, Pang YK, Jaya JM, Tan CH, Koh HL. Beta-amyrin
from Ardisia elliptica Thunb. is more potent than aspirin in inhibiting collagen-induced
platelet aggregation. Indian Journal of Experimental Biology, 2010, 48: 275-279.

8. Lau AJ, Chua TK, Pang YK, Toh DF, Koh HL. Antiplatelet and anticoagulant effects of
Panax notoginseng: Comparison of raw and steamed Panax notoginseng with other Panax
species. Journal of Ethnopharmacology, 2009, 125: 380-386.

7. Chui WK, Pastorin G, Lau AJ. Learning the use of medicinal herbs in phytotherapy: A
tripartite approach for pharmacy students. Pharmacy Education, 2009, 9 (1), May 10.

Updated: July 8, 2013 3

6. Chan ECY, Yap SL, Lau AJ, Leow PC, Toh DF, Koh HL. Ultra-performance liquid
chromatography/ time-of-flight mass spectrometry based metabolomics of raw and steamed
Panax notoginseng. Rapid Communications in Mass Spectrometry, 2007, 21: 519-528.

5. Hong DYQ, Lau AJ, Yeo CL, Liu XK, Yang CR, Koh HL, Hong Y. Genetic diversity and
variation of saponin contents in Panax notoginseng roots from a single farm. Journal of
Agricultural and Food Chemistry, 2005, 53: 8460-8467.

4. Koh HL, Lau AJ, Chan ECY. Hydrophilic interaction liquid chromatography with tandem
mass spectrometry for the determination of underivatized dencichine (-N-oxalyl-L-,-
diaminopropionic acid) in Panax medicinal plant species. Rapid Communications in Mass
Spectrometry, 2005, 19: 1237-1244.

3. Lau AJ, Seo BH, Woo SO, Koh HL. High-performance liquid chromatographic method with
quantitative comparisons of whole chromatograms of raw and steamed Panax notoginseng.
Journal of Chromatography A, 2004, 1057: 141-149.

2. Lau AJ, Woo SO, Koh HL. Analysis of saponins in raw and steamed Panax notoginseng
using high performance liquid chromatography with diode array detection. Journal of
Chromatography A, 2003, 1011: 77-87.

1. Lau AJ, Holmes MJ, Woo SO, Koh HL. Analysis of adulterants in a traditional herbal
medicinal product using LC-MS-MS. Journal of Pharmaceutical and Biomedical Analysis,
2003, 31: 401-406.

Book Chapter

1. Lau AJ and Koh HL. Quality control of herbs: principles and procedures, using Panax as an
example. In: Leung PC, Fong H, Xue CCL, eds. Annals of Traditional Chinese Medicine,
Current review of Chinese medicinequality control of herbs and herbal materials, 2006,
volume 2, 87-115.

Abstracts

27. Sharma D, Lau AJ, Sherman MA, Chang TKH. Agonism of human pregnane X receptor by
rilpivirine and etravirine: Comparison with first generation non-nucleoside reverse
transcriptase inhibitors. Canadian Society for Pharmaceutical Sciences, Vancouver, British
Columbia, Canada, 11-14 June 2013.

26. Lau AJ and Chang TKH. Functional analysis of splice variants of human constitutive
androstane receptor: Investigation with flavonol (3-hydroxyflavone) and its metabolites.
Experimental Biology Annual Meeting, Boston, Massachusetts, U.S.A., 20-24 April 2013.

25. Lau AJ and Chang TKH. Selective activation of human pregnane X receptor, vitamin D
receptor, and glucocorticoid receptor by flavonols. Society of Toxicology 52nd Annual
Meeting, San Antonio, Texas, U.S.A., 10-14 March 2013.

Updated: July 8, 2013 4

24. Lau AJ and Chang TKH. Differential effect of galangin and its hydroxylated metabolites on
the activity of various isoforms of human constitutive androstane receptor. International
Society for the Study of Xenobiotics, 18th North American Regional Meeting, Dallas, Texas,
U.S.A., 14-18 October 2012.

23. Lau AJ and Chang TKH. Comparison of galangin and flavonol on activation of the human
pregnane X receptor: Effect of C5 and C7 hydroxylation of flavonol. Mechanism-Based
Natural Product Development Conference, Whistler, British Columbia, Canada, 21-22
September 2012.

22. Lau AJ, Yang G, Yap CW, Chang TKH. Regulation of human pregnane X receptor function
by individual ginkgolides. Experimental Biology Annual Meeting, San Diego, California,
U.S.A., 21-25 April 2012. [American Society of Pharmacology and Experimental
Therapeutics (ASPET) Young Scientist Travel Award; and Postdoctoral Scientist Award
from the Drug Metabolism Division of ASPET]

21. Lau AJ, Yang G, Chang TKH. Functional analysis of the SV23, SV24, and SV25 splice
variants of human constitutive androstane receptor (CAR): Comparison of Ginkgo biloba
extract with other known activators of CAR. Society of Toxicology 51st Annual Meeting, San
Francisco, California, U.S.A., 11-15 March 2012. [Emil A. Pfizter Postdoctoral Award]

20. Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TKH. Induction of a human constitutive
androstane receptor target gene (CYP2B6) by Ginkgo biloba extract is independent of the
glucocorticoid receptor. International Society for the Study of Xenobiotics, 4th Asia Pacific
Regional Meeting, Tainan, Taiwan, 22-25 April 2011. Published in Drug Metabolism
Reviews 2011, 43 (S1): 26-27. [Best Presentation Award - Postdoctoral Research]

19. Lau AJ, Yang G, Chang TKH. Ginkgo biloba extract differentially activates the SV23 and
SV25 splice variants of human constitutive androstane receptor. International Society for the
Study of Xenobiotics, 4th Asia Pacific Regional Meeting, Tainan, Taiwan, 22-25 April 2011.
Published in Drug Metabolism Reviews 2011, 43 (S1): 77.

18. Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TKH. Meclizine is not an inverse
agonist or antagonist of human constitutive androstane receptor. Experimental Biology
Annual Meeting, Washington, D.C., U.S.A., 9-13 April 2011. Published in FASEB J 2011,
25: 1014.7.

17. Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TKH. Meclizine is an agonist of human
pregnane X receptor. Experimental Biology Annual Meeting, Washington, D.C., U.S.A., 9-13
April 2011. Published in FASEB J 2011, 25: 1014.5.

16. Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TKH. Species-dependent and receptor-
selective effect of bilobalide on the activity of constitutive androstane receptor and pregnane
X receptor. Society of Toxicology 50th Annual Meeting, Washington, D.C., U.S.A., 6-10
March 2011. Published in The ToxicologistAn official Journal of the Society of Toxicology
2011, 120 (Supplement 2): 377.

Updated: July 8, 2013 5

15. Lau AJ, Rajaraman G, Baucom CC, Yang G, Chang TKH. Differential role of ginkgolide A
and bilobalide in the modulation of CYP3A and CYP2B6 expression by Ginkgo biloba
extract in primary cultures of human hepatocytes. Experimental Biology Annual Meeting,
Anaheim, California, U.S.A., 24-28 April 2010. Published in FASEB J 2010, 24: 757.6.
[American Society of Pharmacology and Experimental Therapeutics (ASPET) Young
Scientist Travel Award]

14. Lau AJ and Chang TKH. Differential activation of rat and human pregnane X receptor by
terpene trilactones. Experimental Biology Annual Meeting, Anaheim, California, U.S.A., 24-
28 April 2010. Published in FASEB J 2010, 24: 757.5. [American Society of Pharmacology
and Experimental Therapeutics (ASPET) Young Scientist Travel Award]

13. Lau AJ and Chang TKH. Partial contribution of ginkgolide A to rat and human pregnane X
receptor activation by Ginkgo biloba extract. Society of Toxicology 49th Annual Meeting, Salt
Lake City, Utah, U.S.A., 7-11 March 2010. Published in The ToxicologistAn official
Journal of the Society of Toxicology 2010, 114 (Number 1): 1133. [Society of Toxicology
Postdoctoral Fellow Travel Award]

12. Lau AJ and Chang TKH. Interaction between Ginkgo biloba extract and bupropion. 6th
Natural Health Product Research Conference, Vancouver, Canada, 18-21 February 2009.
Published in Pharmaceutical Biology 2009, 47 (Supplement 1): 31.

11. Lau AJ, Chua TK, Pang YK, Koh HL. Comparative study of the antiplatelet and
anticoagulant activities of different Panax species. PharmSci@Asia Symposium, Fudan
University, China, 28 June 2007. [Best Poster Award- 1st Prize]

10. Lau AJ, Chua TK, Pang YK, Koh HL. Platelet aggregation and blood coagulation inhibitory
activities of Panax species. Office of Life Sciences Conference, Singapore, 5-6 February
2007.

9. Lau AJ, Yeo CL, Hong DYQ, Liu XK, Yang CR, Hong Y, Koh HL. A study on the saponin
contents and genetic diversity in individual Panax notoginseng roots from a good agricultural
practice farm. 18th Singapore Pharmacy Congress, Singapore, 1-2 July 2006.

8. Lau AJ, Chan EC, Koh HL. Analysis of dencichine, a haemostatic agent, in Panax species
using hydrophilic interaction chromatography-tandem mass spectrometry. Inaugural AAPS-
NUS Student Chapter Symposium, Singapore, 16 September 2005. [Best Presenter Award]

7. Lau AJ, Chan EC, Koh HL. Liquid chromatography-tandem mass spectrometry for the
determination of dencichine, a haemostatic agent in Panax medicinal plant species.
Inaugural Inter-varsity Symposium, 17th Singapore Pharmacy Congress, Singapore, 1-3 July
2005. [Best Presenter Award for the Pharmaceutical and Medicinal Chemistry section]

6. Lau AJ, Tanaka N, Chan EC, Koh HL. Determination of dencichine in Panax species using
liquid chromatography-tandem mass spectrometry. Inaugural International Congress on
Complementary and Alternative Medicines (ICCAM), Singapore, 26-28 February 2005.

Updated: July 8, 2013 6

5. Lau AJ, Seo BH, Woo SO, Koh HL. Chromatographic pattern matching of raw and steamed
Panax notoginseng. 15th International Symposium on Pharmaceutical and Biomedical
Analysis, Florence, Italy, 2-6 May 2004.

4. Lau AJ, Seo BH, Woo SO, Koh HL. Chromatographic pattern matching of Panax
notoginseng, a Chinese herbal medicine. 16th Singapore Pharmacy Congress, Singapore, 22-
23 November 2003. [Best Poster Award- 1st Prize]

3. Koh HL, Lau AJ, Seo BH, Woo SO. Differentiation of raw and steamed Panax notoginseng
using HPLC with chromatographic pattern matching. The 1st World Congress on Chinese
Medicine, Melbourne, Australia, 21-24 November 2003.

2. Lau AJ, Woo SO, Koh HL. Analysis of raw and steamed Panax notoginseng using HPLC-
DAD. AAPS Annual Meeting and Exposition, Toronto, Canada, 10-14 November 2002.

1. Koh HL, Lau AJ, Nah LJ, Woo SO. Prevalence of laxatives in over the counter slimming
products. 5th American Chinese Pharmaceutical Association (ACPA) International
Conference, Singapore, 28-30 May 2001.

Patents and Intellectual Property Rights

1. Koh HL and Lau AJ. Anti-thrombotic activities of extracts and components from raw and
steamed Panax notoginseng, US Provisional Patent, No. 60/828,078, 4 Oct 2006.

Other Contributions

1. Member of Editorial Committee, Zhao ZZ and Xiao PG (eds). The Encyclopaedia of

Contemporary Medicinal Plants, Volumes 1 to 4, Hong Kong Jockey Club Institute of
Chinese Medicine Ltd, Shanghai World Publishing Corporation, 2009.

Updated: July 8, 2013 7