Potensi Sari Ikan Gabus (Channa striata) Sebagai Nutrisi Pencerdas Otak Pada Hewan Uji Mencit

Putih (Mus usculus L) (PUTRA SANTOSO, WARNETY MUNIR)

o "Kendati ikan gabus memiliki potensi gizi yang tinggi bagi pertumbuan dan
perkembangan sistem saraf, namun hingga saat ini penelitian-penelitian mengenai
hal tersebut masih sangat terbatas. Beberapa penelitian sebelumnya lebih terfokus
kepada efek pemulihan luka dan efek antioksidan serta peningkatan kapasitas
fisiologis darah (Page-McCaw et al., 2007; Jais et al., 2007, Daud, 2011). Oleh
sebab itu, penelitian tentang pemanfaatan ikan gabus sebagai nutrisi pencerdas
otak sangat penting untuk dilakukan. "

[Show description]

File Research Aug 2015 Journal of Food Biochemistry

Putra Santoso Warnety Munir

View research

Randomized Controlled Trial on the Effect of Channa striatus Extract on Measurement of the
Uterus, Pulsatility Index, Resistive Index of Uterine Artery and Superficial Skin Wound Artery in
Post Lower Segment Caesarean Section Women
o "In addition, this fish is synonymous with use in a postnatal diet [2] and
recuperation from illness or surgery [3] . In postpartum mothers, Channa striatus
is consumed to accelerate the wound healing process [2,4]. Animal studies have
shown that Channa striatus extract influences the different phases of wound
healing by enhancing dermal wound healing [4,5]. "

[Show abstract]

Full-text Article Jul 2015

Mohd Rizal Abu Bakar Azidah Abdul Kadir Siti Zubaidah Abdul Wahab+7

more authors ... Ahmad Helmy Abdul Karim

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The Effect of Channa striatus (Haruan) Extract on Pain and Wound Healing of Post-Lower Segment
Caesarean Section Women
o "C. striatus extract contains biochemical components , such as amino acids and
fatty acids, which are important for the synthesis of collagen fibres during wound
healing [1, 2], particularly glycine. This species also has high contents of
 arachidonic acid and polyunsaturated fatty acids that can promote prostaglandin
synthesis [1, 2], which plays a vital role in healing the wounds [5, 6]. Thus, we
undertook this study to assess the effects of C. striatus extract that may play
possible roles or have great potential in wound healing and reducing postoperative
pain in humans. "

[Show abstract]

Full-text Article Apr 2015

Siti Zubaidah Ab Wahab Azidah Abdul Kadir Nik Hazlina bt Nik

Hussain+7 more authors ... Julia Omar

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Haruan Fish Extract as Potential Agent for Cancer Therapy

o "The important polyunsaturated fatty (PUFA) acids content of Haruan fish that
are beneficial to anti-cancer studies include; EPA and DHA. Several experimental
models and tissue culture studies reported the protective effects of theses omega-3
fatty acids on colon [21,24], breast23242526 and prostate cancers27282932]. "

Full-text Article Jan 2015

I Buhari Roslida Abd Hamid

Read full-text

Angiotensin IConverting Enzyme Inhibitory Peptides from Snakehead Fish Sarcoplasmic Protein
Hydrolysate
o "Other pharmacological properties of this freshwater fish include anti-microbial,
anti-inflammatory, induction of platelet aggregation and anti-nociceptive
properties of the mucus (Mat Jais 2007). Its chemical composition includes high
levels of essential amino acids that could directly improve wound healing but
 ongoing efforts are pursuing the isolation of other bioactive compounds from
snakehead fish protein (Mat Jais 2007). Previously, we isolated bioactive peptides
from hydrolyzed snakehead fish myofibrillar protein with significant ACE
inhibitory activities (Ghassem et al. 2011a). "

[Show abstract]

Full-text Article Apr 2014

Masomeh Ghassem Abdul Salam Babji Mamot Said+1

more author ... Keizo Arihara

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Channa striatus capsules induces cytokine conversion in pulmonary tuberculosis patients

o "These results are consistent with a previous study showing that active TB
possessed more monofunctional immune responses primarily characterized by
exclusive TNF- production [24]. Several chemical constituents of Channa
striatus which may take part as active substances to decrease TNF- production,
including poly-unsaturated fatty acids (PUFA) 3 and 6 [25, 26], vitamins A, B,
E and D, and several minerals (Ca, Na, Mg, Zn) [9,[26][27][28]are presented in
Table 4. IFN- appears to be essential though not sufficient, for maintenance of
latency [9]. IFN- activates alveolar macrophages to produce several substances
for growth inhibition and killing of MTB. "

[Show abstract]

Full-text Article Jun 2013

Novita Paliliewu E A Datau Julia C. Matheos Eko E Surachmanto

Read full-text

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Potensi Sari Ikan Gabus (Channa striata) Sebagai Nutrisi Pencerdas Otak Pada Hewan Uji Mencit Putih
(Mus usculus L) (PUTRA SANTOSO, WARNETY MUNIR)

Kendati ikan gabus memiliki potensi gizi yang tinggi bagi pertumbuan dan perkembangan sistem saraf,
namun hingga saat ini penelitian-penelitian mengenai hal tersebut masih sangat terbatas. Beberapa
penelitian sebelumnya lebih terfokus kepada efek pemulihan luka dan efek antioksidan serta
peningkatan kapasitas fisiologis darah (Page-McCaw et al., 2007; Jais et al., 2007, Daud, 2011). Oleh
sebab itu, penelitian tentang pemanfaatan ikan gabus sebagai nutrisi pencerdas otak sangat penting
untuk dilakukan. "

Randomized Controlled Trial on the Effect of Channa striatus Extract on Measurement of the Uterus,
Pulsatility Index, Resistive Index of Uterine Artery and Superficial Skin Wound Artery in Post Lower
Segment Caesarean Section Women

"In addition, this fish is synonymous with use in a postnatal diet [2] and recuperation from illness or
surgery [3] . In postpartum mothers, Channa striatus is consumed to accelerate the wound healing
process [2,4]. Animal studies have shown that Channa striatus extract influences the different phases of
wound healing by enhancing dermal wound healing [4,5]. "

Haruan Fish Extract as Potential Agent for Cancer Therapy

o "The important polyunsaturated fatty (PUFA) acids content of Haruan fish that
are beneficial to anti-cancer studies include; EPA and DHA. Several experimental
models and tissue culture studies reported the protective effects of theses omega-3
fatty acids on colon [21,24], breast23242526 and prostate cancers27282932]. "

Full-text Article Jan 2015

Angiotensin IConverting Enzyme Inhibitory Peptides from Snakehead Fish Sarcoplasmic Protein
Hydrolysate
o "Other pharmacological properties of this freshwater fish include anti-microbial,
anti-inflammatory, induction of platelet aggregation and anti-nociceptive
properties of the mucus (Mat Jais 2007). Its chemical composition includes high
levels of essential amino acids that could directly improve wound healing but
ongoing efforts are pursuing the isolation of other bioactive compounds from
snakehead fish protein (Mat Jais 2007). Previously, we isolated bioactive peptides
from hydrolyzed snakehead fish myofibrillar protein with significant ACE
inhibitory activities (Ghassem et al. 2011a). "
 Channa striatus capsules induces cytokine conversion in pulmonary tuberculosis patients
o "These results are consistent with a previous study showing that active TB
possessed more monofunctional immune responses primarily characterized by
exclusive TNF- production [24]. Several chemical constituents of Channa
striatus which may take part as active substances to decrease TNF- production,
including poly-unsaturated fatty acids (PUFA) 3 and 6 [25, 26], vitamins A, B,
E and D, and several minerals (Ca, Na, Mg, Zn) [9,[26][27][28]are presented in
Table 4. IFN- appears to be essential though not sufficient, for maintenance of
latency [9]. IFN- activates alveolar macrophages to produce several substances
for growth inhibition and killing of MTB. "

Article: Channa striatus capsules induces cytokine conversion in pulmonary tuberculosis patients

Novita Paliliewu Eulis A. Datau Julia C. Matheos Eko E. Surachmanto

ABSTRACT: Objective: This study aimed to investigate whether Channa striatus capsule induces sputum
and cytokine conversion in pulmonary tuberculosis (TB) patients. Methods: Randomized, placebo-
controlled, double-blind pilot study was conducted to pulmonary TB patients who admitted to
Department of Internal Medicine, Faculty of Medicine, University of Sam Ratulangi, Manado, North
Sulawesi, Indonesia. A total of 36 pulmonary TB patients were randomly divided into two equal groups
(n = 18) including one group received standart antituberculosis drugs plus Channa striatus capsule and
another group received standart antituberculosis drugs plus placebo. Channa striatus capsule was given
at a dose of 2 g each time, 3 times per day, for 12 weeks. The levels of tumor necrosis factor (TNF)-,
interferon (IFN)-, and interleukin (IL)-10 were analyses using enzyme linked immunosorbent assay
(ELISA) method. Results: The rate of positive sputum smear decline was more pronounced in the Channa
striatus group but did not reach statistically different value between groups. The levels of TNF-, IFN-,
and IL-10 were not significantly different in Channa striatus group compared to placebo group at
baseline (week 0). But at week 12, the supplementation of Channa striatus capsule significantly
decreased TNF-, IFN-, and IL-10 levels compared to baseline. In placebo groups, there were no
significant differences for IL-10 levels at week 12, but the levels of TNF- and IFN- significantly
decreased. Conclusion: Adjunctive supplementation of Channa striatus capsules accelerated the
beneficial therapeutic effect of TB chemotherapy by improving cytokine response. [J Exp Integr Med
2013; 3(3.000): 237-242]

Full-text available Article Jun 2013

Innate and adaptive immune molecules of striped murrel Channa striatus

o "At a higher concentration of the hexane-soluble fraction, 20 mg kg 1 , the total
protein content was also upregulated in the murrel against fungal infection
(Uthayakumar et al. 2014b). Paliliewu et al. (2013) observed that a capsule from
snakehead murrel stimulated the sputum and cytokines conversion in pulmonary
tuberculosis patients. Initially, the cytokine level remained constant after
administration with snakehead murrel capsule; however, on week 12 the cytokine
levels were reduced, and thus, the sputum smear declined. "
Nutritional supplements for people being treated for active tuberculosis
Chapter in Cochrane database of systematic reviews (Online) 6(6) June 2016 with 14 Reads

DOI: 10.1002/14651858.CD006086.pub4
In book: Cochrane Database of Systematic Reviews

1st Liesl Grobler

2nd Sukrti Nagpal

3rd Thambu D Sudarsanam

4th David Sinclair

34.4 Liverpool School of Tropical Medicine

Abstract
Background: Tuberculosis and malnutrition are linked in a complex relationship. Tuberculosis may cause
undernutrition through increased metabolic demands and decreased intake, and nutritional deficiencies
may worsen the disease, or delay recovery by depressing important immune functions. At present, there
is no evidence-based nutritional guidance for adults and children being treated for tuberculosis.
Objectives: To assess the effects of oral nutritional supplements in people being treated with
antituberculous drug therapy for active tuberculosis. Search methods: We searched the Cochrane
Infectious Disease Group Specialized Register, Cochrane Central Register of Controlled Trials (CENTRAL;
Issue 1, 2016), MEDLINE (from 1946 to 4 February 2016), EMBASE (from 1980 to 4 February 2016),
LILACS (from 1982 to 4 February 2016), the metaRegister of Controlled Trials (mRCT), the World Health
Organization (WHO) International Clinical Trials Registry Platform (ICTRP), and the Indian Journal of
Tuberculosis up to 4 February 2016, and checked the reference lists of all included studies. Selection
criteria: Randomized controlled trials that compared any oral nutritional supplement given for at least
four weeks with no nutritional intervention, placebo, or dietary advice only for people being treated for
active tuberculosis. The primary outcomes of interest were all-cause death, and cure at six and 12
months. Data collection and analysis: Two review authors independently selected trials for inclusion,
and extracted data and assessed the risk of bias in the included trials. We presented the results as risk
ratios (RR) for dichotomous variables, and mean differences (MD) for continuous variables, with 95%
confidence intervals (CIs). Where appropriate, we pooled data from trials with similar interventions and
outcomes. We assessed the quality of the evidence using the Grading of Recommendation Assessment,
Development and Evaluation (GRADE) approach. Main results: Thirty-five trials, including 8283
participants, met the inclusion criteria of this review. Macronutrient supplementationSix trials assessed
the provision of free food, or high-energy supplements. Only two trials measured total dietary intake,
and in both trials the intervention increased calorie consumption compared to controls.The available
trials were too small to reliably prove or exclude clinically important benefits on mortality (RR 0.34, 95%
CI 0.10 to 1.20; four trials, 567 participants, very low quality evidence), cure (RR 0.91, 95% CI 0.59 to
1.41; one trial, 102 participants, very low quality evidence), or treatment completion (data not pooled;
two trials, 365 participants, very low quality evidence).Supplementation probably produces a modest
increase in weight gain during treatment for active tuberculosis, although this was not seen consistently
across all trials (data not pooled; five trials, 883 participants, moderate quality evidence). Two small
studies provide some evidence that quality of life may also be improved but the trials were too small to
have much confidence in the result (data not pooled; two trials, 134 participants, low quality evidence).
Micronutrient supplementationSix trials assessed multi-micronutrient supplementation in doses up to
10 times the dietary reference intake, and 18 trials assessed single or dual micronutrient
supplementation.Routine multi-micronutrient supplementation may have little or no effect on mortality
in HIV-negative people with tuberculosis (RR 0.86, 95% CI 0.46 to 1.6; four trials, 1219 participants, low
quality evidence), or HIV-positive people who are not taking antiretroviral therapy (RR 0.92, 95% CI 0.69
to 1.23; three trials, 1429 participants, moderate quality evidence). There is insufficient evidence to
know if supplementation improves cure (no trials), treatment completion (RR 0.99, 95% CI 0.95 to 1.04;
one trial, 302 participants, very low quality evidence), or the proportion of people who remain sputum
positive during the first eight weeks (RR 0.92, 95% CI 0.63 to 1.35; two trials, 1020 participants, very low
quality evidence). However, supplementation may have little or no effect on weight gain during
treatment (data not pooled; five trials, 2940 participants, low quality evidence), and no studies have
assessed the effect on quality of life.Plasma levels of vitamin A appear to increase following initiation of
tuberculosis treatment regardless of supplementation. In contrast, supplementation probably does
improve plasma levels of zinc, vitamin D, vitamin E, and selenium, but this has not been shown to have
clinically important benefits. Of note, despite multiple studies of vitamin D supplementation in different
doses, statistically significant benefits on sputum conversion have not been demonstrated. Authors'
conclusions: There is currently insufficient research to know whether routinely providing free food, or
energy supplements improves tuberculosis treatment outcomes, but it probably improves weight gain in
some settings.Although blood levels of some vitamins may be low in people starting treatment for active
tuberculosis, there is currently no reliable evidence that routinely supplementing above recommended
daily amounts has clinical benefits.
Nutritional supplements for people being treated for active tuberculosis. Available from:
https://www.researchgate.net/publication/304614846_Nutritional_supplements_for_p
eople_being_treated_for_active_tuberculosis [accessed Apr 14, 2017].