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Multiple phenotypes of resting-state cognition

is altered in Insomnia Disorder. A pilot study

Article May 2016

DOI: 10.1016/j.sleh.2016.05.003

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8 authors, including:

Laura Palagini Mauro Mauri

Universit di Pisa Universit di Pisa
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Klaus Linkenkaer-Hansen Dieter Riemann

VU University Amsterdam University Medical Center Freiburg
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Available from: Laura Palagini

Retrieved on: 13 September 2016
Multiple phenotypes of resting-state cognition is altered in Insomnia Disorder. A pilot study

1
Laura Palagini, 2Nicola Cellini, 1Mauro Mauri, 1Irene Mazzei, 3,4Sonja Simpraga, 1Liliana
dellOsso, 3,4Klaus Linkenkaer-Hansen, 5Dieter Riemann

Background: Research has supported the role of cognitive processes in the development and

maintenance of insomnia, yet a standardized characterization of mind-wandering experiences in

insomniacs is lacking.

Objectives: The aim was to understand the quantitative nature of thoughts and feelings during mind

wandering in insomniacs and healthy controls and their relationship to sleep-related parameters.

Methods: We used the 5 minutes eyes-closed wakeful rest as an experimental model condition of

mind wandering. Forty-seven individuals with insomnia disorder according to the DSM-5

(48.6615.62 years; 31 females) and 29 healthy controls (50.6615.14 years; 17 females)

participated in the experiments and completed the Amsterdam Resting-State Questionnaire (ARSQ)

immediately after the resting session. Participants also completed the Insomnia Severity Index (ISI),

the Pittsburgh Sleep Quality Index (PSQI), the Dysfunctional Beliefs about Sleep (DBAS).

Statistical analyses included multiple regression to elucidate the independent determinants of ARSQ

phenotypes. Results: Participants with insomnia presented higher ISI, PSQI, and DBAS scores than

healthy controls. Insomniacs had strikingly different scores on most dimensions of the ARSQ, in

particular Discontinuity of Mind, Self, Sleepiness and Health Concern that correlated positively

with ISI and DBAS. Multiple regressions highlighted that for insomniacs ISI was the best predictor

of both Discontinuity of Mind and Health Concern. Conclusions: Resting-state activity in

insomnia is altered and it seems to be related to unhelpful beliefs and insomnia severity. Resting-

state neuroimaging in combination with the ARSQ could reveal important associations between

these aberrant cognitive scores and their underlying systems-level brain mechanisms.

Acknowledgements

Many thanks to Dott. Antonio Palagini for everything he has done in this world