Nigella sativa linn.
and Migrain Medication
BACKGROUND
Migraine is a primary headache disorder characterized by
recurrent headaches that are moderate to severe. Typically, the
headaches affect one half of the head, are pulsating in nature,
and last from two to 72 hours [1]. The migraine are believed to
be related to a mix of environmental and genetic factors [2].
Worldwide, migraines affect nearly 15% or approximately one
billion people [3]. About 1530% of people with migraines
experience migraines with an aura and those who have
migraines with aura also frequently have migraines without
aura. There are four possible phases to a migraine, although
not all the phases are necessarily experienced [3]:
The prodrome, which occurs hours or
days before the headache
The aura, which immediately precedes
the headache
The pain phase, also known as
headache phase
The postdrome, the effects
experienced following the end of a
migraine attack
Nigella sativa Linn. is regarded as one of the greatest healing
medicine in Islam. The aqueous and oil extracts of the seeds
have been shown to possess antitumor, anti diabetic,
cardiovascular activity, antioxidant, anti inflammatory,
analgesic and antimicrobial activities.
METHOD AND MATERIAL
The capsules contain 500 mg of Nigella sativa Linn. versus
placebo capsules were given to woman aged 16 to 23 years
old. A total of 30 women that attacked migraine without aura
were randomized to Nigella sativa Linn. or placebo in 3
treatment arms of A- Nigella sativa Linn. 3 times daily (10),
B-Nigella sativa Linn. breakfast then placebo at lunch and
dinner (10), and C-placebo 3 times daily (10). Every 2 day in
ten day, the woman were asked about the symptoms.
RESULTS
A.T.U Author is with the UIN Maulana Malik Ibrahim Malang, Indonesia
(phone: +6288227046922; e-mail: dutabesar7@gmail.com)
Amalia Tri Utami
The data was analyzed by SPSS. Using the P-value approach:
The p-value is p =0. 013 and since p=0.0130.05, It is
concluded that the null hypothesis Ho is not rejected.
DISCUSSION
In Saudi Arabia and neighboring countries N.
sativa oil is used as a topical treatment for pain
and stiffness in joints. Fixed oil of N. sativa and
thymoquinone were demonstrated to block
cycloxygenase and 5- lipooxygenase pathways of
arachidonate metabolism in the rat peritoneal
leukocytes via dose-dependent inhibition of the
formation of thromboxane B2 and leukotriene B4,
synthesized by the activation of these enzymes,
thus confirming its traditional use in arthritic
conditions [4]. Later, volatile oil of N. sativa and
the aqueous suspension of its crushed seeds
were shown to inhibit carrageenan induced pain
and edema in the hind paw of rats and the
analgesic and anti-inflammatory effects were
comparable to those of indomethacin and aspirin
[5,6]. The results of these studies indicate the
participation of the peripheral mechanisms in the
control of pain by the N. sativa.
CONCLUSIONS
These data suggest there are protective effect of Nigella sativa
Linn. to migraine.
KeywordsMigrain, Nigella sativa linn, Medication
REFERENCES
1. Aminoff, Roger P. Simon, David A.
Greenberg, Michael J. (2009). Clinical
neurology (7 ed.). New York, N.Y:
Lange Medical Books/McGraw-Hill.
pp. 8588.
2. Piane M, Lulli P, Farinelli I, Simeoni S,
De Filippis S, Patacchioli FR, Martelletti
P (2007). "Genetics of migraine and
pharmacogenomics: some
considerations". The journal of
headache and pain. 8 (6): 3349.
3. Vos, T; Flaxman, AD; Naghavi, M;
Lozano, R; Michaud, C; Ezzati, M;
Shibuya, K; Salomon, JA; et al. (2012).
"Years lived with disability (YLDs) for
1160 sequelae of 289 diseases and
injuries 19902010: a systematic
analysis for the Global Burden of
Disease Study 2010". Lancet. 380
(9859): 216396.
4. Houghton PJ, Zarka R, de lasHeras B, Hoult
JR (1995) Fixed oil of Nigella Sativa and
derived thymoquinone inhibit eicosanoid
generation in leukocytes and membrane
lipid peroxidation. Planta Med. 61: 33-36.
5. Mutabagani A, El-Mahdy SAM (1997) A
study of the anti-inflammatory activity of
Nigella Sativa L and thymoquinone in rats.
Saudi Pharm J 5 : 110-113.
6. Al-Ghamdi MS (2001) The anti-
inflammatory, analgesic and antipyretic
activity of Nigella sativa. J Ethnopharmacol
76: 45-48.