2017 INDUSTRY PARTNERING SUMMIT

1
SCHEDULE OF EVENTS
Wednesday, June 14, 2017 | Michael F. Sorrell Center, Room 2001 (Linder Reading Room), UNMC | Omaha, Nebraska

9:00 a.m. Breakfast & Networking

9:30 a.m. Opening Remarks

Technology & Start-up Presentations

9:40 a.m. Extension sheath for angioplasty Greg Gordon, M.D.

Sympathetic vasomotion monitoring for renal

10:00 a.m.
denervation Peter Pellegrino, Ph.D.
Intravascular cutting system for aortic dissection
10:20 a.m.
Jason MacTaggart, M.D.

10:40 a.m. Miniaturized surgical robots Shane Farritor, Ph.D.

11:00 a.m. Automated REBOA device Alexey Kamenskiy, Ph.D.

11:20 a.m. Wound irrigation system Thang Nguyen, A.P.R.N.

11:40 a.m. Lunch & Networking

1:00 p.m. Fistula maturation system Marius Florescu, M.D.

Detection of disease worsening in COPD

1:20 p.m.
Jennifer Yentes, Ph.D.

1:40 p.m. Intuitool Jake Riggle, M.D.

2:00 p.m. Portable laparoscope Chandrakanth Are, M.D.

2:20 p.m. Networking

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 2017 INDUSTRY PARTNERING SUMMIT
2 UNMC Startup
Extension sheath
for angioplasty
A new medical de-
vice could transform
how coronary angio-
plasty procedures are
performed throughout
the United States.
The device, Stand
Tall, is an external
support sheath that al-
lows physicians access
to the preferred route
when performing cer-
tain angioplasty pro-
cedures, such as per-
cutaneous coronary
interventions.
The procedure in-
volves a physician in-
serting a small tube, or
catheter, into an artery
in a patients wrist or
groin. Using continu-
ous X-ray imaging to
mark the progress, the
physician advances the
tube to the patients
heart, where a special
dye is released to re-
veal arteries that are
narrowed or blocked
by atherosclerosis.
By virtue of human
anatomy, the safest,
most efficient route
is through the radial
artery inside the left
wrist and forearm.
But most physicians
are right-handed,
which complicates the
left radial artery ap-
proach. Physicians are
forced to perform the
procedure with their
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Improved patient
outcomes & satisfaction
Faster recovery
Decreased costs
Reduced staff needs
Greater sterility
Lower radiation doses
Decreased fatigue &
stress for physicians
Increased site stability
non-dominant hand, or in
awkward and uncomfort-
able positions that often
lead to occupational inju-
ries.
More often, physicians
use the more complicat-
ed approach, which is
through the right radial
artery, despite recent stud-
ies that show the left side is
the superior approach site.
The Stand Tall de-
vice reorients the opera-
tor so that the left artery
approach is every bit as
easy as the right artery
approach. It allows doc-
tors, patients and hospital
administrators to reap the
benefits of improved pro-
cedural performance, bet-
ter outcomes and shorter
procedure times.
 2017 INDUSTRY PARTNERING SUMMIT
UNMC Technology
Sympathetic vasomotion
monitoring for renal denervation
Researchers at UNMC heart rate and the vas-
have developed a device omotion of blood ves-
capable of making high sels. Disruption of the
blood pressure more sympathetic nervous
treatable by accurately system can contribute
measuring the rhythmic to a variety of chron-
constriction and relax- ic diseases, including
ation of blood vessels, high blood pressure.
known as sympathetic One potentially ef-
vasomotion. fective way to treat
The sympathetic nerv- high blood pressure is
ous system controls the to destroy, or ablate,
bodys automated func- all or parts of the sym-
tions such as digestion, pathetic nerves of the
kidneys. The problem,
however, is until now
there has not been an
accurate, real-time
tool that helps clini-
Real-time tool cians determine if the
procedure is targeting
the proper areas of the
helps clinicians kidneys.
UNMCs detection
determine if system non-invasively
monitors sympathetic
proper areas nerve activity in real
time and determines
if a renal denerva-
of kidneys are tion procedure was
successful. This tech-
targeted for nology will help sig-
nificantly increase the
denervation
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3
success rate of renal
denervation proce-
dures.
UNMC researchers
have shown that the
sympathetic vasom-
tion detection system
can accurately detect
renal denervation in
rat and rabbit models.
A current study in pigs
is expected to further
validate the systems
ability and accuracy.
The sympathetic
vasomotion detection
system is a versatile
tool that can also mon-
itor and detect other
diseases or conditions
associated with the
sympathetic nervous
system.
In addition to their
work with renal den-
ervation, UNMC re-
searchers are also in-
vestigating the devices
use as a screening tool
for blood pressure-re-
lated fainting and
non-invasive hemody-
namic monitoring.
 2017 INDUSTRY PARTNERING SUMMIT

4 UNMC Technology

Intravascular cutting
system for aortic dissection Surgical jet
AquaBlade, a new medical device invented at
the University of Nebraska Medical Center, could
for aortic
provide a less invasive treatment for life-threat-
ening tears in artery walls, also called arterial dis- dissection
sections.
AquaBlade is an innovative surgical instru-
ment that uses a catheter to deliver a specialized
cutting tool through a patients artery where it
uses a high-pressure water jet to repair arterial
dissections such as in the aorta.
Aortic dissections occur when there is a tear
or damage to the inner wall or lining of the aorta.
Aortic dissections can lead to the development of
kidney failure, strokes and severe internal bleeding. Current treatments for
aortic dissection often require open-heart surgery, which carries a 15 percent
risk of death and an extended recovery period.
AquaBlade eliminates most of those risks while also minimizing the time of
recovery. It is currently at the conceptual stage, preparing a functional proto-
type for preclinical testing.

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 2017 INDUSTRY PARTNERING SUMMIT

UNMC Startup 5

Miniaturized surgical robots

Virtual Incision is a startup company devel-

oping a first-of-its-kind, miniaturized robot
Robot platform for abdominal surgical procedures.
In March 2016, Virtual Incision announced
features a small, a successful first-in-human use of the device.
self-contained The robot-assisted colon resection proce-
dures were completed in Asuncin, Paraguay,
surgical device as part of the safety and feasibility trial for the
technology. The surgeries were successful and
inserted through the patients are recovering well, according to
a news release from the company at the time.
a single mid- The device is designed for colon resection,
a procedure to treat patients with lower gas-
line umbilical trointestinal diseases including diverticulitis,
pre-cancerous and cancerous lesions of the
incision in the colon, inflammatory bowel disease and colon
polyps that are too large to be removed endo-
abdomen scopically.

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 2017 INDUSTRY PARTNERING SUMMIT
6 UNMC Technology
Automated REBOA device
A new automated
bleeding-control sys-
tem that can reduce
deaths related to cata-
strophic internal bleed-
ing has been developed
at the University of Ne-
braska Medical Center.
Internal bleeding is
a common result of in-
juries from car crash-
es, falls and gunshot
wounds, accounting
for more than half of
deaths in all Ameri-
cans between 1- and
44-years-old. Depend-
ing on the severity of
the injury, the risk of
Save
death increases if the
internal bleeding is not patients
controlled in the first
hour after the incident.
In the hospital,
from
surgeons can stop se-
vere bleeding using a
catastrophic
procedure called RE-
BOA or Resuscitative bleeding
Endovascular Balloon
Occlusion of the Aor-
ta. In this procedure a
balloon is placed in the
blood vessel near the
injury site and is then
inflated to block blood
flow and prevent fur- this approach is that tra-
ther blood loss. ditional REBOA devic-
The problem with es block all blood flow,
which can lead to per-
manent damage if organs
and tissue downstream
of the device are starved
from their blood supply
for too long.
UNMCs novel de-
vice does more than just
block flow. The innova-
tive design has the ability
to bypass the damaged
area and maintain blood
supply to vital organs and
tissues downstream of the
injury. The automated
REBOA device precise-
ly controls inflation and
regulates the amount
of blood flow to down-
stream tissue, decreasing
user error.
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 2017 INDUSTRY PARTNERING SUMMIT

UNMC Technology 7

Wound irrigation system

Inspired by their
frustrations of repeatedly
plunging a syringe into a
sterile solution to spray a
wound, emergency room
personnel at UNMC
found a way to save time
and energy with a new
irrigation system.
Wound cleaning is
an art where the doctor
or nurse must pour the
sterile saline solution into
a basin, load the solution
into a syringe, and spray
the liquid from the syringe
with the same force and
consistency each time.

Fitted to a sterile This method delivers inconsistent pressures,

solution particularly for deep wounds, which require
Ergonomic design greater amounts of force.
Cost-efficient UNMCs pressurized wound irrigation
system uses a standard sterile solution bottle
Adjustable fluid fitted with a specialized cap that connects to a
pressure uniquely designed irrigation wand. Providers
Continuous wound are then able to initiate the flow of the saline
irrigation solution and adjust the fluid pressure with the
press of a finger.
Improve wound The inventors have also developed a portable
cleansing version that allows the user to clean wounds
Faster irrigation outside a healthcare facility.
process UNeMed is seeking a partner to complete
preclinical testing and help place this irrigation
system in ERs across the nation.

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 2017 INDUSTRY PARTNERING SUMMIT
8 UNMC Technology
Fistula maturation system
Healthcare providers now have
a better, more reliable way to im-
prove dialysis in patients with kid-
ney failure.
Hemodialysis simulates kidney
function by filtering toxins from a
patients blood, outside the body. For
dialysis to work properly, dialysis
machines must filter as much blood
as possible during each treatment.
An arteriovenous or AV fistula
is a point of entry and exit to the
blood vessels that also allows large
amounts of uninterrupted blood
flow. This portal serves as a con-
nection between an artery and a
vein in the patients arm and allows
the vein to grow large and strong,
providing reliable access to blood
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Device
makes
better AV
fistulas
vessels each time.
AV fistulas are a complex and
imperfect solution, even when per-
formed by an expert team of sur-
geons and support staff.
The problem with creating AV
fistulas is that they require weeks
or months to mature and strength-
en before a patient can undergo
hemodialysis. Many patients un-
dergoing dialysis are never able to
mature a large fistula.
UNMC physician, Marius
Florescu, M.D., has a new device
that represents the first major
improvement for the AV fistula
in more than 40 years. His device
promotes better AV fistula creation
and maturation for hemodialysis.
 2017 INDUSTRY PARTNERING SUMMIT

UNO Technology 9

Detection of disease worsening in COPD

Chronic obstructive
pulmonary disorder, or
COPD, is one of the largest
and fastest growing causes
of death in the world.
People that live with
COPD suffer chronic
breathlessness and the risk
of exacerbations: A sud-
den worsening of symp-
toms. Exacerbations are
deadly, and are often only
treatable in the intensive
care unit.
A new invention from
the University of Nebraska
warns people with COPD
about worsening symp-
toms, before they happen.

The device monitors the synchroniza-

Wearable tech tion between breathing and walking. In
enables remote laboratory studies, patients with COPD
were less able to synchronize their breath-
monitoring ing and walking. The worse the disease got,
Novel algorithms the worse their ability to synchronize.
predict symptom Initial results from a national clinical
worsening study matched laboratory results. The in-
ventors are currently working to further
Enables refine the device and improve the analysis.
preventative For the first time ever, a wearable device
treatment has the potential to predict the worsening
Powerful data of COPD symptoms, even exacerbations.
Early detection opens the door to new
analysis system treatment protocols focused on preventing
is inexpensive, worsening symptoms, exacerbations and
scalable costly hospitalizations.

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 2017 INDUSTRY PARTNERING SUMMIT

10 UNMC Technology

Minimally
Intuitool makes invasive
laparoscopy easier surgery
As the world pushes to make minimally
invasive surgery easier and safer, surgical
procedures need smaller and smaller inci-
made less
sions.
Engineers and surgeons at the Universi- risky, safer
ty of Nebraska Medical Center found a way
to meet those needs, while making those for patients
procedures safer for patients and easier for
surgeonsa groundbreaking new surgical
tool called Intuitool.
Minimally invasive, or laparoscopic, sur-
gery is difficult for any surgeon. During a through an opening about
procedure, a surgeon must hold the instru- the size of Abraham Lin-
ment, often at awkward angles, for hours colns copper-plated head.
at a time. The surgeon cant see the tools Intuitool is the next
directly, instead relying on two-dimension- generation of laparoscopic
al video displays. And everything must fit tools, with robust articu-
lation and superior ergo-
nomic design and feel. Its
rod-driven articulation
system conveys the max-
imum amount of power
with minimal exertion.
Multiple publications over
eight years demonstrate
how Intuitool is safer, eas-
ier, and quicker to learn.
UNeMed is seeking a
partner to license a port-
folio of international pat-
ent applications teaching
multiple aspects of the
Intuitool, or an entrepre-
neur eager to arm sur-
geons with better tools.

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 2017 INDUSTRY PARTNERING SUMMIT

UNMC Technology 11

Portable laparoscope
One of the greatest advances in
surgery is the advent of laparoscop-
ic surgery, now a standard of care
in most countries.
Looking to extend the use of
laparoscopic surgery into devel-
oping economies, Chandra Are,
M.D., a surgical oncologist at the
University of Nebraska Medical
Center invented a portable system
that takes laparoscopic surgery be-
yond the dedicated operating room
and into the hands of surgeons in a
non-traditional environment with
minimal support.
For physicians and hospitals in
emerging economies, one of the
main down sides to laparoscopic
surgery is that it requires expensive
laparoscopic suites, with state-of-
the-art equipment.
Dr. Ares portable laparoscope
technology allows physicians in
emerging economies to keep up
with the standard of care and prac-
tice laparoscopic surgery. This
ground-breaking system takes the
function of a laparoscopic suite and
reproduces it in a portable system
enabling laparoscopic investigation
in a variety of non-traditional set-
tings.

Inexpensive to
manufacture &
employ
Requires minimal
clinical support
Improves access
in emerging
economies
Expands
laparoscope
beyond the OR

Simulation graphic: UNeMed

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 2017 INDUSTRY PARTNERING SUMMIT

12

Michael Dixon, Ph.D.

President & CEO
UNeMed
licensing
Steve Schreiner, Ph.D.
Vice President &
personnel &
Director Marketing and Licensing
support staff
Jason Nickla, J.D., L.L.M.
Vice President &
Director of Intellectual Property

Matt Boehm, Ph.D.

Licensing Manager
Jeff Andersen, J.D. Val Gunderson
Contracts Specialist Office Manager

Joe Runge, J.D., M.S.

Business Development Manager
Bo Han, M.D., M.B.A. Cori Harsh
Sr. Business Dev. Specialist Financial Manager

Qian Zhang, Ph.D., M.B.A.

Licensing Specialist
Charlie Litton Anne Rivas
Communications Office Associate

Catherine Murari-Kanti, Ph.D.

Licensing Associate
D.J. Thayer, M.B.A Mindy Ware
Director of International & Patent Specialist
Domestic Business Affairs

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