LONG QUIZ 1

1. Proteins, carbohydrates and lipids converted into amino acids, glucose and fatty acids is in what stage of
metabolism? Stage I (From polymers to monomers)

2. Depending on the state and needs of the cell. One of the following metabolic pathways can be anabolic or catabolic.
Krebs cycle

3. One of the following pathways is mitochondrial. FA acid synthesis, Glycolysis, Ketogenesis, PPP (the rest cytosolic)

4. Which of the following lipoproteins transports TAG that is synthesized in the liver? VLDL

5. The following statements are true about committed step EXCEPT: it is a step common to several metabolic pathways

6. Which of the following regulatory mechanisms represents long term or coarse control metabolic pathways: allosteric
modification, covalent modification, increase in the synthesis of key enzymes, negative feedback

7. Which of the following pathways will be stimulated when there is scarcity of glucose? gluconeogenesis

8. increase in which of the following factors will accelerate metabolic pathways, except
a. demand for end products
b. reduced co-enzymes
c. substrate concentration
d. transport proteins

9. after a fat rich meal, dietary fats are transported to the adipose tissue and muscles because these tissues contain.
a. Lipoprotein lipase
-hindi kasama ang hormone sensitive at ang pancreatic lipase

10.During the fed state this is the major fuel of nearly all tissues: Glucose

11.Insulin induces the activity of the following enzymes in the fed state, except:
a.PFK 1
b.hexokinase
c. glycogen phosphorylase
d.pyruvate dehydrogenase

12. Digestion of carbohydrates starts in the oral cavity due to the presence of ptyalin which is specific for:
a. cellulose
b. maltose
c.lactose
d.starch

13. in the small intestines glucose is actively transported along with:

a.calcium
b.fats
c. sodium
d.water

14. the most common cause of galactosemia or failure to metabolize galactose is a deficiency of which of the
following enzymes:
a. Galactose-1 phosphate uridyltranferase
b.galactokinase
c.4epimerase
d. phosphoglucomutase

15. This enzyme of galactose metabolism makes it possible for UDP-glucose to be converted to UDP-galactose

a. Galactose-1 phosphate uridylyltransferase (GALT)

b. UDP-galactose 4-epimerase (GALE) [ANSWER]
c. Galactokinase (GALK)
d. Phosphoglucomutase

16. PFK-1 which is the rate limitng enzyme of glycolysis is inhibited by which of the following the following allosteric
modifiers?

a. Acetyl coA
b. ADP
c. AMP
d. ATP [ANSWER]

17. Which of the following sugars bypasses pfk-1 step thereby resulting to overproduction of acoa and devt of
hypertriglyceridemia, hypercholesterolemia and atherosclerosis

a. Fructose [ANSWER]
b. Galactose
c. Glucose
d. Mannose

18. In the liver, glucose is converted to glucose-6-phosphate by:

[ANSWER] Glucokinase

19. In an erythrocyte that is producing 2,3-biphosphoglycerate, what would be the net ATP produced?

a. 0 [ANSWER]
b. 2
C. 7
d. 9

20. If the end product of glycolysis is pyruvate, what would be the net ATP produced?

a. 0
b. 2
C. 7 [ANSWER]
d. 9

21. During anaerobiosis, NADH is reoxidized to NAD through:

a. Formation of ATP via ETC

b. Entering oxidative phosphorylation
C. Reduction of pyruvate to lactate [ANSWER]
d. Conversion of pyruvate to acetyl coA

22. In this tissue, the end product of glycolysis is always lactate

A. cardiac
B. erythrocyte
C. liver
D. skeletal muscle
Answer: B

23. Which of the following statements is correct about hexokinase?

A. high Km value for glucose
B. responsible for storing normal blood glucose levels after meals
C. it is inhibited by G-6-P
D. specific for glucose
Answer: C

24. Which of the following patterns will inhibit pyruvate dehydrogenase?

A. decreased Acetyl-CoA
B. decreased ATP
C. increased ADP
D. increased NADH
Answer: D

25. In an exercising muscle, what is the end product of glycogenolysis?

A. glucose-1-phosphate
B. glucose-6-phosphate
C. lactate
D. pyruvate
Answer: C

26. Absence of enzyme pyruvate dehydrogenase or deficiency of its coenzymes will result to which of the following
conditions?
A. hemolysis
B. lactic acidosis
C. liver failure
D. hypoglycemia
Answer: B

27. Cyclic AMP causes reciprocal control of glycogenesis and glycogenolysis. In its presence, which of the following will
happen?
A. glycogen synthase is active while glycogen phosphorylase becomes inactive
B. both glycogen synthase and glycogen phosphorylase will become active
C. both glycogen synthase and glycogen phosphorylase will become inactive
D. glycogen synthase becomes inactive while glycogen phosphorylase is active
Answer: D

28. Malfunction of the enzyme glycogen phosphorylase such as in ??????? disease will result to
Answer: Poor exercise tolerance

29. This enzyme determines if an organ is capable of releasing free glucose into the systemic circulation from G6P

a. Glucokinase
b. Phosphoglucomutase
c. Glucose-6-phosphatase
d. Glucose-6-phosphatase dehydrogenase (?)

30. According to the rate of absorption, what common oligosaccharide is the fastest to be absorbed?
a. fructose
b. galactose
c. glucose
d. mannose

31. The essential glycosuria, which sugar (pentose) is unused by the body and is excreted through the urine is..L xylulose

32. What is the most important product of the non-oxidative phase of PPP? Ribose

33. Failure of the Rapoport-Leubering cycle in RBC will result to..Decrease unloading of oxygen to tissues

34. In the hexosamine pathway, which of the following is the donor of nitrogento produce amino sugars for connective
tissue synthesis? Glutamine

35. What enzyme in the hexose monophosphate shuntrefers to 2 carbon units from a ketone sugar donor to an aldose
sugar acceptor..transketolase

36. Deficiency of glucose-6-phosphate dehydrogenase will manifest under certain conditions as

A. acidosis
B. hemolytic anemia
C. hypoglycemia
D.weakness
Answer: B. hemolytic anemia

37. Lack of gulonolactone oxidase in man and other primates is the reason for the supplementation of:
Answer: Vitamin C

38. Glycerol from TAG is able to enter the main gluconeogenic pathway by converting back to which of the following
metabolic intermediates?
A. alpha-ketoglutarate
B. DHAP and Glyceraldehyde-3-phosphate
C. fructose-6-phosphate and glucose-6-phosphate
D.pyruvate and phosphoenolpyruvate
Answer: B. DHAP and G-3-P

39. Which of the following hormones stimulates both hepatic and muscle glycogenolysis?
A. epinephrine
B.glucagon
C. glucocorticoid
D. growth hormone
Answer: A. epinephrine

40. The following non-carbohydrate sources can be converted to glucose except

A. amino acids
B.glycerol
C.propionic acid or propionate
D. even-numbered fatty acid
Answer: D. even-numbered fatty acid

41. Which hormone stimulates the synthesis and activity of all four key enzymes of gluconeogenesis
A. epinephrine
B. glucagon
C.glucocorticoid
D.growth hormone
Answer: B. glucagon

42. During fasting and starvation, what is the allosteric inhibitor of pyruvate dehydrogenase, allosteric activator of
pyruvate carboxylase
A. Acetyl-CoA
B. Adenosine triphosphate
C. cyclic AMP
D. citrate
Answer: A. Acetyl-CoA

43: organs that have the complete 4 enzymes of gluconeogenesis are:

a liver and muscle
b liver and kidneys
c liver and adipose
d liver and intestines

44: pyruvate carboxylase and phosphoenol pyruvate carboxykinase are gluconeogenic enzymes that circumvent which
irreversible step in glycolysis
a. pyruvate - > acetyl coa
b. pyruvate to alanine
c pyruvate to oxaloacetate
d pyruvate to phosphoenol pyruvate

45: the liver during fasting can directly contribute to blood sugar through transamination of pyruvate to glycogen to
which of the ff amino acid?
Ans: alanine

46: which of the following describes polyol pathway?

Ans: pathway that synthesizes fructose from glucose

47: what metabolite is being replenished or refilled in the major anapleurotic step in the body?
A acetyl
B glucose
C oxaloacetate
D pyruvate

48. hypoglycemia can result from which of the ff conditions except

A glucose phosphatase deficiency
B glycogen storage diseases
C impaired fatty acid oxidation
D decreased insulin secretion (hyperglycemia)

49. which of the ff is correct about type 1 DM

A Strong genetic basis
B Prone to ketoacidosis
C Onset is gradual and insidious
D patient is overweight to obese

50. Lactate, which is considered a metabolic by product is recycled back to glucose thru:
Ans: Cori cycle