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DRUG MOA RESISTANCE CI ADR

Alkylators: Transfer alkyl Pregnancy


CARMUSTINE group, forms DNA repair Lactation Alopecia
LOMUSTINE unstable Decrease entry Severe Nausea
SEMUSTINE compound into cell leukopenia Vomiting
Ethylene Inactivation of
Immonium alkylating group
*cell cycle Ion and DNA
nonspecific* Alkylation & CD

Antimetabolite: High affinity to Reduced Myelosuppresion


*(S phase DHFR, inhibit it transport Pregnancy Stomatitis
specific)* completely Pneumonitis
Folate analogue Increased
METHOTREXATE Drug efflux

Pyrimidine dTMPDeficiency
analogue: same inhibition of same Same except
FLUROURACIL raltitrexed pneumonitis
FLUDARABINE enzyme
PENTOSTATIN cytosine
arabinoside

Fludarabine
Purine analogue: same Inhibits DNA same Hepatotoxicity
MERCAPTO polymerase Myelosuppresion
PURINE Altered mental
FLUDARABINE Merceptopurine status
PENTOSTATIN Incorporation
leads halting of
DNA & RNA
synthesis
Topoisomerase
Inhibitors Inhibits Inadequate Pregnancy and Bone marrow
*(S phase Topoisomerase accumulation lactation Suppression
Specific)* And prevents Interstitial lung
TOPOTECAN DNA resealing Alteration in disease
IRINOTECAN topoisomerase
binding
Vinka alkaloids Binds to B-
*(M phase tubulin and Mutation in B Neurologic Alopecia
Specific)* inhibits tubulin disease
VINCRISTINE Polymerization Intrathecal Mylosuppression
VINBLASTINE Into Reduced Administration Peripheral
VINDESINE microtubules intracellular Neuropathy
Prevents level pregnancy
spindle Secondary to
formation EFFLUX
Antibiotic:
Bleomycin Binds to Fe2+ Increased Pregnancy Interstitial
*(G2 phase and complex Hydrolase Pneumonitis
Specific)* leads to free activity
radical Hypersensitivity
formation when DNA repair Erythema
Oxygen is Hyperkeratosis
added and DNA Inactivation of
breaks Bleomycin

Myelosuppression
Platinum Cross link DNA DNA repair None of major
compounds Strand and significance Tinnitus and
*(cell cycle inhibit DNA Efflux hearing loss
nonspecific)*: synthesis transporter
CISPLASTIN and function Hyperuricemia
CARBOPLASTIN
OXALIPLATIN Peripheral
Neuropathy

Hypersensitivity

*(Cell cycle
Nonspecific Alkylate DNA Delay and
Antibiotics)*: and cause prolonged
MITOMYCIN C Breakage of Myelosuppression
DNA strand
ACTINOMYCIN D Intercalation of
DNA
Prevents DNA
Transcription
and messenger
RNA synthesis

Increased
Taxanes: Microtubule MDR efflux Pregnancy Myelosuppression
PACLITAXEL Inhibition pump Lactation Neurotoxicity
DOCETAXEL By binding to B Severe hepatic Resistant
Tubulin Overexpression impairment Fluid retention
Stabilizing the of mutated
microtubule and isoform of B
Preventing its tubulin
assembly
Tyrosine kinase
Inhibitor: Tyrosine pregnancy Bonemarrow
IMATINIB receptor gets Suppression
ERLOTINIB deactivated and
Unregulated Hemorrhage
Cell growth Fluid retention
inhibited

Cardiac
Hormonal Inhibit the cerebrovascular
ESTROGEN endogenous complications
Diethylstilbestrol androgens
dependent Carcinoma of the
metastatic male breast
prostatic
carcinoma
management of
Progestins endometrial
carcinoma

therapy for
Metastatic
hormone-
dependent
breast cancer.
Antiestrogen: Used in
TOMOXIFEN postmenopause
recovering from
metastatic
breast cancer.

Estrogen
receptor-
positive
Tumors

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