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fordrugdeliverynanoparticles
MariaHelenaA.ZaninandMarioR.GongoraRubio
CenterforProcessandProductsTechnology
ChemicalProcessesandParticleTechnologyLaboratory
CTPPLPP
Summary
ParticleandencapsulationtechnologyatIPT
Technologicalsolutionstoactiveencapsulation
Microfluidics
Microfluidicsasabottomupnanofabrication
technique
CurrentworkinmicrofluidicsatIPT
Technologicalperspectives
Technologyteam
Encapsulation?
Objectives
Controlledreleaseornot
Protectionagainstexternalagents
Reductionoflossestotheenvironment
Others
Actives
drugs,fragrances,flavours,minerals,
vitamins,colorants,pesticides
Encapsulation:Technologyofindustrialinterest
FOOD
INDUSTRY
COSMETIC TEXTILE
INDUSTRY INDUSTRY
PHARMACEUTICAL AGROCHEMISTRY
INDUSTRY INDUSTRY
Howtochoosetheencapsulationtechnique?
Pointstobeconsidered
Activeagent
Polymer
Physicalandphisicochemicalpropertyofactiveandpolymer
Compatibilityofpolymerandactive
Routeofactiveagentdelivery
Scalableprocess
Cost
MicronanoencapsulationatIPT
Technology
Spraydrying
Coacervation
Emulsion/solvent
extraction
Gelification
Polymerisation
Electrospinning
Microfluidics
Technologicalsolutions to
activeencapsulationatIPT
Spraydryer
Microencapsulationofpolimineralstothefoodindustry
Previouswork:Industrialandgovernmental funding
Complex coacervation
Microcapsulescontainingvitamintothecosmeticapplication
Previouswork:Industrialfunding
Emulsificationandsolvent evaporation
80%PHBHV-20%PLA
dissolved
80%PHBHV-20%PEG
dispersed 2000x
Emulsification solidlipidic nanoparticles
Developmentofnanocarriesbasedonwaxtoencapsulate benzophenone3 tocosmetic
application.Previouswork:Doctorarethesis
Governmentfunding CNPq
Active+melted
Lipid(85 5C)
HPLC
Franzdiffusion
cell Buffersolution7.4
Agitation
H2O+Surfactant (5%Tween80)
(85 5C)
Highpressure
homogeneizer(HPH)
(600bar)
Interfacialpolimerization
Developmentofnanofibersbyelectrospinningprocessusingbiocompatiblepolymer
toincorporatedrugs.Currentproject:Governmentfunding CNPq/IPT.
CNPq/IPT
Microfluidicsapplications
Microreactorsfor: Microreactorsfor:
Microcrystallization Transesterification(Biodiesel)
NanoPrecipitation Reformers
MicroNanoEncapsulation Catalyticmaterialscreening
Hydrogenation
Biosensors
Micromixers
Continuousseparators
Microdestillation
MicroFluidicsfor Heatexchangers
watertreatment
and
Microsensors
Definition
Microfluidicisascienceofdesigningandmanufacturingdevicesin a
microscale , dealing with volumes of fluids on order of nanoliters or
picoliters.
Usingmicrofabricationtechniquesispossibletomanufacturedevicesin
materialssuchassilicon,glasses,polymersandceramics.
Physical characteristics
BottomuporTopdown?
Top-down Bottom-up
Microfluidicutilizationforparticlemorphologicalcontrol
R.K.Shaha,etal.MaterialsToday,vol11,number4,April2008.
Scaleoutinmicrofluidics
Microfluidicsscalingofproductionis
obtainedbyusingthesamedevices
inparallel.
Scale-Up Scale-out
Microfluidics
MicroprocessesNanoparticles
Liposomes
Nanocrystals
Emulsions
BatchVsContinuous
Microfluidic devices
MineralOil
Drop
Polymeric Outlet
Solution
MineralOil
MineralOil Droplet
Oulet
Polymeric
Solution
Currentworksin
microfluidicsatIPT
Emulsiongeneratorsusingglassdevices
J.N.Schianti,etal.Emulsionproductionusingglass
microfluidicdevices,Proc:IBERSENSOR2010
Microandnanoparticleswithmicromixers
MicrographsofPLGA(Poly(DLlactideco ComparisonbetweenTurraxagitation
glycolide)) microspherescontainingBSA andmicromixerparticlesobtained
(Bovineserumalbumin)(750x) usingmicromixers.
80
60
R eleased B SA (% )
40
20
0
0 50 100 150 200 250
Time (hours)
Micromixer ED2 Micromixer BD1 Conventional mechanical agitation
M.RibeiroCosta,etal.PreparationofproteinloadedPLGA
microspheresbyanemulsion/solventevaporationprocess
employingLTCCmicromixers, PowderTechnologyVol190,
p.107111,(2009)
(DCM/BD1/Q36)
Nanoliposomeproductionviamicrofluidics
BOTTOM - UP
Liposome
MicrofluidicHydrodynamic
Focusing
J.N.Schianti,etal.Glassflowfocusingmicrofluidicdevicefor
nanoliposomeproduction,Proc:IBERSENSOR2010
Nanocrystallizationprocessbymicrofluidics
Crystallizationprocesstoobtain rifampicinamorphousnanoparticles
BOTTOM - UP
Nanocrystals
MicrofluidicFlowFocusing
Technologicalperspectives
Microfabricationofunitoperationdevicesforchemical
processintensification,includingsynthesisofmicroand
nanoparticlesforfeasibleproducts.
Microfabricationofdevicesadaptedtotheencapsulation
processinordertodesigncapsuleoremulsionwithsizeand
morphologycontrolledincontinuousprocess.
Introductionofnewmicrofluidictechniquesforproductionof
drugdeliverynanostructuredparticles.
TechnologyTeam
CTPP Director
Dr.MariaFilomenadeA.Rodrigues(Filomena@ipt.br)
LPP
Laboratoryhead
Dr.WagnerAldeia(waldeia@ipt.br)
Researcher(PhD) 8
Researcher(MSc.) 1
Researcher 6
Laboratorytechnicians 5
Students
PhDstudent 3
PostDoctorate 1
Thankyouforyourattention!!!