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TETRACYCLINE (3)

TETRACYCLINE (3) Tetracycline, also called Deschloro Biomycin, is a naphthalene (a white crystalline compound) antibiotic that

Tetracycline, also called Deschloro Biomycin, is a naphthalene (a white crystalline compound) antibiotic that discovered in 1940s and is produced by the Streptomyces genus of Actinobacteria (Gaillard, T., 2015). It’s work as blocking the Aminoacyl-tRNA that about to bind to the ribosome acceptor site during protein synthesis. Therefore, the bacteria couldn’t synthesis the protein which is essential to them. Tetracycline is generally used to treat a wide variety of infections caused by bacteria such as skin, intestines, respiratory tract, acne etc. (Tetracycline, 2017).

PROPERTIES (1)

TETRACYCLINE (3) Tetracycline, also called Deschloro Biomycin, is a naphthalene (a white crystalline compound) antibiotic that

APPLICATIONS (2)

Tetracycline is a member of the tetracycline family it’s useful for antimicrobial action. It’s usually used to treating infections caused that by streptococci, staphylococci, Gram-negative bacilli, rickettsiae, and certain protozoans and viruses. Tetracycline can also produced biosynthetically by fermentation with a strain of Streptomyces aureofaciens or chemically produced by hydrogenolysis of chlortetracycline. Tetracyclines are the stopper for bacterial protein synthesis by binding to the 30S ribosomal subunit. Tetracycline will act as an inhibitor of growth (bacteriostatic) rather than a killer of the infectious agent (bactericidal) and it is only effective against multiplying microorganisms.

Tetracycline antibiotics include;

Chlortetracycline (CAS # : 57-62-5) Demeclocycline Hydrochloride (CAS # : 64-73-3) Demethylchlortetracycline (CAS # : 127-33-3) Dihydrostreptomycin Sesquisulfate (CAS # : 5490-27-7) Doxycycline (CAS # : 564-25-0) Duramycin (CAS # : 1391-36-2) Meclocycline Sulfosalicylate (CAS # : 73816-42-9) Methacycline Hydrochloride (CAS # : 3963-95-9) Minocycline (CAS # : 10118-90-8) Neomycin (CAS # : 1404-04-2) Oxytetracycline (CAS # : 6153-64-6) Streptomycin (CAS # : 57-92-1) Tetracycline (CAS # : 60-54-8) Vancomycin (CAS # : 123409-00-7)

REFERENCES

  • 1. Tetracycline. (2017). Retrieved May 14, 2017, fromhttps://pubchem.ncbi.nlm.nih.gov/compound/tetracycline#section=Top

REFERENCES 1. Tetracycline. (2017). Retrieved May 14, 2017, from ​ https://pubchem.ncbi.nlm.nih.gov/compound/tetracycline#section=Top 2. (n.d.). Retrieved May 21,http://www.chemicalland21.com/lifescience/phar/TETRACYCLINE%20HYDROCH LORIDE.htm 3. Gaillard, T., Madamet, M., & Pradines, B. (2015). Tetracyclines in malaria. Malaria Journal, 14(1). doi:10.1186/s12936-015-0980-0 " id="pdf-obj-2-13" src="pdf-obj-2-13.jpg">