IPGA SPONSORED NATIONAL SEMINAR ON

REMODELLING THE PHARMACY EDUCATION IN INDIA

APRIL 11th, 2015

as well as callus tissue. Aqueous and methanolic extract were selected for TPC quantification. The
paper describes a rapid, highly efficient, economical and easier technique for extraction of secondary
metabolites of this medicinally important tree which can be applied commercially.

Poster Code JCP/IPGA/206

GREEN CHEMISTRY: INNOVATION IN ACADEMIC LABORATORY

Anshul Sain*1, Narendra Sharma1 and Santosh Gupta1

1
Vidyasthali Institute of Technology, Science and Management, Jaipur (Raj.)

Green Chemistry is defined as invention, design, development and application of Chemical products
and processes to reduce or to eliminate the use and generation of substances hazardous to human
health and environment. This paper suggests modifications of the hazardous laboratory experiments,
currently practiced in our academic laboratory. Traditional methods of organic synthesis are orders of
magnitude too slow to satisfy the demands for these compounds. The efficiency of microwave flash-
heating chemistry in dramatically reducing reaction times (reduced from days and hours to minutes
and seconds)has recently been proven in several different fields of organic chemistry. The time saved
by using microwaves is potentially important in traditional organic synthesis but could be of even
greater importance in high speed combinatorial and medicinal chemistry.

Poster Code JCP/IPGA/207

REFORMING SOLUBILITY AND FLOW PROPERTIES OF DRUGS USING
SPHERICAL AGGLOMERATION TECHNIQUES

Arindam Chatterjee*1, Birendra Shrivastav1, Madan Mohan Gupta2, Manish Jaimini3, Pankaj Arora4
1
School of Pharmaceutical Sciences, Jaipur National University, Jaipur
2
School of Pharmacy, Faculty of Medical Sciences, The University of The West Indies
3
Department of Pharmaceutics, Jaipur College of Pharmacy, Jaipur
4
Dept. of Pharmaceutical Chemistry, Jaipur College of Pharmacy, Jaipur

Spherical agglomeration is a technique wherein the particles are precipitated and agglomerated with
or without the addition of binders. This technique provides micro crystals having a uniform spherical
shape. Spherical Crystallization technique comprises three techniques Antisolvent method or spherical
crystallization (Two Solvent system and Three solvent system), Quasi emulsion solvent diffusion,
Crystallo-co agglomeration and Ammonia diffusion techniques. Spherical crystallization is the
process of obtaining larger crystals during the process of crystallization. Crystallization is the process
of forming solid crystals that occurs when molecules start aggregating and precipitating from solution
or molten state. Under controlled conditions like solvent composition, mixing rate, temperature
crystals can be agglomerated into spherical dense agglomerates. Spherical Crystallization technique
can be applied to produce compacted spherical particles of drug having improved uniformity in shape
and size of particles, lower bulk density, better flow properties which in turn improves the
compressibility and compactibility, making the drug suitable for direct tableting. Till now poor
physico-mechanical properties of drugs have been improved by granulation techniques. Wet
granulation technique is a common technique which is both energy consuming and also may impart
instability to the moisture and heat labile drugs. Other methods were less favorable being less
economical than direct compression tableting. Direct tableting technique has been successfully
applied to many drugs on industrial scale. So spherical crystallization technique when used in
commercial scale will be economical increasing the revenue and decreasing patient cost burden.

ORGANIZED BY 3
JAIPUR COLLEGE OF PHARMACY, JAIPUR, RAJASTHAN-302022