ARB Lisinopril Equivalent Dose

Dosing for CHF

Dose
12.5 mg 2.5 mg QDAILY
QDAILY
25 mg 5 mg QDAILY
Initial: 12.5 mg QDAILY i QDAILY
Losartan
Target: 50 mg QDAILY 50 mg 10 mg ii QDAILY
QDAILY
100 mg 20-40 mg QDAILY
QDAILY
40 mg 2.5-5 mg QDAILY
QDAILY
80 mg 10 mg iv QDAILY
QDAILY
Initial: 40 mg BID iii 160 mg 20 mg QDAILY v
Valsartan v
Target: 160 mg BID QDAILY
160 mg 40mg QDAILY
BID
320 mg 40 mg vi QDAILY
QDAILY
Initial: 5 mg QDaily vii
Lisinopril
Target/Max: 20-40 mg QDaily viii
***This table is an estimation of equivalent dosing extrapolated from available studies.
You must exercise clinical judgment when choosing a dose of either medication and must
take into account multiple factors including, but not limited to blood pressure, renal
function and heart rate. These tables are for your review only and have not been reviewed
by any cardiologists nor are they endorsed by VISN 17 or VANTHCS***

i
Losartan Indications/Dosage. Clinical Pharmacology. 2009.
ii
Akinboboye O, Chou R, Bermann S. Augmentation of myocardial blood flow in hypertensive heart
disease by angiotensin antagonists. Journal of the American College of Cardiology. 2002;(40)4:705-709.
iii
Valsartan Indications/Dosage. Clinical Pharmacology. 2009.
iv
Benz J, Oshrain C, Henry D, Avery C, et al. Valsartan, a new angiotensin II receptor antagonist: A
double-blind study comparing the incidence of cough with lisinopril and hydrochlorothiazide. Journal of
Clinical Pharmacology. 1997;(37)2:101-107.
v
De Tommasi E, Iacoviello M, Romito R, Ceconi C, Guida P, Massari F, et al. Comparison of the effect of
valsartan and lisinopril on autonomic nervous system activity in chronic heart failure. American Heart
Journal. 2003; (5):E17.
vi
Menne J, Farsang C, Dek L, Klebs S, Meier M, Handrock R, et al. Valsartan in combination with lisinopril
versus the respective high dose monotherapies in hypertensive patients with microalbuminuria: the
VALERIA trial. Journal Of Hypertension. 2008;(9)1860-7.
vii
Lisinopril Indications/Dosage. Clinical Pharmacology. 2009.
viii
Hunt SA, Abraham WT, Chin MH et al. ACC/AHA Guideline Update for the Diagnosis and Management of
Chronic Heart Failure in the Adult. J Am Coll Cardiol. 2005 Sep 20;46(6):e182.