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Index

Note: Page numbers followed by f refer to figures; those followed by t refer to tables.

A Acute myeloid leukemia Adenomatous hyperplasia, atypical, 260-261,


Abacterial prostatitis, chronic, 540-541 vs. diffuse large B-cell lymphoma, 779 260f
Abdomen, spindle cell tumors of, vs. Langerhans cell histiocytosis, 816-817 prostatic, 543-544
immunohistochemistry panel Acute necrotizing eosinophilic myocarditis, 955 vs. prostatic adenocarcinoma, 550-551
interpretation for, 15t Acute respiratory distress syndrome, 226-227, vs. prostatic basal cell carcinoma, 553
Abscess 227t Adenomatous polyp, vs. hyperplastic gastric
bone, vs. osteoid osteoma, 839 Acute thyroiditis, vs. granulomatous polyp, 339
brain, 1040-1041, 1040f thyroiditis, 122-123 Adenomyoma, atypical polypoid, endometrial,
breast Adamantinoma, 871-872, 872f 636-637, 636f
subareolar, 701-702, 702f vs. osteofibrous dysplasia, 865 Adenomyosis, myometrial, 643, 643f
vs. diabetic mastopathy, 705 Addison disease, 461-462, 462f Adenopathy, HIV-associated
vs. granulomatous lobar mastitis, 703 differential diagnosis of, 462 vs. autoimmune lymphoproliferative
hepatic primary, 461 syndrome, 754
bacterial, 413, 414f secondary, 461 vs. progressive transformation of germinal
parasitic, 413 Adenocarcinoma. See specific type and at centers, 753
splenic, vs. cytomegalovirus infection, 830 anatomic site. Adenosarcoma
Acantholytic dermatosis, transient, vs. Adenofibroma of endometrium, 637-638, 638f
pemphigus, 75 endometrial, 637, 637f vs. endometrial adenofibroma, 637
Acanthoma, clear cell, 84, 84f papillary, vs. endocervical polyp, 617 vs. endometrial polyp, 631
vs. poroma, 93 vs. endometrial adenosarcoma, 638 vs. endometrial stromal sarcoma,
Acanthosis, glycogen, of esophagus, 321-322, vs. endometrial polyp, 631 641-642
322f Adenohypophysis, spindle cell oncocytoma of Adenosis
Acanthosis nigricans, vs. seborrheic keratosis, 83 vs. pituicytoma, 1030 breast, 709-710, 709f
Acid-fast bacilli, Ziehl-Neelsen staining of, 6, 7f vs. pituitary adenoma, 1030 vs. tubular carcinoma, 730
Acinar cell adenocarcinoma Adenoid cystic carcinoma sclerosing. See Sclerosing adenosis.
of prostate gland, 548-549 cytoarchitectural patterns of, 160-161 vaginal, 613, 613f
vs. well-differentiated pancreatic neoplasm, of breast, 735, 735f Adenosquamous carcinoma
457 of salivary glands, 160-161, 160f of pancreas, 453
Acinar cell carcinoma of trachea, 214, 215f of prostate gland, 554-555
of exocrine pancreas, 455, 455f vs. basal cell adenoma, 158 of uterine cervix, 626-627
of salivary glands, 161-162, 162f vs. epithelial-myoepithelial carcinoma, 166 poorly differentiated. See Glassy cell
vs. invasive ductal adenocarcinoma, 454 vs. polymorphous low-grade carcinoma.
vs. pancreatoblastoma, 456 adenocarcinoma, 163 vs. metaplastic carcinoma, 732
vs. solid pseudopapillary neoplasm, 459 vs. small cell carcinoma, 170 vs. prostatic epithelial metaplasia, 545
Acne vulgaris, 77-78, 77f Adenoma. See specific type and at anatomic site. Adenovirus infection, in immunocompromised
Acquired cystic kidney disease, 515-516, 515f Adenomatoid hamartoma, respiratory epithelial patients, 352-353
vs. autosomal dominant polycystic kidney vs. nasal polyp, 176 Adnexal carcinoma, microcystic. See
disease, 515 vs. sinonasal (Schneiderian) papilloma, 180 Microcystic adnexal carcinoma.
Acquired melanocytic nevus, 101-103, 102f Adenomatoid nodule Adrenal cortical adenoma, 466-469
variants of, 101-103, 102f vs. Graves disease, 126 ACTH-dependent, 464
Acral lentiginous melanoma, 103 vs. thyroglossal duct cyst, 129 ACTH-independent, 464
Actinic cheilitis, vs. leukoplakia, 193 Adenomatoid tumor clinical features of, 466
Actinic keratosis, 85-86, 86f fallopian tube, 691, 691f Conn syndrome and, 466-467
Actinomycosis, vs. nocardiosis, 247 myometrial, 646-647, 647f Cushing syndrome and, 466-467
Acute bronchiolitis, 225t odontogenic, 202-203, 202f differential diagnosis of, 468
Acute demyelinating encephalomyelitis, 1046 paratesticular, 577-578, 577f histopathology of, 466-467, 467f-469f
Acute hemorrhagic leukoencephalitis, 1046 vs. myometrial adenomyosis, 643 oncocytic, 467
Acute interstitial pneumonia, 226-227, 226f vs. Sertoli cell tumor, 573 pathology of, 466, 467f-469f

1071
1072 Index

Adrenal cortical adenoma (Continued) Alopecia areata, vs. lichen planopilaris, 45 Anaplastic large cell lymphoma, 119-120,
pigmented, 467 Alveolar adenoma 120f
vs. malignant melanoma, 481 diagnostic features of, 259t nodal, 781-783, 782f
vs. adrenal cortical carcinoma, 470 vs. atypical adenomatous hyperplasia, 261 vs. diffuse large B-cell lymphoma, 779
vs. adrenal cortical hyperplasia, 466 Alveolar rhabdomyosarcoma. See also vs. Langerhans cell histiocytosis, 766
vs. congenital adrenal hyperplasia, 464 Rhabdomyosarcoma. vs. mixed cellularity Hodgkin lymphoma,
vs. pheochromocytoma, 475 head and neck, 188 788
Adrenal cortical carcinoma, 470-472, 471f metastatic, vs. precursor B-cell lymphoblastic vs. nodular sclerosing Hodgkin
vs. adrenal cortical adenoma, 468 lymphoma, 781 lymphoma, 772
vs. renal cell carcinoma, clear cell type, 522 soft tissue, 920, 920f vs. peripheral T-cell lymphoma, 785
Adrenal gland vs. alveolar soft part sarcoma, 945 vs. Rosai-Dorfman disease, 764
congenital hyperplasia of, 463-464, 463f vs. Burkitt lymphoma, 784 splenic, vs. Hodgkin lymphoma, 804
cortex of vs. desmoplastic small round cell tumor, 944 Anaplastic meningioma, 1021
adenoma of. See Adrenal cortical vs. Ewing sarcoma/peripheral vs. secondary CNS tumor, 1034
adenoma. neuroectodermal tumor, 942-943 Anaplastic oligodendroglioma, 996-997
carcinoma of, 470-472, 471f vs. precursor B-cell lymphoblastic Anaplastic small cell hepatoblastoma, vs.
vs. adrenal cortical adenoma, 468 lymphoma, 781 embryonal (undifferentiated) sarcoma,
vs. renal cell carcinoma, clear cell Alveolar sarcoma 444
type, 522 soft part, 944-945, 944f Androgen insensitivity syndrome, vs. Sertoli
hyperplasia of, 464-466 vs. paraganglioma, 928 cell tumor, 573
insufficiency of, 461-462, 462f Alzheimer disease, 1047-1049, 1047f Anemia, autoimmune hemolytic, 810-811,
cysts of, 482-483 plaque in, Congo red staining of, 5f 810f
ganglioneuroblastoma of, 476-477 Amebiasis, 377-378, 377f vs. hereditary spherocytosis, 808
ganglioneuroma of, 475-476, 476f Amelanotic melanoma Aneurysmal bone cyst, 878-879, 878f
malignant melanoma of, 478f, 480-481 metastatic, vs. lymphoepithelial carcinoma, secondary, 879
metastatic tumors of, 484-485, 484f 171 vs. chondroblastoma, 853
myelolipoma of, 481-482, 482f vs. ciliary body adenoma, 1059 vs. clear cell chondrosarcoma, 859
neuroblastoma of, 477-479, 478f, Ameloblastic fibroma, vs. ameloblastoma, 201 vs. giant cell reparative granuloma, 871
479t-480t Ameloblastoma vs. osteoblastoma, 841
pheochromocytoma of, 473-475, 474f acanthomatous pattern of, 201 vs. telangiectatic osteosarcoma, 844
pseudocysts of, 482-483, 483f follicular pattern of, 200 vs. unicameral bone cyst, 879
Adrenal medullary hyperplasia, 472-473, oral cavity, 200-201, 200f Angiocentric glioma, 1003-1004
472f plexiform pattern of, 200 vs. astroblastoma, 1002
Adrenogenital syndrome, 463-464, 463f vs. adenomatoid odontogenic tumor, 203 Angiofibroma
classic form of, 463 American cutaneous leishmaniasis, 70 nasopharyngeal, 177-178, 177f
lipoid, 463, 463f Amiodarone toxicity, vs. bleomycin toxicity, vs. nasal polyp, 177
nonclassic form of, 463 241, 242f Angiofollicular hyperplasia. See Castleman
Adrenoleukodystrophy, vs. demyelinating Amplification methods, 25-31 disease.
diseases, 1046 ligase chain reaction, 30 Angiokeratoma, 105-106, 106f
Adrenomyeloneuropathy, vs. demyelinating nucleic acid, 25-30, 26f-27f, 28t-29t Angioleiomyoma, 109-110, 110f, 922
diseases, 1046 nucleic acid sequencebased, 30 Angiolipoma, 912-913, 912f
Adult granulosa cell tumor PCR, 25 Angiomatoid fibrous histiocytoma, 938, 938f
ovarian, 667-668, 667f signal, 30-31 Angiomatosis, bacillary
vs. malignant serous tumor, 657 strand displacement, 30 vs. pyogenic granuloma, 107
vs. hypercalcemic small cell carcinoma, 686 transcription-mediated, 30 vs. splenic angiosarcoma, 821
vs. juvenile granulosa cell tumor, 669 Amplification refractory mutation system vs. splenic inflammatory pseudotumor, 825
Adult (autosomal dominant) polycystic kidney (ARMS), 27 Angiomyofibroblastoma
disease, 514-515, 514f Amyloid, electron microscopy of, 10 of vulva, 608, 608f
vs. acquired cystic kidney disease, 516 Amyloid angiopathy, 1037f vs. aggressive angiomyxoma, 609
Adult rhabdomyoma, 918-919 Amyloid goiter, vs. multinodular goiter, 127 Angiomyolipoma
differential diagnosis of, 919 Amyloidosis, 762-763, 762f renal, 517-518, 517f
vs. granular cell tumor, 924 cardiac, 956-957, 957f vs. renal cell carcinoma, clear cell type,
Agarose gel electrophoresis, 32 differential diagnosis of, 957 522
Alcian blue stain, 4f, 6 laryngeal, 210-211, 210f vs. liposarcoma/lipomatous tumor, 915
Alcoholic hepatitis, vs. viral hepatitis, 413 pulmonary, vs. inflammatory Angiomyxoma, aggressive
Alcoholic liver disease, 415-416 myofibroblastic tumor, 273 of vulva, 608-609, 608f
Alcoholic steatohepatitis, 415-416, 416f splenic, 834, 834f vs. angiomyofibroblastoma, 608
vs. fatty liver of pregnancy, 418 vs. vasculitis, 828 vs. leiomyosarcoma, 609
Alcohols, used in fixation, 2 Anal canal, 401-404 vs. myxoma, 937
Aldehydes, used in fixation, 2 adenocarcinoma of, 404 Angiosarcoma
Allergic bronchopulmonary aspergillosis, vs. carcinoma of, 402-403, 402f breast, 738-740, 739f-740f
aspergillosis, 250 condyloma acuminatum of, 401, 401f, 403 postmastectomy (Stewart-Treves
Allergic contact dermatitis, 50 intraepithelial squamous neoplasia of, 402- syndrome), 740-741
Allergic (eosinophilic) esophagitis, 316f 403, 402f vs. hemangioma, 738
Allergic fungal sinusitis, 175, 175f neoplasia of, 403f vs. pseudoangiomatous stromal
Allergy, cows milk, vs. eosinophilic Paget disease of, 404 hyperplasia, 714
gastroenteritis, 364 Anaplastic astrocytoma, 988-991, 989f cardiac, 968
Allograft rejection, in liver transplantation, 425 Anaplastic ependymoma, 999-1000 cutaneous, 108-109, 109f
Index 1073

Angiosarcoma (Continued) Arthritis Autoimmune lymphoproliferative syndrome,


epithelioid osteo-. See Osteoarthritis. 754-755, 754f, 795-796, 796f
vs. epithelioid sarcoma, 941 rheumatoid. See Rheumatoid arthritis. vs. follicular lymphoid hyperplasia, 747
vs. hemangioendothelioma, 934 Asbestosis, 239-240, 239f vs. HIV-associated lymphadenopathy, 748
vs. primary malignant pericardial tumor, Ascariasis, 413-414 vs. infectious mononucleosis, 749
971 Aspergillosis, 249-250, 250f Autoimmune pancreatitis, 445-446, 446f
hepatobiliary, 442, 442f in immunocompromised patients, 352-353 Autosomal dominant polycystic kidney disease,
vs. epithelioid hemangioendothelioma, Aspergillus 514-515, 514f
441 diagnostic features of, 250t vs. acquired cystic kidney disease, 516
vs. hepatic hemangioma, 440 Grocott methenamine silver stain of, 6f Autosomal recessive polycystic kidney disease,
vs. infantile hemangioendothelioma, 441 Aspergillus esophagitis, 313 512, 512f
osseous, 862, 862f Asthma, 222, 222f vs. medullary cystic kidney disease, 514
vs. epithelioid hemangioendothelioma, vs. chronic bronchitis, 222 vs. medullary sponge kidney, 513
861 Astroblastoma, 1002-1003 vs. renal dysplasia, 511
vs. hemangioma, 860 vs. angiocentric glioma, 1004 Avascular necrosis, osteoarthritis secondary to,
pericardial, 971 vs. ependymoma, 1000 883
postirradiation, vs. postmastectomy vs. papillary glioneuronal tumor, 1009
angiosarcoma, 741 Astrocytic tumors, 988-991. See also specific B
soft tissue, 934-935, 935f tumor. Bacillary angiomatosis
splenic, 820-821, 820f Astrocytoma. See also specific variant for details. vs. pyogenic granuloma, 107
vs. hemangioma, 930 anaplastic, 988-991, 989f vs. splenic angiosarcoma, 821
vs. Kaposi sarcoma, 108 diffuse, 988-991 vs. splenic inflammatory pseudotumor, 825
vs. littoral cell angioma, 819 oligodendroglioma and, 998 Bacille Calmette-Gurin cystitis, 492-493
vs. nasopharyngeal angiofibroma, 178 pilocytic, 992-993, 992f Bacteria, histologic staining of, 6, 7f
vs. salivary hemangioma, 157 pilomyxoid, 993 Bacterial abscess, hepatic, 413, 414f
vs. splenic hemangioma, 818 pure, vs. mixed gliomas, 998 Bacterial cellulitis, vs. pyoderma gangrenosum,
Ankylostoma duodenale infestation (hookworm), subependymal giant cell, 995-996, 995f 60
379 vs. angiocentric glioma, 1004 Bacterial cystitis, 490
Antiglomerular basement membrane disease, vs. cerebral infarct/hematoma, 1038 vs. interstitial (Hunner) cystitis, 494
237-238 vs. demyelinating diseases, 1046 vs. treatment-related cystitis, 493
immunofluorescence patterns in, 7t vs. pineocytoma, 1016 Bacterial esophagitis, 313
1-Antitrypsin deficiency, 420-421, 420f vs. progressive multifocal Bacterial infections. See also specific infection.
Aonchotheca (Capillaria) philippinensis leukoencephalopathy, 1045 in immunocompromised patients, 351f-
infestation, 378-379, 378f Atheroembolism, cholesterol, vs. medium-vessel 352f, 352-353
Aortic dissection, 984-985, 984f vasculitis, 976 pulmonary, 246-249
Aortic valve, 959f Atherosclerosis, vs. fibromuscular dysplasia, pyogenic. See also Abscess.
calcific disease of, 960-961 983 of spleen, 831-832
regurgitation of, 959-960 Atopic dermatitis, 51 Bacterial lymphadenitis
pure, 960-961 Atresia vs. CMV/herpes lymphadenitis, 756
stenosis of, 959-960 esophageal, 310-311 vs. histiocytic necrotizing lymphadenitis,
Aortitis intestinal, 346-347 757
giant cell, 973f Atrophic vulvitis, chronic, 599, 599f Bacterial orchitis, 559-560
isolated, 975 Atrophic-type adenocarcinoma, of prostate Bacterial prostatitis, chronic, 540-541
Apocrine adenoma, tubular, vs. gland, 550 Balanitis xerotica obliterans, 587, 587f
syringocystadenoma papilliferum, 97 Atrophy Bal concentric sclerosis, 1045-1046
Apocrine carcinoma, of breast, 733-734, 734f cervical, vs. cervical intraepithelial Barrett esophagus, 318f
vs. granular cell tumor, 706 neoplasia, 619-620 adenocarcinoma associated with, 321,
Apocrine neoplasms, of skin, 91 cystic, vs. endometrial hyperplasia, 631 321f
Aponeurotic fibroma, calcifying, 896-897, 896f vaginal, vs. vaginal intraepithelial neoplasia, dysplastic lesions of, 319-320, 319f
vs. calcifying fibrous pseudotumor, 900 612 vs. squamous papilloma/carcinoma, 326
vs. superficial fibromatosis, 894 Atypical teratoid/rhabdoid tumor, 1013 Bartholin duct cyst, vs. vulvar cyst, 600
Appendiceal adenocarcinoma, 406-407, 406f vs. choroid plexus carcinoma/papilloma, Bartholin gland carcinoma, 597, 605-606
Appendicitis, 405 1014 Basal cell adenoma
Appendix, 404-405, 404f Autoeczematization reaction, 51 of salivary glands, 158-159, 158f
carcinoids of, 407, 407f-408f Autoimmune encephalitis, nonspecific, vs. subtypes of, 158
metastatic disease to, 409 encephalitis/meningoencephalitis, 1044 Basal cell carcinoma, 90-91, 91f
neoplasms of, 405f-406f Autoimmune gastritis, vs. Helicobacter pylori of prostate gland, 552-553
ruptured, 407 gastritis, 333 sclerosing, vs. microcystic adnexal
Arachnoid cyst, vs. neuraxial cyst, 1027 Autoimmune hemolytic anemia, 810-811, carcinoma, 98
Arrhythmogenic right ventricular dysplasia, 810f vs. ameloblastoma, 201
952 vs. hereditary spherocytosis, 808 vs. basal cell adenoma, 159
Arteriovenous malformation, 1035-1036, 1035f Autoimmune hepatitis, 421-422, 421f vs. dermatofibroma, 113
Arteritis vs. drug-induced liver disease, 415 vs. sebaceous gland carcinoma, 1055
giant cell, 973-974, 974f vs. viral hepatitis, 413 vs. syringoma, 92
healed, vs. fibromuscular dysplasia, 983 Autoimmune hepatitisPBC syndrome, vs. vs. trichoepithelioma, 88
necrotizing, 977f biliary cirrhosis, 422 vs. vulvar squamous cell carcinoma, 604
vs. thromboangiitis obliterans, 982 Autoimmune inflammation, Addison disease Basal cell hyperplasia, prostatic, 543-544,
Takayasu, 973-975 due to, 462f 543f
1074 Index

Basaloid carcinoma Bone Breast (Continued)


of anal canal, 402f, 403 Paget disease of, 880-881, 880f juvenile or virginal hypertrophy of, 705-
vs. vulvar squamous cell carcinoma, 604 vs. metastatic bone tumors, 882 706, 705f
Basement membrane, electron microscopy of, tumors of. See specific tumor. lesions of, myoepithelial and basal cells in,
8 Bone cyst antibody panel demonstrating, 15t
B-cell(s), 11 aneurysmal. See Aneurysmal bone cyst. lobular carcinoma in situ of, 722-723, 722f
B-cell lymphoma unicameral, 879 male, carcinoma of, 742-743, 742f
diffuse large. See Diffuse large B-cell vs. aneurysmal bone cyst, 879 medullary carcinoma of, 727-728, 728f
lymphoma. Borderline leprosy, 68 metaplastic carcinoma of, 732, 732f
extranodal, of small intestine, 400 Borderline mucinous tumor, ovarian, 658f- metastatic tumors of, 743-744, 743f
vs. Castleman disease, 760 659f, 659-660 mucinous (colloid) carcinoma of, 728-729,
Beckwith-Wiedemann syndrome, 533 Borderline serous tumor, ovarian, 654f-655f, 728f
Benign epithelial tumor, diagnostic features of, 655-656 nipple of. See Nipple.
259t Botryoid rhabdomyosarcoma, vs. fetal/genital papillary carcinoma of, 730-731, 731f
Benign familial pemphigus, vs. pemphigus, rhabdomyoma, 919 phyllodes tumor of, 717-719, 718f
75 Bouin solution, used in fixation, 2 plasma cell mastitis of, 702-703, 702f
Benign fibrous histiocytoma, vs. nonossifying Bowen disease, 402f, 403, 588f, 589 pseudoangiomatous stromal hyperplasia of,
fibroma, 865 vs. Bowenoid papulosis, 590 714-715, 714f
Benign lymphoepithelial lesions (Mikulicz vs. erythroplasia of Queyrat, 589 radial sclerosing lesion of, 710-711
disease), 148-149, 148f vs. Paget disease of nipple, 737 secretory carcinoma of, 733, 733f
vs. lymphoepithelial carcinoma, 171 vs. squamous cell carcinoma, 86, 87f subareolar abscess of, 701-702, 702f
vs. sialadenitis, 148 Bowenoid papulosis, 402-403, 590 triple negative carcinomas of, 726-727,
Benign mucinous tumor, ovarian, 657-659, vs. Bowen disease, 589 727f
658f-659f vs. erythroplasia of Queyrat, 589 tubular carcinoma of, 729-730, 729f
Benign prostatic hyperplasia, 543, 543f Brain abscess, 1040-1041, 1040f Brenner tumor, 664-665, 664f
Benign serous tumor, ovarian, 653-655, Branch DNA, 31 Bronchial (bronchogenic) cyst, 220-221, 221f,
654f-655f Branchial cleft cyst, 129-130, 129f 283
Benign vascular tumors, vs. spiradenoma, vs. lymphoepithelial cyst, 150 vs. pericardial cyst, 970
94 vs. parathyroid cyst, 143 vs. teratoma, 301
Berger disease (IgA nephropathy) vs. thyroglossal duct cyst, 129 vs. thymic cyst, 282
immunofluorescence patterns in, 7t Breast Bronchiectasis, 223-224
vs. immune complex small-vessel vasculitis, adenocarcinoma of Bronchiolar metaplasia, vs. pulmonary
981 HER-2-neu in, immunohistochemistry for, adenocarcinoma, 263
Bielschowsky stain, 6 11f Bronchiolitis, 225t
Bile duct adenoma, vs. mesenchymal immunohistochemistry panel for, 14t vs. mucosa-associated lymphoid tissue
hamartoma, 443 villi in, electron microscopy of, 9, 10f (MALT) lymphoma, 276
Bile duct hamartoma, 432, 432f adenoid cystic carcinoma of, 735, 735f vs. pulmonary Langerhans cell histiocytosis,
vs. mesenchymal hamartoma, 443 adenoma of, 715-716, 715f 277
vs. peribiliary duct hamartoma, 433 adenosis of, 709-710, 709f Bronchioloalveolar carcinoma, 263-265, 264f
Biliary cirrhosis, 422-423, 422f angiosarcoma of, 738-740, 739f-740f nonmucinous, vs. atypical adenomatous
vs. sclerosing cirrhosis, 423 postmastectomy (Stewart-Treves hyperplasia, 261
vs. viral hepatitis, 413 syndrome), 740-741 Bronchitis
Biliary cystadenocarcinoma, 433-434, 434f apocrine carcinoma of, 733-734, 734f chronic, 222
Biliary cystadenoma, 433-434, 434f atypical ductal hyperplasia of, 719-721, vs. asthma, 223
Biliary duct adenoma, 432-433, 433f 719f-720f follicular, vs. mucosa-associated lymphoid
Biliary obstruction atypical lobular hyperplasia of, 722-723, tissue (MALT) lymphoma, 276
extrahepatic or intrahepatic, vs. sclerosing 722f Bronchocentric granulomatosis, vs.
cirrhosis, 423-424 carcinoma of, vs. metastatic thyroid tumors, aspergillosis, 250
vs. nonalcoholic fatty liver/nonalcoholic 142 Bronchogenic cyst. See Bronchial
steatohepatitis, 417 diabetic mastopathy of, 704-705, 705f (bronchogenic) cyst.
Biliary papillomatosis, 434-435, 435f ductal carcinoma in situ of, 719-721, 719f- Bronchopulmonary sequestration, 219-220,
Bioprosthetic heart valves, 963 720f, 721t 220f
Biopsy, of ileum, 369 fat necrosis of, 704, 704f extralobular, 220
Birbeck granules, in Langerhans cell fibroadenoma of, 716-717, 716f intralobular, 220
histiocytosis, 9f fibrocystic changes of, 707-708, 707f-708f vs. congenital pulmonary airway
Bladder. See Urinary bladder. fibromatosis of, spindle cell areas in, malformation, 219
Blastoma, pleuropulmonary, 274-275, 274f immunohistochemistry comparison of, Brown and Brenn Gram stain, 6
vs. congenital pulmonary airway 14t Brown bowel syndrome (ceroidosis), vs.
malformation, 219 granular cell tumor of, 706, 706f melanosis coli, 382
Blastomyces dermatitidis, diagnostic features of, granulomatous lobar mastitis of, 703, Brown tumor, vs. giant cell reparative
252t 703f granuloma, 871
Blastomycosis, 69f, 70, 254-255, 254f hemangioma of, 738, 738f Brunner gland nodules, vs. small intestinal
differential diagnosis of, 252t infiltrating ductal carcinoma of, 723-725, adenoma/adenocarcinoma, 360
Bleomycin toxicity, 241-242, 241f 724f, 724t Buerger disease (thromboangiitis obliterans),
Blood vessels infiltrating lobular carcinoma of, 725-726, 982
heritable disorders of, 983-985, 984f 725f Buffering, affecting fixation, 3
inflammation of. See Vasculitis. inflammatory carcinoma of, 736, 736f Bullous impetigo, vs. subcorneal pustular
Blue nevus, 102f, 103 intraductal papilloma of, 711-713, 711f dermatosis, 74
Index 1075

Bullous pemphigoid, 75-76, 75f Carcinoma in situ Cavernous hemangioma, 105-106, 106f
immunofluorescence patterns in, 7t ductal. See Ductal carcinoma in situ. central nervous system, 1035-1036
in inflammatory esophagitis, 315 lobular, 722-723, 722f soft tissue, 929-930
Burkitt lymphoma, 783-784, 783f penile vs. glomus tumor, 931
vs. infectious mononucleosis, 749 Bowen disease, 588f, 589 vs. intraocular malignant melanoma,
vs. precursor B-cell lymphoblastic erythroplasia of Queyrat, 588-589, 588f 1057-1058
lymphoma, 781 pulmonary, 258-260 vs. pyogenic granuloma, 107
vs. thymoma, 289 urothelial, 497-498, 498f C-cell hyperplasia, vs. medullary thyroid
vs. interstitial (Hunner) cystitis, 494 carcinoma, 138
C vs. treatment-related cystitis, 497-498, Celiac sprue, 356f-357f
Calcifying aponeurotic fibroma, 896-897, 896f 498f Cell(s). See also specific cell.
vs. calcifying fibrous pseudotumor, 900 vs. urothelial dysplasia, 497 surface of, electron microscopy of, 9-10
vs. superficial fibromatosis, 894 vs. urothelial hyperplasia, 497 ultrastructure of, electron microscopy of,
Calcifying epithelial odontogenic tumor Carcinoma showing thymus-like differentiation 8-10
(Pindborg tumor), 201-202, 201f (CASTLE), vs. poorly differentiated thyroid Cellular ependymoma, 999
Calcifying epithelioma of Malherbe, 89, 89f carcinoma, 139 Cellulitis
Calcifying fibrous pseudotumor, 900, 900f Carcinosarcoma. See also Sarcomatoid bacterial, vs. pyoderma gangrenosum, 60
Calcinosis carcinoma. eosinophilic, 60
scrotal, 594, 594f of endometrium, 638-639 orbital. See Orbital cellulitis.
tumoral, vs. pseudogout, 885 of fallopian tube, 693 Cementoblastoma, of oral cavity, 203, 204f
Campylobacteriosis, in immunocompetent of prostate gland, 548, 550 Central nervous system
hosts, 349-350 of salivary gland, 168-169, 169f astrocytic tumors of, 988-991
Canalicular adenoma, vs. basal cell adenoma, of urinary bladder, 509-510 choroid plexus tumors of, 1014-1015
158-159 vs. atypical polypoid adenomyoma, 637 embryonal tumors of, 1010-1012
Candida, diagnostic features of, 252t vs. carcinoma ex mixed tumor, 168 ependymal tumors of, 999-1000
Candida esophagitis, 313, 313f vs. endometrial adenosarcoma, 638 mixed gliomas of, 998
Candidiasis vs. inflammatory myofibroblastic tumor, neoplasms of. See also specific neoplasm.
disseminated, 42 508 and related entities, 1017-1020
in immunocompromised patients, 352-353 vs. phyllodes tumor, 718 cytogenetic abnormalities of, 23t-24t
vs. inflammatory esophagitis, 315 Cardiac amyloidosis, 956-957, 957f neuroepithelial tumors of, 1002-1003
Capillary gel electrophoresis, 32 Cardiac angiosarcoma, 968 neuronal and gliomal tumors of,
Capillary hemangioma, 105-106, 106f Cardiac fibroma, 966 1004-1006
lobular. See Pyogenic granuloma. Cardiac myxoma, 964-965, 964f non-neoplastic conditions of, 1035-1036.
orbital, 1066-1067, 1067f Cardiac rhabdomyoma, 965-966 See also specific condition.
vs. rhabdomyosarcoma, 1070 Cardiac rhabdomyosarcoma, 968 oligodendroglial tumors of, 996-998
soft tissue, 929-930 Cardiac sarcoidosis, 958, 958f pineal parenchymal tumors of, 1015-1016
vs. infantile hemangioendothelioma, 441 Cardiac sarcoma, 968-969 secondary tumors of, 1033-1034, 1033f
Capillary telangiectasia, 1035-1036 Cardiac valve disease, 959-961, 959f Cephalocele
Capsular fibrosis, inguinal lymph node, vs. regurgitant, 959 vs. microphthalmos with cyst, 1069
syphilis, 750 stenotic, 959 vs. orbital lymphangioma, 1068
Carbohydrates, histologic staining of, 4-6, 5f Cardiomyopathy, 949-954 Cerebellum, dysplastic ganglioglioma of
Carcinoid heart disease, 960-961 arrhythmogenic right ventricular dysplasia (Lhermitte-Duclos), 1005
Carcinoid tumor and, 952 Cerebral infarction, 1036-1038, 1037f
atypical, vs. small cell lung carcinoma, 266 differential diagnosis of, 953 vs. demyelinating diseases, 1046
of appendix, 407, 407f-408f dilated, 949-952 Ceroidosis (brown bowel syndrome), vs.
of larynx, 213f, 214 hypertrophic, 949-952, 950f melanosis coli, 382
of lungs, 269-270, 269f metabolic, 950, 953 Cervical atrophy, vs. cervical intraepithelial
of ovary, 683-684 mitochondrial, 950 neoplasia, 619-620
of small and large intestine, 360-362, restrictive, 950-952 Cervical intraepithelial neoplasia, 618-620,
360f-361f toxic, 953 619f
of stomach, 343f Carney complex, gene mutations in, 464 vs. condyloma acuminatum, 618
of thymus, 292 Carney triad, vs. pulmonary hamartoma, 271 Cervix, uterine. See Uterine cervix.
vs. granulosa cell tumor, 574 Caruncle, urethral, 584, 584f Chalazion (stye), vs. sebaceous gland
adult, 668 Castleman disease carcinoma, 1055
vs. metastatic thyroid tumors, 142 nodal, 759-761, 760f Cheilitis, actinic, vs. leukoplakia, 193
vs. ovarian mucinous tumor, 658 vs. syphilis, 750 Chemical esophagitis, 314
vs. paraganglioma, 927 splenic, 794-795, 794f Cholangiocarcinoma (Klatskin tumor), 435-
vs. Sertoli cell tumor, 671 vs. amyloidosis, 834 436, 435f
Carcinoid-adenocarcinoma, mixed, vs. vs. follicular lymphoma, 802 vs. angiosarcoma, 442
intestinal carcinoid, 361 vs. inflammatory pseudotumor, 825 vs. epithelioid hemangioendothelioma, 441
Carcinoma. See specific type and at anatomic site. thymic, 298-299, 298f vs. gallbladder carcinoma, 437
Carcinoma ex mixed tumor vs. thymoma, 289 vs. hepatocellular carcinoma, 430
of salivary glands, 151-152, 152f, 168, 168f Cat-scratch disease, 755-756, 755f Cholangitis, sclerosing, 423-424, 423f
vs. basal cell adenoma, 158 vs. CMV/herpes lymphadenitis, 756 vs. biliary cirrhosis, 422
vs. epithelial-myoepithelial carcinoma, 166 vs. granulomatous lobar mastitis, 703 Cholera, in immunocompetent hosts,
vs. pleomorphic salivary adenoma, 152 vs. histiocytic necrotizing lymphadenitis, 758 349-350
Carcinoma ex pleomorphic adenoma. See vs. infectious mononucleosis, 749 Cholesterol atheroembolism, vs. medium-vessel
Carcinoma ex mixed tumor. vs. sarcoidosis, 768 vasculitis, 976
1076 Index

Chondroblastic osteosarcoma Choroid meningioma Clear cell carcinoma


vs. chondroblastoma, 853 vs. chordoma, 1033 of ovary, 663-664, 663f
vs. chondrosarcoma, 205 vs. choroid glioma, 1003 of periurethral glands, 585-586, 585f
vs. intramedullary chondrosarcoma, 855 Choroid plexus, normal, vs. choroid plexus of thymus, 291
Chondroblastoma, 852-853, 852f carcinoma/papilloma, 1014 of vagina, 614, 614f
vs. chondromyxoid fibroma, 854 Choroid plexus carcinoma, 1014-1015 vs. cervical microglandular hyperplasia, 617
vs. clear cell chondrosarcoma, 859 vs. secondary CNS tumor, 1034 vs. dysgerminoma, 677
Chondrocalcinosis, osteoarthritis secondary to, vs. teratoid/rhabdoid tumor, 1013 vs. nephrogenic adenoma, 496
883 Choroid plexus papilloma, 1014-1015 vs. oncocytoma, 156
Chondrocalcinosiscalcium pyrophosphate vs. ependymoma, 1000 vs. ovarian malignant serous tumor, 657
deposition disease (pseudogout), 885 vs. papillary glioneuronal tumor, 1009 vs. perivascular epithelioid cell tumor, 947
vs. gout, 884 vs. papillary tumor of pineal region, 1017 vs. yolk sac tumor, 678
Chondroid syringoma, 92 Choroid plexus tumors, 1014-1015. See also Clear cell chondrosarcoma, 858-859, 858f
Chondroid tumors, 848-849. See also specific specific tumor. vs. chondroblastoma, 853
tumor. Choroidal melanocytoma, vs. intraocular Clear cell cribriform hyperplasia
Chondroma malignant melanoma, 1058 prostatic, 543-544
periosteal, 851-852, 851f Choroidal nevus, vs. intraocular malignant vs. cribriform adenocarcinoma, 544
vs. periosteal osteosarcoma, 846 melanoma, 1057-1058 Clear cell ependymoma, 999
vs. calcifying aponeurotic fibroma, 897 Choroidal osteoma, vs. intraocular malignant vs. oligodendroglioma, 997
vs. chondrosarcoma, 205 melanoma, 1058 Clear cell (nodular) hidradenoma, 95, 95f
Chondromatosis, synovial, 885-886, 885f Chromatin, electron microscopy of, 8 Clear cell sarcoma, 945-946, 946f
Chondromyxoid fibroma, 853-854, 853f Chromoblastomycosis, 70 of kidney, 537, 537f
vs. chondroblastoma, 853 Chromogenic in situ hybridization (CISH), 34, of small intestine, 396f
Chondrosarcoma 35f vs. diffuse large B-cell lymphoma, 779
clear cell, 858-859, 858f Chronic bronchitis, 222 vs. malignant peripheral nerve sheath
vs. chondroblastoma, 853 vs. asthma, 223 tumor, 929
dedifferentiated, 856-857, 856f Chronic eosinophilic pneumonia, vs. vs. mesoblastic nephroma, 536
vs. fibrosarcoma, 867 pulmonary Langerhans cell histiocytosis, vs. perivascular epithelioid cell tumor, 947
vs. malignant fibrous histiocytoma, 868 277 Clear cell syringoma, 92
vs. mesenchymal chondrosarcoma, 858 Chronic fibrosis pleuritis, vs. mesothelioma, Clearing, in tissue processing, 2
intramedullary, 854-856, 855f 280 Clostridium difficileassociated colitis, 372, 372f-
vs. chondromyxoid fibroma, 854 Chronic hypersensitivity pneumonia, vs. 373f, 375
vs. clear cell chondrosarcoma, 859 unusual interstitial pneumonia, 229-230 Clot, postmortem, vs. splenic vasculitis, 828
vs. dedifferentiated chondrosarcoma, Chronic lymphocytic leukemia/small Cocaine abuse, vs. extranodal NK/T-cell
856 lymphocytic lymphoma lymphoma, 192
juxtacortical, vs. periosteal chondroma, morphologic and immunophenotypic Coccidioides immitis, diagnostic features of,
851 features of, 797t 252t
low-grade, vs. enchondroma, 850 splenic, 798-799, 798f Coccidioidomycosis, 253-254, 253f
mesenchymal, 857-858, 857f vs. mantle cell lymphoma, 801 differential diagnosis of, 252t
vs. dedifferentiated chondrosarcoma, 856 vs. prolymphocytic leukemia, 800 splenic, 833
vs. lymphoma, 875 vs. hairy cell leukemia, 812 Coccidiosis, in immunocompromised patients,
myxoid, vs. ossifying fibromyxoid tumor, vs. hepatosplenic T-cell lymphoma, 813 352-353
937 Chronic lymphocytic lymphoma, vs. mucosa- Colitis
of oral cavity, 203-205, 205f associated lymphoid tissue (MALT) Clostridium difficileassociated, 372, 372f-
periosteal, vs. periosteal osteosarcoma, 846 lymphoma, 276 373f, 375
secondary joint involved, vs. synovial Chronic lymphocytic thyroiditis, 123-124, 123f collagenous, 373-375, 374f
chondromatosis, 886 Chronic myelogenous leukemia, 815-816, 815f vs. inflammatory bowel disease, 368
synovial, vs. synovial chondromatosis, 886 Churg-Strauss syndrome, 977-978 cytomegalovirus-associated, 348f, 351f
vs. chordoma, 877, 1033 clinical and pathologic features of, 243t diversion, vs. inflammatory bowel disease,
vs. osteochondroma, 849 splenic involvement in, 827-828 368
vs. osteosarcoma, 843 Ciliary body adenoma, 1058-1059, 1058f infectious (acute self-limited), 372, 375
Chordoma, 877-878, 877f, 1032-1033, 1032f Ciliated cyst, vs. vulvar cyst, 601 vs. inflammatory bowel disease, 368
vs. chondrosarcoma, 205 Cirrhosis, 425-426, 425f ischemic, 373, 373f, 375
vs. choroid glioma, 1003 biliary, 422-423, 422f. See also Biliary vs. enteric infections, 350
vs. myxopapillary ependymoma, 1001 cirrhosis. lymphocytic, 373-375, 374f
Choriocarcinoma dysplasia in, vs. hepatocellular carcinoma, vs. inflammatory bowel disease, 368
gestational, 697-699, 698f 430 pseudomembranous, vs. enteric infections,
vs. exaggerated placental site, 694 Indian childhood, vs. nonalcoholic fatty 351
vs. hydatidiform mole, 696-697 liver/nonalcoholic steatohepatitis, 417 radiation, 372-373, 373f, 375
vs. placental site trophoblastic tumor, macroregenerative nodule in, vs. ulcerative, 366f-367f, 367-368
699 hepatocellular carcinoma, 430 glandular dysplasia in, 310, 371
mediastinal, 304 sclerosing, vs. viral hepatitis, 413 vs. inflammatory bowel disease, 368
ovarian, 680-681, 680f vs. focal nodular hyperplasia, 427 Collagen
testicular, 570-571, 570f Clark dysplastic nevus, 101-103, 102f electron microscopy of, 10
vs. embryonal carcinoma, 566 Clear cell acanthoma, 84, 84f hyalinized, vs. cardiac amyloidosis, 957
vs. seminoma, 564 vs. poroma, 93 Collagenous colitis, 373-375, 374f
Choroid glioma, 1003 Clear cell acinic cell carcinoma, vs. vs. inflammatory bowel disease, 368
vs. chordoma, 1033 oncocytoma, 156 Collagenous gastritis, 334
Index 1077

Collecting ducts of Bellini, carcinoma of, 525- Connective tissue diseaseassociated vasculitis, Cyst(s) (Continued)
526, 525f vs. immune complex small-vessel bronchial (bronchogenic), 220-221, 221f,
vs. mucinous tubular and spindle cell vasculitis, 981 283
carcinoma, 527 Consensus PCR method, 26 cutaneous, 81
vs. renal cell carcinoma, papillary type, 523 Constrictive bronchiolitis, 225t dermoid. See Dermoid cyst.
vs. renal medullary carcinoma, 526 Contact dermatitis, allergic, 50 echinococcal (hydatid), 413-414
Colloid (mucinous) adenocarcinoma Contact ulcer, vs. vocal cord nodule or polyp, endothelial, 483
of pancreas, 453-454 209 enteric duplication, 283
of prostate gland, 548-549 Conventional intramedullary osteosarcoma, epidermal inclusion, 81-83, 82f
vs. epithelial metaplasia, 545 841-843, 841f epidermoid. See Epidermoid cyst.
vs. colitis, 376 vs. low-grade surface osteosarcoma, 847 esophageal, 283
Colloid cyst, 1026, 1027f vs. osteofibrous dysplasia, 865 foregut, 283-284, 283f
Colonic adenoma, 383f vs. periosteal osteosarcoma, 846 lymphoepithelial. See Lymphoepithelial cyst.
Colonic mucosal ganglioneuroma, 391f, 394 vs. telangiectatic osteosarcoma, 844 mesothelial, 284
Colorectal adenocarcinoma Cornea, squamous cell carcinoma of, 1054 multilocular (cystic nephroma), 530-531,
metastatic, immunophenotype of, 16t Corpus luteum, vs. corpus luteum cyst, 648 530f
vs. villous adenoma, 505 Corpus luteum cyst, 647-648, 648f neuraxial, 1026-1028, 1027f
Colorectal carcinoma hemorrhagic, vs. endometriosis, 653 oral cavity
classification of, 386-388 Corrosive esophagitis, vs. infectious esophagitis, dentigerous, 198, 198f
clinical features of, 388 313 radicular, 196-197, 197f
diagnosis of, 388-389 Costochondral cartilage, prominent, vs. parathyroid, 143
differential diagnosis of, 389 enchondroma, 850 pericardial, 970
histopathology of, 388 Cover-slipping, in tissue processing, 2 salivary duct, 150, 150f
pathology of, 388 Cowden disease, 391, 393 splenic, 821-823, 821f
Colorectal perineuroma, 391f, 394 Cows milk allergy, vs. eosinophilic thymic, 281-282, 282f
Common variable immunodeficiency, 795 gastroenteritis, 364 thyroglossal duct, 128-129, 128f
Concentration, affecting fixation, 3 Craniopharyngioma, 1031-1032, 1031f Cystadenocarcinoma
Condyloma acuminatum. See also Verruca vs. pituitary adenoma, 1029 biliary, 433-434, 434f
entries. vs. Rathke cyst, 1027-1028 papillary
anal, 401, 401f, 403 Creutzfeldt cells, 1046 vs. acinic cell carcinoma, 162
cervical, 617-618, 618f Creutzfeldt-Jakob disease, 1047-1049 vs. cystadenoma, 157
penile, 588, 588f Cribriform basal cell tumors, of prostate gland, serous pancreatic, 448-449, 448f
vs. benign esophageal lesions, 323 552 vs. mucoepidermoid carcinoma, 165
vs. oral squamous papilloma, 194 Crohn disease, 366-368, 366f Cystadenoma
vs. penile verrucous carcinoma, 592 vs. amebiasis, 377 biliary, 433-434, 434f
vs. urothelial squamous cell carcinoma, 507 vs. diverticular disease, 363 endometroid, vs. ovarian endometriosis, 653
vs. vaginal squamous papilloma, 611 Cronkhite-Canada syndrome, 390f, 392-393 mucinous. See Mucinous cystadenoma.
vulvar, 601-602, 602f Cryoglobulinemic vasculitis, 980 papillary. See Papillary cystadenoma.
Congenital adrenal hyperplasia (adrenogenital Cryptococcosis, 70, 255, 255f salivary gland, 156-157, 156f
syndrome), 463-464, 463f differential diagnosis of, 252t serous. See Serous cystadenoma.
classic form of, 463 Cryptococcus neoformans, diagnostic features of, Cystic atrophy, vs. endometrial hyperplasia,
lipoid, 463, 463f 252t 631
nonclassic form of, 463 Cryptogenic organizing pneumonia, 227-228, Cystic fibrosis, vs. bronchiectasis, 224, 224f
Congenital lobar emphysema, 221-222 228f Cystic hygroma. See Lymphangioma.
Congenital melanocytic nevus, 100-101, 100f vs. unusual interstitial pneumonia, 230 Cystic medial degeneration, 984-985, 984f
Congenital polycystic disease, vs. cystadenoma, Cryptorchidism, 558-559, 558f Cystic nephroma, 530-531, 530f
157 Cushing syndrome, adrenal cortical carcinoma vs. mixed epithelial and stromal tumor, 532
Congenital pulmonary airway malformation, associated with, 466-467, 467f-469f vs. multilocular cystic renal cell carcinoma,
218-219, 218f Cutaneous cyst, 81 525
type 1, 219 Cutaneous leiomyoma, 921-922 Cystic pancreatic neoplasms, vs. pseudocyst,
type 2, 219 Cutaneous leiomyosarcoma, 110-111, 111f 447
type 3, 219 Cutaneous leukoclastic vasculitis, vs. immune Cystic partially differentiated nephroblastoma,
type 4, 219 complex small-vessel vasculitis, 981 535-536
vs. bronchopulmonary sequestration, 220 Cutaneous lupus erythematosus, 48, 49f vs. metanephric adenoma, 519
vs. pleuropulmonary blastoma, 275 Cutaneous small cell undifferentiated vs. renal cell carcinoma, papillary type, 523
Congestive splenomegaly, 826-827, 826f carcinoma, 115-116, 115f Cystic teratoma
vs. autoimmune hemolytic anemia, 811 Cutaneous T-cell lymphoma, 118-119, 119f mature (dermoid cyst), 674-675, 675f
vs. hereditary spherocytosis, 808 CD30-positive, 119-120, 120f vs. foregut cyst, 284
Congo red stain, 4, 5f vs. Langerhans cell histiocytosis, 118 vs. pancreatic lymphoepithelial cyst, 448
Conjunctiva Cutaneous tuberculosis, 69 vs. thymic cyst, 282
malignant melanoma of, 1052, 1052f Cylindrical cell papilloma, sinonasal, 179-180 Cystic thymoma, vs. thymic cyst, 282
primary acquired melanosis of, 1052-1053, Cylindroma, 94, 94f Cystic Warthin tumor. See also Warthin tumor.
1053f malignant, 94 vs. salivary duct cyst, 150
squamous cell carcinoma of, 1054, 1054f vs. spiradenoma, 94 Cysticercosis, vs. neuraxial cyst, 1028
Conn syndrome, adrenal cortical carcinoma Cyst(s). See also Pseudocyst(s); specific cyst for Cystitis, 490
associated with, 466-467, 467f-469f detail. bacterial, 490
Connective tissue, histologic staining of, 4, adrenal, 482-483 infectious, 490
4f-5f branchial cleft, 129-130, 129f interstitial (Hunner), 493-494
1078 Index

Cystitis (Continued) Dermatofibroma (Continued) Diffuse large B-cell lymphoma


noninfectious, 491-492, 492f vs. leiomyoma, 110 gastric, 344-345
treatment-related, 492-493, 493f vs. neurofibroma, 114 mediastinal, 296-297, 296f
Cystitis cystica, 494-495, 494f vs. soft tissue leiomyoma, 922 vs. germinoma, 302
vs. bladder adenocarcinoma, 506 Dermatofibrosarcoma, vs. vulvar nodal, 777-779, 778f
Cystitis glandularis, 494-495, 494f leiomyosarcoma, 609 vs. anaplastic large cell lymphoma, 782
vs. bladder adenocarcinoma, 506 Dermatofibrosarcoma protuberans, 113-114, vs. angioimmunoblastic T-cell lymphoma,
Cytogenetic analysis, 21-22 113f 787
technical overview of, 21f, 22t-24t vs. cutaneous leiomyosarcoma, 111 vs. Burkitt lymphoma, 783
Cytokeratins 7 and 20, immunophenotypic vs. dermatofibroma, 112 vs. histiocytic necrotizing lymphadenitis,
distribution of, 13t Dermatomyositis, 50f 758
Cytomegalovirus colitis, 348f, 351f Gottron papules in, 50 vs. mantle cell lymphoma, 776
Cytomegalovirus encephalitis, 1042 heliotrope rash in, 50 vs. marginal zone lymphoma, 777
Cytomegalovirus esophagitis, 313, 313f vs. cutaneous lupus erythematosus, 48 vs. myeloid sarcoma, 789
Cytomegalovirus infection Dermatopathic lymphadenopathy, 752, vs. peripheral T-cell lymphoma, 785
in immunocompromised patients, 351f, 752f vs. precursor B-cell lymphoblastic
352-353 Dermatophytosis lymphoma, 781
of spleen, 829-830 superficial (tinea), 41f splenic, 802-803, 802f
Cytomegalovirus lymphadenitis, 756-757 vs. subcorneal pustular dermatosis, 74 vs. Hodgkin lymphoma, 804
vs. histiocytic necrotizing lymphadenitis, Dermatosis vs. reactive lymphoid hyperplasia without
757-758 fibrosing, 78 germinal center formation, 794
Cytomegalovirus mononucleosis, vs. infectious vesiculobullous, 73 Diffuse toxic goiter (Graves disease), 125-126,
mononucleosis, 749 Dermoid cyst, 82 125f
Cytomegalovirus pneumonia, 245f, 246t, orbital, 1066, 1066f Dilated cardiomyopathy, 949-952
274-275 ovarian, 674-675, 675f Diphyllobothrium latum infestation (fish
Cytometry, flow, 20-21, 20f ruptured, vs. orbital pseudotumor, 1064 tapeworm), 378f, 379
Cytoplasm, electron microscopy of, 8-9, 9t vs. microphthalmos with cyst, 1069 Disseminated juvenile xanthogranuloma, vs.
Cytoplasmic granules, classification of, 9t vs. testicular teratoma, 569 Langerhans cell histiocytosis, 816
Desmoid tumor. See Fibromatosis. Diversion colitis, vs. inflammatory bowel
D Desmoplastic fibroma, 866, 866f disease, 368
Darier disease, vs. pemphigus, 75 vs. fibrosarcoma, 867 Diverticular disease, 363
De Quervain thyroiditis, 122-123, 123f vs. fibrous dysplasia, 864 Diverticulum
Decalcification, affecting fixation, 3 vs. low-grade surface osteosarcoma, 847 esophageal, 310-311
Degenerate PCR method, 26 vs. nonossifying fibroma, 865 Meckel, 346-347, 346f
Dehydration, in tissue processing, 2 Desmoplastic infantile ganglioglioma/ DNA
Dementia, 1047-1049, 1047f astrocytoma, 1005 branch, 31
Demyelinating diseases, 1045-1047, 1045f. See vs. supratentorial primitive neuroectodermal extraction of, 24
also specific disease. tumor, 1012-1013 quantification, purity, and integrity of,
vs. astrocytic tumors, 991 Desmoplastic small round cell tumor, 943-944, 24-25
vs. cerebral infarct/hematoma, 1038 943f storage of, 25
Dendritic cell sarcoma, vs. mast cell disease, vs. Ewing sarcoma/peripheral DNA methylation assays, 37-38
762 neuroectodermal tumor, 943 DNA microarray technology, 36
Dentigerous cyst Desmoplastic trichoepithelioma, vs. microcystic Dot blotting, 34
of oral cavity, 198, 198f adnexal carcinoma, 98 Drug eruption, fixed, 57f
vs. odontogenic keratocyst, 199 Desquamative interstitial pneumonia, 231-232, Drug esophagitis, 314
vs. radicular cyst, 197 231f Drug hepatitis, vs. viral hepatitis, 413
Denys-Drash syndrome, 533 vs. cryptogenic organizing pneumonia, Drug toxicity, vs. fatty liver of pregnancy, 418
Dermatitis 228 Drug-induced vasculitis, 979
interface, 44-45, 55 Detritic synovitis, vs. pigmented villonodular Ductal carcinoma in situ, 719-721, 719f-720f,
nodular and diffuse, 59 synovitis, 887 721t
eosinophils predominant in, 60 Devic disease, 1046 vs. fibrocystic changes, 708
histiocytes predominant in, 61-62 Diabetic mastopathy, 704-705, 705f vs. florid papillomatosis, 714
neutrophils predominant in, 59 Diaphragmatic hernia, 311-312 vs. intraductal papilloma, 712
perivascular Diffuse alveolar damage, 226-227 Ductal cells, in epithelial-myoepithelial
superficial, 41 vs. cryptogenic organizing pneumonia, carcinoma, 165
superficial and deep, 54 228 Ductal hyperplasia, atypical, 719-721,
eosinophils predominant in, 55 Diffuse astrocytoma, 988-991 719f-720f
lymphocytes predominant in, 54-55 vs. ependymoma, 1000 Ductal-type adenocarcinoma, of prostate gland,
psoriasiform, 52-53, 58-59 vs. gangliocytoma/ganglioglioma, 1005 547f-548f, 548-549
with minimal epidermal changes, 41-42, vs. oligodendroglioma, 997 Duodenum, follicular lymphoma of, 397f, 400
54-55 vs. pilocytic astrocytoma, 992-993 Duplication
eosinophils predominant in, 55 Diffuse bronchiolitis, 225t esophageal, 310-311
lymphocytes predominant in, 54-55 Diffuse dermatitis. See Nodular and diffuse gastric, 328-329
Dermatitis herpetiformis, 76-77, 76f dermatitis. Duplication cyst, enteric, 283
immunofluorescence patterns in, 7t Diffuse idiopathic pulmonary neuroendocrine Dysembryoplastic neuroepithelial tumor, 1006-
Dermatofibroma, 112-113, 112f cell hyperplasia, 261 1007, 1006f
vs. dermatofibrosarcoma protuberans, Diffuse interstitial lung disease, vs. atypical vs. gangliocytoma/ganglioglioma, 1005
113-114 adenomatous hyperplasia, 261 vs. oligodendroglioma, 997
Index 1079

Dysgerminoma, 676-677, 676f Emphysema, 224-226, 225f Endometrium (Continued)


vs. choriocarcinoma, 681 congenital lobar, 221-222 serous carcinoma of, immunohistochemistry
vs. clear cell carcinoma, 663 interstitial, 226 of, 16t
vs. diffuse large B-cell lymphoma, 779 Encephalitis, 1041-1044 stromal nodule of, 640-641, 640f
vs. embryonal carcinoma, 679 vs. cerebral infarct/hematoma, 1038 stromal sarcoma of
vs. gonadoblastoma, 685 vs. vasculitis, 1039 high-grade, 642
vs. yolk sac tumor, 678 Encephalomyelitis, acute demyelinating, 1046 low-grade, 641
Dyshidrotic dermatitis, 51 Enchondroma, 849-851, 850f Endometroid cystadenoma, vs. ovarian
Dyspepsia, nonulcer, 332 vs. intramedullary chondrosarcoma, 855 endometriosis, 653
Dysplastic ganglioglioma, cerebellar Endocarditis, infective, 962-963, 962f Endoplasmic reticulum, electron microscopy of,
(Lhermitte-Duclos), 1005 Endocervical carcinoma 9
Dysplastic nodules, vs. cirrhosis, 426 immunohistochemistry approach to, 16t Endothelial cyst, 483
with synchronous squamous cell carcinoma, Entamebiasis, 413-414
E vs. adenosquamous carcinoma, 626 Enteric duplication cyst, 283
Eccrine neoplasms, of skin, 91 Endocervical polyp, 616-617, 616f Enteric infections
Eccrine poroma, vs. clear cell acanthoma, Endodermal sinus tumor, mediastinal, 299, in immunocompetent hosts, 348f. See also
84 303f-304f Immunocompetent hosts.
Echinococcal cyst Endometrial adenocarcinoma, 633-636, in immunocompromised patients, 352f. See
hydatid, 413-414 633f-634f also Immunocompromised patients.
parasitic, 483, 822-823 direct extension of Enterobius vermicularis infestation (pinworm),
Ectopias, esophageal, 310-311 vs. cervical adenosquamous carcinoma, 378-379, 379f
Ectopic pregnancy, 690-691, 690f. See also 626 Enterocolitis, lymphocytic, vs. celiac sprue, 357
Pregnancy. vs. cervical invasive adenocarcinoma, Enterogenous cyst, 1026
vs. salpingitis, 688 626 Enteropathy-associated T-cell lymphoma, 400,
Edema, ovarian, 651 endometrioid, immunohistochemistry 400f
vs. fibroma, 666 approach to, 16t Enzyme immunoassay (EIA), 37
Ehlers-Danlos syndrome, type IV, 983, 985 vs. chronic endometritis, 629 Eosin stains, 3-4
Elastin stain, 4, 4f vs. endometrial hyperplasia, 632 Eosinophilic cellulitis, 60
Elastofibroma, 893-894, 893f Endometrial hyperplasia, 631-632, 632f Eosinophilic esophagitis, 316f
vs. Gardner fibroma, 898 vs. atypical polypoid adenomyoma, 637 vs. reflux esophagitis, 317
Electron microscopy, 8-10, 9f-10f vs. chronic endometritis, 629 Eosinophilic gastritis, 334
of cell surface, 9-10 vs. endometrial adenocarcinoma, 636 Eosinophilic gastroenteritis, 364
of cell ultrastructure, 8-10 vs. endometrial polyp, 630 Eosinophilic granuloma, 118, 765
of cytoplasm, 8-9, 9t Endometrioid adenocarcinoma vs. chondroblastoma, 853
of extracellular matrix, 10 immunohistochemistry approach to, 16t Eosinophilic myocarditis, 955
of filaments and tubules, 9, 10t vs. ovarian malignant mucinous tumor, differential diagnosis of, 956
of nucleus, 8 660 Eosinophilic pleuritis, reactive, vs. pulmonary
of single membranebound structures, 9 vs. ovarian malignant serous tumor, 657 Langerhans cell histiocytosis, 277
scanning microscope in, 8 vs. yolk sac tumor, 678 Eosinophilic pneumonia, 234-235, 234f
technical overview of, 8 Endometrioid carcinoma, vs. Sertoli-Leydig cell acute, 234
transmission microscope in, 8 tumor, 672 chronic, 234-235
use of, 8 Endometrioid tumor, ovarian, 661-662, 661f vs. pulmonary Langerhans cell
Embedding, in tissue processing, 2 Endometrioma, 654f-655f histiocytosis, 277
Embryonal carcinoma Endometriosis Eosinophilic pulmonary disease, 234-235, 234f
mediastinal, 303, 303f fallopian, 689, 689f Eosinophilic pulmonary infiltrates, 979
ovarian, 679-680, 679f ovarian, 652-653 Eosinophilic pustular folliculitis, vs. acne
testicular, 566-567, 566f vs. bladder adenocarcinoma, 506 vulgaris, 78
vs. choriocarcinoma, 681 vs. cervical adenocarcinoma in situ, 624 Eosinophils
vs. dysgerminoma, 677 vs. colorectal carcinoma, 389 predominant in dermatitis with minimal
vs. seminoma, 564 vs. hemorrhagic corpus luteum cyst, 648 epidermal changes, 55
vs. yolk sac tumor, 568 vs. salpingitis isthmica nodosa, 689-690 predominant in nodular/diffuse dermatitis,
Embryonal rhabdomyosarcoma. See also Endometritis 60
Rhabdomyosarcoma. acute, 629 Ependymal cyst, vs. neuraxial cyst, 1027
head and neck, 188, 919-920, 920f chronic, 629-630, 629f Ependymal tumors, of central nervous system,
soft tissue, 919-920, 920f vs. endometrial hyperplasia, 631 999-1000. See also specific tumor.
vaginal, 615-616, 615f Endometrium, 629 Ependymoblastoma, 1012-1013
vs. fetal/genital rhabdomyoma, 919 adenocarcinoma of. See Endometrial Ependymoma, 999-1000, 999f
vs. fibrous hamartoma of infancy, 895 adenocarcinoma. myxopapillary, 1000-1001
vs. inflammatory myofibroblastic tumor, adenofibroma of, 637, 637f vs. chordoma, 1033
901 adenosarcoma of, 637-638, 638f papillary, vs. papillary glioneuronal tumor,
vs. lymphoblastic lymphoma, 298 atypical polypoid adenomyoma of, 636-637, 1009
vs. mesenchymal chondrosarcoma, 858 636f variants of, 999-1000
vs. neuroblastoma, 306 hyperplasia of. See Endometrial hyperplasia. vs. angiocentric glioma, 1004
Embryonal (undifferentiated) sarcoma, 443- metaplastic carcinoma of, 638-639, 639f vs. astroblastoma, 1002-1003
444, 444f polyps of, 630-631, 630f vs. central and extraventricular
vs. mesenchymal hamartoma, 443 vs. endometrial hyperplasia, 631 neurocytomas, 1008
Embryonal tumors, of central nervous system, proliferative, vs. endometrial hyperplasia, vs. choroid plexus carcinoma/papilloma,
1010-1012. See also specific tumor. 631 1014
1080 Index

Ependymoma (Continued) Epithelioid sarcoma, 940-941, 941f Esophagus (Continued)


vs. medulloblastoma, 1011 penile, 593-594, 593f metastatic disease to, 409-410
vs. meningioma, 1021 sclerosing, 906-907, 907f rare neoplasms of, 327-328
vs. papillary tumor of pineal region, 1017 vs. hemangioendothelioma, 934 squamous cell carcinoma of, 324f
vs. spinal cord paraganglioma, 1010 vs. ischemic fasciitis, 893 variants of, 326-327
vs. subependymoma, 1002 vs. vulvar squamous cell carcinoma, 604 squamous papilloma of, 324f
Ephelis (iris freckle), 1060 Epithelioid trophoblastic tumor undifferentiated carcinoma of, 326
Epidermal inclusion cyst, 81-83, 82f vs. exaggerated placental site, 694 differential diagnosis of, 327
vs. vulvar cyst, 600 vs. gestational choriocarcinoma, 698 Esthesioneuroblastoma (olfactory
Epidermal nevus Epithelioid variant, of salivary myoepithelioma, neuroblastoma), 187-188, 187f
vs. nevus sebaceus, 98 153 vs. extranodal NK/T-cell lymphoma, 192
vs. seborrheic keratosis, 83 Epithelioma, sebaceous. See Sebaceoma. vs. sinonasal melanoma, 190
Epidermal spongiosis, 50-52 Epstein-Barr virus encephalitis, 1042 Ethanol, used in fixation, 2
Epidermodysplasia verruciformis, vs. verrucae, Epstein-Barr virus hepatitis, vs. viral hepatitis, Ewing sarcoma, 872-874, 873f
85 413 extraskeletal, 942-943, 942f
Epidermoid cells, in mucoepidermoid Epstein-Barr virusassociated vs. desmoplastic small round cell tumor,
carcinoma, 164 lymphoproliferative disorders, 979 944
Epidermoid cyst Erosive gastritis, acute, 330-331, 330f vs. adrenal neuroblastoma, 306, 479
orbital, 1066 vs. Helicobacter pylori gastritis, 334 vs. Burkitt lymphoma, 784
splenic, 821-822, 821f vs. peptic ulcer disease, 335 vs. diffuse large B-cell lymphoma, 779
vs. craniopharyngioma, 1032 Erythema elevatum diutinum, vs. vs. mesenchymal chondrosarcoma, 858
vs. microphthalmos with cyst, 1069 leukocytoclastic vasculitis, 72 vs. precursor B-cell lymphoblastic
vs. testicular teratoma, 569 Erythema induratum, vs. erythema nodosum, lymphoma, 781
Epidermolysis bullosa acquisita 80 vs. rhabdomyosarcoma, 921
immunofluorescence patterns in, 7t Erythema multiforme, 46f vs. sinonasal melanoma, 190
vs. bullous pemphigoid, 76 in inflammatory esophagitis, 315 Exaggerated placental site, 694
Epididymis, papillary cystadenoma of, 578 vs. fixed drug eruption, 57 vs. placental site trophoblastic tumor, 699
Epididymitis, 576-577 vs. graft-versus-host disease, 47 Exophytic papilloma, sinonasal, 179
Epithelial cysts, 483 Erythema nodosum, 79-80, 80f Extracellular matrix, electron microscopy of,
Epithelial metaplasia, of prostate gland, Erythema nodosum migrans, 79 10
545 Erythroplasia of Queyrat, 588-589, 588f Extragastrointestinal stromal tumor, vs. soft
Epithelial neoplasms vs. Bowen disease, 589 tissue leiomyosarcoma, 923
benign, diagnostic features of, 259t vs. Bowenoid papulosis, 590 Extramammary Paget disease. See under Paget
cytogenetic abnormalities in, 23t-24t Escherichia coli infection, in immunocompetent disease.
malignant, 261 hosts, 347-350, 348f Extramedullary hematopoiesis, 806-807,
vs. angiosarcoma, 109 Esophageal adenocarcinoma, vs. Barrett 806f
Epithelial papilloma, of fallopian tube, 692, esophagus, 319-320 vs. splenic pyogenic bacterial infection, 832
692f Esophageal atresia, 310-311 Extranodal NK/T-cell lymphoma, 191-192,
Epithelial-myoepithelial carcinoma Esophageal cyst, 283 191f
of salivary glands, 165-166, 166f vs. thymic cyst, 282 Eye. See Ocular entries; specific part.
vs. adenoid cystic carcinoma, 161 Esophageal diverticula, 310-311
Epithelial-stromal tumors, ovarian, 653. See Esophageal duplication, 310-311 F
also specific tumor. Esophageal ectopia Fabry disease, 950
Epithelioid angiosarcoma gastric, 310-311 Fallopian tube, 688-689
vs. epithelioid sarcoma, 941 pancreatic, 310-311 adenomatoid tumor of, 691, 691f
vs. hemangioendothelioma, 934 sebaceous, 310-311 benign tumors of, 691
vs. primary malignant pericardial tumor, Esophageal (diaphragmatic) hernia, 311-312 epithelial papilloma of, 692, 692f
971 Esophageal necrosis, acute, vs. injurious malignant tumors of, 692
Epithelioid cell tumor, perivascular, 946-947, esophagitis, 314 metastatic tumors of, 693
947f Esophageal rings, 311-312 sarcoma and mixed tumors of, 693
Epithelioid cyst, splenic Esophageal webs, 311 serous carcinoma of, 692-693, 693f
vs. hematoma, 835 Esophagitis tumor-like lesions of, 688
vs. parasitic cyst, 822 eosinophilic, 316f Familial adenomatous polyposis, 389f-390f,
vs. pseudocyst, 822 infectious, 313f 391-393
Epithelioid hemangioendothelioma inflammatory, 315-316 fundic gland polyps associated with,
hepatic, 441, 441f injurious, 314 337f-338f
vs. angiosarcoma, 442 reflux, 309, 317-318 Familial juvenile nephronophthisis, 513-514
vs. cholangiocarcinoma, 436 Esophagus, 310-312 Fasciitis
vs. hemangioma, 440 Barrett, 318f ischemic, 892-893, 892f
osseous, 860-861, 860f adenocarcinoma associated with, 321, nodular, 890-891, 890f. See also Nodular
vs. angiosarcoma, 862 321f fasciitis.
vs. hemangioma, 860 dysplastic lesions of, 319-320, 319f proliferative, 891-892, 891f
penile, 592 vs. squamous papilloma/carcinoma, Fat(s), histologic staining of, 4
soft tissue, 933-934, 933f 326 Fat necrosis
vs. angiosarcoma, 935 benign lesions of, 322f of breast, 704, 704f
vs. thymic carcinoma, 291 congenital and acquired abnormalities of, of pancreas, vs. subcutaneous fat necrosis,
Epithelioid hemangioma, 930 310-312, 310f 81
vs. angiosarcoma, 109 granular cell tumor of, 323-324, 323f subcutaneous, of newborn, 80-81, 81f
Index 1081

Fatty liver disease Fibromatosis (Continued) Fibrous histiocytoma, benign (Continued)


nonalcoholic, 416-417 desmoid-type, 898-899, 899f vs. angiomatoid fibrous histiocytoma,
of pregnancy vs. calcifying fibrous pseudotumor, 900 938
acute, 417-418, 417f vs. fibrosarcoma, 906 vs. nonossifying fibroma, 865
vs. alcoholic liver disease/alcoholic vs. Gardner fibroma, 898 malignant. See Malignant fibrous
steatohepatitis, 415 vs. inflammatory myofibroblastic tumor, histiocytoma.
vs. nonalcoholic fatty liver/nonalcoholic 901 vs. hemangiopericytoma/myopericytoma,
steatohepatitis, 417 vs. lipofibromatosis, 896 932
Fetal rhabdomyoma, 918-919 vs. low-grade fibromyxoid sarcoma, 903 vs. inflammatory myofibroblastic tumor,
differential diagnosis of, 919 ovarian, 651 273
Fibers, histologic staining of, 6, 6f vs. fibroma, 666 vs. nodular fasciitis, 890
Fibrillary astrocytoma, 990 penile (Peyronie disease), 586-587, 586f vs. xanthogranuloma, 62
vs. ependymoma, 1000 small bowel, 395f Fibrous pseudotumor
vs. gangliocytoma/ganglioglioma, 1005 superficial, 894-895, 894f calcifying, 900, 900f
Fibroadenoma, of breast, 716-717, 716f vs. calcifying aponeurotic fibroma, 896-897 paratesticular, 579
Fibroblastic polyp, benign, of colon, 391f, 394 vs. fibrocystic breast changes, 708 Fibrous tumor
Fibrocystic changes vs. gastrointestinal stromal tumor, 398 pericardial, 970-971
of breast, 707-708, 707f-708f vs. infantile fibrosarcoma, 905 solitary. See Solitary fibrous tumor.
vs. diabetic mastopathy, 705 vs. nodular fasciitis, 890-891 Fibrovascular polyp, of esophagus, 322, 322f
Fibroelastoma, papillary, 966-968, 967f vs. paratesticular fibrous pseudotumor, 579 Fibroxanthoma, atypical, vs. squamous cell
vs. cardiac myxoma, 965 Fibromuscular dysplasia, 982-983 carcinoma, 87
Fibroepithelial polyp Fibromyxoid sarcoma, low-grade, 903, 903f Filaments, electron microscopy of, 9, 10t
urethral, 583 vs. desmoid-type fibromatosis, 899 Fite method, of bacillus staining, 6
vaginal, 610, 610f vs. fibrosarcoma, 906 Fixation
vs. papillary urothelial carcinoma, 490 vs. low-grade myofibroblastic sarcoma, 904 alcohols used in, 2
vs. vaginal squamous papilloma, 611 vs. myxofibrosarcoma, 908 aldehydes used in, 2
Fibroid polyp, inflammatory vs. sclerosing epithelioid sarcoma, 907 decalcification in, 3
of esophagus, 322, 322f Fibromyxoid tumor, ossifying, 937, 937f factors affecting, 3
of stomach, 338 Fibrosarcoma in light microscopy, 2-3
Fibroid tumor. See Leiomyoma. infantile, 904-905, 905f in tissue processing, 2
Fibrolipoma, vs. elastofibroma, 894 vs. low-grade myofibroblastic sarcoma, mercurials used in, 2
Fibroma 904 oxidizing agents used in, 2
ameloblastic, vs. ameloblastoma, 201 vs. myofibroma/myofibromatosis, picrates used in, 2-3
calcifying aponeurotic. See Calcifying 897-898 Fixed drug eruption, 57f
aponeurotic fibroma. low-grade, vs. desmoplastic fibroma, 866 Flat urothelial lesions, of urinary bladder, 496.
cardiac, 966 osseous, 867, 867f See also specific lesion.
chondromyxoid, 853-854, 853f penile, 593 Flexner-Wintersteiner rosette, 1060-1061,
vs. chondroblastoma, 853 soft tissue, 905-906 1061f
desmoplastic, 866, 866f vs. cardiac fibroma, 966 Florid papillomatosis, of nipple, 713-714, 713f
vs. fibrosarcoma, 867 vs. clear cell sarcoma, 946 Flow cytometry, 20-21, 20f
vs. fibrous dysplasia, 864 vs. desmoid-type fibromatosis, 899 technical overview, 21
vs. low-grade surface osteosarcoma, 847 vs. inflammatory myofibroblastic tumor, Fluorescence in situ hybridization (FISH), 34,
vs. nonossifying fibroma, 865 273 36f
Gardner, 898 vs. malignant fibrous histiocytoma, 868 Fluorescence microscopy, 7-8, 7t
nonossifying, 865-866, 865f vs. malignant peripheral nerve sheath Foamy gland adenocarcinoma, of prostate
vs. giant cell reparative granuloma, 871 tumor, 929 gland, 550
vs. giant cell tumor, 870 vs. osteosarcoma, 843 Focal nodular hyperplasia
nuchal, vs. Gardner fibroma, 898 vs. soft tissue leiomyosarcoma, 923-924 of liver, 426-427, 426f
of tendon sheath, vs. giant cell tumor of vs. solitary fibrous tumor, 902 vs. hepatic adenoma, 428
tendon sheath, 909 vs. superficial fibromatosis, 894 vs. hepatocellular carcinoma, 430
ossifying vs. synovial sarcoma, 940 Focal regenerative hyperplasia, vs. cirrhosis,
of long bones. See Osteofibrous dysplasia. Fibrosing dermatosis, 78 426
ovarian, 665-666, 665f Fibrosing pleuritis, chronic, vs. mesothelioma, Follicular bronchiolitis, 225t
vs. fibromatosis, 651 280 Follicular bronchitis, vs. mucosa-associated
vs. sclerosing stromal tumor, 670 Fibrous dysplasia, 863-864, 863f lymphoid tissue (MALT) lymphoma, 276
vs. stromal hyperplasia, 650 vs. adamantinoma, 872 Follicular cyst, ovarian, 647-648, 648f
vs. thecoma, 667 vs. desmoplastic fibroma, 866 vs. serous cystadenoma, 654-655
renal medullary, 532, 532f vs. enchondroma, 850 Follicular cystitis, 491-492
tendon sheath, vs. superficial fibromatosis, vs. low-grade surface osteosarcoma, 847 Follicular dendritic cell sarcoma, vs. splenic
894 vs. nonossifying fibroma, 865 inflammatory pseudotumor, 825
Fibromatosis vs. osteofibrous dysplasia, 865 Follicular keratosis
breast, spindle cell areas in, vs. Paget disease of bone, 880 vs. squamous cell carcinoma, 87
immunohistochemistry comparison of, Fibrous hamartoma of infancy, 895, 895f vs. trichilemmoma, 90
14t vs. lipofibromatosis, 896 Follicular lymphoid hyperplasia
deep Fibrous histiocytoma nonspecific, 746-747, 746f
vs. low-grade myofibroblastic sarcoma, angiomatoid, 938, 938f vs. autoimmune lymphoproliferative
904 benign. See also Dermatofibroma. syndrome, 754
vs. sclerosing epithelioid sarcoma, 907 deep, 909-910 vs. Castleman disease, 760
1082 Index

Follicular lymphoid hyperplasia, nonspecific Frontotemporal lobar degeneration, Gastric carcinoma (Continued)
(Continued) 1047-1049 WHO classification of, 342
vs. common variable immunodeficiency, Fundic gland polyp, of stomach, 337f-338f, 338 with ulcer, vs. peptic ulcer disease, 335
795 Fungal esophagitis, 313, 313f Gastric duplication, 328-329
vs. HIV-associated lymphadenopathy, vs. benign esophageal lesions, 323 Gastric dysplasia, 340-341
748 Fungal granuloma, vs. tuberculous Gastric lymphoma, 344-345, 344f
vs. progressive transformation of lymphadenitis, 767 Gastric polyps, non-neoplastic, 337f-338f
germinal centers, 753 Fungal infection. See also specific infection. Gastric sarcoma, vs. inflammatory fibroid polyp,
vs. syphilis, 750 deep, 69f 339
vs. Toxoplasma lymphadenitis, 751 in immunocompromised patients, 351f, Gastric ulcer, 341-342
vs. follicular lymphoma, 769 352-353 Gastric xanthelasma, 329f-330f
vs. small lymphocytic lymphoma, 774 of lungs, 249. See also specific infection. Gastritis
Follicular lymphoma vs. lichen simplex chronicus, 600 acute erosive, 330-331, 330f
duodenal, 397f, 400 vs. sarcoidosis, 67, 768 vs. Helicobacter pylori gastritis, 334
nodal, 768-770, 769f Fungal lymphadenitis, vs. histiocytic vs. peptic ulcer disease, 335
vs. follicular hyperplasia, 747 necrotizing lymphadenitis, 758 chronic
vs. HIV-associated lymphadenopathy, Fungal sinusitis vs. acute erosive gastritis, 331
748 allergic, 175, 175f vs. Barrett esophagus, 319
vs. infectious mononucleosis, 749 invasive, 175, 175f vs. reactive gastropathy, 332
vs. mantle cell lymphoma, 776 Fungi collagenous, 334
vs. mast cell disease, 762 histologic staining of, 6, 6f eosinophilic, 334
vs. nodular sclerosing Hodgkin hyphal, differential diagnosis of, 250t granulomatous, 334
lymphoma, 771-772 yeast-like, differential diagnosis of, 252t Helicobacter heilmannii, vs. Helicobacter pylori
splenic, 801-802, 801f Fusarium, diagnostic features of, 250t gastritis, 334
vs. chronic lymphocytic leukemia and Helicobacter pylori, 332-334, 332f-333f
small lymphocytic lymphoma, G vs. reactive gastropathy, 332
799 Gallbladder carcinoma, 436-438, 437f vs. reflux esophagitis, 317
thymic Gangliocytoma, 1004-1006, 1004f lymphocytic, 334
vs. Castleman disease, 299 Ganglioglioma, 1004-1006 associated with Mntrier disease,
vs. follicular hyperplasia, 285 vs. desmoplastic cerebellar ganglioglioma, 336f
Follicular neoplasms 1005 vs. MALT lymphoma, 345
of skin, 88. See also specific neoplasm. vs. desmoplastic infantile ganglioglioma/ Gastroenteritis
vs. chronic lymphocytic thyroiditis, 124 astrocytoma, 1005 eosinophilic, 364
Follicular splenic hyperplasia, reactive, 792- vs. dysembryoplastic neuroepithelial tumor, Salmonella, 349-350
793, 792f-793f 1006-1007 Gastroesophageal reflux disease, 317-318
Follicular thymic hyperplasia, 285 Ganglioma faciale, vs. leukocytoclastic Gastrointestinal adenoma, 383-385
Follicular thyroid adenoma, 131-132, 132f vasculitis, 72 colonic, 383f
variants of, 132 Ganglion cell tumor mixed, 385
vs. dyshormogenetic goiter, 128 vs. pilocytic astrocytoma, 993 serrated
vs. follicular thyroid carcinoma, 134 vs. pleomorphic xanthoastrocytoma, 994 sessile, 383f-384f
vs. hyalinizing trabecular tumor, 131 Ganglioneuroblastoma, 1012-1013 traditionally defined, 383f, 385, 394
vs. multinodular goiter, 127 adrenal, 476-477 tubular, 385
vs. papillary thyroid carcinoma, 136 subtypes of, 477 tubulovillous, 382f, 385
immunohistochemistry panel vs. neuroblastoma, 479 villous, 385
distinguishing, 19t mediastinal, 305-306 Gastrointestinal neoplasms
Follicular thyroid carcinoma, 133-134, 133f differential diagnosis of, 306 mesenchymal, 397f. See also specific
capsular invasion of, 133 features of, 306t neoplasm.
vascular (angioinvasive) invasion of, 134 vs. proliferative fasciitis, 891 metastatic, 409-410, 409f
vs. follicular thyroid adenoma, 132 Ganglioneuroma Gastrointestinal polyps, 384f
vs. medullary thyroid carcinoma, 138 adrenal, 475-476, 476f adenomatous, 383-385
vs. papillary thyroid carcinoma, 136 vs. ganglioneuroblastoma, 477 pedunculated tubulovillous, 382f
Folliculitis, 77 mediastinal, 305-306 serrated
Foregut cyst differential diagnosis of, 306 sessile, 383f-384f
of mediastinum, 283-284, 283f features of, 306t traditionally defined, 383f
vs. teratoma, 301 mucosal, intestinal, 391f, 394 hyperplastic, 382f-383f, 383-385, 391f,
Foreign pigment, vs. dermatopathic Gardner fibroma, 898 394
lymphadenopathy, 752 Gastric adenocarcinoma, vs. gastric carcinoid, inflammatory, 383-384
Foreign-body granuloma, 67, 67f 344 Gastrointestinal spindle cell tumors,
vs. cat-scratch disease, 756 Gastric adenoma, 340-341 immunohistochemistry panel
vs. sarcoidosis, 67, 768 Gastric antral vascular ectasia, vs. reactive interpretation for, 15t
vs. Toxoplasma lymphadenitis, 751 gastropathy, 332 Gastrointestinal stromal tumor, 395f, 396-398
vs. tuberculous lymphadenitis, 767 Gastric carcinoid, 343f CD117-negative, 398
Formalin, used in fixation, 2 Gastric carcinoma, 339-342, 339f-340f vs. benign esophageal lesion, 323
Formalin pigment artifact, vs. malaria, 831 early, 341 vs. inflammatory fibroid polyp, 339
Fracture, stress, vs. osteoid osteoma, 839 rare types of, 342 vs. perivascular epithelioid cell tumor, 947
Fracture callus risk factors for, 340 Gastrointestinal tract
vs. intramedullary chondrosarcoma, 855 vs. adenocarcinoma associated with Barrett lower, 345-347. See also specific part.
vs. osteosarcoma, 843 esophagus, 321 congenital anomalies of, 345-347, 346f
Index 1083

Gastrointestinal tract, lower (Continued) Giant cell tumor Gluten-sensitive enteropathy, 356f-357f
infections of of bone, 869-870, 869f Glycogen acanthosis, esophageal, 321-322,
in immunocompetent hosts, 348f. See vs. aneurysmal bone cyst, 879 322f
also Immunocompetent hosts. vs. chondroblastoma, 853 Glycogen storage disease, 950
in immunocompromised patients, vs. giant cell reparative granuloma, 871 differential diagnosis of, 805t
352f. See also vs. malignant fibrous histiocytoma, 868 GNAS 1 mutation, in McCune-Albright
Immunocompromised patients. vs. nonossifying fibroma, 865 syndrome, 464
secondary malignancies in, 409-410, 409f vs. osteoblastoma, 841 Goblet cell carcinoid tumor, of appendix, 408,
Gastropathy vs. osteosarcoma, 843 408f
hypertrophic, 335f-336f vs. pigmented villonodular synovitis, Goiter
reactive, 331f 887 diffuse toxic, 125-126, 125f
Gastroschisis, 346-347 vs unicameral bone cyst, 879 dyshormogenetic, 127-128, 127f
Gaucher disease, 804-806, 804f of tendon sheath, 908-909, 909f multinodular, 126, 126f
differential diagnosis of, 805t vs. calcifying aponeurotic fibroma, 897 Golgi apparatus, electron microscopy of, 9, 9t
vs. Langerhans cell histiocytosis, 816 Giant multilocular prostatic cystadenoma, vs. Gonadoblastoma
vs. Mycobacterium avium-intracellulare phyllodes tumor, 556 ovarian, 685, 685f
infection, 830 Giardiasis, in immunocompromised patients, vs. mixed germ cell tumor, 684
Gel electrophoresis, 32 351f, 352-353 vs. sex cord tumor with annular tubules,
agarose, 32 Giemsa stain, 6 672
capillary, 32 Glassy cell carcinoma Goodpasture syndrome, 237-238, 238f, 979
polyacrylamide, 32 of uterine cervix, 627 Gorlin syndrome, 665
pulsed-field, 32 vs. cervical squamous cell carcinoma, 622 Gottron papules, 50
Gemistocytic astrocytoma, 990 Gleason grading system, of prostate Gout, 884, 884f
vs. subependymal giant cell astrocytoma, adenocarcinoma, 549t vs. pseudogout, 885
995-996 Glial heterotopia, heterotopic, vs. nasal polyp, Graft-versus-host disease, 47, 47f, 365,
Genital rhabdomyoma, 918-919 177 365f
differential diagnosis of, 919 Glial neoplasms, vs. secondary CNS tumors, acute phase, 47
Genital warts 1034 grades in, 47
anal, 401, 401f, 403 Glial nodule, subependymal, vs. subependymal chronic phase, 47
penile, 588, 588f giant cell astrocytoma, 996 in inflammatory esophagitis, 315
Germ cell tumor. See also specific tumor. Glioblastoma lichenoid, 45
central nervous system, 1026, 1026f variants of, 990 vs. biliary cirrhosis, 422
immunohistochemistry approach to, 17t vs. pleomorphic xanthoastrocytoma, 994 Granular cell tumor
nonseminomatous, mediastinal, 303-305, Glioblastoma multiforme, 988-991, 989f neurohypophyseal
303f-304f. See also specific tumor. vs. brain abscess, 1041 vs. pituicytoma, 1030
ovarian, 674 vs. cerebral infarct/hematoma, 1038 vs. pituitary adenoma, 1030
testicular, intratubular, 563, 563f with oligodendroglial features, 998 of breast, 706, 706f
vs. testicular choriocarcinoma, 570 Glioma(s) of esophagus, 323-324, 323f
vs. testicular teratoma, 569 angiocentric, 1003-1004 of oral cavity, 196, 196f
vs. testicular torsion, 562 vs. astroblastoma, 1002 of soft tissue, 924-925, 924f
vs. thymic carcinoma, 291 choroid, 1003 of stomach, 396f
Germinoma. See Seminoma (germinoma). vs. chordoma, 1033 of vulva, 607-608
Gestational choriocarcinoma, 697-699, 698f mixed, 998 vs. adult rhabdomyoma, 919
vs. exaggerated placental site, 694 vs. cerebral infarct/hematoma, 1038 vs. alveolar soft part sarcoma, 945
vs. hydatidiform mole, 696-697 vs. progressive multifocal vs. fat necrosis of breast, 704
vs. placental site trophoblastic tumor, 699 leukoencephalopathy, 1045 vs. gastrointestinal stromal tumor, 399
Gestational trophoblastic disease, 694 Gliomatosis cerebri, 988-991 Granuloma
choriocarcinoma in, 697-699, 698f Glioneuronal tumor(s), 1004-1006. See also eosinophilic, 118, 765
exaggerated placental site in, 694 specific tumor. vs. chondroblastoma, 853
hydatidiform mole in papillary, 1008-1009 foreign-body. See Foreign-body granuloma.
complete mole, 695-696, 695f vs. rosette-forming glioneuronal tumor, fungal, vs. tuberculous lymphadenitis,
invasive mole, 695f, 697 1009 767
partial mole, 696-697 rosette-forming, 1009 giant cell, vs. oral pyogenic granuloma,
placental site nodule (plaque) in, 694 Glioneuronal tumor with neuropil-like islands, 195
placental site trophoblastic tumor in, 699- 990 infectious, 68, 83
700, 699f Gliosarcoma, 988-991 Majocchi, vs. acne vulgaris, 78
Giant cell aortitis, 973f Glomangioma, 105, 106f necrobiotic, 63-64
Giant cell arteritis, 973-974, 974f vs. hemangiopericytoma/myopericytoma, palisading, 63-64
Giant cell astrocytoma, subependymal, 995- 933 pyogenic. See Pyogenic granuloma.
996, 995f Glomangiopericytoma. See reticulocytic, 62-63, 62f
Giant cell cystitis, 491-492, 492f Hemangiopericytoma. sarcoidal, 66-67
Giant cell glioblastoma, 990 Glomerulonephritis, membranoproliferative, splenic, vs. amyloidosis, 834
Giant cell myocarditis, 954f, 956 immunofluorescence patterns in, 7t Granuloma annulare, 63f
differential diagnosis of, 956 Glomus, 105 vs. epithelioid sarcoma, 941
vs. cardiac sarcoidosis, 958 Glomus tumor, 931, 931f vs. necrobiosis lipoidica, 65
Giant cell reparative granuloma, 870-871, of stomach, 396f vs. necrobiotic xanthogranuloma, 66
871f vs. gastrointestinal stromal tumor, 399 vs. rheumatoid nodule, 65
vs. giant cell tumor, 870 Glutaraldehyde, used in fixation, 2 Granuloma inguinale, vs. leishmaniasis, 71
1084 Index

Granulomatosis Hamartoma (Continued) Hemangioma (Continued)


lymphomatoid, 979 splenic, 823-824, 823f salivary gland, 157-158, 157f
Wegener. See Wegener granulomatosis. vs. hemangioma, 818 soft tissue, 929-931, 929f
Granulomatous diseases vs. Hodgkin lymphoma, 804 spindle cell, 930
of spleen, 832-833 vs. inflammatory pseudotumor, 825 splenic, 817-818, 817f
vs. granulomatous thyroiditis, 123 vs. littoral cell angioma, 819 vs. angiosarcoma, 820
Granulomatous gastritis, 334 Hand-Schller-Christian disease, 118 vs. hamartoma, 824
Granulomatous hypophysitis, vs. pituitary Hashimoto thyroiditis, 123-124, 123f vs. hematoma, 835
adenoma, 1030 vs. granulomatous thyroiditis, 123 vs. littoral cell angioma, 819
Granulomatous lobar mastitis, 703, 703f vs. Riedel thyroiditis, 125 venous, 1035-1036
vs. diabetic mastopathy, 705 vs. thyroid lymphoma, 141 vs. angiosarcoma, 935
vs. plasma cell mastitis, 703 Heart, 949-954. See also Cardiac; vs. dermoid/epidermoid cyst, 1066
vs. subareolar abscess, 702 Cardio- entries. vs. lymphangiectasia, 380
Granulomatous orchitis, 559f, 560 carcinoid disease of, 960-961 vs. lymphangioma, 936
infectious, 560 metastatic tumors of, 972 vs. oral pyogenic granuloma, 195
noninfectious, 560 rheumatic disease of vs. orbital lymphangioma, 1068
vs. testicular malakoplakia, 560 clinical features of, 960 vs. peliosis hepatis, 439
Granulomatous prostatitis, 540-542, 541f gross pathology of, 960-961 Hemangiopericytoma, 178f
vs. lymphoma, 558 histopathology of, 961 CNS, 1022-1023, 1022f
Granulomatous rosacea, vs. acne vulgaris, 78 valvular disease of, 959-961, 959f osseous, 861-862, 861f
Granulomatous synovitis, infectious, vs. gout, regurgitant, 959 soft tissue, 932-933, 932f
884 stenotic, 959 vs. endometrial stromal nodule, 640-641
Granulomatous thyroiditis, 122-123, 123f Heart valves. See also named valve. vs. endometrial stromal sarcoma, 641
vs. Riedel thyroiditis, 125 prosthetic, 963-964 vs. hemangioma, 930
Granulosa cell tumor commonly implanted, 963 vs. meningioma, 1021
ovarian complications of, 963 vs. mesenchymal chondrosarcoma, 858
adult. See Adult granulosa cell tumor. Helicobacter heilmannii gastritis, vs. Helicobacter vs. nasopharyngeal angiofibroma, 177-178
juvenile. See Juvenile granulosa cell pylori gastritis, 334 vs. solitary fibrous tumor, 902
tumor. Helicobacter pylori gastritis, 332-334, 332f-333f vs. splenic angiosarcoma, 821
vs. gynandroblastoma, 673 vs. reactive gastropathy, 332 vs. synovial sarcoma, 939-940
testicular, 573-574, 573f vs. reflux esophagitis, 317 Hematoma
vs. yolk sac tumor, 568 Heliotrope rash, 50 intracerebral, 1037-1038
vs. carcinoid tumor, 684 Hemangioblastoma, 1023-1024, 1023f splenic, 835
Graves disease, 125-126, 125f vs. pilocytic astrocytoma, 993 vs. hemangioma, 818
vs. dyshormogenetic goiter, 128 Hemangioendothelioma, 933-934, 933f Hematopoiesis, extramedullary, 806-807, 806f
vs. multinodular goiter, 127 epithelioid. See Epithelioid vs. splenic pyogenic bacterial infection, 832
Graves orbitopathy, 1064-1065, 1065f hemangioendothelioma. Hematopoietic elements, histologic staining of,
vs. lymphoma, 1063 infantile, 440-441 6
Grocott methenamine silver (GMS) stain, 6, 6f splenic Hematopoietic neoplasms. See also specific
Grover disease, vs. pemphigus, 75 vs. angiosarcoma, 820-821 neoplasm.
Gynandroblastoma vs. hemangioma, 818 cytogenetic abnormalities in, 23t-24t
ovarian, 673 vs. littoral cell angioma, 819 Hematoxylin and eosin (H&E) stain, 3-4
vs. mixed germ cell tumor, 684 Hemangioma, 105-106, 106f Hemochromatosis, 418-419, 418f
Gynecomastia, 741-742, 741f breast, 738, 738f vs. malaria, 831
vs. angiosarcoma, 739-740 Hemolysis with hemosiderosis, vs.
H vs. pseudoangiomatous stromal dermatopathic lymphadenopathy, 752
Hailey-Hailey disease, vs. pemphigus, 75 hyperplasia, 714 Hemolytic anemia, autoimmune, 810-811,
Hairy cell leukemia, 812-813, 812f capillary, 105-106, 106f 810f
morphologic and immunophenotypic lobular. See Pyogenic granuloma. vs. hereditary spherocytosis, 808
features of, 797t orbital, 1066-1067, 1067f Hemophagocytic syndrome, vs. Langerhans cell
vs. hepatosplenic T-cell lymphoma, 813 vs. rhabdomyosarcoma, 1070 histiocytosis, 816, 817f
vs. Langerhans cell histiocytosis, 816 soft tissue, 929-930 Hemorrhage, subretinal, vs. intraocular
vs. littoral cell angioma, 819 vs. infantile hemangioendothelioma, 441 malignant melanoma, 1058
vs. mast cell disease, 815 cavernous, 105-106, 106f Hemorrhagic cystitis, 492-493
vs. splenic marginal zone lymphoma, 798 central nervous system, 1035-1036 Hemorrhagic lung disease, 237
Halo nevus, 102f, 103 soft tissue, 929-930 Hemosiderosis
Hamartoma vs. glomus tumor, 931 idiopathic pulmonary, 237, 237f
bile duct, 432, 432f vs. intraocular malignant melanoma, vs. Goodpasture syndrome, 238
fibrous, of infancy. See Fibrous hamartoma 1057-1058 vs. hemochromatosis, 419
of infancy. vs. pyogenic granuloma, 107 Hemosiderotic synovitis, vs. pigmented
mesenchymal, 442-443, 443f epithelioid, 930 villonodular synovitis, 887
peribiliary gland (biliary duct adenoma), vs. angiosarcoma, 109 Henoch-Schnlein purpura, 980
432-433, 433f hepatic, 439-440, 440f Hepatic. See also Liver entries.
pulmonary, 270-271, 270f intramuscular, 930 Hepatic abscess
respiratory epithelial adenomatoid vs. angiolipoma, 913 bacterial, 413, 414f
vs. nasal polyp, 176 juvenile, 157 parasitic, 413
vs. sinonasal (Schneiderian) papilloma, vs. angiolipoma, 913 Hepatic adenoma, 427-428, 427f
180 osseous, 842, 859f vs. hepatocellular carcinoma, 430
Index 1085

Hepatic fibrosis, vs. cirrhosis, 426 Hidradenoma, clear cell (nodular), 95, 95f Hodgkin lymphoma, nodular sclerosing
Hepatic hemangioma, 439-440, 440f Hidradenoma papilliferum (Continued)
Hepatic metastases, 438-439 vs. syringocystadenoma papilliferum, 97 vs. progressive transformation of
Hepatitis vulvar, 607, 607f germinal centers, 753
autoimmune, 421-422, 421f. See also Hidrocystoma, 82f, 83 vs. thymoma, 289
Autoimmune hepatitis. Hirschsprung disease, 362-363 of central nervous system, 1025
viral, 411-413, 412f. See also Viral hepatitis. Histiocytes, 11 of mediastinum, 294-295, 295f
Hepatitis A virus, 411 predominant in nodular/diffuse dermatitis, of spleen, 803-804, 803f
Hepatitis B virus, 411 61-62 vs. diffuse large B-cell lymphoma, 803
Hepatitis C virus, 412 Histiocytic necrotizing lymphadenitis (Kikuchi- vs. inflammatory pseudotumor, 825
recurrent, vs. liver transplant rejection, Fujimoto disease), 757-758, 757f of thyroid gland, 141
424 vs. cat-scratch disease, 756 vs. anaplastic large cell lymphoma, 782
vs. fatty liver of pregnancy, 418 vs. CMV/herpes lymphadenitis, 756 vs. angioimmunoblastic T-cell lymphoma,
Hepatitis D virus, 412 vs. Toxoplasma lymphadenitis, 751 786-787
Hepatitis E virus, 412 vs. tuberculous lymphadenitis, 767 vs. cutaneous CD30-positive T-cell
Hepatitis G virus, 412 Histiocytic sarcoma, vs. anaplastic large cell lymphoma, 120
Hepatoblastoma, 430-431, 431f lymphoma, 782 vs. diffuse large B-cell lymphoma, 296
types of, 431 Histiocytoma, fibrous. See Fibrous histiocytoma. vs. infectious mononucleosis, 749, 829
vs. hepatocellular carcinoma, 430 Histiocytosis vs. mast cell disease, 762
Hepatocellular adenoma, vs. focal nodular Langerhans cell. See Langerhans cell vs. nodular lymphocyte predominant
hyperplasia, 427 histiocytosis. Hodgkin lymphoma, 773
Hepatocellular carcinoma, 428-430, 428f malignant, vs. Langerhans cell histiocytosis, vs. peripheral T-cell lymphoma, 785
differential diagnosis of, 817 vs. reactive lymphoid hyperplasia without
immunohistochemical panel sinus. See Sinus histiocytosis. germinal center formation, 794
approach to, 15t Histologic stains. See also specific stain. vs. Rosai-Dorfman disease, 764
metastatic, vs. metastatic adrenal tumors, of carbohydrates and mucoproteins, 4-6, 5f vs. splenic pyogenic bacterial infection, 832
485 of connective tissue, 4, 4f-5f Homer-Wright rosette, 1060-1061
patterns of, 429 of fats and lipids, 4 Hormone(s), 11
vs. angiosarcoma, 442 of hematopoietic and nuclear elements, 6 Horn cysts, 83
vs. cholangiocarcinoma, 436 of microorganisms, 6, 6f-7f Human immunodeficiency virusassociated
vs. cirrhosis, 426 of nerves and fibers, 6, 6f adenopathy. See Adenopathy,
vs. embryonal (undifferentiated) sarcoma, of pigments and minerals, 6 HIV-associated.
444 used in light microscopy, 3-6 Human immunodeficiency virusassociated
vs. gallbladder carcinoma, 437 Histoplasma capsulatum, diagnostic features of, encephalitis, 1042
Hepatocytes 252t Human immunodeficiency virusassociated
containing eosinophilic globules, 420f Histoplasma esophagitis, 313 enteropathy, in immunocompromised
in hepatitis B, 412f Histoplasmosis, 70, 251-253, 252f patients, 352-354
Hepatoid carcinoma, 454 differential diagnosis of, 228f Human immunodeficiency virusassociated
vs. yolk sac tumor, 678 in immunocompromised patients, 352-353 lymphadenopathy. See
Hepatosplenic T-cell lymphoma, 813-814, 813f splenic, 832-833 Lymphadenopathy, HIV-associated.
morphologic and immunophenotypic vs. leishmaniasis, 71 Hunner (interstitial) cystitis, 493-494
features of, 797t vs. Mycobacterium avium-intracellulare vs. bacterial cystitis, 490
vs. marginal zone lymphoma, 798 infection, 830 Hyalinized collagen, vs. cardiac amyloidosis, 957
HepPar-1, immunohistochemistry for, 12f vs. Rosai-Dorfman disease, 764 Hyalinizing trabecular tumor, 130-131, 131f
HER-2-neu, in breast adenocarcinoma, vs. Whipple disease, 356 vs. medullary thyroid carcinoma, 138
immunohistochemistry for, 11f Hodgkin lymphoma Hyalinosis, splenic, vs. amyloidosis, 834
Hereditary spherocytosis, 808, 808f cystic degeneration of, vs. thymic cyst, 282 Hybrid tumors, vs. penile verrucous carcinoma,
vs. autoimmune hemolytic anemia, 811 differential diagnosis of, antibody panel for, 592
vs. sickle cell disease, 809-810 19t Hybrid capture assay, 31
Hernia, esophageal (diaphragmatic), 311-312 mixed cellularity, 787-788, 787f Hybridization method(s), 32-36
Herpes simplex virus infection nodular lymphocyte predominant, 772-773, DNA microarray, 36
in immunocompromised patients, 352-353 773f dot blotting, 34
vs. pemphigus, 75 vs. follicular lymphoma, 770 in situ hybridization, 34, 34f-36f
Herpesvirus encephalitis, 1042-1043 vs. mantle cell lymphoma, 776 Northern blotting, 33-34
Herpesvirus esophagitis, 312, 312f-313f vs. nodal marginal zone lymphoma, 777 Southern blotting, 32, 33f
Herpesvirus gestationis, vs. bullous pemphigoid, vs. nodular sclerosing Hodgkin Hydatidiform mole
76 lymphoma, 771 complete, 695-696, 695f
Herpesvirus lymphadenitis, 756-757 vs. paracortical hyperplasia, 759 invasive, 695f, 697
vs. histiocytic necrotizing lymphadenitis, vs. small lymphocytic lymphoma, 775 partial, 695f, 696-697
757-758 nodular sclerosing, 770-772, 771f vs. gestational choriocarcinoma, 698
Heterotopia, pancreatic, 329 vs. follicular lymphoid hyperplasia, 747 Hydrocele, testicular, 559
Heterotopic gastric mucosa, vs. small intestinal vs. follicular lymphoma, 770 21-Hydroxylase deficiency, congenital adrenal
adenoma/adenocarcinoma, 360 vs. histiocytic necrotizing lymphadenitis, hyperplasia due to, 463, 463f
Heterotopic glial heterotopia, vs. nasal polyp, 758 Hygroma, cystic. See Lymphangioma.
177 vs. mediastinal germinoma, 302 Hypereosinophilic syndrome, 955
Hibernoma vs. mediastinitis, 294 Hyperparathyroidism
vs. adult rhabdomyoma, 919 vs. mixed cellularity Hodgkin lymphoma, primary, 143
vs. granular cell tumor, 924 788 secondary, 143
1086 Index

Hyperplastic nodule, vs. follicular thyroid Immunocompromised patients (Continued) In situ hybridization (ISH), 34, 34f
adenoma, 132 herpes simplex virus infection in, 352-353 applications of, 34
Hyperplastic polyp histoplasmosis in, 352-353 chromogenic, 34, 35f
colorectal, 382f-383f, 383-385, 391f, 394 microsporidiosis in, 352-353 fluorescence, 34, 36f
gastric, 337-338, 337f mucormycosis in, 352-353 Inclusion cyst, epidermal, 81-83, 82f
Hyperreactio luteinalis, ovarian, 649 Mycobacterium avium-intracellulare infection vs. vulvar cyst, 600
Hypersensitivity angiitis (Churg-Strauss in, 352f, 353 Incontinentia pigmenti, 52f
disease), 827-828 spirochetosis in, 351f, 352-353 Indeterminate colitis, vs. inflammatory bowel
Hypersensitivity myocarditis, 955 tuberculosis in, 352-353 disease, 368
Hypersensitivity pneumonitis, 233-234, 233f Immunodeficiency Indian childhood cirrhosis, vs. nonalcoholic
vs. nonspecific interstitial pneumonia, 231 common variable, 795 fatty liver/nonalcoholic steatohepatitis,
vs. sarcoidosis, 236 thymic histology in, 299-300 417
Hypertension, pulmonary, 242-245, 243f Immunofluorescence Infantile fibrosarcoma, vs. myofibroma/
grading system for, 244t direct, 7 myofibromatosis, 897-898
revised clinical classification of, 244t indirect, 7, 7t Infantile ganglioglioma, desmoplastic, 1005
Hypertrophic cardiomyopathy, 949-952, 950f Immunohistochemistry, 10-20 vs. supratentorial primitive neuroectodermal
differential diagnosis of, 953 introduction to, 10 tumor, 1012-1013
Hypertrophic gastropathy, 335f-336f quality application of, ground rules for, Infantile hemangioendothelioma, 440-441
Hypertrophic scar, vs. keloid, 112 11-12 Infantile (autosomal recessive) polycystic
Hyphal fungi, differential diagnosis of, 250t tabular approach to, 12 kidney disease, 512, 512f. See also
Hypocomplement urticarial vasculitis, vs. in differential diagnosis of hepatocellular Autosomal recessive polycystic kidney
immune complex small-vessel vasculitis, carcinoma, 15t disease.
981 in differential diagnosis of Hodgkin Infarct
Hypoganglionosis, vs. Hirschsprung disease, lymphoma, 19t cerebral, 1036-1038, 1037f
362 in differential diagnosis of uterine cervix prostatic, 542-543, 542f
Hypophysitis, vs. pituitary adenoma, 1029 lesions, 17t splenic
in FISH analysis of molar pregnancy, 17t vs. abscess, 832
I of atypical glandular proliferative prostate vs. amyloidosis, 834
Iatrogenic lung disease, 240 lesions, 18t vs. cytomegalovirus infection, 830
Idiopathic pulmonary arterial hypertension, of cytokeratins 7 and 20, 13t vs. hematoma, 835
243, 244t of endocervical adenocarcinoma and vs. sickle cell disease, 809
Idiopathic thrombocytopenic purpura, 811, endometrioid adenocarcinoma, 16t Infection(s). See also specific infection.
811f of gastrointestinal and abdominal spindle in prosthetic heart valves, 963
vs. autoimmune hemolytic anemia, cell tumors, 15t Infectious (acute self-limited) colitis, 372, 375
810-811 of germ cell tumors, 17t vs. inflammatory bowel disease, 368
IgA nephropathy (Berger disease) of lung adenocarcinoma and breast Infectious cystitis, 490
immunofluorescence patterns in, 7t adenocarcinoma, 14t Infectious esophagitis, 313f
vs. immune complex small-vessel vasculitis, of lung mesothelioma and vs. inflammatory esophagitis, 315
981 adenocarcinoma, 14t vs. injurious esophagitis, 314
Ileal pouches, biopsy of, 369 of metaplastic carcinoma, phyllodes vs. reflux esophagitis, 317
Ileum tumor, and breast fibromatosis, vs. squamous papilloma/carcinoma, 326
biopsy of, 369 14t Infectious granuloma, 68, 83
carcinoid tumor of, 360f-361f of myoepithelial and basal cells in breast Infectious granulomatous synovitis, vs. gout,
Immature squamous metaplasia lesions, 15t 884
vs. cervical intraepithelial neoplasia, 620 of ovarian and colorectal carcinoma, 16t Infectious mononucleosis, 748-750, 749f
vs. vaginal intraepithelial neoplasia, 612 of ovarian sex cordstromal tumors and splenic involvement in, 828-829, 829f
Immature teratoma, 681-682, 681f endometrioid adenocarcinoma, 16t vs. autoimmune lymphoproliferative
vs. mature cystic teratoma, 675 of papillary thyroid carcinoma vs. syndrome, 754
vs. mature solid teratoma, 676 follicular thyroid adenoma, 19t vs. follicular lymphoid hyperplasia, 747
Immune complex small-vessel vasculitis, of pleomorphic cutaneous spindle cell vs. HIV-associated lymphadenopathy, 748
980-981 tumors, 19t vs. nodular sclerosing Hodgkin lymphoma,
Immunocompetent hosts of primary and metastatic ovarian 772
campylobacteriosis in, 349-350 adenocarcinoma, 16t Infectious myocarditis, vs. cardiac sarcoidosis,
cholera in, 349-350 of primary metastatic carcinoma sites, 958
enteric infections in, 348f 13t Infectious panniculitis, vs. erythema nodosum,
Escherichia coli infection in, 347-350, 348f of prostate vs. urothelial carcinomas, 18t 80
salmonellosis in, 349-350 of renal cell neoplasms, 18t Infective endocarditis, 962-963, 962f
shigellosis in, 349-350 of serous carcinoma and poorly Infertility, male, 562-563, 562f
yersiniosis in, 349-350 differentiated endometrioid Infiltrating carcinoma, vs. atypical polypoid
Immunocompromised patients adenocarcinoma of ovary and adenomyoma, 637
adenovirus infection in, 352-353 endometrium, 16t Infiltrating ductal carcinoma, 723-725, 724f,
AIDS-related enteropathy in, 352-354 of small B-cell lymphoma, 19t 724t
aspergillosis in, 352-353 of small round cell tumors, 19t vs. fat necrosis, 704
candidiasis in, 352-353 of trophoblastic lesions, 17t vs. infiltrating lobular carcinoma, 726
coccidiosis in, 352-353 of undifferentiated tumors, 12t vs. medullary carcinoma, 728
cytomegalovirus infection in, 351f, 352-353 technical overview of, 10-11, 11f-12f vs. pancreatitis, 447
enteric infections in, 352f Impetigo, bullous, vs. subcorneal pustular Infiltrating lobular carcinoma, 725-726, 725f
giardiasis in, 351f, 352-353 dermatosis, 74 vs. adenosis, 710
Index 1087

Inflammation, autoimmune, Addison disease Intestinal adenocarcinoma, vs. intestinal Juvenile adenoma
due to, 462f carcinoid, 361 vs. juvenile breast hypertrophy, 705-706
Inflammatory bowel disease, 366f-367f. See also Intestinal atresia, 346-347 vs. phyllodes tumor, 717-718
Crohn disease; Ulcerative colitis. Intestinal ganglioneuromatosis, 391f, 394 Juvenile granulosa cell tumor, 669
dysplasia in, 370f Intestinal neuronal dysplasia, vs. Hirschsprung vs. adult granulosa cell tumor, 669
vs. amebiasis, 377 disease, 362-363 vs. embryonal carcinoma, 680
vs. colitis, 376 Intraductal papillary mucinous neoplasm vs. yolk sac tumor, 568
vs. diverticular disease, 363 of exocrine pancreas, 450-451, 451f Juvenile hemangioendothelioma, vs. hepatic
vs. enteric infections, 350 vs. mucinous cystic neoplasms, 450 hemangioma, 440
Inflammatory carcinoma, of breast, 736, 736f vs. pancreatic intraepithelial neoplasia, 452 Juvenile hemangioma, 157
Inflammatory dermatoses, vs. urticaria vs. serous cystic neoplasms, 449 vs. angiolipoma, 913
pigmentosa, 117 Intraductal papillary neoplasia, of liver, 434- Juvenile hypertrophy, of breast, 705-706, 705f
Inflammatory esophagitis, 315-316 435, 435f Juvenile laryngeal papilloma, vs. vocal cord
Inflammatory myofibroblastic tumor, 900-901, Intraductal papilloma nodule or polyp, 209
901f of breast, 711-713, 711f Juvenile laryngotracheal papillomatosis,
of lungs, 272-274, 273f vs. cystadenoma, 157 diagnostic features of, 259t
of spleen, 824-825, 824f Intraepithelial neoplasia Juvenile nephronophthisis, familial, 513-514
vs. diffuse large B-cell lymphoma, 803 prostatic, 545-546, 546f. See also Prostatic Juvenile polyposis syndrome, 390f, 392-393
vs. hamartoma, 824 intraepithelial neoplasia. sporadic, 394
vs. Hodgkin lymphoma, 804 vulvar, 602-603, 603f. See also Vulvar Juvenile xanthogranuloma, disseminated, vs.
of urinary bladder, 508, 508f intraepithelial neoplasia. Langerhans cell histiocytosis, 816
vs. carcinosarcoma, 510 Intraepithelial squamous neoplasia, of anal Juxtacortical chondrosarcoma, vs. periosteal
vs. rhabdomyosarcoma, 509 canal, 402-403, 402f chondroma, 851
vs. calcifying fibrous pseudotumor, 900 Intramedullary osteosarcoma, conventional, Juxtaglomerular cell tumor, 533
vs. cardiac fibroma, 966 841-843, 841f
vs. gastrointestinal stromal tumor, 399 vs. low-grade surface osteosarcoma, 847 K
vs. rhabdomyosarcoma, 921 vs. osteofibrous dysplasia, 865 Kamino bodies, 101-103
vs. soft tissue leiomyosarcoma, 923 vs. periosteal osteosarcoma, 846 Kaposi sarcoma, 107-108, 108f
Inflammatory polyp vs. telangiectatic osteosarcoma, 844 classic, 107
fibroid Intramuscular hemangioma, 930 endemic, 107
of esophagus, 322, 322f Intravascular papillary endothelial hyperplasia, epidemic, 107
of stomach, 338 vs. angiosarcoma, 109 iatrogenic immunosuppression, 107
gastrointestinal, 383-384 Intussusception, 346-347 penile, 592
vs. sinonasal (Schneiderian) papilloma, 180 Invader chemistry assay, 31 vs. angiolipoma, 913
Inflammatory pseudotumor. See Inflammatory Invasive adenocarcinoma, vs. vs. angiosarcoma, 109
myofibroblastic tumor. bronchioloalveolar carcinoma, 264 vs. hemangioendothelioma, 934
Infundibular cyst, 81-83, 82f Invasive ductal adenocarcinoma vs. hemangioma, 106, 930-931
Inguinal lymph node of exocrine pancreas, 453f vs. infection in immunocompromised
capsular fibrosis of, vs. syphilis, 750 vs. pancreatic intraepithelial neoplasia, 452 patients, 354
sclerosis in, vs. amyloidosis, 763 vs. pancreatic metastases, 459 vs. nasopharyngeal angiofibroma, 178
Injurious esophagitis, 314 vs. solid pseudopapillary neoplasm, 459 vs. nodular fasciitis, 890
Inlet patch, in cervical esophagus, 310, 310f vs. well-differentiated pancreatic neoplasm, vs. oral pyogenic granuloma, 195
vs. Barrett esophagus, 319 457 vs. postmastectomy angiosarcoma, 741
Insect bite reactions (papular urticaria), 55f Invasive fungal sinusitis, 175, 175f vs. splenic angiosarcoma, 821
vs. lymphomatoid papulosis, 57 Invasive intraductal adenocarcinoma, vs. Kaposiform hemangioendothelioma, 933-934
vs. pityriasis lichenoides, 56 acinar cell carcinoma, 455 Kawasaki disease, 975-976
Insular cell carcinoid tumor, of appendix, 407, Invasive urothelial carcinoma, 502-504, 502f differential diagnosis of, 976
407f Inverted papilloma Keloid, 111-112, 111f
Interface dermatitis, 44-45, 55 sinonasal, 179 Keratoacanthoma
Intermediate-type cells, in mucoepidermoid urothelial, 499-500, 500f vs. squamous cell carcinoma, 86, 87f
carcinoma, 165 vs. invasive urothelial carcinoma, 504 vs. verrucae, 85
Interstitial cell tumor, renomedullary, 532, 532f vs. papillary urothelial carcinoma, 490 Keratocyst, odontogenic, 199-200, 199f
Interstitial (Hunner) cystitis, 493-494 Iridocorneal endothelial syndrome, 1060 vs. dentigerous cyst, 198
vs. bacterial cystitis, 490 Iris freckle (ephelis), 1060 vs. radicular cyst, 197
Interstitial emphysema, 226 Iris leiomyoma, 1060 Keratosis
Interstitial pneumonia, 226-227 Iris melanoma, 1059-1060, 1059f actinic, 85-86, 86f
acute, 226-227, 226f Iris nevus, 1059-1060 follicular
clinical, radiologic, and prognostic features Ischemic cerebral infarcts, 1036-1038 vs. squamous cell carcinoma, 87
of, 227t Ischemic colitis, 373, 373f, 375 vs. trichilemmoma, 90
desquamative, 231-232, 231f vs. enteric infections, 350 lichenoid, 45
vs. cryptogenic organizing pneumonia, Ischemic fasciitis, 892-893, 892f seborrheic, 45-46, 83f
228 vs. poroma, 93
lymphoid, 232-233, 232f J Keratosis follicularis, vs. pemphigus, 75
vs. hypersensitivity pneumonitis, 234 Jaw Kidney(s), 511-512. See also Neph-; Renal
nonspecific, 230-231, 230f. See also osteoblastoma of, vs. cementoblastoma, 203 entries.
Nonspecific interstitial pneumonia. osteosarcoma of, 205-206, 206f acquired cystic disease of, 515-516, 515f
unusual, 228-230, 229f. See also Unusual Joint disease, 882-883. See also specific disease. adult (autosomal dominant) polycystic
interstitial pneumonia. Jones silver stain, 4, 5f disease of, 514-515, 514f
1088 Index

Kidney(s) (Continued) Laryngotracheal papillomatosis, juvenile, Leishmaniasis, 70f, 414


angiomyolipoma of, 517-518, 517f diagnostic features of, 259t American cutaneous, 70
carcinoma of. See specific neoplasm. Larynx, 208-209 Oriental cutaneous, 71
infantile (autosomal recessive) polycystic amyloidosis of, 210-211, 210f vs. malaria, 831
disease of, 512, 512f neuroendocrine carcinoma of, 213-214, Lentigo maligna melanoma, 103
interstitial cell tumor and fibroma of, 532, 213f Lepromatous leprosy, 68
532f papilloma of, 209-210, 210f Leprosy, 68f
medullary cystic disease of, 513-514 squamous cell carcinoma of, 211-213, borderline, 68
medullary sponge, 513, 513f 211f-212f lepromatous, 68
metanephric adenoma of, 519-520, 519f vocal cord nodule or polyp of, 208-209, tuberculoid, 68
mixed epithelial and stromal tumor of, 531- 209f vs. sarcoidosis, 67
532, 531f Laser capture technology, 25, 25f vs. Mycobacterium avium-intracellulare
oncocytoma of, 520-521, 520f Leder stain, 6 infection, 830
papillary adenoma of, 518-519, 518f Legionella pneumonia, 246-247 Letterer-Siwe disease, 117, 765, 816
Kikuchi-Fujimoto disease. See Histiocytic Leiomyoblastoma, 394-395 Leukemia
necrotizing lymphadenitis (Kikuchi- Leiomyoma acute
Fujimoto disease). cutaneous, 109-110, 110f vs. chronic myelogenous leukemia, 816
Klatskin tumor. See Cholangiocarcinoma metastasizing, vs. vs. extramedullary hematopoiesis, 807
(Klatskin tumor). lymphangioleiomyomatosis, 272 acute myeloid. See Acute myeloid leukemia.
Koebner phenomenon, 45 mitotically active, vs. myometrial vs. diffuse large B-cell lymphoma, 779
Krukenberg tumor, vs. ovarian malignant leiomyosarcoma, 646 vs. Langerhans cell histiocytosis,
mucinous tumor, 660 myometrial, 643-645, 644f 816-817
Kufs disease, vs. dementia, 1049 variants of, 645 chronic lymphocytic. See Chronic
of colonic muscularis mucosae, 395f lymphocytic leukemia/small
L of iris, 1060 lymphocytic lymphoma.
Lactating adenoma, vs. secretory carcinoma, paratesticular, 579-580 chronic myelogenous, 815-816, 815f
733 prostatic, vs. phyllodes tumor, 556 vs. hairy cell leukemia, 813
Lambl excrescences, vs. papillary fibroblastoma, soft tissue, 921-922, 922f T-cell large granular lymphocytic, vs. splenic
967 uterine, 643-645 marginal zone lymphoma, 798
Langerhans cell histiocytosis, 117-118, 117f, vs. cutaneous leiomyosarcoma, 111 vs. Ewing sarcoma, 873
765-766, 765f vs. deep benign fibrous histiocytoma, 910 vs. medulloblastoma, 1011
Birbeck granules in, 9f vs. fallopian adenomatoid tumor, 691 Leukemic infiltration, vs. congestive
lymph node, 765-766, 765f vs. inflammatory myofibroblastic tumor, splenomegaly, 827
pulmonary, 277-278, 277f 901 Leukocytoclastic vasculitis, 71-72, 71f
splenic, 816-817 vs. orbital rhabdomyosarcoma, 1070 vs. Sweet syndrome, 59
vs. dermatopathic lymphadenopathy, 752 vs. paratesticular fibrous pseudotumor, 579 Leukodystrophies, vs. demyelinating diseases,
vs. lymphoma, 875 vs. perivascular epithelioid cell tumor, 947 1046
vs. malakoplakia, 491 vs. pulmonary hamartoma, 271 Leukoencephalitis, acute hemorrhagic, 1046
vs. mast cell disease, 762 vs. renomedullary interstitial cell tumor, Leukoencephalopathy, progressive multifocal,
vs. Mycobacterium avium-intracellulare 532 1044-1045, 1044f
infection, 830 vs. schwannoma, 307, 925 vs. demyelinating diseases, 1046
vs. Rosai-Dorfman disease, 764 vs. soft tissue leiomyosarcoma, 923 Leukoplakia, of oral cavity, 193-194, 193f
vs. unusual interstitial pneumonia, 230 Leiomyomatosis, intravenous, vs. endometrial Lewy body dementia, 1045, 1048
vs. urticaria pigmentosa, 117 stromal sarcoma, 641 Leydig cell tumor
vs. xanthogranuloma, 62 Leiomyosarcoma ovarian, 674, 674f
Large airway disease, obstructive, 222 cutaneous, 110-111, 111f testicular, 571-572, 571f
Large B-cell lymphoma fallopian tube, 693 vs. Leydig cell hyperplasia, 571
diffuse. See Diffuse large B-cell lymphoma. myometrial, 646 Libman-Sacks endocarditis, vs. infective
vs. lymphoblastic lymphoma, 298 paratesticular, 579-580, 580f endocarditis, 963
Large cell lung carcinoma, 268-269, 268f penile, 593 Lichen nitidus, 45
Large cell lymphoma prostatic, vs. phyllodes tumor, 556 Lichen planopilaris, vs. alopecia areata, 45
vs. infectious mononucleosis, 749, 829 soft tissue, 923-924, 923f Lichen planus, 44, 44f
vs. lymphoepithelial carcinoma, 171 vaginal, 616 in inflammatory esophagitis, 315
vs. mediastinitis, 294 vs. endometrial stromal nodule, 640 vs. balanitis xerotica obliterans, 587
vs. neuroendocrine thymic tumor, 293 vs. endometrial stromal sarcoma, 642 vs. cutaneous lupus erythematosus, 48
Large cell neuroendocrine carcinoma, 268-269 vs. inflammatory myofibroblastic tumor, vs. graft-versus-host disease, 47
vs. carcinoid tumor, 270 508, 901 vs. leukoplakia, 193
Large cell undifferentiated carcinoma, vs. vs. leiomyoma, 110 vs. lichen sclerosus, 599
lymphoepithelial carcinoma, 171 vs. lymphangioleiomyomatosis, 272 Lichen sclerosus
Large granular lymphocytic leukemia vs. malignant fibrous histiocytoma, 911 of vulva, 599, 599f
vs. hepatosplenic T-cell lymphoma, 814 vs. malignant peripheral nerve sheath vs. morphea and scleroderma, 79
vs. mast cell disease, 815 tumor, 929 Lichen simplex chronicus
Large intestine, 345-347. See also specific part. vs. myometrial leiomyoma, 645 of vulva, 600
adenoma and adenocarcinoma of, 386-389, vs. orbital rhabdomyosarcoma, 1070 vs. balanitis xerotica obliterans, 587
387f vs. perivascular epithelioid cell tumor, 947 vs. condyloma acuminatum, 602
carcinoid tumors of, 360-362 vs. placental site trophoblastic tumor, 699 vs. spongiotic dermatitis, 51
metastatic disease to, 409-410 vs. soft tissue leiomyoma, 922 Lichen striatus, 45
Large-vessel vasculitis, 973-975, 973f-974f vulvar, 609 Lichenoid drug eruption, 45
Index 1089

Lichenoid keratosis, benign, 45 Livedo vasculitis, vs. leukocytoclastic vasculitis, Lymphadenitis


Ligase chain reaction (LCR), 30 72 bacterial
Light microscopy, 2-7 Liver. See also Hepatic; Hepato- entries. vs. CMV/herpes lymphadenitis, 756
fixation in, 2-3 alcoholic disease of, 415-416 vs. histiocytic necrotizing lymphadenitis,
histologic stains in, 3-6, 4f-7f cirrhosis of. See Cirrhosis. 757
tissue processing overview in, 2 drug-induced disease of, 414-415 cytomegalovirus, 756-757
Line immunoassay (LIA), 37 fatty. See Fatty liver disease. fungal, vs. histiocytic necrotizing
Linear IgA dermatosis, vs. dermatitis focal nodular hyperplasia of, 426-427, lymphadenitis, 758
herpetiformis, 77 426f herpes, 756-757
Lipids, histologic staining of, 4 inflammatory disease of. See Hepatitis entries. histiocytic necrotizing. See Histiocytic
Lipoblastoma, 914, 914f intraductal papillary neoplasia of, 434-435, necrotizing lymphadenitis (Kikuchi-
vs. fibrous hamartoma of infancy, 895 435f Fujimoto disease).
vs. lipofibromatosis, 896 nonviral infections of, 413-414 luetic. See Syphilis.
vs. myxoid and round cell liposarcoma, Liver flukes, 414 lupus, vs. histiocytic necrotizing
916 Liver transplantation, pathology of, 424-425, lymphadenitis, 757
Lipoblastomatosis, 914 424f suppurative, vs. cat-scratch disease, 756
Lipodermoid, vs. conjunctival squamous cell Lobar emphysema, congenital, 221-222 Toxoplasma. See Toxoplasma lymphadenitis.
carcinoma, 1054 Lobar mastitis, granulomatous, 703, 703f tuberculous. See Tuberculous lymphadenitis.
Lipodystrophy, vs. subcutaneous fat necrosis, Lobular carcinoma in situ, 722-723, 722f Lymphadenoma
81 Lobular hyperplasia, of breast, atypical, 722- sebaceous, of salivary glands, 159, 159f
Lipofibromatosis, 895-896, 896f 723, 722f vs. Warthin tumor, 155
vs. fibrous hamartoma of infancy, 895 Loeys-Dietz syndrome, 983, 985 Lymphadenopathy
vs. lipoblastoma/lipoblastomatosis, 914 Lung(s). See also Pulmonary; Respiratory dermatopathic, 752, 752f
vs. pleomorphic lipoma, 914 entries. HIV-associated, 747-748, 747f
Lipogranuloma bacterial infections of, 246-249 vs. Castleman disease, 760
sclerosing, vs. paratesticular liposarcoma, fungal infections of, 249 vs. follicular hyperplasia, 747
581 hemorrhagic diseases of, 237 vs. infectious mononucleosis, 749
splenic, 833 iatrogenic diseases, 240 vs. lymphoma, 172
Lipoid congenital adrenal hyperplasia, 463, infectious diseases, 245 vs. syphilis, 750
463f neoplastic conditions of, 258-260 vs. Toxoplasma lymphadenitis, 751
Lipoma benign epithelial tumors as, 259t massive, sinus histiocytosis with, 763-765,
paratesticular, 577 lymphoproliferative disorders as, 275 763f
pleomorphic, 913-914, 913f malignant epithelial tumors as, 261 Lymphangiectasia, 379-380
vs. liposarcoma/lipomatous tumor, 915 malignant mesothelioma as, 279-280 artifact mimicking, 380f
vs. myxoid and round cell liposarcoma, mesenchymal tumors as, 270 vs. pneumatosis intestinalis, 381
916 preinvasive epithelial lesions as, 258 Lymphangioleiomyomatosis, 271-272, 271f
vs. pleomorphic liposarcoma, 917 non-neoplastic conditions of, 218-219 Lymphangioma, 935-936, 936f
soft tissue, 911-912, 911f pediatric and congenital, 218 orbital, 1067-1068, 1067f
spindle cell, 913-914 obstructive diseases of vs. fallopian adenomatoid tumor, 691
vs. liposarcoma/lipomatous tumor, 915 large airway, 222 vs. lymphangiectasia, 380
vs. myxoid and round cell liposarcoma, small airway, 224 vs. myometrial adenomatoid tumor, 647
916 restrictive and interstitial diseases of, 226 vs. oral pyogenic granuloma, 195
vs. myelolipoma, 482 transplantation of, 257-258 vs. salivary hemangioma, 157
vs. paratesticular liposarcoma, 581 rejection in, 257f vs. serous cystic neoplasm, 449
vs. pulmonary hamartoma, 271 grading scheme for, 258t vs. splenic hemangioma, 818
vs. thymolipoma, 286 vascular conditions of, 242 vs. thymic cyst, 282
Lipomatous tumor, atypical, 915 viral infections of, 245-246 Lymphoblastic lymphoma
Liposarcoma Lupus erythematosus mediastinal, vs. diffuse large cell lymphoma,
dedifferentiated, 917-918, 918f cutaneous, 48, 49f 296
vs. pleomorphic liposarcoma, 917 systemic. See Systemic lupus erythematosus. mediastinal, 297-298, 297f
karyotype analysis of, 21f Lupus lymphadenitis, vs. histiocytic necrotizing vs. neuroblastoma, 306
myxoid. See Myxoid liposarcoma. lymphadenitis, 757 vs. thymoma, 289
paratesticular, 580-581 Lupus vulgaris, 69 nodal
pleomorphic, 917, 917f Luteinized thecoma vs. Burkitt lymphoma, 783-784
vs. malignant fibrous histiocytoma, 911 vs. pregnancy luteoma, 652 vs. diffuse large B-cell lymphoma, 779
vs. pleomorphic lipoma, 914 vs. stromal hyperthecosis, 650 vs. myeloid sarcoma, 789
sclerosing, vs. sclerosing epithelioid sarcoma, Luteoma vs. paracortical hyperplasia, 759
907 pregnancy, 651-652, 652f Lymphocytes, predominant in dermatitis with
spindle cell, vs. fibrosarcoma, 906 vs. thecoma, 667 minimal epidermal changes, 54-55
vs. chordoma, 878 stromal, ovarian, 673 Lymphocytic colitis, 373-375, 374f
vs. paratesticular lipoma, 577 Luxol fast blue stain, 6, 6f vs. inflammatory bowel disease, 368
well-differentiated, 21f, 915 Lymph node(s) Lymphocytic enterocolitis, vs. celiac sprue,
vs. lipoma, 912 follicular hyperplasia of. See Follicular 357
vs. spindle cell/pleomorphic lipoma, lymphoid hyperplasia. Lymphocytic gastritis, 334
913-914 inguinal. See Inguinal lymph node. associated with Mntrier disease, 336f
Littoral cell angioma, 818-819, 819f myeloid sarcoma in, 789f vs. MALT lymphoma, 345
vs. splenic hamartoma, 824 scarring of, vs. amyloidosis, 763 Lymphocytic hypophysitis, vs. pituitary
vs. splenic hemangioma, 818 tuberculosis in, 766f adenoma, 1029
1090 Index

Lymphocytic infiltrate, atypical, vs. small cell Lymphoma (Continued) Malaria


lung carcinoma, 266 of salivary gland, 171-172, 172f hepatic involvement in, 414
Lymphocytic myocarditis, 954-955, 954f of small intestine, 399f-400f splenic involvement in, 831
differential diagnosis of, 955-956 of stomach, 344-345, 344f vs. Mycobacterium avium-intracellulare
Lymphocytic thyroiditis, nonspecific, vs. of testis, 575-576, 575f infection, 830
chronic lymphocytic thyroiditis, 124 of thyroid gland, 141-142, 141f vs. sickle cell disease, 810
Lymphocytosis, reactive, vs. CNS lymphoma, vs. thyroid teratoma, 130 Male breast, carcinoma of, 742-743, 742f
1025 vs. undifferentiated thyroid carcinoma, Male infertility, 562-563, 562f
Lymphoepithelial carcinoma 141 Malignancy-associated vasculitis, vs. immune
epithelial component of, 171 sclerosing, vs. sclerosing epithelioid sarcoma, complex small-vessel vasculitis, 981
lymphoid component of, 171 907 Malignant cylindroma, 94
of salivary glands, 170-171, 171f small lymphocytic. See Small lymphocytic Malignant fibrous histiocytoma
vs. Mikulicz disease, 149 lymphoma/chronic lymphocystic giant cell, vs. giant cell tumor of tendon
Lymphoepithelial cyst, 149-150, 149f disease. sheath, 909
in HIV patients, vs. Warthin tumor, 155 T-cell. See T-cell lymphoma. inflammatory, vs. inflammatory
of pancreas, 448, 448f vs. adrenal neuroblastoma, 479 myofibroblastic tumor, 901
of salivary glands, 149-150, 149f vs. astrocytic tumors, 991 osseous, 868-869, 868f
vs. mucocele, 151 vs. cervical small cell carcinoma, 628 soft tissue, 910-911, 910f
vs. sialadenitis, 148 vs. congestive splenomegaly, 827 vs. aggressive angiomyxoma, 609
Lymphoepithelial lesions, benign (Mikulicz vs. cutaneous lupus erythematosus, 48-49 vs. dedifferentiated chondrosarcoma, 856
disease), 148-149, 148f vs. dysgerminoma, 677 vs. dedifferentiated liposarcoma, 918
vs. sialadenitis, 148 vs. Ewing sarcoma, 873 vs. deep benign fibrous histiocytoma, 910
Lymphogranuloma venereum, vs. cat-scratch vs. Ewing sarcoma/peripheral vs. embryonal (undifferentiated) sarcoma,
disease, 756 neuroectodermal tumor, 943 444
Lymphoid hyperplasia vs. follicular splenic hyperplasia, 792-793 vs. fibrosarcoma, 867
orbital, 1062-1063, 1062f vs. gastric carcinoid, 344 vs. gastrointestinal stromal tumor, 398
rectal, 401f vs. hypercalcemic small cell carcinoma, 686 vs. giant cell reparative granuloma, 871
Lymphoid infiltrate, in red pulp, vs. vs. infiltrating lobular carcinoma, 726 vs. osteosarcoma, 843
extramedullary hematopoiesis, 807 vs. invasive urothelial carcinoma, 504 vs. pleomorphic liposarcoma, 917
Lymphoid interstitial pneumonia, 232-233, vs. medulloblastoma, 1011 vs. reticulocytic granuloma, 63
232f vs. Merkel cell carcinoma, 116 vs. soft tissue leiomyosarcoma, 923
vs. hypersensitivity pneumonitis, 234 vs. noninfectious cystitis, 492 vs. splenic angiosarcoma, 821
vs. mucosa-associated lymphoid tissue vs. olfactory neuroblastoma, 188 vs. vulvar leiomyosarcoma, 609
(MALT) lymphoma, 276 vs. orbital pseudotumor, 1064 Malignant histiocytosis, vs. Langerhans cell
vs. nonspecific interstitial pneumonia, 231 vs. rhabdomyosarcoma, 921 histiocytosis, 817
Lymphoid papulosis vs. seminoma, 564 Malignant melanoma, 103-105, 104f
vs. cutaneous CD30-positive T-cell vs. sinonasal melanoma, 190 amelanotic
lymphoma, 120 vs. squamous cell carcinoma, 507 vs. cervical squamous cell carcinoma,
vs. pityriasis lichenoides, 56 vs. testicular malakoplakia, 560-561 623
Lymphoma vs. thymic carcinoma, 292 vs. vaginal squamous cell carcinoma,
anaplastic large cell. See Anaplastic large cell vs. thymoma, 289 613
lymphoma. with necrosis, vs. tuberculous lymphadenitis, vs. vulvar squamous cell carcinoma, 604
Burkitt. See Burkitt lymphoma. 767 intraocular, 1056-1058, 1056f
diffuse large B-cell. See Diffuse large B-cell Lymphomatoid granulomatosis, 979 of adrenal gland, 478f, 480-481
lymphoma. Lymphomatoid papulosis, 57f vs. metastatic malignant melanoma, 485
extranodal NK/T-cell, 191-192, 191f Lymphomatous polyposis, of colon, 397f of conjunctiva, 1052, 1052f
follicular. See Follicular lymphoma. Lymphoplasmacytic lymphoma of esophagus, 327-328
Hodgkin. See Hodgkin lymphoma. vs. nodal marginal zone lymphoma, 777 differential diagnosis of, 328
lymphoblastic. See Lymphoblastic vs. small lymphocytic lymphoma, 775 of iris, 1059-1060, 1059f
lymphoma. Lymphoproliferative disorders of vulva, 605
lymphoplasmacytic Epstein-Barr virusassociated, 979 superficial spreading, vs. extramammary
vs. nodal marginal zone lymphoma, 777 post-transplant, 278-279, 278f Paget disease, 607
vs. nodal small lymphocytic lymphoma, pulmonary, 275. See also specific disorder. vs. acquired melanocytic nevi, 103
775 vs. autoimmune lymphoproliferative vs. anal adenocarcinoma, 404
mantle cell. See Mantle cell lymphoma. syndrome, 796 vs. epithelioid hemangioendothelioma, 441
marginal zone. See Marginal zone vs. common variable immunodeficiency, 795 vs. epithelioid sarcoma, 941
lymphoma. Lynch syndrome, 388 vs. ganglioneuroblastoma/ganglioneuroma,
mucosa-associated lymphoid tissue. See Lysosomes, electron microscopy of, 9, 9f 306
Mucosa-associated lymphoid tissue vs. metastatic thyroid tumors, 142
(MALT) lymphoma. M vs. neuroendocrine carcinoma, 214
non-Hodgkin. See Non-Hodgkin lymphoma. Majocchi granuloma, vs. acne vulgaris, 78 vs. neuroendocrine thymic tumor, 293
of bone/joints, 874-875, 874f Malakoplakia vs. nonseminomatous germ cell tumors,
of central nervous system, 1024-1025, of prostate gland, 540-542 304
1024f of testis, 560-561, 561f vs. Paget disease of nipple, 737
vs. vasculitis, 1039-1040 of urinary bladder, 491, 491f vs. reticulocytic granuloma, 63
of esophagus, vs. small cell carcinoma, 328 vs. orchitis, 560 vs. scrotal Paget disease, 595
of orbit, 1062-1063 vs. xanthogranulomatous pyelonephritis, Malignant mixed germ cell tumor, ovarian,
of prostate gland, 557-558 517 684, 684f
Index 1091

Malignant mixed mesodermal tumor Mastitis Melanocytoma, choroidal, vs. intraocular


endometrial, 638-639 granulomatous lobar, 703, 703f malignant melanoma, 1058
vs. immature teratoma, 682 plasma cell, 702-703, 702f Melanoma
Malignant mixed mllerian tumor. See also Mastocytosis. See Mast cell disease. amelanotic, vs. ciliary body adenoma, 1059
Carcinosarcoma. Mastopathy, diabetic, 704-705, 705f malignant. See Malignant melanoma.
ovarian, 662-663, 662f Matrical carcinoma, vs. pilomatricoma, 89 metastatic. See Metastatic melanoma.
vs. endometrioid adenocarcinoma, 661 Mature cystic teratoma, ovarian, 674-675, 675f sinonasal, 189-190, 190f
vs. Sertoli-Leydig cell tumor, 672 Mature solid teratoma vs. olfactory neuroblastoma, 188
Malignant mucinous tumor, ovarian, 658f- ovarian, 675-676, 676f spindle cell, vs. inflammatory myofibroblastic
659f, 660-661 vs. immature teratoma, 682 tumor, 901
Malignant nodular hidradenoma, vs. clear cell Maxillary sinus, squamous cell carcinoma of, Melanosis, primary acquired, of conjunctiva,
hidradenoma, 95 181f 1052-1053, 1053f
Malignant peripheral nerve sheath tumor, 928- May-Grnwald stain, 6 Melanosis coli, 381-382, 381f
929, 928f, 1018-1019 MayoAccess Test Catalog, 28-30, 36 Membrane immunochromatographic tests, 37
vs. clear cell sarcoma, 946 Mechanical heart valves, 963 Membranoproliferative glomerulonephritis,
vs. epithelioid sarcoma, 941 Meckel diverticulum, 346-347, 346f immunofluorescence patterns in, 7t
vs. fibrosarcoma, 906 Mediastinal cyst, vs. bronchogenic cyst, 221 Membranous glomerulopathy,
vs. infantile fibrosarcoma, 905 Mediastinitis, chronic, 294 immunofluorescence patterns in, 7t
vs. neurofibroma, 927 Mediastinum Mntrier disease, 335f-336f, 336
vs. schwannoma, 925 diffuse large B-cell lymphoma of, 296-297, differential diagnosis of, 337
vs. soft tissue leiomyosarcoma, 923 296f Meningeal hyperplasia, vs. meningioma, 1021
vs. synovial sarcoma, 940 foregut cysts of, 283-284, 283f Meningioma, 1020-1022, 1020f
Malignant primary tumor, pericardial, germinoma (seminoma) of, 301-302, 302f anaplastic, 1021
971-972 Hodgkin lymphoma of, 294-295, 295f vs. secondary CNS tumor, 1034
Malignant serous tumor, ovarian, 654f-655f, lymphoblastic lymphoma of, 297-298, 297f atypical, 1021
656-657 metastatic tumors of, 308 choroid
Malrotation, intestinal, 345-347 neurogenic tumors of, 305-307, 305f, vs. chordoma, 1033
MammPrint test, 36 306t-307t vs. choroid glioma, 1003
Mantle cell lymphoma nonseminomatous germ cell tumors of, 303- classic, 1020-1021
flow cytometry and, 1 305, 303f-304f papillary
nodal, 775-776, 776f schwannoma of, 307-308 vs. astroblastoma, 1003
vs. follicular lymphoma, 769-770 teratoma of, 300-301, 300f-301f vs. papillary glioneuronal tumor, 1009
vs. marginal zone lymphoma, 777 with additional malignant components, vs. hemangioblastoma, 1024
vs. paracortical hyperplasia, 759 301 vs. hemangiopericytoma, 1022-1023
vs. small lymphocytic lymphoma, 775 Medium-vessel vasculitis, 975-976 vs. peripheral nerve sheath tumor, 1019
small intestinal, 399f-400f, 400 Medullary breast carcinoma, 727-728, 728f Meningoencephalitis, 1041-1044,
splenic, 800-801 Medullary cystic kidney disease, 513-514 1041f-1042f
morphologic and immunophenotypic vs. autosomal recessive polycystic kidney Menstruation, vs. acute endometritis, 629
features of, 797t disease, 512 Mercurials, used in fixation, 2
vs. chronic lymphocytic leukemia and vs. medullary sponge kidney, 513 Merkel cell carcinoma, 115-116, 115f
small lymphocytic lymphoma, 799 vs. renal dysplasia, 511 Mesenchymal chondrosarcoma, 857-858,
vs. follicular lymphoma, 802 Medullary pancreatic carcinoma, 454 857f
Marfan syndrome, 983, 984f, 985 Medullary sponge kidney, 513, 513f vs. dedifferentiated chondrosarcoma, 856
elastin/Alcian blue stain and, 4, 4f vs. autosomal recessive polycystic kidney vs. lymphoma, 875
Marginal zone hyperplasia, splenic, 793f disease, 512 Mesenchymal hamartoma, 442-443, 443f
Marginal zone lymphoma vs. medullary cystic kidney disease, 514 vs. bile duct hamartoma, 432
nodal, 777 vs. renal dysplasia, 511-512 vs. embryonal (undifferentiated) sarcoma,
vs. follicular lymphoma, 770 Medullary thyroid carcinoma, 136-138, 137f 444
vs. mast cell disease, 762 vs. follicular thyroid adenoma, 132 vs. peribiliary duct hamartoma, 433
vs. small lymphocytic lymphoma, 775 vs. hyalinizing trabecular tumor, 131 Mesenchymal osteosarcoma, vs. Ewing
splenic, 796-798 vs. neuroendocrine thymic tumor, 293 sarcoma, 874
morphologic and immunophenotypic vs. papillary thyroid carcinoma, 136 Mesenchymal tumors. See also specific tumor.
features of, 797t vs. poorly differentiated thyroid carcinoma, gastrointestinal, 397f
vs. chronic lymphocytic leukemia and 139 pulmonary, 270
small lymphocytic lymphoma, vs. undifferentiated thyroid carcinoma, 140 Mesoblastic nephroma, 536, 536f
799 Medulloblastoma, 1010-1011, 1010f vs. clear cell sarcoma, 537
vs. follicular lymphoma, 802 vs. CNS lymphoma, 1025 vs. rhabdoid tumor, 538
vs. mantle cell lymphoma, 801 vs. secondary CNS tumor, 1034 vs. Wilms tumor, 535
vs. prolymphocytic leukemia, 800 vs. teratoid/rhabdoid tumor, 1013 Mesodermal stromal polyp
vs. hairy cell leukemia, 812 Medulloepithelioma, 1012-1013 of vagina, 610
Marjolin ulcer, 87. See also Squamous cell vs. ciliary body adenoma, 1059 vs. sarcoma botryoides, 616
carcinoma. Megakaryocyte(s), 11 Mesonephric-like cyst, vs. vulvar cyst, 601
Mass spectrometry, 38 Melanocytic neoplasms, vs. angiosarcoma, 109 Mesothelial cyst, 284
Masson trichrome stain, 4, 4f Melanocytic nevus(i) vs. foregut cyst, 284
Mast cell disease, 761-762, 761f, 814-815, acquired, 101-103, 102f vs. testicular hydrocele, 559
814f variants of, 101-103, 102f vs. vulvar cyst, 601
splenic, vs. hairy cell leukemia, 812 congenital, 100-101, 100f Mesothelial hyperplasia, reactive, vs.
vs. hairy cell leukemia, 812 vs. malignant melanoma, 105 mesothelioma, 280
1092 Index

Mesothelioma, 279, 279f Metastatic melanoma MicroRNA, 38


immunohistochemistry panel for, 14t amelanotic, vs. lymphoepithelial carcinoma, Microscopic polyangiitis, 977-978
of pericardium, 971 171 Microscopy
of tunica vaginalis, 582, 582f vs. dermatopathic lymphadenopathy, 752 electron, 8-10. See also Electron microscopy.
sarcomatoid, vs. pericardial fibrous tumor, vs. Langerhans cell histiocytosis, 766 fluorescence, 7-8, 7t
971 vs. malignant melanoma, 481 light, 2-7. See also Light microscopy.
variants of, 279-280 vs. Rosai-Dorfman disease, 764 Microsporidiosis, in immunocompromised
vs. fallopian adenomatoid tumor, 691 vs. splenic angiosarcoma, 821 patients, 352-353
vs. paratesticular adenomatoid tumor, 578 Metastatic small cell carcinoma Middle lobe syndrome, vs. bronchiectasis, 224
vs. primary malignant pericardial tumor, vs. lymphoma, 875 Migratory thrombophlebitis, 72-73, 72f
971 vs. Merkel cell carcinoma, 116 Mikulicz disease, 148-149, 148f
vs. pulmonary adenocarcinoma, 263 vs. paracortical hyperplasia, 759 vs. lymphoepithelial carcinoma, 171
Metabolic cardiomyopathy, 950, 953 vs. prostatic neuroendocrine (small cell) vs. sialadenitis, 148
Metanephric adenoma, renal, 519-520, 519f carcinoma, 553 Miliary tuberculosis, 832-833
vs. papillary adenoma, 518-519 vs. small cell carcinoma, 507 Milk allergy, cows, vs. eosinophilic
vs. renal cell carcinoma, papillary type, 523 Metastatic squamous cell carcinoma gastroenteritis, 364
Metaplastic carcinoma vs. Bartholin gland carcinoma, 606 Mineral(s), histologic staining of, 6
of breast, 732, 732f vs. cervical squamous cell carcinoma, 623 Mineral dust bronchiolitis, 225t
of endometrium, 638-639, 639f vs. sebaceous lymphadenoma, 159 Mitochondria, electron microscopy of, 8-9
spindle cell areas in, immunohistochemistry vs. urothelial squamous cell carcinoma, Mitochondrial cardiomyopathy, 950
comparison of, 14t 507 Mitral annular calcification, 960-961
vs. endometrial stromal sarcoma, 641-642 vs. vaginal squamous cell carcinoma, 613 Mitral valve, 959f
vs. myometrial leiomyosarcoma, 646 Metastatic tumors prolapse of, 960-961
Metastatic carcinoma endocrine, vs. hepatocellular carcinoma, regurgitation of, 959
of uterine cervix, 628-629 430 stenosis of, 959
osteoblastic, vs. Paget disease of bone, 880 nonendocrine, vs. hepatocellular carcinoma, Mixed epithelial and stromal tumor, renal, 531-
vs. adamantinoma, 872 430 532, 531f
vs. anaplastic large cell lymphoma, 782 of adrenal glands, 484-485, 484f Mixed germ cell tumor, ovarian, 684, 684f
vs. angiosarcoma, 862 of bone, 881-882, 881f Mixed gliomas, 998
vs. astrocytic tumors, 991 of breast, 743-744, 743f Mixed mesodermal tumor, malignant. See
vs. Bartholin gland carcinoma, 606 of fallopian tube, 693 Malignant mixed mesodermal tumor.
vs. bladder adenocarcinoma, 506 of heart, 972 Mixed mllerian tumor, malignant. See
vs. cervical invasive adenocarcinoma, 626 of kidney, 538. See also Renal cell Malignant mixed mllerian tumor.
vs. cholangiocarcinoma, 436 carcinoma, metastatic. Mixed nonteratomatous germ cell tumors,
vs. chordoma, 877 of oral cavity, 208, 208f mediastinal, 304, 304f
vs. choroid plexus carcinoma/papilloma, of ovary, 686-687, 687f Molar pregnancy. See also Pregnancy.
1014 of pancreas, 459 FISH analysis of, 17t
vs. ciliary body adenoma, 1059 of paranasal sinuses, 192 Molecular pathology techniques, 24-38
vs. collecting duct carcinoma, 526 of parathyroid glands, 147, 147f amplification methods, 25-31
vs. diffuse large B-cell lymphoma, 779 of pericardium, 972 emerging methodologies in, 37-38
vs. endometrial adenocarcinoma, 636 of salivary glands, 173, 173f gel electrophoresis, 32
vs. endometriosis, 689 of thyroid gland, 142, 142f hybridization methods, 32-36, 33f-36f
vs. ependymoma, 1000 vs. undifferentiated thyroid carcinoma, introduction to, 24
vs. epithelioid hemangioendothelioma, 861 140 nucleic acid amplification methods, 25-30
vs. fallopian adenomatoid tumor, 691 of urinary bladder, 510 nucleic acid extraction methods, 24-25
vs. giant cell tumor, 870 primary sites of, antibody reagents nucleic acid sequencing, 37, 37f
vs. Hodgkin lymphoma, 804 identifying, 13t other methods of, 25-31, 26f-27f, 28t-29t
vs. intraocular malignant melanoma, 1058 vs. adrenal cortical carcinoma, 470 protein analytical methods, 37
vs. Langerhans cell histiocytosis, 766 vs. colorectal carcinoma, 389 signal amplification techniques, 30-31
vs. mixed cellularity Hodgkin lymphoma, Methanol, used in fixation, 2 tissue microdissection methods, 25, 25f
788 Methotrexate pneumonitis, 242f web resources for, 38
vs. mixed germ cell tumor, 684 Methotrexate toxicity, vs. bleomycin toxicity, Molluscum contagiosum
vs. multiple myeloma, 876 241 of vulva, 601, 601f
vs. myeloid sarcoma, 789 Michaelis-Gutmann bodies, 491, 491f vs. verrucae, 85
vs. myometrial adenomatoid tumor, 647 Microcystic adnexal carcinoma, 97-98, 97f Monoclonal antibody, definition of, 10
vs. myxopapillary ependymoma, 1001 vs. syringoma, 92 Monocyte(s), 11
vs. nodular lymphocyte predominant vs. trichoepithelioma, 88 Monodermal teratoma, ovarian, 682-684,
Hodgkin lymphoma, 773 Microglandular hyperplasia 683f
vs. osteosarcoma, 843 of uterine cervix, 617, 617f Monomorphic adenoma, vs. polymorphous low-
vs. paratesticular adenomatoid tumor, 578 vs. cervical adenocarcinoma in situ, 624 grade adenocarcinoma, 163
vs. primary malignant pericardial tumor, vs. cervical invasive adenocarcinoma, 626 Mononucleosis, infectious. See Infectious
971 vs. endocervical polyp, 616 mononucleosis.
vs. pulmonary adenocarcinoma, 263 Microinvasive adenocarcinoma, vs. cervical Morphea, 78-79, 78f
vs. Rosai-Dorfman disease, 764 adenocarcinoma in situ, 624 Mucha-Habermann disease, 55
vs. salpingitis isthmica nodosa, 690 Micronodular pneumocyte hyperplasia, vs. Mucicarmine stain, 4
vs. sclerosing epithelioid sarcoma, 907 atypical adenomatous hyperplasia, 261 Mucinous carcinoma
vs. spinal cord paraganglioma, 1010 Microorganisms, histologic staining of, 6, 6f-7f metastatic, vs. chordoma, 1033
vs. vaginal adenosis, 613 Microphthalmos with cyst, 1068-1069, 1068f of breast, 728-729, 728f
Index 1093

Mucinous carcinoma (Continued) Multiple endocrine neoplasia IIA (MEN IIA), Myofibroblastic tumor, inflammatory. See
renal tubular, 527, 527f 136 Inflammatory myofibroblastic tumor.
vs. renal cell carcinoma, sarcomatoid adrenal medullary hyperplasia associated Myofibroma, 897-898, 897f
type, 529 with, 472 vs. infantile fibrosarcoma, 905
vs. endometrioid carcinoma, 661 Multiple endocrine neoplasia IIB (MEN IIB), vs. low-grade myofibroblastic sarcoma, 904
Mucinous cyst 136 Myofibromatosis, 897-898
vs. struma ovarii, 683 adrenal medullary hyperplasia associated vs. infantile fibrosarcoma, 905
vs. vulvar cyst, 600 with, 472 vs. low-grade myofibroblastic sarcoma, 904
Mucinous cystadenoma Multiple ligation-dependent probe amplification Myometrium, 643
appendiceal, 405f, 406 (MLPA), 31 adenomatoid tumor of, 646-647, 647f
diagnostic features of, 259t Multiple myeloma, 875-877, 876f adenomyosis of, 643, 643f
ovarian, 658f-659f Multiple sclerosis, 1045-1046, 1045f leiomyoma of, 643-645, 644f
vs. transitional cell carcinoma, 665 demyelination in, Luxol fast blue staining of, leiomyosarcoma of, 646
Mucinous tumor 6f Myopericytoma, 932-933
cystic Marburg type of, 1045 Myositis, 891-892
of exocrine pancreas, 449f-450f vs. progressive multifocal Myositis ossificans, 892, 892f
vs. intraductal papillary mucinous leukoencephalopathy, 1045 vs. parosteal osteosarcoma, 845
neoplasms, 451 vs. vasculitis, 1039 Myospherulosis, vs. sinusitis, 175
vs. serous cystic neoplasms, 449 Multiplex PCR method, 26 Myxofibrosarcoma, 907-908, 908f
ovarian Mycobacterial pneumonia, atypical, 249, 249f low-grade, vs. low-grade fibromyxoid
benign, 657-659, 658f-659f Mycobacterial pseudotumor, vs. splenic sarcoma, 903
borderline, 658f-659f, 659-660 inflammatory pseudotumor, 825 Myxoglobulosis, of appendix, 406f, 407
malignant, 658f-659f, 660-661 Mycobacteriosis, vs. Rosai-Dorfman disease, Myxoid chondrosarcoma, vs. ossifying
vs. Sertoli-Leydig cell tumor, 672 764 fibromyxoid tumor, 937
Mucocele Mycobacterium avium-intracellulare infection Myxoid liposarcoma, 916, 916f
of appendix, 403, 405-406 in immunocompromised patients, 352f, 353 round cell, 916, 916f
of salivary glands, 151, 151f of spleen, 830-831, 830f vs. ischemic fasciitis, 893
Mucocele-like tumor, vs. mucinous carcinoma, vs. Langerhans cell histiocytosis, 816 vs. lipoblastoma/lipoblastomatosis, 914
729 vs. Whipple disease, 356 vs. lipoma, 912
Mucoepidermoid carcinoma Mycobacterium tuberculosis, 247-248, 248f. See vs. malignant fibrous histiocytoma, 911
of salivary glands, 164-165, 164f also Tuberculosis. vs. myxofibrosarcoma, 908
of thymus, 290f, 291 Mycosis fungoides, 118-119, 119f Myxoid neurofibroma
vs. acinic cell carcinoma, 162 metastatic, vs. dermatopathic vs. low-grade fibromyxoid sarcoma, 903
vs. oncocytoma, 156 lymphadenopathy, 752 vs. myxoma, 937
Mucopolysaccharidoses, differential diagnosis vs. secondary syphilis, 58 Myxoid sarcoma, vs. cardiac myxoma, 965
of, 805t Myelofibrosis, vs. congestive splenomegaly, Myxoma
Mucoproteins, histologic staining of, 4-6, 5f 827 cardiac, 964-965, 964f
Mucormycosis, in immunocompromised Myeloid cell(s), 11 papillary, vs. papillary fibroblastoma, 967
patients, 352-353 Myeloid sarcoma, 788-789, 789f soft tissue, 936-937, 936f
Mucosa-associated lymphoid tissue (MALT) vs. precursor B-cell lymphoblastic vs. cardiac sarcomas, 968-969
lymphoma lymphoma, 780 vs. lipoma, 912
gastric, 344-345, 344f Myelolipoma vs. myxofibrosarcoma, 908
pulmonary, 275-276, 276f adrenal, 481-482, 482f vs. neurofibroma, 927
vs. chronic lymphocytic thyroiditis, 124 vs. adrenal cysts and pseudocysts, 483 vs. nodular fasciitis, 890
Mucosal ganglioneuroma, colonic, 391f, MYH-associated polyposis syndrome, 392 Myxopapillary ependymoma, 1000-1001
394 Myoblastoma, granular cell. See Granular cell vs. chordoma, 1033
Mucosal prolapse syndromes, 375 tumor.
Mucous cells, in mucoepidermoid carcinoma, Myocardial infarction, vs. cardiac sarcoidosis, N
164 958 Nasal polyp, 176-177, 176f
Mucous cyst, of vulva, 600-601, 600f Myocarditis, 954-956, 954f Nasopharyngeal angiofibroma, 177-178, 177f
Mucus gland adenoma, diagnostic features of, acute necrotizing eosinophilic, 955 vs. nasal polyp, 177
259t differential diagnosis of, 955-956 Nasopharyngeal carcinoma, 182-184, 183f
Mucus retention cyst, vs. salivary duct cyst, eosinophilic, 955 vs. extranodal NK/T-cell lymphoma,
150 giant cell, 954f, 956 191-192
Muir-Tore syndrome, in sebaceous carcinoma, hypereosinophilic syndrome, 955 vs. oral squamous cell carcinoma, 207
100 hypersensitivity, 955 vs. sinonasal undifferentiated carcinoma,
Muir-Turcot syndrome, 392 lymphocytic, 954-955, 954f 182
Mllerian papilloma, vs. sarcoma botryoides, Myoepithelial carcinoma vs. squamous cell carcinoma of tonsil, 185
615 vs. epithelial-myoepithelial carcinoma, 166 Nasopharyngeal lymphoepithelial carcinoma,
Multifocal leukoencephalopathy, progressive, vs. salivary myoepithelioma, 153-154 metastatic, vs. salivary lymphoepithelial
1044-1045, 1044f Myoepithelial cells, in epithelial-myoepithelial carcinoma, 171
vs. demyelinating diseases, 1046 carcinoma, 165 Nasopharyngeal papillary carcinoma, vs.
Multilocular cyst (cystic nephroma), 530-531, Myoepithelial-rich mixed tumor, vs. salivary sinonasal adenocarcinoma, 186
530f myoepithelioma, 153 Nasopharyngeal spindled lesions,
Multilocular cystic renal cell carcinoma, 524- Myoepithelioma clinicopathologic comparisons of, 174t
525, 524f of salivary glands, 153-154, 153f Nasopharynx, 173. See also Nasopharyngeal
Multinodular goiter, 126, 126f variants of, 153 entries.
Multiple endocrine neoplasia I (MEN I), 464 Myofibroblastic sarcoma, low-grade, 904 Natural killer cell(s), 11
1094 Index

Necator americanus infestation (hookworm), Neuroblastoma, adrenal (Continued) Neurofibroma, 1018-1019


379 prognosis of, 479t cutaneous, 114-115, 114f
Necrobiosis lipoidica, 64f risk groups for, 480t myxoid
vs. granuloma annulare, 64 vs. ganglioneuroblastoma, 477 vs. low-grade fibromyxoid sarcoma,
vs. necrobiotic xanthogranuloma, 66 mediastinal, 305-306 903
vs. rheumatoid nodule, 65 differential diagnosis of, 306 vs. myxoma, 937
Necrobiotic granuloma, 63-64 features of, 306t soft tissue, 926-927, 926f
Necrobiotic xanthogranuloma, 66f metastatic vs. dermatofibroma, 112, 114
Necrosis, reactive processes with, 755-756 vs. Ewing sarcoma, 873 vs. dermatofibrosarcoma protuberans,
Necrotizing arteritis, 977f vs. lymphoma, 875 114
vs. thromboangiitis obliterans, 982 vs. orbital rhabdomyosarcoma, vs. ganglioneuroma, 476
Necrotizing sarcoidosis, vs. tuberculous 1069-1070 vs. leiomyoma, 110
lymphadenitis, 766 olfactory (esthesioneuroblastoma), 187-188, vs. palisaded and encapsulated neuroma,
Necrotizing sialometaplasia, vs. sialadenitis, 187f 114
148 vs. extranodal NK/T-cell lymphoma, vs. paratesticular fibrous pseudotumor,
Neoplastic conditions, of lungs, 258-260 192 579
benign epithelial tumors as, 259t vs. sinonasal melanoma, 190 vs. schwannoma, 115, 307, 925
lymphoproliferative disorders as, 275 renal cell carcinoma associated with, 529 Neurofibromatosis, vs. fibromuscular dysplasia,
malignant epithelial tumors as, 261 vs. Burkitt lymphoma, 784 983
malignant mesothelioma as, 279-280 vs. central and extraventricular Neurogenic tumors, of mediastinum, 305-307,
mesenchymal tumors as, 271 neurocytomas, 1008 305f, 306t-307t. See also specific tumor.
preinvasive epithelial lesions as, 258 vs. Ewing sarcoma/peripheral Neurohypophysis, granular cell tumor of
Nephroblastoma. See also Wilms tumor. neuroectodermal tumor, 942 vs. pituicytoma, 1030
cystic, partially differentiated, 535-536 vs. lymphoblastic lymphoma, 298 vs. pituitary adenoma, 1030
vs. metanephric adenoma, 519 vs. pheochromocytoma, 475 Neuroma, palisaded and encapsulated, vs.
vs. renal cell carcinoma, papillary type, vs. precursor B-cell lymphoblastic neurofibroma, 114
523 lymphoma, 781 Neuronal tumors, 1004-1006. See also specific
Nephroblastomatosis, 535 vs. rhabdomyosarcoma, 921 tumor.
Nephrogenic adenoma, 495-496, 496f vs. Wilms tumor, 534 Neutrophils, predominant in nodular/diffuse
urethral, 584, 584f Neurocytoma dermatitis, 59
vs. bladder adenocarcinoma, 506 central, 1007-1008, 1007f Nevus(i)
vs. capillary hemangioma, 496 vs. oligodendroglioma, 997 acquired, melanocytic, 101-103, 102f
vs. invasive urothelial carcinoma, 504 vs. rosette-forming glioneuronal tumor, variants of, 101-103, 102f
vs. low-grade papillary urothelial carcinoma, 1009 choroidal, vs. intraocular malignant
496 vs. supratentorial primitive melanoma, 1057-1058
vs. prostatic and clear cell adenocarcinoma, neuroectodermal tumor, conjunctival, vs. malignant melanoma,
496 1012-1013 1052
Nephrogenic rests, 535 extraventricular, 1007-1008 iris, 1059-1060
Nephrogenic systemic fibrosis, vs. morphea and Neuroectodermal tumor strawberry, 1066
scleroderma, 79 of bone Nevus sebaceus, 98-99, 98f
Nephroma vs. Ewing sarcoma, 873 Newborn, subcutaneous fat necrosis of, 80-81,
cystic, 530-531, 530f vs. lymphoma, 875 81f
vs. mixed epithelial and stromal tumor, peripheral Niemann-Pick disease, 805f
532 vs. lymphoblastic lymphoma, 298 differential diagnosis of, 805t
vs. multilocular cystic renal cell vs. olfactory neuroblastoma, 188 Nikolsky sign, in pemphigus, 74
carcinoma, 525 vs. sinonasal melanoma, 190 Nipple
mesoblastic, 536, 536f vs. undifferentiated pancreatic neoplasm, florid papillomatosis of, 713-714, 713f
vs. clear cell sarcoma, 537 458 Paget disease of, 736-737, 737f
vs. rhabdoid tumor, 538 primitive Nocardiosis, 247, 247f
vs. Wilms tumor, 535 vs. immature teratoma, 682 Nodular and diffuse dermatitis, 59
Nephronophthisis, familial juvenile, vs. Wilms tumor, 534 eosinophils predominant in, 60
513-514 Neuroendocrine carcinoma histiocytes predominant in, 61-62
Nerve(s), histologic staining of, 6, 6f metastatic neutrophils predominant in, 59
Nerve sheath myxoma, vs. myxoma, 937 vs. CNS lymphoma, 1025 Nodular fasciitis, 890-891, 890f
Nerve sheath tumor, peripheral, 1017-1019, vs. medulloblastoma, 1011 vs. calcifying fibrous pseudotumor, 900
1017f. See also specific tumor. vs. supratentorial primitive vs. deep benign fibrous histiocytoma, 910
malignant. See Malignant peripheral nerve neuroectodermal tumor, 1012 vs. desmoid-type fibromatosis, 899
sheath tumor. of larynx, 213-214, 213f vs. myofibroma/myofibromatosis, 897
Nested PCR method, 26 of prostate gland, 553-554 vs. proliferative fasciitis, 892
Neural neoplasms, 114 vs. lymphoma, 558 Nodular hyperplasia
Neuraxial cysts, 1026-1028, 1027f of rectum and anal canal, 402f vs. dyshormogenetic goiter, 128
Neurilemmoma. See Schwannoma. of thymus, 292-293, 292f vs. follicular thyroid carcinoma, 134
Neuroblastoma, 1012-1013 poorly differentiated. See Small cell Nodular melanoma, 103
adrenal, 477-479, 478f, 479t-480t carcinoma. Nodular regenerative hyperplasia
differential diagnosis of, 479 Neuroendocrine granules, in small cell vs. cirrhosis, 426
features of, 477-478 carcinoma, 9f vs. focal nodular hyperplasia, 427
histopathology of, 478-479, 478f Neuroepithelial tumors, 1002-1003. See also vs. hepatic adenoma, 428
pathology of, 478, 478f specific tumor. Nodular stage, of Kaposi sarcoma, 107, 108f
Index 1095

Nodular vasculitis, vs. migratory Nucleic acid Oncocytoma (Continued)


thrombophlebitis, 73 extraction methods of, 24-25 vs. conjunctival squamous cell carcinoma,
Nodule. See specific type and at anatomic site. DNA, 24 1054
Nonalcoholic steatohepatitis, 416-417 DNA/RNA quantification, purity, and vs. Warthin tumor, 155
vs. alcoholic liver disease/alcoholic integrity assay in, 24-25 Oncogenes, 11, 11f, 22, 22t
steatohepatitis, 415-416 RNA, 24 Opportunistic infection, vs. graft-versus-host
vs. viral hepatitis, 413 storage of, 25 disease, 365
Nonbacterial thrombotic endocarditis, vs. Nucleic acid amplification methods, 25-30, Oral cavity, 193-194
infective endocarditis, 962-963 26f-27f, 28t-29t adenomatoid odontogenic tumor of, 202-
Non-Hodgkin lymphoma Nucleic acid sequencebased amplification 203, 202f
of central nervous system, 1025 (NASBA), 30 ameloblastoma of, 200-201, 200f
of testis, 575-576, 575f Nucleic acid sequencing, 37, 37f cementoblastoma of, 203, 204f
of thyroid gland, 141 Nucleolus, electron microscopy of, 8 chondrosarcoma of, 203-205, 205f
vs. Hodgkin lymphoma, 295 Nucleus, electron microscopy of, 8 dentigerous cyst of, 198, 198f
vs. nasopharyngeal carcinoma, 183 Nummular dermatitis, 51 granular cell tumor of, 196, 196f
vs. prostatic neuroendocrine (small cell) leukoplakia of, 193-194, 193f
carcinoma, 553 O odontogenic keratocyst of, 199-200, 199f
vs. prostatic rhabdomyosarcoma, 557 Obstructive lung diseases, 222 osteosarcoma of, 205-206, 206f
vs. prostatic small cell carcinoma, 170 large airway, 222 Pindborg tumor of, 201-202, 201f
vs. prostatitis, 542 small airway, 224 pyogenic granuloma of, 195, 195f
Noninfectious cystitis, 491-492, 492f Ocular lesions. See also specific lesion. radicular cyst of, 196-197, 197f
vs. bacterial cystitis, 490 adult, 1052 squamous cell carcinoma of, 207-208,
vs. interstitial (Hunner) cystitis, 494 external, 1052 207f
Noninvasive papillary urothelial carcinoma internal, 1056-1058 squamous papilloma of, 194, 194f
high-grade, 502, 502f childhood, 1060-1062 tumors metastasizing to, 208, 208f
vs. noninvasive low-grade papillary Ocular trauma, penetrating, 1060 Orbit
urothelial carcinoma, 501 Odontogenic keratocyst, 199-200, 199f adult lesions of, 1062-1063
low-grade, 501, 501f vs. dentigerous cyst, 198 childhood lesions of, 1066
vs. noninvasive high-grade papillary vs. radicular cyst, 197 cystic, 1066
urothelial carcinoma, 502 Odontogenic tumor solid, 1069-1070
vs. papillary urothelial neoplasm of adenomatoid, 202-203, 202f Orbital capillary hemangioma, 1066-1067,
malignant potential, 501 calcifying epithelial, 201-202, 201f 1067f
Nonkeratizing squamous cell carcinoma, of Oil red O stain, 4 vs. rhabdomyosarcoma, 1070
larynx, 211 Olfactory neuroblastoma Orbital cellulitis
Nonmolar pregnancy. See also Pregnancy. (esthesioneuroblastoma), 187-188, 187f vs. dermoid/epidermoid cyst, 1066
vs. gestational choriocarcinoma, 698 vs. extranodal NK/T-cell lymphoma, 192 vs. lymphoma, 1063
vs. hydatidiform mole, 696 vs. sinonasal melanoma, 190 vs. pseudotumor, 1064
Non-neoplastic conditions, of lungs, 218-219 Oligoastrocytoma, vs. dysembryoplastic vs. rhabdomyosarcoma, 1070
pediatric and congenital, 218 neuroepithelial tumor, 1007 vs. thyroid orbitopathy, 1065
Nonossifying fibroma, 865-866, 865f Oligodendroglial tumors, 996-998. See also Orbital lymphangioma, 1067-1068, 1067f
vs. giant cell reparative granuloma, 871 specific tumor. Orbital pseudotumor, 1063-1064, 1064f
vs. giant cell tumor, 870 Oligodendroglioma, 996-997, 996f vs. lymphangioma, 1068
Nonseminomatous germ cell tumors, of anaplastic, 996-997 vs. lymphoma, 1063
mediastinum, 303-305, 303f-304f. See astrocytoma and, 998 vs. rhabdomyosarcoma, 1070
also specific tumor. pure, vs. mixed gliomas, 998 vs. thyroid orbitopathy, 1065
Nonspecific autoimmune encephalitis, vs. vs. astrocytic tumors, 991 Orbital rhabdomyosarcoma, 1069-1070,
encephalitis/meningoencephalitis, 1044 vs. central and extraventricular 1069f
Nonspecific interstitial pneumonia, 230-231, neurocytomas, 1008 Orbital tumor, solid
230f vs. cerebral infarct/hematoma, 1038 vs. lymphoma, 1063
vs. cryptogenic organizing pneumonia, vs. CNS lymphoma, 1025 vs. pseudotumor, 1064
228 vs. dysembryoplastic neuroepithelial tumor, Orchitis, 559-560, 559f
vs. desquamative interstitial pneumonia, 1007 chronic, vs. lymphoma, 576
232 vs. progressive multifocal Oriental cutaneous leishmaniasis, 71
vs. hypersensitivity pneumonitis, 234 leukoencephalopathy, 1045 Oropharynx, squamous cell carcinoma of, 184-
Nonspecific lymphocytic thyroiditis, vs. chronic with neurocytic differentiation, 997 185, 184f
lymphocytic thyroiditis, 124 Omphalocele, 345-346 Ossifying fibroma
Nonurachal adenocarcinoma, of bladder, Oncocytic nodule, parathyroid, vs. parathyroid of long bones. See Osteofibrous dysplasia.
505-506 adenoma, 146 vs. osteosarcoma, 206
Nonvasculitic autoimmune inflammatory Oncocytic salivary metaplasia, vs. oncocytoma, Ossifying fibromyxoid tumor, 937, 937f
meningoencephalitis, vs. vasculitis, 156 Osteoarthritis, 882-883
1039-1040 Oncocytoma vs. rheumatoid arthritis, 883
Nonviral infections, 413, 414f adenohypophyseal, vs. pituicytoma, 1030 Osteoblastic osteosarcoma, vs. osteoblastoma,
Nora lesion (parosteal osteochondromatous of adenohypophysis, vs. pituitary adenoma, 841
proliferation), vs. osteochondroma, 849 1030 Osteoblastoma, 840-841, 840f
Northern blot assay, 33-34 of kidney, 520-521, 520f vs. cementoblastoma, 203
Norwegian scabies, 61 vs. renal cell carcinoma, chromophobe vs. clear cell chondrosarcoma, 859
Nuchal fibroma, vs. Gardner fibroma, 898 type, 524 vs. low-grade surface osteosarcoma, 847
Nuclear elements, histologic staining of, 6 of salivary glands, 155-156, 155f vs. osteoid osteoma, 839
1096 Index

Osteoblastoma (Continued) Ovary, 647-648 P


vs. osteoma, 838 adenocarcinoma of Paget disease
vs. osteosarcoma, 843 immunophenotype of, 16t extramammary (vulvar), 606-607, 606f
vs. Paget disease of bone, 880 primary and metastatic, vs. vulvar intraepithelial neoplasia, 603
Osteochondroma, 848-849, 848f immunohistochemistry panel for, vs. vulvar malignant melanoma, 605
vs. parosteal osteosarcoma, 845 16t of anal canal, 404
Osteochondromatosis, 848 Brenner tumor of, 664-665, 664f of bone, 880-881, 880f
Osteoclast-rich tumor, vs. gastrointestinal cancer of, 653t vs. metastatic bone tumors, 882
stromal tumor, 399 choriocarcinoma of, 680-681, 680f of nipple, 736-737, 737f
Osteofibrous dysplasia, 864-865, 864f clear cell carcinoma of, 663-664, 663f vs. florid papillomatosis, 714
vs. adamantinoma, 872 corpus luteum cyst of, 647-648, 648f of penis, 594-595, 595f
vs. fibrous dysplasia, 863 dysgerminoma of, 676-677, 676f of scrotum, 594-595
Osteoid osteoma, 838-840, 839f edema of, 651 perianal, 403f
vs. osteoblastoma, 841 embryonal carcinoma of, 679-680, 679f Palisading granuloma, 63-64
Osteoid tumors, 838. See also specific tumor. endometrioid tumor of, 661-662, 661f Palmoplantar warts, 84
Osteoma, 838, 838f endometriosis of, 652-653 Palpation thyroiditis, vs. granulomatous
choroidal, vs. intraocular malignant epithelial-stromal tumor of, 653 thyroiditis, 123
melanoma, 1058 fibroma of, 665-666, 665f Pancreas
Osteomyelitis fibromatosis of, 651 endocrine
chronic follicular cyst of, 647-648, 648f undifferentiated neoplasms of, 457-458
vs. lymphoma, 875 germ cell tumor of, 674 well-differentiated neoplasms of, 456-
vs. multiple myeloma, 876 gonadoblastoma of, 685, 685f 457, 457f
vs. Paget disease of bone, 880 granulosa cell tumor of vs. acinar cell carcinoma, 455
vs. rheumatoid arthritis, 884 adult, 667-668, 667f vs. invasive ductal adenocarcinoma,
vs. osteosarcoma, 843 juvenile, 669 454
Osteosarcoma gynandroblastoma of, 673 vs. pancreatoblastoma, 456
chondroblastic, 206 hypercalcemic small cell carcinoma of, 686, vs. solid pseudopapillary neoplasm,
vs. chondroblastoma, 853 686f 459
vs. chondrosarcoma, 205 hyperreactio luteinalis of, 649 vs. undifferentiated neoplasm, 458
vs. intramedullary chondrosarcoma, 855 Leydig cell tumor of, 674, 674f exocrine
conventional intramedullary, 841-843, 841f malignant mixed mllerian tumor of, 662- acinar cell carcinoma of, 455, 455f
vs. low-grade surface osteosarcoma, 847 663, 662f intraductal papillary mucinous neoplasms
vs. osteofibrous dysplasia, 865 metastatic tumor of, 686-687, 687f of, 450-451, 451f
vs. periosteal osteosarcoma, 846 miscellaneous conditions of, 647 intraepithelial neoplasia of, 452-455
vs. telangiectatic osteosarcoma, 844 mixed germ cell tumor of, 684, 684f invasive ductal adenocarcinoma of, 453f
extraskeletal, vs. myositis ossificans, 892 mucinous tumor of mucinous cystic neoplasms of, 449f-450f
fibroblastic, 206 benign, 657-659, 658f-659f serous cystic neoplasms of, 448-449,
giant cellrich, 842 borderline, 658f-659f, 659-660 448f
vs. giant cell reparative granuloma, 871 malignant, 658f-659f, 660-661 metastases to, 459
vs. giant cell tumor, 870 polycystic, 649-650, 649f neoplasms of uncertain direction of
high-grade surface, 846-847 polyembryoma of, 680 differentiation of, 458-459
vs. parosteal osteosarcoma, 845 sclerosing stromal tumor of, 669-670, 670f non-neoplastic conditions of, 445-447
vs. periosteal osteosarcoma, 846 serous carcinoma of, immunohistochemistry Pancreatic fat necrosis, vs. subcutaneous fat
low-grade surface, 847 of, 16t necrosis, 81
vs. fibrous dysplasia, 864 serous tumor of Pancreatic heterotopia, 329
mesenchymal, vs. Ewing sarcoma, 874 benign, 653-655, 654f-655f Pancreatic intraepithelial neoplasia, 452, 452f
of jaw, 205-206, 206f borderline, 654f-655f, 655-656 vs. intraductal papillary mucinous
osteoblastic, 206 malignant, 654f-655f, 656-657 neoplasms, 451
vs. osteoblastoma, 841 Sertoli cell tumor of, 670-671, 670f Pancreatic pseudocyst, 447
parosteal, 844-845, 845f Sertoli-Leydig cell tumor of, 671-672, 671f vs. mucinous cystic neoplasm, 450
vs. high-grade surface osteosarcoma, 847 sex cord tumor with annular tubules of, 672 Pancreatitis
vs. osteochondroma, 849 sex cordstromal tumor of, 665 autoimmune, 445-446, 446f
vs. osteoma, 838 immunohistochemistry approach to, 16t chronic, 446f, 448
vs. periosteal osteosarcoma, 846 stromal hyperplasia of, 650-651 vs. invasive ductal adenocarcinoma, 454
periosteal, 845-846 stromal hyperthecosis of, 650-651, 650f Pancreatoblastoma, 455-456, 456f
vs. parosteal osteosarcoma, 845 stromal luteoma of, 673 vs. acinar cell carcinoma, 455
vs. periosteal chondroma, 851 teratoma of vs. invasive ductal adenocarcinoma, 454
telangiectatic, 206, 843-844, 844f immature, 681-682, 681f vs. solid pseudopapillary neoplasm, 459
vs. aneurysmal bone cyst, 879 mature cystic, 674-675, 675f vs. well-differentiated pancreatic neoplasm,
vs. chondrosarcoma, 206 mature solid, 675-676, 676f 457
vs. Ewing sarcoma, 873 monodermal Panniculitis, 79
vs. lymphoma, 875 carcinoid tumor, 683-684 infectious, vs. erythema nodosum, 80
vs. malignant fibrous histiocytoma, 868 struma ovarii, 682-683, 683f poststeroid, vs. subcutaneous fat necrosis, 81
vs. metastatic bone tumors, 881 thecoma of, 666-667, 666f vs. liposarcoma/lipomatous tumor, 915
vs. myxoid and salivary neoplasms, 206 transitional cell carcinoma of, 664-665, Pannus overgrowth, in prosthetic heart valves,
vs. ossifying fibroma, 206 664f 963
vs. osteoblastoma, 206 yolk sac tumor of, 677-679, 678f Papillary adenocarcinoma, metastatic, vs.
vs. osteoid osteoma, 839 Oxidizing agents, used in fixation, 2 papillary glioneuronal tumor, 1009
Index 1097

Papillary adenofibroma, vs. endocervical polyp, Papilloma Paratesticular adnexa, 576-577. See also specific
617 choroid plexus, 1014-1015 part.
Papillary adenoma vs. papillary glioneuronal tumor, adenomatoid tumor of, 577-578, 577f
diagnostic features of, 259t 1009 fibrous pseudotumor of, 579
renal, 518-519, 518f epithelial, of fallopian tube, 692, 692f leiomyoma of, 579-580
vs. renal cell carcinoma, papillary type, intraductal leiomyosarcoma of, 579-580, 580f
523 of breast, 711-713, 711f lipoma of, 577
Papillary carcinoma vs. cystadenoma, 157 liposarcoma of, 580-581
of breast, 730-731, 731f vs. papillary carcinoma, 731 rhabdomyosarcoma of, 581
vs. epididymal papillary cystadenoma, 578 laryngeal, 209-210, 210f smooth muscle hyperplasia of, 580f
Papillary cystadenocarcinoma juvenile, vs. vocal cord nodule, 209 Parathyroid cyst, vs. thymic cyst, 282
vs. acinic cell carcinoma, 162 sinonasal (Schneiderian), 179-180, 179f Parathyroid glands, 145-146
vs. cystadenoma, 157 vs. sinonasal adenocarcinoma, 186 adenoma of, 126-127, 144f
Papillary cystadenoma vs. squamous cell carcinoma of sinonasal cystic, vs. parathyroid cyst, 143
of epididymis, 578 region, 181 degenerated, vs. parathyroid cyst, 143
oncocytic, vs. Warthin tumor, 155 squamous. See Squamous papilloma. intrathyroidal, vs. follicular thyroid
Papillary cystadenoma lymphomatosum. See tracheal, vs. tracheal carcinoma, 215 adenoma, 132
Warthin tumor. urothelial. See Urothelial papilloma. vs. parathyroid carcinoma, 146-147
Papillary endothelial hyperplasia, vs. vs. condyloma acuminatum, 602 vs. parathyroid hyperplasia, 145
angiosarcoma, 935 Papillomatosis carcinoma of, 144f, 146-147
Papillary ependymoma, 999 biliary, 434-435, 435f vs. parathyroid adenoma, 146
vs. papillary glioneuronal tumor, 1009 florid, of nipple, 713-714, 713f cysts of, 143
Papillary fibroelastoma, 966-968, 967f juvenile laryngotracheal, diagnostic features hyperplasia of, 143-145, 330f
vs. cardiac myxoma, 965 of, 259t vs. parathyroid adenoma, 146
Papillary glioneuronal tumor, 1008-1009 Papulosis vs. parathyroid carcinoma, 146
vs. rosette-forming glioneuronal tumor, Bowenoid, 402-403 oncocytic nodules of, vs. parathyroid
1009 lymphoid, vs. cutaneous CD30-positive T- adenoma, 146
Papillary hidradenoma, of vulva, 607, 607f cell lymphoma, 120 tumors metastasizing to, 147, 147f
Papillary meningioma Paracoccidioidomycosis, 70 Paravalvular leak, in prosthetic heart valves,
vs. astroblastoma, 1003 Paracortical hyperplasia, nonspecific, 758-759, 963
vs. papillary glioneuronal tumor, 1009 758f Parosteal osteochondromatous proliferation
Papillary myxoma, vs. papillary fibroblastoma, Paracortical lymphoid hyperplasia (Nora lesion), vs. osteochondroma, 849
967 vs. angioimmunoblastic T-cell lymphoma, Parosteal osteosarcoma, 844-845, 845f
Papillary oncocytic cystadenoma, vs. Warthin 786 vs. high-grade surface osteosarcoma, 847
tumor, 155 vs. diffuse large B-cell lymphoma, 779 vs. osteochondroma, 849
Papillary squamous carcinoma, vs. sinonasal vs. mantle cell lymphoma, 776 vs. osteoma, 838
(Schneiderian) papilloma, 180 vs. peripheral T-cell lymphoma, 785 vs. periosteal osteosarcoma, 846
Papillary thyroid carcinoma, 134-136, 135f vs. small lymphocytic lymphoma, 774 Parotid duct cyst, vs. Warthin tumor, 155
histologic variants of, 135 Paraganglioma Patch stage, of Kaposi sarcoma, 107, 108f
vs. branchial cleft cyst, 129 laryngeal, 213f, 214 Pathwork Tissue of Origin Test, 36
vs. chronic lymphocytic thyroiditis, 124 soft tissue, 927-928, 927f Pauci-immune small-vessel vasculitis, 977-
vs. follicular thyroid adenoma, 132 spinal cord, 1009-1010 980, 977f
immunohistochemistry panel vs. adult rhabdomyoma, 919 vs. immune complex small-vessel vasculitis,
distinguishing, 19t vs. alveolar soft part sarcoma, 945 981
vs. follicular thyroid carcinoma, 134 vs. ganglioneuroblastoma/ganglioneuroma, PDE11A mutation, in Carney complex, 464
vs. Graves disease, 126 306 Peliosis
vs. hyalinizing trabecular tumor, 131 vs. glomus tumor, 931 vs. congestive splenomegaly, 827
vs. medullary thyroid carcinoma, 138 vs. hemangioblastoma, 1024 vs. splenic hemangioma, 818
vs. undifferentiated thyroid carcinoma, 140 vs. hyalinizing trabecular tumor, 131 Peliosis hepatis, 439
Papillary tumor, of pineal region, 1016-1017 vs. myxopapillary ependymoma, 1001 Pemphigoid, bullous. See Bullous pemphigoid.
Papillary urothelial carcinoma vs. neuroendocrine thymic tumor, 293 Pemphigus, 74-75, 74f
of ureter Paranasal sinuses. See also Sinonasal entries. benign familial, 75
high-grade, 489, 489f inflammation of, 173-176, 175f Pemphigus foliaceus, vs. subcorneal pustular
low-grade, 489, 489f tumors metastasizing to, 192 dermatosis, 74
of urinary bladder Paraneoplastic encephalitis, vs. encephalitis/ Pemphigus vulgaris
noninvasive high-grade, 502, 502f meningoencephalitis, 1044 immunofluorescence patterns in, 7t
noninvasive low-grade, 501, 501f Paraneoplastic vasculitis, vs. immune complex in inflammatory esophagitis, 315
vs. bacterial cystitis, 490 small-vessel vasculitis, 981 Penetrating ocular trauma, 1060
vs. nephrogenic adenoma, 496 Parasites, histologic staining of, 6 Penetration, affecting fixation, 3
vs. noninfectious cystitis, 492 Parasitic abscess, 413 Penis, 586-587
Papillary urothelial hyperplasia, 498-499 Parasitic cyst, 483 carcinoma in situ of
Papillary urothelial lesions, 498. See also specific splenic, 822-823 Bowen disease, 588f, 589
lesion. vs. epidermoid cyst, 822 erythroplasia of Queyrat, 588-589,
Papillary urothelial neoplasm of malignant Parasitic infestations. See also specific infection. 588f
potential, 500-501, 500f in immunocompromised patients, 351f, condyloma acuminatum of, 588, 588f
vs. noninvasive low-grade papillary 352-353 epithelioid hemangioendothelioma of, 592
urothelial carcinoma, 501 intestinal, 336f, 378f-379f fibromatosis of (Peyronie disease), 586-587,
vs. urothelial papilloma, 499 vs. eosinophilic pulmonary disease, 235 586f
1098 Index

Penis (Continued) Phenytoin adenopathy, vs. infectious Pityriasis lichenoides acuta, vs. lymphomatoid
fibrosarcoma of, 593 mononucleosis, 749 papulosis, 57
Kaposi sarcoma of, 592 Pheochromocytoma Pityriasis lichenoides chronica, 56
leiomyosarcoma of, 593 clinical features of, 473 Pityriasis rosea, vs. spongiotic dermatitis, 51
Paget disease of, 594-595, 595f differential diagnosis of, 475 Pityriasis rubra pilaris, 54f
sarcoma of, 592 histopathology of, 473-475, 474f vs. psoriasis, 53
epithelioid, 593-594, 593f pathology of, 473, 474f Pityriasis versicolor, vs. dermatophytosis, 42
squamous cell carcinoma of, 590-591, 590f pigmented, vs. malignant melanoma, 481 Placenta accreta, increta, or percreta, vs.
verrucous carcinoma of, 591-592 vs. adrenal cortical carcinoma, 470-472 hydatidiform mole, 697
Peptic ulcer disease, 334-335, 335f vs. adrenal medullary hyperplasia, 473 Placental site, exaggerated, 694
Perianal skin Photoallergic dermatitis, 50-51 Placental site nodule (plaque), 694
condyloma acuminatum of, 401f Phyllodes tumor vs. exaggerated placental site, 694
Paget disease of, 403f of breast, 717-719, 718f vs. placental site trophoblastic tumor, 699
Periapical cyst, of oral cavity, 196-197, 197f vs. fibroadenoma, 716 Placental site trophoblastic tumor, 699-700,
Peribiliary gland hamartoma, 432-433, 433f of prostate gland, 556, 556f 699f
vs. bile duct hamartoma, 432 spindle cell areas in, immunohistochemistry vs. ectopic pregnancy, 691
Peribronchiolar metaplasia, vs. atypical comparison of, 14t vs. exaggerated placental site, 694
adenomatous hyperplasia, 261 Picrates, used in fixation, 2-3 vs. gestational choriocarcinoma, 698
Peribronchiolar smooth muscle hyperplasia, vs. Pigmented villonodular synovitis, 886-887, vs. placental site nodule, 694
lymphangioleiomyomatosis, 272 886f Plaque stage, of Kaposi sarcoma, 107, 108f
Pericardial cysts, 970 Pigments, histologic staining of, 6 Plasma cell balanitis, vs. balanitis xerotica
Pericarditis Pill esophagitis, vs. reflux esophagitis, 317 obliterans, 587
acute, 969 Pilocytic astrocytoma, 992-993, 992f Plasma cell granuloma. See Inflammatory
constrictive, 969-970 vs. angiocentric glioma, 1004 myofibroblastic tumor.
Pericardium, 969 vs. craniopharyngioma, 1031-1032 Plasma cell mastitis, 702-703, 702f
fibrous tumors of, 970-971 vs. dysembryoplastic neuroepithelial tumor, vs. granulomatous lobar mastitis, 703
malignant tumors of, 971-972 1007 vs. subareolar abscess, 702
metastatic tumors of, 972 vs. gangliocytoma/ganglioglioma, 1005 Plasma membrane, electron microscopy of, 8
Perineuroma vs. hemangioblastoma, 1024 Plasmacytoid variant, of salivary
central nervous system, 1018-1019 vs. medulloblastoma, 1011 myoepithelioma, 153
colorectal, 391f, 394 vs. oligodendroglioma, 997 Plasmacytoma
Periodic acidSchiff (PAS) stain, 4 vs. pilomyxoid astrocytoma, 993 solitary, 875-877
Periosteal chondroma, 851-852, 851f vs. pituicytoma, 1030 vs. Castleman disease, 299
vs. periosteal osteosarcoma, 846 vs. pleomorphic xanthoastrocytoma, 994 vs. inflammatory myofibroblastic tumor,
Periosteal chondrosarcoma, vs. periosteal vs. rosette-forming glioneuronal tumor, 273
osteosarcoma, 846 1009 vs. medullary thyroid carcinoma, 138
Periosteal osteosarcoma, 845-846 Pilomatricoma (pilomatrixoma), 89, 89f vs. splenic inflammatory pseudotumor, 825
vs. parosteal osteosarcoma, 845 Pilomyxoid astrocytoma, 993 Pleomorphic sarcoma. See Malignant fibrous
vs. periosteal chondroma, 851 vs. angiocentric glioma, 1004 histiocytoma.
Peripheral nerve sheath tumor, 1017-1019, Pinborg tumor (calcifying epithelial Pleomorphic thyroid carcinoma. See Thyroid
1017f. See also specific tumor. odontogenic tumor), 201-202, 201f gland, undifferentiated (anaplastic)
malignant. See Malignant peripheral nerve Pineal cyst, vs. pineal parenchymal tumor, carcinoma of.
sheath tumor. 1015 Pleuritis
Peripheral neuroectodermal tumor, 942-943 Pineal gland chronic fibrosis, vs. mesothelioma, 280
vs. CNS lymphoma, 1025 normal, vs. pineal parenchymal tumors, reactive eosinophilic, vs. pulmonary
vs. lymphoblastic lymphoma, 298 1015-1016 Langerhans cell histiocytosis, 277
vs. olfactory neuroblastoma, 188 papillary tumor of, 1016-1017 Pleuropulmonary blastoma, 274-275, 274f
vs. sinonasal melanoma, 190 Pineal parenchymal tumor, 1015-1016. See vs. congenital pulmonary airway
vs. synovial sarcoma, 940 also specific tumor. malformation, 219
vs. undifferentiated pancreatic neoplasm, of intermediate differentiation, 1015-1016 Pneumatosis intestinalis, 380-381, 381f
458 vs. pineoblastoma, 1016 vs. lymphangiectasia, 380
Peripheral T-cell lymphoma. See T-cell Pineoblastoma, 1016 Pneumoconioses, 238
lymphoma, peripheral. vs. pineocytoma, 1015 Pneumocystis jiroveci (carinii) pneumonia, 255-
Periurethral cyst, vs. vulvar cyst, 601 Pineocytoma, 1015-1016 256, 256f
Periurethral glands, adenocarcinoma of, 585- vs. pineoblastoma, 1016 vs. Mycobacterium avium-intracellulare
586, 585f Pinguecula, 1053-1054, 1053f infection, 830
Perivascular dermatitis vs. conjunctival squamous cell carcinoma, Pneumocyte hyperplasia, type 2, vs.
superficial, 41 1054 bronchioloalveolar carcinoma, 264
superficial and deep, 54 Pituicytoma, 1030 Pneumonia
eosinophils predominant in, 55 Pituitary adenoma, 1028-1030, 1028f cryptogenic organizing, 227-228, 228f
lymphocytes predominant in, 54-55 vs. olfactory neuroblastoma, 188 cytomegalovirus, 245f, 246t, 274-275
Permanganate, used in fixation, 2 vs. pituicytoma, 1030 eosinophilic, 234-235, 234f. See also
Peutz-Jeghers syndrome, 390f, 392-393 Pituitary carcinoma, 1028-1030 Eosinophilic pneumonia.
sporadic, 394 Pituitary hyperplasia, 1028-1030 interstitial. See also Interstitial pneumonia.
Peyronie disease (penile fibromatosis), 586- Pityriasis lichenoides, 56f clinical, radiologic, and prognostic
587, 586f vs. secondary syphilis, 58 features of, 227t
Pharyngeal pouch cyst, vs. parathyroid cyst, Pityriasis lichenoides et varioliformis acuta, Legionella, 246-247
143 55-56 mycobacterial, atypical, 249, 249f
Index 1099

Pneumonia (Continued) Polypoid adenocarcinoma, vs. endometrial Prolymphocytic leukemia


Pneumocystis jiroveci (carinii), 255-256, 256f polyp, 630 splenic, 800, 800f
vs. Mycobacterium avium-intracellulare Polypoid adenomyoma, atypical vs. chronic lymphocytic leukemia and
infection, 830 endometrial, 636-637, 636f small lymphocytic lymphoma, 799
viral, diagnostic features of, 246t vs. endometrial adenocarcinoma, 636 vs. hepatosplenic T-cell lymphoma, 813-814
Pneumonitis Polypoid cystitis, 491-492 Prostate gland, 540-542
hypersensitivity, 233-234, 233f vs. invasive urothelial carcinoma, 504 adenocarcinoma of
vs. nonspecific interstitial pneumonia, 231 Polyposis syndromes, 389f, 391f. See also differential diagnosis of, 550-551
vs. sarcoidosis, 236 specific syndrome. Gleason grading system of, 549t
methotrexate, 242f Poorly differentiated adenocarcinoma, vs. immunohistochemistry in, 18f
radiation, 240-241, 240f prostatitis, 542 subtypes of, 546-552, 547f-548f
Pneumothorax, vs. congenital lobar Porocarcinoma, vs. poroma, 93 TNM staging of, 551t
emphysema, 221 Poroma, 92-93, 92f vs. invasive urothelial carcinoma, 504
Polyacrylamide gel electrophoresis, 32 eccrine, vs. clear cell acanthoma, 84 vs. nephrogenic adenoma, 496
Polyangiitis, microscopic, 977-978 Porphyria cutanea tarda, vs. bullous vs. prostatic hyperplasia, 544
Polyarteritis nodosa, 975-976 pemphigoid, 76 vs. prostatic infarct, 543
differential diagnosis of, 976, 978-979 Postinfectious bronchial damage, vs. vs. prostatic intraepithelial neoplasia,
splenic involvement in, 827-828 bronchiectasis, 223 546
vs. migratory thrombophlebitis, 73 Postirradiation angiosarcoma, vs. vs. seminal vesicle carcinoma, 583
Polyclonal antibody, definition of, 10 postmastectomy angiosarcoma, 741 vs. transitional cell carcinoma, 554
Polycystic kidney disease Postmastectomy angiosarcoma (Stewart-Treves vs. urothelial carcinoma,
autosomal dominant, 514-515, 514f. See syndrome), 740-741 immunohistochemistry panel
also Autosomal dominant polycystic Postmortem clot, vs. splenic vasculitis, 828 distinguishing, 18t
kidney disease. Post-radioactive iodine therapy, vs. adenosquamous carcinoma of, 554-555
autosomal recessive, 512, 512f. See also dyshormogenetic goiter, 128 basal cell carcinoma of, 552-553
Autosomal recessive polycystic kidney Poststeroid panniculitis, vs. subcutaneous fat epithelial metaplasia of, 545
disease. necrosis, 81 hyperplasia of, 543-544, 543f
Polycystic ovarian syndrome, 649-650, 649f Post-transplant lymphoproliferative disorder, infarction of, 542-543, 542f
Polyembryoma, ovarian, 680 vs. liver transplant rejection, 425 intraepithelial neoplasia of. See Prostatic
Polymerase chain reaction (PCR), 25, 26f Precursor B-cell lymphoblastic lymphoma, 780- intraepithelial neoplasia (PIN).
basic method of, 26 781, 780f lesions of, atypical glandular proliferative,
contamination control in, 27 vs. mantle cell lymphoma, 776 immunohistochemistry approach to,
efficiency of, 26 Pregnancy 18t
essential ingredients in, 26 ectopic, 690-691, 690f lymphoma of, 557-558
in pathology practice, 27-30, 28t-29t vs. salpingitis, 688 neuroendocrine (small cell) carcinoma of,
method variations in, 26-27 fatty liver of. See Fatty liver disease, of 553-554
other methods of, 27 pregnancy. phyllodes tumor of, 556, 556f
real-time quantitative, 27 molar, FISH analysis of, 17t rhabdomyosarcoma of, 557
reverse transcription, 26, 27f nonmolar squamous cell carcinoma of, 554-555, 555f
Polymerase chain reaction (PCR)based assays, vs. gestational choriocarcinoma, 698 transitional cell carcinoma of, 554
FDA-approved, 28t-29t vs. hydatidiform mole, 696 Prostatic intraepithelial neoplasia (PIN), 545-
Polymorphous light eruption, 54 vs. polycystic ovarian syndrome, 650 546, 546f
vs. cutaneous lupus erythematosus, 48 Pregnancy luteoma, 651-652, 652f vs. prostatic adenocarcinoma, 551
Polymorphous low-grade adenocarcinoma vs. thecoma, 667 vs. prostatic hyperplasia, 544
of salivary glands, 162-163, 163f Primary acquired melanosis, of conjunctiva, Prostatic urethral polyp, 584-585
vs. adenoid cystic carcinoma, 161 1052-1053, 1053f Prostatitis, 540-542, 541f
vs. epithelial-myoepithelial carcinoma, 166 Primary cilia dyskinesis, vs. bronchiectasis, chronic, vs. lymphoma, 558
vs. pleomorphic adenoma, 152 224 Prosthetic heart valves, 963-964
Polyp(s) Primitive neuroectodermal tumor commonly implanted, 963
benign fibroblastic, of colon, 391f, 394 supratentorial, 1012-1013 complications of, 963
endometrial, 630-631, 630f vs. immature teratoma, 682 Protein analytical methods, 37
fibroepithelial, vs. papillary urothelial vs. medulloblastoma, 1011 Protoplasmic astrocytoma, 990
carcinoma, 490 vs. secondary CNS tumors, 1034 Prussian blue stain, 6
fibrovascular, of esophagus, 322, 322f vs. Wilms tumor, 534 Pseudallescheria boydii, diagnostic features of,
gastric, non-neoplastic, 337f-338f Primitive precursor cell neoplasms. See also 250t
gastrointestinal, 382f-384f. See also specific neoplasm. Pseudoangiomatous stromal hyperplasia, of
Gastrointestinal polyps. cytogenetic abnormalities in, 23t-24t breast, 714-715, 714f
inflammatory, vs. sinonasal (Schneiderian) Prion, 1047 vs. angiosarcoma, 740
papilloma, 180 PRKAR1A mutation, in Carney complex, vs. hemangioma, 738
inflammatory fibroid. See Inflammatory 464 Pseudocarcinomatous epidermal hyperplasia,
polyp, fibroid. Progressive multifocal leukoencephalopathy, vs. squamous cell carcinoma, 87
nasal, 176-177, 176f 1044-1045, 1044f Pseudocyst(s). See also Cyst(s).
urethral, 583-584 vs. demyelinating diseases, 1046 adrenal, 482-483, 483f
fibroepithelial, 583 Progressive transformation of germinal pancreatic, 447
prostatic, 584-585 centers, 752-753, 753f vs. mucinous cystic neoplasm, 450
uterine cervical, 616-617, 616f vs. HIV-associated lymphadenopathy, splenic, 822
vaginal, 610, 610f 748 vs. epidermoid cyst, 822
vocal cord, 208-209 Proliferative fasciitis, 891-892, 891f vs. parasitic cyst, 823
1100 Index

Pseudoepitheliomatous hyperplasia Pyogenic bacterial infections. See also Abscess. Regenerative atypia, vs. Barrett esophagus, 320
vs. vaginal squamous cell carcinoma, 613 of spleen, 831-832 Renal. See also Kidney(s).
vs. vulvar squamous cell carcinoma, Pyogenic granuloma, 106-107, 106f Renal cell carcinoma
604-605 oral cavity, 195, 195f associated with neuroblastoma, 529
Pseudogout, 885 soft tissue, 930 associated with Xp11.2/TFE3 translocation,
vs. gout, 884 vs. hemangioma, 105 528, 528f
Pseudohorn cysts, 83 vs. nasopharyngeal angiofibroma, 177 vs. renal cell carcinoma, papillary type,
Pseudohyperplastic adenocarcinoma, of 523
prostate gland, 550 R chromophobe type, 523-524, 523f
Pseudomembranous colitis, vs. enteric Radial scar vs. oncocytoma, 521
infections, 351 of breast, 710, 710f vs. renal cell carcinoma, clear cell type,
Pseudomyxoma peritonei, of appendix, vs. infiltrating ductal carcinoma, 724 522
406-407 Radial sclerosing lesion, of breast, 710-711 clear cell type, 521-522, 521f
Pseudotumor(s). See also Tumor(s). Radiation changes, vs. vaginal intraepithelial vs. juxtaglomerular cell and renin-
fibrous neoplasia, 612 secreting tumors, 533
calcifying, 900, 900f Radiation colitis, 372-373, 373f, 375 vs. oncocytoma, 521
of paratesticular adnexa, 579 Radiation cystitis, 492-493, 493f vs. renal cell carcinoma, chromophobe
inflammatory. See Inflammatory Radiation dermatitis, vs. morphea and type, 524
myofibroblastic tumor. scleroderma, 79 vs. renal cell carcinoma associated with
mycobacterial, vs. splenic inflammatory Radiation esophagitis, 314 Xp11.2/TFE3 translocation, 528
pseudotumor, 825 Radiation pneumonitis, 240-241, 240f vs. xanthogranulomatous pyelonephritis,
orbital. See Orbital pseudotumor. Radicular cyst 517
Psoriasiform dermatitis, 52-53, 58-59 of oral cavity, 196-197, 197f cystic
Psoriasis, 53f vs. dentigerous cyst, 198 vs. cystic nephroma, 531
vs. clear cell acanthoma, 84 vs. odontogenic keratocyst, 199 vs. mixed epithelial and stromal tumor,
vs. chronic spongiotic dermatitis, 51 Rash, heliotrope, 50 532
vs. pityriasis rubra pilaris, 54 Rathke cyst, 1026, 1027f metastatic
vs. secondary syphilis, 58 RB gene, 1060 vs. acinic cell carcinoma, 162
vs. subcorneal pustular dermatosis, 74 Reactive astrocytosis, vs. astrocytic tumors, vs. alveolar soft part sarcoma, 945
PTEN-associated polyposis syndrome, 392-393 991 vs. clear cell adenocarcinoma, 614
Pterygium, 1053-1054, 1053f Reactive atypia, vs. cervical intraepithelial vs. clear cell chondrosarcoma, 859
vs. conjunctival squamous cell carcinoma, neoplasia, 620 vs. hemangioblastoma, 1024
1054 Reactive eosinophilic pleuritis, vs. pulmonary vs. metastatic adrenal tumors, 485
Pulmonary. See also Lung(s). Langerhans cell histiocytosis, 277 vs. oncocytoma, 156
Pulmonary adenocarcinoma, 261-263, 262f Reactive gastropathy, 331f vs. salivary myoepithelioma, 154
immunohistochemistry panel for, 14t Reactive glandular atypia, vs. cervical vs. serous cystic neoplasm, 449
subtypes of, 262 adenocarcinoma in situ, 623 multilocular cystic, 524-525, 524f
vs. carcinoid tumor, 270 Reactive inflammatory atypia papillary type, 522-523, 522f
vs. mesothelioma, 280 vs. urothelial carcinoma in situ, 498 vs. collecting duct carcinoma, 525
Pulmonary alveolar proteinosis, 239f vs. urothelial dysplasia, 497 vs. metanephric adenoma, 519
vs. silicosis, 239 Reactive lymphocytosis, vs. CNS lymphoma, vs. mucinous tubular and spindle cell
Pulmonary amyloidosis, vs. inflammatory 1025 carcinoma, 527
myofibroblastic tumor, 273 Reactive lymphoid hyperplasia vs. papillary adenoma, 518
Pulmonary blastoma, vs. pleuropulmonary vs. Castleman disease, 794 vs. renal cell carcinoma, clear cell type,
blastoma, 275 without germinal center formation, 519
Pulmonary capillary hemangiomatosis, vs. 793-794 vs. renal cell carcinoma associated with
pulmonary hypertension, 245 Reactive mesothelial hyperplasia, vs. Xp11.2/TFE3 translocation, 528
Pulmonary hamartoma, 270-271, 270f mesothelioma, 280 sarcomatoid type, 529-530
Pulmonary hemosiderosis, idiopathic, 237, Reactive splenic follicular hyperplasia, 792- vs. mucinous tubular and spindle cell
237f 793, 792f-793f carcinoma, 527
vs. Goodpasture syndrome, 238 vs. follicular lymphoma, 802 unclassified type, 530
Pulmonary hypertension, 242-245, 243f Reactive splenic red pulp hyperplasia, vs. vs. metastatic thyroid tumors, 142
grading system for, 244t chronic myelogenous leukemia, 816 with cystic change, vs. multilocular cystic
revised clinical classification of, 244t Real-time quantitative polymerase chain renal cell carcinoma, 525
Pulmonary infiltrates, eosinophilic, 979 reaction (qPCR), 27 Renal cell neoplasms. See also specific neoplasm.
Pulmonary Langerhans cell histiocytosis, 277- Rectal lymphoid hyperplasia, 401f immunohistochemistry panel distinguishing,
278, 277f Rectal tonsil, 401f 18t
Pulmonary sarcomas, vs. pleuropulmonary Rectal ulcer syndrome, solitary, 372f, 374f Renal cysts, vs. cystic nephroma, 531
blastoma, 275 Red pulp, splenic Renal dysplasia, 511-512, 511f
Pulmonary veno-occlusive disease, vs. neoplastic diseases of, 812-813 cystic, vs. cystic nephroma, 531
pulmonary hypertension, 244 non-neoplastic diseases of, 804-806 vs. autosomal recessive polycystic kidney
Pulsed-field gel electrophoresis, 32 Reflux esophagitis, 309, 317-318 disease, 512
Pustular dermatosis, subcorneal (Sneddon- vs. eosinophilic esophagitis, 316 vs. medullary cystic kidney disease, 514
Wilkinson disease), 73-74, 73f vs. infectious esophagitis, 313 vs. medullary sponge kidney, 513
Pyelonephritis, xanthogranulomatous, 516- vs. inflammatory esophagitis, 315 Renal medullary carcinoma, 526-527, 526f
517, 516f vs. injurious esophagitis, 314 vs. collecting duct carcinoma, 525
Pyoderma gangrenosum, 41f, 59-60 Refractory (unclassified) sprue, vs. celiac sprue, Renal medullary fibroma, 532, 532f
vs. Sweet syndrome, 59 357 Renal oncocytoma, 520-521, 520f
Index 1101

Renal sarcoma, vs. renal cell carcinoma, Rhabdomyosarcoma, sinonasal, embryonal Salivary glands (Continued)
sarcomatoid type, 529 (Continued) inflammation of, 147-148, 148f
Renin-secreting tumor, 533 vs. lymphoblastic lymphoma, 298 lymphoepithelial carcinoma of, 170-171,
Renomedullary interstitial cell tumor, 532, vs. neuroblastoma, 306 171f
532f soft tissue, 919-921, 920f lymphoepithelial cyst of, 149-150, 149f
Respiratory bronchiolitis, 225t spindle cell lymphoma of, 171-172, 172f
vs. pulmonary Langerhans cell histiocytosis, vs. infantile fibrosarcoma, 905 Mikulicz disease of, 148-149, 148f
277 vs. soft tissue leiomyosarcoma, 923 mucocele of, 151, 151f
Respiratory epithelial adenomatoid hamartoma urinary bladder, 509 mucoepidermoid carcinoma of, 164-165,
vs. nasal polyp, 176 vaginal, 614-615 164f
vs. sinonasal (Schneiderian) papilloma, 180 vs. adrenal neuroblastoma, 479 myoepithelioma of, 153-154, 153f
Restrictive and interstitial lung diseases, 226 vs. dermoid/epidermoid cyst, 1066 oncocytoma of, 155-156, 155f
Restrictive cardiomyopathy, 950-952 vs. nasal polyp, 177 polymorphous low-grade adenocarcinoma
differential diagnosis of, 953 vs. olfactory neuroblastoma, 187 of, 162-163, 163f
Rete cystadenoma, vs. serous cystadenoma, vs. proliferative fasciitis, 891 salivary duct carcinoma of, 167, 167f
655 vs. sarcoma botryoides, 616 salivary duct cyst of, 150, 150f
Rete testis adenocarcinoma, vs. paratesticular vs. sinonasal melanoma, 190 sebaceous lymphadenoma of, 159, 159f
adenomatoid tumor, 578 vs. thyroid teratoma, 130 tumors metastasizing to, 173, 173f
Retention mucocele, of appendix, 406 Rheumatic heart disease undifferentiated neuroendocrine carcinoma
Reticulin stain, 4 clinical features of, 960 of, 169-170, 170f
Reticulocytic granuloma, 62-63, 62f gross pathology of, 960-961 Warthin tumor of, 154-155, 154f
Reticulohistiocytoma histopathology of, 961 Salmonellosis, in immunocompetent hosts,
cutaneous, 62 Rheumatic nodule, vs. granuloma annulare, 64 349-350
multicentric, 62-63 Rheumatoid arthritis, 883-884, 883f Salpingitis, acute and chronic, 688, 688f
vs. Langerhans cell histiocytosis, 118 splenic involvement in, 827-828 Salpingitis isthmica nodosa, 689-690
Retiform hemangioendothelioma, 933-934 vs. Castleman disease, 794 vs. endometriosis, 689
Retinoblastoma, 1060-1062, 1061f vs. osteoarthritis, 883 Sarcoid, vs. secondary syphilis, 59
trilateral, 1060 vs. syphilis, 750 Sarcoidal granuloma, 66-67
Retinocytoma, 1060 Rheumatoid nodule, 65f Sarcoidosis
Retinoma, 1060 vs. necrobiosis lipoidica, 64 cardiac, 958, 958f
Reverse transcription polymerase chain Rheumatoid synovitis, vs. pigmented cutaneous, 66f
reaction (RT-PCR), 26, 27f villonodular synovitis, 887 differential diagnosis of, 958
Reye syndrome, vs. fatty liver of pregnancy, Rhinoscleroma, 175, 175f lymph node, 767-768, 767f
418 vs. leishmaniasis, 71 necrotizing, vs. tuberculous lymphadenitis,
Rhabdoid tumor, 537-538 Rhinosporidiosis 766
vs. clear cell sarcoma, 537 vs. nasal polyp, 176 pulmonary, 235-236, 236f
vs. medulloblastoma, 1011 vs. sinonasal (Schneiderian) papilloma, 180 splenic, 832-833
vs. mesoblastic nephroma, 536 Ribosomes, electron microscopy of, 9 subcutaneous, vs. erythema nodosum, 80
vs. Wilms tumor, 534 Riedel thyroiditis, 124-125, 124f vs. encephalitis/meningoencephalitis, 1044
Rhabdomyoma vs. granulomatous thyroiditis, 123 vs. granulomatous lobar mastitis, 703
adult, 918-919 Rings, esophageal, 311-312 vs. hypersensitivity pneumonitis, 234
differential diagnosis of, 919 RNA vs. prostatitis, 542
vs. granular cell tumor, 924 extraction of, 24 vs. Toxoplasma lymphadenitis, 751
cardiac, 965-966 quantification, purity, and integrity of, 24-25 vs. vasculitis, 1039
fetal, 918-919 storage of, 25 Sarcoma(s). See also specific type.
differential diagnosis of, 919 Rosai-Dorfman disease, 763-765, 763f cardiac, 968-969
genital, 918-919 vs. Langerhans cell histiocytosis, 766 gastric, vs. inflammatory fibroid polyp, 339
differential diagnosis of, 919 Round cell myxoid liposarcoma, 916, 916f metastatic, vs. dedifferentiated
soft tissue, 918-919 Ruvalcaba-Myhre-Smith syndrome, 392-393 chondrosarcoma, 856
Rhabdomyosarcoma penile, 592
alveolar. See Alveolar rhabdomyosarcoma. S epithelioid, 593-594, 593f
botryoid, vs. fetal/genital rhabdomyoma, Salivary adenoma, pleomorphic, vs. primary, vs. metastatic bone tumors, 882
919 oncocytoma, 156 salivary, vs. carcinosarcoma, 169
cardiac, 968 Salivary duct carcinoma, 167, 167f thyroid, vs. undifferentiated thyroid
embryonal. See Embryonal vs. carcinoma ex mixed tumor, 168 carcinoma, 140
rhabdomyosarcoma. Salivary duct cyst, 150, 150f vs. benign esophageal lesions, 323
orbital, 1069-1070, 1069f vs. mucocele, 151 vs. lymphoma, 875
paratesticular, 581 Salivary glands, 147-148 vs. noninfectious cystitis, 492
pleomorphic, 188, 920 acinic cell carcinoma of, 161-162, 162f vs. paratesticular fibrous pseudotumor, 579
vs. malignant fibrous histiocytoma, 911 adenoid cystic carcinoma of, 160-161, 160f vs. penile squamous cell carcinoma, 591
vs. pleomorphic liposarcoma, 917 basal cell adenoma of, 158-159, 158f vulvar, 610
prostatic, 557 carcinoma ex mixed tumor of, 151-152, Sarcoma botryoides, 615-616, 615f
vs. lymphoma, 558 152f, 168, 168f vs. vaginal polyps, 610
sclerosing, vs. sclerosing epithelioid sarcoma, carcinosarcoma of, 168-169, 169f vs. vaginal rhabdomyosarcoma, 615
907 cystadenoma of, 156-157, 156f Sarcomatoid carcinoma. See also
sinonasal, 188-189, 189f epithelial-myoepithelial carcinoma of, 165- Carcinosarcoma.
alveolar, 188 166, 166f metastatic, vs. inflammatory myofibroblastic
embryonal, 188 hemangioma of, 157-158, 157f tumor, 901
1102 Index

Sarcomatoid carcinoma (Continued) Sebaceous gland hyperplasia Sessile serrated polyp, vs. gastrointestinal polyp,
of esophagus, 326-327 vs. nevus sebaceus, 98 385-386
differential diagnosis of, 327 vs. sebaceous epithelioma, 99 Sex cord tumor with annular tubules
of larynx, 212, 212f Sebaceous gland lymphadenoma, of salivary ovarian, 672
vs. benign esophageal lesions, 323 glands, 159, 159f vs. gonadoblastoma, 685
vs. carcinosarcoma, 169 Seborrheic dermatitis, vs. spongiotic dermatitis, vs. gynandroblastoma, 673
vs. phyllodes tumor, 556 51 Sex cordstromal tumor, ovarian, 665. See also
vs. rhabdomyosarcoma, 509 Seborrheic keratosis, 45-46, 83f specific tumor.
vs. xanthogranulomatous pyelonephritis, vs. poroma, 93 immunohistochemistry approach to, 16t
517 Secretory carcinoma, of breast, 733, 733f Shigellosis, in immunocompetent hosts,
Sarcomatoid mesothelioma, vs. pericardial Sectioning, in tissue processing, 2 349-350
fibrous tumor, 971 Segmental mediolytic arteriopathy, vs. Sialadenitis, 147-148, 148f
Scabies, 61, 61f medium-vessel vasculitis, 976 vs. lymphoma, 172
Scanning electron microscope, 8 Seminal vesicles, carcinoma of, 583 Sialometaplasia
Schneiderian papilloma (sinonasal papilloma), Seminoma (germinoma) necrotizing, vs. sialadenitis, 148
179-180, 179f classic, 563-565, 564f vs. mucoepidermoid carcinoma, 165
vs. sinonasal adenocarcinoma, 186 vs. spermatocytic seminoma, 565-566 Sickle cell disease, 808-810, 809f
vs. squamous cell carcinoma of sinonasal mediastinal, 301-302, 302f vs. hereditary spherocytosis, 808
region, 181 spermatocytic, 565-566, 565f Signal amplification techniques, 30-31
Schwannoma vs. diffuse large B-cell lymphoma, 779 Signet ring cell carcinoma
of central nervous system, 1017-1019, vs. diffuse large cell lymphoma, 296 pancreatic, 454
1017f vs. embryonal carcinoma, 566 prostatic, 549
of mediastinum, 307-308 vs. Leydig cell tumor, 572 vs. appendiceal carcinoid tumor, 408
of soft tissue, 925-926, 925f vs. lymphoma, 576 vs. gastric xanthelasma, 330
of stomach, 396f vs. orchitis, 560 Single membranebound structures, electron
vs. ganglioneuroblastoma/ganglioneuroma, vs. Sertoli cell tumor, 573 microscopy of, 9
306 vs. testicular choriocarcinoma, 570 Silicosis, 238-239
vs. gastrointestinal stromal tumor, 399 vs. testicular malakoplakia, 561 acute, 238
vs. intraocular malignant melanoma, vs. yolk sac tumor, 568 classic, 238
1058 Septic vasculitis, vs. leukocytoclastic vasculitis, Silicotuberculosis, 238
vs. malignant peripheral nerve sheath 72 Singers nodule, 208-209, 209f
tumor, 929 Serous carcinoma Sinonasal adenocarcinoma, 185-187, 186f
vs. meningioma, 1021 of fallopian tube, 692-693, 693f vs. sinonasal (Schneiderian) papilloma,
vs. myxopapillary ependymoma, 1001 of ovary, 654f-655f 180
vs. neurofibroma, 115, 926-927 immunohistochemistry of, 16t Sinonasal lesions, clinicopathologic
vs. soft tissue leiomyosarcoma, 923 Serous cystadenoma comparisons of, 174t
Scleredema, vs. morphea and scleroderma, 79 vs. ovarian benign mucinous tumor, 657 Sinonasal melanoma, 189-190, 190f
Sclerema neonatorum, vs. subcutaneous fat vs. ovarian follicular cyst, 648 vs. olfactory neuroblastoma, 188
necrosis, 81 vs. struma ovarii, 683 Sinonasal neoplasms, differential diagnosis of,
Scleritis, vs. orbital pseudotumor, 1064 Serous cystic neoplasms immunohistochemical markers in, 174t
Scleroderma, 78-79 of exocrine pancreas, 448-449, 448f Sinonasal papilloma (Schneiderian papilloma),
vs. graft-versus-host disease, 47 vs. mucinous cystic neoplasms, 450 179-180, 179f
Sclerosing adenosis Serous tumor. See also specific tumor. vs. sinonasal adenocarcinoma, 186
of breast, 709-710, 709f ovarian vs. squamous cell carcinoma of sinonasal
vs. apocrine carcinoma, 734 benign, 653-655, 654f-655f region, 181
vs. infiltrating ductal carcinoma, 724 borderline, 654f-655f, 655-656 Sinonasal region, squamous cell carcinoma of,
vs. infiltrating lobular carcinoma, 726 malignant, 654f-655f, 656-657 180-181, 181f
vs. tubular carcinoma, 730 Sertoli cell nodule, vs. gonadoblastoma, 575 Sinonasal rhabdomyosarcoma, 188-189, 189f
of prostate gland, 544 Sertoli cell tumor alveolar, 188
vs. adenocarcinoma, 550 ovarian, 670-671, 670f embryonal, 188
vs. basal cell carcinoma, 552-553 vs. gynandroblastoma, 673 vs. lymphoblastic lymphoma, 298
Scrotum, 594 testicular, 572-573, 572f vs. neuroblastoma, 306
idiopathic calcinosis of, 594, 594f vs. Leydig cell tumor, 571 Sinonasal teratocarcinoma, 182f
Paget disease of, 594-595 vs. seminoma, 564 Sinonasal undifferentiated carcinoma, 181-
squamous cell carcinoma of, 595 vs. struma ovarii, 683 182, 182f
Sebaceoma, 99, 99f Sertoli-Leydig cell tumor, ovarian, 671-672, vs. nasopharyngeal carcinoma, 184
vs. sebaceous carcinoma, 100 671f vs. olfactory neuroblastoma, 187-188
Sebaceous carcinoma. See Sebaceous gland vs. benign mucinous tumor, 657-658 vs. sinonasal adenocarcinoma, 186
carcinoma. vs. borderline mucinous tumor, 660 vs. sinonasal melanoma, 190
Sebaceous gland adenoma vs. borderline serous tumor, 656 vs. sinonasal squamous cell carcinoma,
vs. sebaceous epithelioma, 99 vs. endometrioid carcinoma, 661 181
vs. sebaceous gland carcinoma, 1055 vs. gynandroblastoma, 673 Sinus histiocytosis, 763-765
Sebaceous gland carcinoma, 99-100, 100f, vs. Leydig cell tumor, 674 nonspecific
1055-1056, 1055f vs. malignant mixed Mllerian tumor, vs. Langerhans cell histiocytosis, 765
vs. conjunctival squamous cell carcinoma, 662 vs. Rosai-Dorfman disease, 764
1054 vs. malignant mucinous tumor, 660 vs. nasopharyngeal carcinoma, 183-184
vs. sebaceous lymphadenoma, 159 vs. malignant serous tumor, 657 with massive lymphadenopathy (Rosai-
Sebaceous gland epithelioma. See Sebaceoma. vs. polyembryoma, 680 Dorfman disease), 763-765, 763f
Index 1103

Sinusitis Small intestine, 345-347. See also specific part. Spindle cell hemangioma, 930
acute and chronic, 173-176, 175f adenocarcinoma of, 359-360 Spindle cell lipoma, 913-914
fungal adenoma of, 358-359, 359f vs. liposarcoma/lipomatous tumor, 915
allergic, 175, 175f carcinoid tumors of, 360-362, 360f-361f vs. myxoid and round cell liposarcoma, 916
invasive, 175, 175f clear cell sarcoma of, 396f Spindle cell liposarcoma, vs. fibrosarcoma, 906
Sinusoidal dilation, vs. peliosis hepatis, 439 desmoid tumor of, 395f Spindle cell melanoma
Sipple syndrome. See Multiple endocrine lymphoma of, 399f-400f vs. clear cell sarcoma, 946
neoplasia IIA (MEN IIA). metastatic disease to, 409-410, 409f vs. inflammatory myofibroblastic tumor, 901
Skin. See also Cutaneous entries. Small lymphocytic lymphoma/chronic Spindle cell mesothelioma, vs. paratesticular
cystic conditions of, 81. See also specific cyst. lymphocystic disease fibrous pseudotumor, 579
inflammatory conditions of, 41-42. See also nodal, 774-775, 774f Spindle cell oncocytoma, adenohypophyseal
specific condition. vs. follicular lymphoma, 769 vs. pituicytoma, 1030
neoplasms of. See also specific neoplasm. vs. mantle cell lymphoma, 776 vs. pituitary adenoma, 1030
eccrine and apocrine, 91 vs. nodal marginal zone lymphoma, 777 Spindle cell proliferation, postoperative, vs.
fibroblastic, 111 vs. nodular lymphocyte predominant prostatic phyllodes tumor, 556
follicular, 88 Hodgkin lymphoma, 773 Spindle cell rhabdomyosarcoma
hematopoietic, 116 vs. paracortical hyperplasia, 759 vs. infantile fibrosarcoma, 905
melanocytic, 100 splenic, 798-799 vs. soft tissue leiomyosarcoma, 923
neural, 114 morphologic and immunophenotypic Spindle cell sarcoma, vs. thymoma, 289
sebaceous, 98-99 features of, 797t Spindle cell tumor
smooth muscle, 109 vs. mantle cell lymphoma, 801 immunohistochemistry panel interpretation
vascular, 105 vs. prolymphocytic leukemia, 800 for, 15t
proliferations of. See also specific condition. vs. hairy cell leukemia, 812 malignant
epidermal, 83 vs. hepatosplenic T-cell lymphoma, 813 vs. carcinosarcoma, 510
fibroblastic, 111 Small-vessel vasculitis vs. renal angiomyolipoma, 518
hematopoietic, 116 immune complex, 980-981 pleomorphic cutaneous, antibody panel for,
melanocytic, 100 pauci-immune, 977-980, 977f 19t
neural, 114 vs. medium-vessel vasculitis, 976 vs. medullary thyroid carcinoma, 138
smooth muscle, 109 Smooth muscle neoplasms, 109 vs. salivary myoepithelioma, 154
vascular, 105 Smooth muscle tumor, true, vs. gastrointestinal Spindle cell variant, of salivary myoepithelioma,
Skin adnexal carcinoma, vs. Bartholin gland stromal tumor, 398-399 153
carcinoma, 606 Sneddon-Wilkinson disease, 73-74, 73f Spiradenoma, 93-94, 93f
Skull-based neoplasms, differential diagnosis of Soft tissue neoplasms. See also specific neoplasm. Spirochetosis, in immunocompromised patients,
immunohistochemical evaluation of, cytogenetic abnormalities in, 23t-24t 351f, 352-353
diagnostic algorithm for, 174f Solid pseudopapillary neoplasm, 458-459, 458f Spitz nevus, 101, 102f
immunohistochemical markers in, 174t vs. invasive ductal adenocarcinoma, 454 vs. spitzoid melanoma, 105
Small airway diseases, 225t vs. pancreatic acinar cell carcinoma, 455 Spleen
obstructive, 224 vs. well-differentiated pancreatic neoplasm, circulatory abnormalities of, 826-827. See
Small B-cell lymphoma, immunohistochemistry 457 also Splenomegaly, congestive.
panel for, 19t Solitary fibrous tumor, 902-903, 902f cysts and pseudotumoral lesions of, 821-823
Small cell astrocytoma, 990 vs. deep benign fibrous histiocytoma, 910 granulomatous diseases of, 832-833
vs. oligodendroglioma, 997 vs. gastrointestinal stromal tumor, 399 hematologic diseases of, 804-806
Small cell carcinoma vs. hemangiopericytoma, 1023 other conditions involving, 834
metastatic. See Metastatic small cell vs. hemangiopericytoma/myopericytoma, 932 red pulp of
carcinoma. vs. mediastinitis, 294 neoplastic diseases of, 812-813
of endocrine pancreas, 457-458 vs. meningioma, 1021 non-neoplastic diseases of, 804-806
of esophagus, 327-328 vs. mesothelioma, 280 traumatic rupture of, 835
differential diagnosis of, 328 vs. nasopharyngeal angiofibroma, 178 vascular tumors of, 817-818. See also specific
of lung, 266-268, 267f vs. phyllodes tumor, 556 tumor.
neuroendocrine granules in, 9f vs. synovial sarcoma, 940 vasculitides involving, 827-828. See also
vs. carcinoid tumor, 270 Solitary plasmacytoma, 875-877 specific arthritic disease.
of ovary, 686, 686f Solitary rectal ulcer syndrome, 372f, 374f viral and nongranulomatous infections of,
vs. adult granulosa cell tumor, 668 Somatic-type malignancy, vs. testicular 828-829
vs. juvenile granulosa cell tumor, 669 teratoma, 569 white pulp of
of prostate gland, 553-554 Southern blot assay, 32, 33f neoplastic diseases of, 796-798
of urinary bladder, 507-508 Spermatocele, vs. testicular hydrocele, 559 non-neoplastic diseases of, 792-793
of uterine cervix, 627-628, 627f Spherocytosis, hereditary, 808, 808f Splenic infarcts, vs. sickle cell disease, 809
undifferentiated, cutaneous, 115-116, vs. autoimmune hemolytic anemia, 811 Splenic red pulp hyperplasia, vs. chronic
115f vs. sickle cell disease, 809-810 myelogenous leukemia, 816
vs. Burkitt lymphoma, 784 Spider cells, 965 Splenoma. See Hamartoma, splenic.
vs. cervical squamous cell carcinoma, 622 Spinal cord, paraganglioma of, 1009-1010 Splenomegaly, congestive, 826-827, 826f
vs. desmoplastic small round cell tumor, Spindle cell carcinoma vs. autoimmune hemolytic anemia, 811
944 of kidney, 527, 527f vs. hereditary spherocytosis, 808
vs. lymphoblastic lymphoma, 298 vs. renal cell carcinoma, sarcomatoid Spongiosis, epidermal, 50-52
vs. neuroblastoma, 306 type, 529 Spongiotic dermatitis, 51f
Small cell tumors. See also specific tumor. of larynx, 212, 212f vs. mycosis fungoides, 119
round, immunoprofile of, 19t of thymus, 291 vs. psoriasis, 51
vs. osteosarcoma, 843 vs. gastrointestinal stromal tumor, 398 vs. secondary syphilis, 58
1104 Index

Sporotrichosis, 70 Squamous papilloma Stromal tumor


Sprue, celiac, 356f-357f diagnostic features of, 259t extragastrointestinal, vs. soft tissue
Squamous cell carcinoma, 86-87, 87f of esophagus, 324-325 leiomyosarcoma, 923
basaloid of lungs, 258-260, 259f gastrointestinal. See Gastrointestinal stromal
of larynx, 212, 212f of oral cavity, 194, 194f tumor.
of thymus, 291, 291f of vagina, 610-611, 611f sclerosing, 669-670, 670f
vs. adenoid cystic carcinoma, 161 vs. benign esophageal lesions, 323 ovarian, 669-670, 670f
in situ, vs. actinic keratosis, 86 vs. cervical condyloma acuminatum, 618 vs. myometrial adenomyosis, 643
metastatic. See Metastatic squamous cell vs. conjunctival squamous cell carcinoma, Strongyloides stercoralis infestation, 378-379
carcinoma. 1054 Structural deterioration, of prosthetic heart
nonkeratizing vs. sinonasal (Schneiderian) papilloma, 180 valves, 963
vs. cervical glassy cell carcinoma, 627 vs. squamous cell carcinoma, 213, 507 Struma ovarii, 682-683, 683f
vs. cervical small cell carcinoma, 628 Staining, in tissue processing, 2 vs. serous cystadenoma, 655
of conjunctiva, 1054, 1054f Staphylococcal scalded skin syndrome Stye (chalazion), vs. sebaceous gland
of cornea, 1054 vs. erythema multiforme, 46 carcinoma, 1055
of esophagus, 324-325, 324f vs. pemphigus, 75 Subareolar abscess, 701-702, 702f
variants of, 326-327 Status asthmaticus, 223 Subcapsular fibrosis, vs. cirrhosis, 426
vs. granular cell tumor, 324 Status spongiosus, vs. dementia, 1049 Subcorneal pustular dermatosis (Sneddon-
vs. reflux esophagitis, 318 Steatocystoma, 82, 82f Wilkinson disease), 73-74, 73f
of larynx, 211-213, 211f Steatohepatitis Subcutaneous fat necrosis, of newborn, 80-81,
subtypes of, 211-212, 212f alcoholic, 415-416, 416f. See also Alcoholic 81f
of lungs, 265-266, 265f steatohepatitis. Subependymal giant cell astrocytoma, 995-
of oral cavity, 207-208, 207f nonalcoholic, 416-417. See also 996, 995f
of penis, 590-591, 590f Nonalcoholic steatohepatitis. Subependymal glial nodule, vs. subependymal
of prostate gland, 554-555, 555f Stenosis giant cell astrocytoma, 996
of scrotum, 595 intestinal, 346-347 Subependymoma, 1001-1002
of sinonasal region, 181f pyloric, 328-329 Subretinal hemorrhage, vs. intraocular
of thymus Steroid cell tumor malignant melanoma, 1058
keratizing type, 291 lipid-poor, vs. pregnancy luteoma, 652 Sudan black stain, 4
poorly differentiated, nonkeratizing type, ovarian, vs. thecoma, 667 Superficial spreading melanoma, 103
290f, 291 vs. struma ovarii, 683 Suppurative lymphadenitis, vs. cat-scratch
of tonsils or oropharynx, 184-185, 184f Stewart-Treves syndrome (postmastectomy disease, 756
of trachea, 214, 214f angiosarcoma), 740-741 Supratentorial primitive neuroectodermal
of urinary bladder, 506-507 Stomach, 328-329. See also Gastric; Gastritis; tumor, vs. desmoplastic infantile
of uterine cervix, 620-623, 621f-622f Gastro- entries. ganglioglioma, 1012-1013
of vagina, 612-613, 612f congenital and acquired abnormalities of, Sweat duct carcinoma, sclerosing, 97-98, 97f
of vulva, 603-605, 604f 328-329 vs. syringoma, 92
vs. ameloblastoma, 201 fundic gland polyp of, 337f-338f, 338 vs. trichoepithelioma, 88
vs. branchial cleft cyst, 129 hyperplastic polyp of, 337-338, 337f Sweet syndrome, 59, 59f
vs. invasive urothelial carcinoma, 504 inflammatory fibroid polyp of, 338 vs. pyoderma gangrenosum, 60
vs. laryngeal papilloma, 210 metastatic disease to, 409-410 Synovial chondromatosis, 885-886, 885f
vs. metaplastic carcinoma, 732 Storage diseases, differential diagnosis of, 805t Synovial chondrometaplasia, vs. synovial
vs. oral squamous papilloma, 194 Strand displacement amplification (SDA), 30 chondromatosis, 886
vs. penile verrucous carcinoma, 592 Strawberry nevus, 1066 Synovial chondrosarcoma, vs. synovial
vs. Pindborg tumor, 202 Stress fracture, vs. osteoid osteoma, 839 chondromatosis, 886
vs. prostatic epithelial metaplasia, 545 Stromal hyperplasia Synovial disease, 882-883. See also specific
vs. prostatic infarct, 543 ovarian, 650-651 disease.
vs. salivary duct carcinoma, 167 pseudoangiomatous, of breast, 714-715, Synovial sarcoma, 938-940, 939f
vs. scrotal Paget disease, 595 714f vs. carcinosarcoma, 169
vs. sebaceous gland carcinoma, 1055 vs. prostatic phyllodes tumor, 556 vs. epithelioid sarcoma, 941
vs. seborrheic keratosis, 83 Stromal hyperthecosis vs. Ewing sarcoma/peripheral
vs. sinonasal (Schneiderian) papilloma, ovarian, 650-651, 650f neuroectodermal tumor, 943
180 vs. stromal luteoma, 673 vs. fibrosarcoma, 906
vs. sinonasal undifferentiated carcinoma, vs. thecoma, 667 vs. hemangiopericytoma/myopericytoma,
182 Stromal luteoma, ovarian, 673 933
Squamous cell hyperplasia Stromal nodule vs. infantile fibrosarcoma, 905
vs. condyloma acuminatum, 602 endometrial, 640-641, 640f vs. low-grade fibromyxoid sarcoma, 903
vulvar, 600, 600f vs. endometrial stromal sarcoma, 641 vs. malignant peripheral nerve sheath
Squamous dysplasia vs. myometrial leiomyoma, 645 tumor, 929
pulmonary, 258-260 Stromal sarcoma vs. rhabdomyosarcoma, 921
vs. leukoplakia, 193 endometrial vs. soft tissue leiomyosarcoma, 923
Squamous intraepithelial lesion high-grade, 642 vs. solitary fibrous tumor, 902
of uterine cervix, 618-620, 619f low-grade, 641 vs. Wilms tumor, 534
vs. cervical condyloma acuminatum, 618 vs. adult granulosa cell tumor, 668 Synovitis
Squamous metaplasia vs. stromal nodule, 640 detritic, vs. pigmented villonodular synovitis,
vs. cervical squamous cell carcinoma, 622 vs. myometrial leiomyoma, 645 887
vs. prostatic squamous cell carcinoma, vs. myometrial leiomyosarcoma, 646 hemosiderotic, vs. pigmented villonodular
555 vs. ovarian stromal hyperplasia, 651 synovitis, 887
Index 1105

Synovitis (Continued) Tendon sheath fibroma, vs. superficial Thrombus


infectious granulomatous, vs. gout, 884 fibromatosis, 894 formation of, in prosthetic heart valves, 954,
pigmented villonodular, 886-887, 886f Tendon sheath giant cell tumor, 908-909, 909f 963
rheumatoid, vs. pigmented villonodular vs. calcifying aponeurotic fibroma, 897 vs. cardiac myxoma, 965
synovitis, 887 Teratocarcinoma, sinonasal, 182f Thymic carcinoma, 290-292
traumatic, vs. pigmented villonodular Teratocarcinosarcoma, vs. sinonasal basaloid type, 291, 291f
synovitis, 887 adenocarcinoma, 187 clear cell type, 291
Syphilis, 413-414, 750, 750f Teratoid tumor/rhabdoid tumor keratinizing squamous cell type, 291
secondary, 58, 58f atypical, 1013 low-grade vs. high-grade, 291t
vs. autoimmune lymphoproliferative vs. choroid plexus carcinoma/papilloma, mucoepidermoid type, 290f, 291
syndrome, 754 1014 poorly differentiated, nonkeratizing
vs. follicular lymphoid hyperplasia, 747 vs. medulloblastoma, 1011 squamous cell type, 290f, 291
vs. HIV-associated lymphadenopathy, 748 Teratoma spindle cell type, 291
Syphilitic orchitis, 560 cystic vs. nonseminomatous germ cell tumors, 304
Syringocystadenoma papilliferum, 96-97, 96f vs. foregut cyst, 284 Thymic cyst, 281-282, 282f
Syringoma, 91-92, 92f vs. pancreatic lymphoepithelial cyst, 448 vs. foregut cyst, 283
chondroid, 92 vs. thymic cyst, 282 vs. Hodgkin lymphoma, 295
clear cell, 92 mediastinal, 300-301, 300f-301f Thymic follicular hyperplasia, 285
vs. microcystic adnexal carcinoma, 98 with additional malignant components, vs. true thymic hyperplasia, 285
vs. trichoepithelioma, 88 301 Thymic hyperplasia, 294
Systemic lupus erythematosus ovarian vs. thymoma, 289
bullous, vs. dermatitis herpetiformis, 77 immature, 681-682, 681f Thymolipoma, 286
splenic involvement in, 827-828, 827f vs. malignant mixed mllerian tumor, Thymoma, 286-289, 286f-287f
vs. autoimmune lymphoproliferative 662 classification of, 288, 289t
syndrome, 754 mature cystic, 674-675, 675f cystic, vs. thymic cyst, 282
vs. Goodpasture syndrome, 238 mature solid, 675-676, 676f vs. Hodgkin lymphoma, 295
monodermal vs. lymphoblastic lymphoma, 297-298
T carcinoid tumor, 683-684 vs. thymic hyperplasia, 285
Takayasu arteritis, 973-975 struma ovarii, 682-683, 683f vs. thymolipoma, 286
Tanycytic ependymoma, 999 testicular, 569, 569f Thymus
Tattoo ink, vs. dermatopathic thyroid, 130, 130f histology of, in immune deficiency, 299-300
lymphadenopathy, 752 Terminal duct carcinoma, of salivary glands, involution of, vs. thymolipoma, 286
T-cell(s), 11 162-163, 163f neuroendocrine neoplasms of, 292-293, 292f
T-cell large granular lymphocytic leukemia, vs. Testis, 558-559 Thyroglossal duct cyst, 128-129, 128f
splenic marginal zone lymphoma, 798 choriocarcinoma of, 570-571, 570f vs. thyroid teratoma, 130
T-cell lymphoma embryonal carcinoma of, 566-567, 566f Thyroid gland, 122-123
angioimmunoblastic, 786-787, 786f gonadoblastoma of, 574-575, 574f adenoma of, vs. thyroid carcinoma,
vs. mixed cellularity Hodgkin lymphoma, granulosa cell tumor of, 573-574, 573f immunohistochemistry panel
788 hydrocele of, 559 distinguishing, 19t
vs. peripheral T-cell lymphoma, 785 intratubular germ cell tumor of, 563, 563f carcinoma of, vs. parathyroid carcinoma, 147
cutaneous, 118-119, 119f Leydig cell tumor of, 571-572, 571f cysts of
CD30-positive, 119-120, 120f lymphoma of, 575-576, 575f branchial cleft, 129-130, 129f
vs. Langerhans cell histiocytosis, 118 malakoplakia of, 560-561, 561f thyroglossal duct, 128-129, 128f
enteropathy-associated, 400, 400f seminoma of, 563-565, 564f vs. parathyroid cyst, 143
hepatosplenic, 813-814, 813f spermatocytic, 565-566, 565f follicular adenoma of, 131-132, 132f. See
morphologic and immunophenotypic Sertoli cell tumor of, 572-573, 572f also Follicular thyroid adenoma.
features of, 797t teratoma of, 569, 569f follicular carcinoma of, 133-134, 133f. See
vs. marginal zone lymphoma, 798 torsion of, 561-562, 561f also Follicular thyroid carcinoma.
of thyroid gland, 141 undescended, 558-559, 558f goiter of. See Goiter.
peripheral, 784-785, 784f yolk sac tumor of, 567-568, 567f Graves disease of. See Graves disease.
vs. anaplastic large cell lymphoma, 782 Thecoma hyalinizing trabecular tumor of, 130-131,
vs. autoimmune lymphoproliferative luteinized 131f
syndrome, 755 vs. pregnancy luteoma, 652 inflammation of. See Thyroiditis.
vs. diffuse large B-cell lymphoma, 779 vs. stromal hyperthecosis, 650 lymphoma of, 141-142, 141f
vs. histiocytic necrotizing lymphadenitis, ovarian, 666-667, 666f vs. thyroid teratoma, 130
758 vs. adult granulosa cell tumor, 668 vs. undifferentiated thyroid carcinoma, 141
vs. mast cell disease, 761-762 vs. fibroma, 666 medullary carcinoma of, 136-138, 137f. See
vs. nodular sclerosing Hodgkin vs. juvenile granulosa cell tumor, 669 also Medullary thyroid carcinoma.
lymphoma, 772 vs. sclerosing stromal tumor, 670 nodules of, vs. parathyroid adenoma, 146
T-cellrich large B-cell lymphoma, vs. nodular Thromboangiitis obliterans (Buerger disease), papillary carcinoma of, 134-136, 135f. See
lymphocyte predominant Hodgkin 982 also Papillary thyroid cancer.
lymphoma, 773 Thromboembolus poorly differentiated carcinoma of, 138-139,
Telangiectasia, capillary, 1035-1036 organizing, vs. thromboangiitis obliterans, 138f
Telangiectasia macularis eruptiva perstans, 43f, 982 vs. medullary thyroid carcinoma, 138
44 vs. splenic vasculitis, 828 vs. undifferentiated thyroid carcinoma,
Telangiectatic osteosarcoma, 843-844, 844f Thrombophlebitis, migratory, 72-73, 72f 140
vs. aneurysmal bone cyst, 879 Thrombotic thrombocytopenic purpura, splenic sarcoma of, vs. undifferentiated thyroid
Temperature, affecting fixation, 3 involvement in, 827-828 carcinoma, 140
1106 Index

Thyroid gland (Continued) Trichoadenoma, vs. trichoepithelioma, 88 Ulcerative colitis, 366f-367f, 367-368
teratoma of, 130, 130f Trichoblastoma, vs. basal cell carcinoma, 91 glandular dysplasia in, 310, 371
tumors metastasizing to, 142, 142f Trichoepithelioma, 88-89, 88f Ulcerative esophagitis, vs. squamous papilloma/
undifferentiated (anaplastic) carcinoma of, desmoplastic, vs. microcystic adnexal carcinoma, 325-326
139-141, 140f carcinoma, 98 Undifferentiated neuroendocrine carcinoma, of
vs. Riedel thyroiditis, 125 vs. basal cell carcinoma, 91 salivary glands, 169-170, 170f
Thyroid orbitopathy, 1064-1065, 1065f vs. syringoma, 92 Undifferentiated tumors
vs. pseudotumor, 1064 Trichuris trichiura infestation (whipworm), 378- immunohistochemistry approach to, 12t
Thyroiditis 379, 378f of endocrine pancreas, 457-458
chronic lymphocytic (Hashimoto thyroiditis), Triple negative carcinomas, of breast, 726-727, Unicameral bone cyst, 879
123-124, 123f 727f vs. aneurysmal bone cyst, 879
granulomatous (de Quervain thyroiditis), Trophoblastic lesions. See also specific lesion. Unusual interstitial pneumonia, 228-230,
122-123, 123f immunohistochemistry approach to, 17t 229f
Riedel, 124-125, 124f True smooth muscle tumor, vs. gastrointestinal vs. asbestosis, 240
Time interval, affecting fixation, 3 stromal tumor, 398-399 vs. cryptogenic organizing pneumonia,
Tinea barbae, 41 TTF-1, immunohistochemistry for, 12f 228
Tinea capitis, 41 Tubal metaplasia, vs. cervical adenocarcinoma vs. desquamative interstitial pneumonia,
Tinea corporis, 41 in situ, 624 232
Tinea cruris, 41 Tuberculoid leprosy, 68 vs. hypersensitivity pneumonitis, 234
Tinea pedis, 41 vs. sarcoidosis, 67 vs. nonspecific interstitial pneumonia,
Tinea unguium, 41 Tuberculosis 231
Tissue microdissection, 25 Addison disease due to, 462f vs. pulmonary Langerhans cell
applications of, 25 cutaneous, 69 histiocytosis, 277
methods of, 25f in immunocompromised patients, 352-353 Urachal adenocarcinoma, of bladder, 505-506
Tissue processing, in light microscopy, overview in lymph node, 766f Ureter, 488
of, 2 miliary, 832-833 urothelial carcinoma of, 488-490, 489f
Toluidine blue stain, 6 Mycobacterium, 247-248, 248f Ureteritis cystica, 488
Tonsils, squamous cell carcinoma of, 184-185, Tuberculous lymphadenitis, 766-767, 766f Urethra, 583-585
184f vs. cat-scratch disease, 756 carcinoma of, 585
Torsion, testicular, 561-562, 561f vs. histiocytic necrotizing lymphadenitis, caruncle of, 584, 584f
Torulopsis glabrata, diagnostic features of, 758 nephrogenic adenoma of, 584, 584f
252t vs. sarcoidosis, 768 polyps of, 583-584
Toxic cardiomyopathy, 953 Tuberculous mastitis fibroepithelial, 583
Toxicity vs. granulomatous lobar mastitis, 703 prostatic, 584-585
amiodarone, 241, 242f vs. plasma cell mastitis, 703 Urinary bladder, 490
bleomycin, 241-242, 241f Tubular apocrine adenoma, vs. adenocarcinoma of, 505-506
drug, vs. fatty liver of pregnancy, 418 syringocystadenoma papilliferum, 97 vs. cystitis cystica et of glandularis, 495
Toxoplasma lymphadenitis, 751, 751f Tubular carcinoid tumor, of appendix, 408, vs. seminal vesicle carcinoma, 583
vs. autoimmune lymphoproliferative 408f vs. villous adenoma, 505
syndrome, 754 Tubular carcinoma, of breast, 729-730, 729f carcinosarcoma of, 509-510
vs. follicular lymphoid hyperplasia, 747 vs. adenoma, 715 cystitis of, 490. See also Cystitis.
vs. infectious mononucleosis, 749 vs. adenosis, 710 inflammatory myofibroblastic tumor of, 508,
Trabecular tumor, hyalinizing, 130-131, vs. fibroadenoma, 716 508f
131f vs. infiltrating ductal carcinoma, 724 inflammatory pseudotumor of, 508
vs. medullary thyroid carcinoma, 138 vs. radial sclerosing lesion, 711 invasive urothelial carcinoma of, 502-504,
Trachea, malignancies of, classification of, Tubules, electron microscopy of, 9, 10t 502f
214 Tularemia, vs. cat-scratch disease, 756 inverted papilloma of, 499-500, 500f
Transcription-mediated amplification (TMA), Tumid lupus erythematosus, 48 malakoplakia of, 491, 491f
30 Tumor(s). See also Pseudotumor(s); specific metastatic tumor of, 510
Transitional cell carcinoma tumor. nephrogenic adenoma of, 495-496, 496f
of ovary, 664-665, 664f metastatic. See Metastatic entries. papillary neoplasm of, malignant potential
of prostate gland, 554 undifferentiated of, 500-501, 500f
vs. prostatic adenocarcinoma, 555 immunohistochemistry approach to, 12t papillary urothelial carcinoma of
vs. prostatic epithelial metaplasia, 545 of endocrine pancreas, 457-458 noninvasive high-grade, 502, 502f
vs. seminal vesicle carcinoma, 583 Tumor suppressor genes, 22t noninvasive low-grade, 501, 501f
Transmission electron microscope, 8 Tumoral calcinosis, vs. pseudogout, 885 rhabdomyosarcoma of, 509
Transplantation Tumor-node-metastasis (TNM) staging, of small cell carcinoma of, 507-508
liver, pathology of, 424-425, 424f prostate adenocarcinoma, 551t squamous cell carcinoma of, 506-507
lung, 257-258 Tunica vaginalis, mesothelioma of, 582, 582f urothelial carcinoma in situ of, 497-498,
rejection in, 257f Turcot syndrome, 392 498f
grading scheme for, 258t Typhoid fever, 349-350 urothelial dysplasia of, 497, 497f
Traumatic splenic rupture, vs. hematoma, 835 urothelial hyperplasia of, 496-497
Traumatic synovitis, vs. pigmented villonodular U papillary, 498-499
synovitis, 887 Ulcer urothelial lesions of
Trichilemmal cyst, 82, 82f gastric, 341-342 flat, 496
calcified, vs. pilomatricoma, 89 Marjolin, 87. See also Squamous cell papillary, 498
Trichilemmoma, 90, 90f carcinoma. urothelial papilloma of, 499, 499f
vs. clear cell hidradenoma, 95 peptic, 334-335, 335f villous adenoma of, 504-505, 505f
Index 1107

Urothelial carcinoma Vagina (Continued) Viral hepatitis, 411-413, 412f


of ureter intraepithelial neoplasia of, 611-612, 611f acute, 412
high-grade papillary, 489, 489f leiomyosarcoma of, 616 chronic, 412
low-grade papillary, 489, 489f polyps of, 610, 610f vs. alcoholic liver disease/alcoholic
of urinary bladder rhabdomyosarcoma of, 614-615 steatohepatitis, 415
invasive, 502-504, 502f embryonal, 615-616, 615f vs. autoimmune hepatitis, 421
noninvasive high-grade, 502, 502f squamous cell carcinoma of, 612-613, vs. drug-induced liver disease, 415
noninvasive low-grade, 501, 501f 612f vs. nonalcoholic fatty liver/nonalcoholic
vs. carcinosarcoma, 510 squamous papilloma of, 610-611, 611f steatohepatitis, 417
vs. collecting duct carcinoma, 525 Vaginal atrophy, vs. vaginal intraepithelial vs. Wilson disease, 420
vs. cystitis cystica et of glandularis, 495 neoplasia, 612 Viral infections. See also specific infection.
vs. inverted papilloma, 500 Vaginal intraepithelial neoplasia, 611-612, in immunocompromised patients, 351f,
vs. prostate carcinoma, 611f 352-353
immunohistochemistry panel Vascular conditions, of lungs, 242 of lungs, 245-246
distinguishing, 18t Vascular dementia, 1047-1049 Viral lymphadenitis, 756-757
vs. squamous cell carcinoma, 507 Vascular malformations, within central Viral lymphadenopathy
Urothelial carcinoma in situ, 497-498, 498f nervous system, 1035-1036, 1035f HIV-associated. See Lymphadenopathy,
vs. interstitial (Hunner) cystitis, 494 Vascular tumors, 861-862. See also specific HIV-associated.
vs. treatment-related cystitis, 497-498, 498f tumor. vs. mixed cellularity Hodgkin lymphoma,
vs. urothelial dysplasia, 497 benign, vs. spiradenoma, 94 788
vs. urothelial hyperplasia, 497 Vasculitis, 71 Viral orchitis, 559-560
Urothelial dysplasia, 497, 497f cerebral, 1038-1040, 1039f Viral pneumonia, diagnostic features of, 246t
vs. urothelial carcinoma in situ, 498 drug-induced, 979 Virginal hypertrophy, of breast, 705-706, 705f
vs. urothelial hyperplasia, 496 infection-induced, 979 Vitiligo, 42-43, 42f
Urothelial hyperplasia, 496-497 large-vessel, 973-975, 973f-974f vs. dermatophytosis, 42
vs. ureteritis cystica et glandularis, 488 leukocytoclastic, 71-72, 71f Vocal cord nodule, 208-209, 209f
Urothelial papilloma, 499, 499f vs. Sweet syndrome, 59 vs. amyloidosis, 211
inverted, 499-500, 500f medium-vessel, 975-976 Vocal cord polyp, 208-209
vs. invasive urothelial carcinoma, 504 noninfectious, vs. encephalitis/ Volume, affecting fixation, 3
vs. papillary urothelial carcinoma, 490 meningoencephalitis, 1044 Volvulus, 346-347
vs. papillary urothelial hyperplasia, 499 small-vessel Von Brunn nests
vs. papillary urothelial neoplasm of immune complex, 980-981 florid proliferation of, 500
malignant potential, 501 pauci-immune, 977-980, 977f vs. invasive urothelial carcinoma, 504
Urticaria, 43, 43f urticarial, 44 vs. ureteritis cystica et glandularis, 488
papular, 55f Venous cerebral infarcts, 1036-1038 Von Meyenburg complex (bile duct
vs. dermatophytosis, 42 Venous hemangioma, 1035-1036 hamartoma), 432, 432f
Urticaria pigmentosa, 116-117, 116f Vermiform appendix. See Appendix. Vulva, 599
macular variant, 43f, 44 Verocay bodies, 1018-1019 aggressive angiomyxoma of, 608-609, 608f
Uterine adenocarcinoma, vs. myometrial Verruca(e), 84-85. See also Condyloma angiomyofibroblastoma of, 608, 608f
adenomatoid tumor, 647 acuminatum. Bartholin gland carcinoma of, 597, 605-606
Uterine cervix, 616-617 genital condyloma acuminatum of, 601-602, 602f
adenocarcinoma in situ of, 623-624, 623f anal, 401, 401f, 403 granular cell tumor of, 607-608
adenocarcinoma of, 624-626, 625f penile, 588, 588f intraepithelial neoplasia of. See Vulvar
adenosquamous carcinoma of, 626-627 vs. trichilemmoma, 90 intraepithelial neoplasia (VIN).
condyloma acuminatum of, 617-618, 618f Verruca plana, 85 leiomyosarcoma of, 609
glassy cell carcinoma of, 627 Verruca vulgaris, 84, 85f lichen sclerosus of, 599, 599f
intraepithelial neoplasia of. See Cervical vs. oral squamous papilloma, 194 malignant melanoma of, 605
intraepithelial neoplasia. vs. seborrheic keratosis, 83 molluscum contagiosum of, 601, 601f
lesions of, differential diagnosis of, Verrucous carcinoma mucous cyst of, 600-601, 600f
immunohistochemistry expression of of esophagus, 326 Paget disease of, 606-607, 606f
p16 in, 17t differential diagnosis of, 327 papillary hidradenoma of, 607, 607f
metastatic adenocarcinoma of, 628-629 of larynx, squamous cell type, 211-212, sarcoma of, 610
microglandular hyperplasia of, 617, 617f 212f squamous cell carcinoma of, 603-605,
polyps of, 616-617, 616f of penis, 591-592 604f
small cell carcinoma of, 627-628, 627f vs. anal neoplasia, 404 squamous cell hyperplasia of, 600, 600f
squamous cell carcinoma of, 620-623, vs. oral squamous cell carcinoma, 207 Vulvar intraepithelial neoplasia (VIN), 602-
621f-622f vs. penile squamous cell carcinoma, 591 603, 603f
squamous intraepithelial lesion of, 618-620, vs. squamous cell carcinoma, 86-87, 87f vs. condyloma acuminatum, 602
619f vs. vulvar squamous cell carcinoma, 604 vs. extramammary Paget disease, 607
Uterus, 629-630 Verrucous hyperplasia, vs. squamous cell vs. vulvar malignant melanoma, 605
endometrium of, 629. See also Endometrial carcinoma, 213
entries; Endometrium; Endometritis. Vesiculobullous dermatosis, 73 W
myometrium of, 643. See also Myometrium. Villus(i), in breast adenocarcinoma, electron WAGR syndrome, 533
microscopy of, 9, 10f Waldenstrms macroglobulinemia, vs. chronic
V Villous abnormalities, vs. celiac sprue, 357- lymphocytic leukemia and small
Vagina, 610 358, 358f lymphocytic lymphoma, 799
adenosis of, 613, 613f Villous adenoma, of urinary bladder, 504-505, Wart(s). See Condyloma acuminatum;
clear cell adenocarcinoma of, 614, 614f 505f Verruca entries.
1108 Index

Warthin tumor, 154-155, 154f Wilms tumor (Continued) Xp11.2/TFE3 translocation, renal cell
cystic, vs. salivary duct cyst, 150 vs. nephrogenic rests and carcinoma associated with, 528, 528f
vs. cystadenoma, 157 nephroblastomatosis, 535 vs. renal cell carcinoma, papillary type,
vs. lymphoepithelial cyst, 150 vs. rhabdoid tumor, 538 523
vs. oncocytoma, 156 Wilson disease, 419-420, 419f
Warthin-Starry and Steiner stain, 6 vs. nonalcoholic fatty liver/nonalcoholic Y
Warty (condylomatous) carcinoma, vs. vulvar steatohepatitis, 417 Yeast-like fungi, differential diagnosis of,
squamous cell carcinoma, 604 World Health Organization (WHO) 252t
Web(s), esophageal, 311 classification Yersiniosis, in immunocompetent hosts,
Web resources, for molecular pathology of gastric carcinoma, 342 349-350
techniques, 38 of thymoma, 288, 289t Yolk sac tumor
Wegener granulomatosis, 242f, 977-978 Wright stain, 6 mediastinal, 299, 303f-304f
clinical and pathologic features of, 243t ovarian, 677-679, 678f
vs. extranodal NK/T-cell lymphoma, 192 X testicular, 567-568, 567f
vs. Goodpasture syndrome, 238 Xanthelasma, gastric, 329f-330f vs. choriocarcinoma, 681
vs. migratory thrombophlebitis, 73 Xanthoastrocytoma, pleomorphic, 994, 994f vs. clear cell carcinoma, 663
West Nile virus encephalitis, 1042 vs. gangliocytoma/ganglioglioma, 1005 vs. dysgerminoma, 677
Western blot assay, 37 vs. pilocytic astrocytoma, 993 vs. embryonal carcinoma, 566, 679
Wheals, urticarial, 43 Xanthogranuloma, 61-62, 62f vs. juvenile granulosa cell tumor, 574, 669
Whipple disease, 355f disseminated juvenile, vs. Langerhans cell vs. seminoma, 564
vs. infection in immunocompromised histiocytosis, 816
patients, 354 necrobiotic, 66f Z
White pulp, splenic vs. craniopharyngioma, 1032 Zellballen appearance, of pheochromocytoma,
neoplastic diseases of, 796-798 vs. Langerhans cell histiocytosis, 118 473, 474f
non-neoplastic diseases of, 792-793 vs. necrobiotic xanthogranuloma, 66 Ziehl-Neelsen stain, for acid-fast bacilli, 6, 7f
Wickham striae, 44 Xanthogranulomatous cystitis, vs. Zollinger-Ellison syndrome, 336
Wilms tumor, 533-535, 534f malakoplakia, 491 differential diagnosis of, 337
metastatic, vs. pleuropulmonary blastoma, Xanthogranulomatous pyelonephritis, 516- Zona glomerulosa hyperplasia, adrenal, 465,
275 517, 516f 465f
vs. adrenal neuroblastoma, 479 Xanthoma Zygomycetes, diagnostic features of, 250t
vs. clear cell sarcoma, 537 vs. necrobiotic xanthogranuloma, 66 Zygomycosis, 251, 251f
vs. mesoblastic nephroma, 536 vs. xanthogranuloma, 62 differential diagnosis of, 226f