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Violence and schizophrenia: examining the evidence

ELIZABETH WALSH, ALEC BUCHANAN and THOMAS FAHY


BJP 2002, 180:490-495.
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Violence and schizophrenia: examining the evidence VIOLENCE STUDIES

Three different approaches have been used


ELIZABETH WALSH, ALEC BUCHANAN and THOMAS FAHY
to examine the association between schizo-
phrenia and violence. These include studies
estimating the prevalence of:
(a) violent acts in those with schizophrenia;
(b) schizophrenia in individuals who have
committed violent acts;
(c) violence in those with and without
schizophrenia, regardless of involve-
The conclusions of those reaching the ment with the mental health or criminal
Background It is now accepted that
putative link between schizophrenia and justice systems (community-based
people with schizophrenia are significantly epidemiological studies).
violence changed in the late twentieth
more likely to be violentthan other
century. Until the early 1980s the con-
members of the general population. A less sensus was that those with schizophrenia Studies estimating the prevalence
acknowledged fact is thatthe proportion were no more likely than the general of violent acts among those with
of societal violence attributable to population to be violent. New epidemio- schizophrenia
schizophrenia is small. logical evidence has emerged, however,
Two main designs have been used: cross-
that has radically challenged this view. It
sectional studies and cohort studies using
Aims To critically examine the is now generally accepted that people
case linkage technology.
with schizophrenia, albeit by virtue of
epidemiological evidence for the
the activity of a small subgroup, are
association between violence and significantly more likely to be violent than
Cross-sectional studies
schizophrenia and estimate the impact of members of the general population, but With violence being a main selection criter-
this association on society. the proportion of societal violence attri- ion for admission, studies of violence com-
butable to this group is small. This review mitted before and during hospitalisation
Method A selective review of the key provides an overview of the main studies are of limited usefulness because they will
literature on the epidemiology of violence that have influenced current thinking overestimate any association. Discharged
about the association, followed by an patients are a selected group because they
and schizophrenia.Population-attributable
epidemiological appraisal of the diffi- are generally judged not to pose a threat
risks for violence in schizophrenia are or to pose less threat than those retained
culties inherent in this type of research.
calculated from population-based studies. It attempts to differentiate those most at in hospital. As such, one would expect
risk of behaving violently and concludes lower rates of violence to be recorded at
Results Most studies confirm the this time than prior to admission.
with some estimate of the absolute risk
association between violence and posed to the community by those with
schizophrenia.Recent good evidence schizophrenia. hospitalisation. Humphreys et al
Before hospitalisation.
supports a small but independent (1992) estimated that 20% of first-admission
patients with schizophrenia had behaved in
association.Comorbid substance abuse
METHOD a life-threatening manner prior to admis-
considerably increases this risk.The sion. Volavka et al (1997) estimated that
proportion of violent crime in society Computerised Medline and Psycinfo searches 20% of first-contact patients with schizo-
attributable to schizophrenia consistently were performed from January 1990 to phrenia had assaulted another person at
December 2000 using the terms VIO- some time in the past.
falls below10%.
LENCE, ASSAULT, SCHIZOPHRENIA,
Conclusions Less focus on the relative SEVERE MENTAL ILLNESS, MAJOR hospitalisation. These studies have
During hospitalisation.
MENTAL DISORDER and PSYCHOSIS. suggested relatively high rates of
risk and more on the absolute risk
riskof
of
We wished to conduct a critique of the main assaultativeness (Karson & Bigelow, 1987;
violence posed to society by people with Walker & Seifert, 1994). Results must be
epidemiological studies that have established
schizophrenia would serve to reduce the the link between the risk of violence and viewed with particular caution, however,
associated stigma. Strategies aimed at schizophrenia. We focus on these and on because violence may be more of a response
reducing this small risk require further some older studies to demonstrate the differ- to the contextual setting of a confined ward
ing methodologies employed in this type of than to an individuals mental state.
attention, in particular treatment for
research. This is not an all-inclusive review,
substance misuse. and the choice of articles reflects the authors discharge. The
Following discharge. two most
qualitative assessment of current themes of comprehensive studies published to date
Declaration of interest E.W. was
importance in this area of research. For on violence risk after discharge fail to pro-
funded by a WellcomeT
WellcomeTraining
raining Fellowship. additional reviews, see Mullen (1997) and vide separate data for schizophrenia (Stead-
Eronen et al,
al, (1998). man et al,
al, 1998; Link et al,al, 1992, see

490
V I OL E N C E A N D S C H I ZO P H R E NI A

below). Monahan & Applebaum (2000), as or 1985 (when community care was birth cohort. Three Axis I disorders were
part of the MacArthur Risk Assessment becoming the norm). Compared with uniquely associated with violence after
Study, estimated the prevalence of com- general population controls, both groups controlling for demographic risk factors
munity violence in discharged patients by were significantly more likely to be con- and all other comorbid disorders: alcohol
diagnosis. Violence was measured from victed for all categories of criminal offend- dependence, marijuana dependence and
multiple sources every 10 weeks for a year. ing, except sexual offences. Those with schizophrenic spectrum disorder.
Of the 17% of patients with a diagnosis of comorbid substance abuse accounted for a
schizophrenia, 9% were violent in the first disproportionate level of offending. The
20 weeks after discharge. This compares increased number of convictions in those Studies estimating the prevalence
with a violence prevalence of 19% for with schizophrenia in the 1985 group of schizophrenia in individuals who
depression, 15% for bipolar disorder, compared with the 1975 groupgroup seemed to have committed violent acts
17.2% for other psychotic disorders, 29% reflect a general increase in offending in
Numerous studies have estimated the prev-
for substance misuse disorders and 25% those of a similar age, gender and place of
alence of schizophrenia among prison
for personality disorder alone. The fact that residence. As such, the shift to community
inmates. Despite problems of unstandar-
this and other studies have found rates of care was not marked by any significant
dised diagnoses and the frequent absence
violence to be lower in those with schizo- change in relative rates of conviction in
of comparison data among the general
phrenia than in those with other diagnoses schizophrenia. The effect of community
population, the evidence suggests an
(Harris et al,
al, 1993; Wallace et al,
al, 1998) care on risk of violence in schizophrenia
over-representation of those with schizo-
should not be misinterpreted to suggest that requires further study. One study examin-
phrenia among offender populations.
schizophrenia may be irrelevant or even a ing homicide statistics in the UK has
Taylor & Gunn (1984), using validated
protective factor against violence. It is reported little fluctuation in the numbers
diagnoses, studied the psychiatric status of
probably true that schizophrenia is less of of people with mental illness committing
male prisoners remanded to a prison in
a violence risk than substance misuse, homicide between 1957 and 1995 and a
south London. Nine per cent of those sub-
personality disorder and possibly other 3% annual decline in their contribution to
sequently convicted of non-fatal violence
mental disorders, but when compared with the official statistics (Taylor & Gunn,
and 11% convicted of fatal violence had
the general population, as this review 1999).
schizophrenia, which are substantially
amply demonstrates, the evidence is over-
higher prevalences than would have been
whelmingly in favour of an increased risk
expected in the general population for the
of violent behaviour.
Unselected birth cohort studies same area (0.10.4%).
Teplin (1990) compared the prevalence
Hodgins (1992), in a 30-year follow-up of
of schizophrenia among 728 male prisoners
an unselected Swedish birth cohort, found
Retrospective cohorts using case linkage with that of the general population. The
that compared with those with no mental
prevalence in the jail population (2.7%)
Three studies using slightly different disorder, males with major mental disorder
was found to be three times higher than
methodologies have drawn similar conclu- had a 4-fold and women a 27.5-fold
that of the general population (0.91%)
sions. In the first, 644 patients with schizo- increased risk of violent offences. No sepa-
after controlling for socio-demographic
phrenia followed for up to 15 years on a rate data were provided for schizophrenia.
factors.
police register, were found to be four times A later study using the same methodology
Eronen et al (1996), in a study of 693
more likely to have committed a violent revealed similar findings (Hodgins et al, al,
people convicted of homicide in Finland,
crime than the general population (Lind- 1996).
found schizophrenia to be associated with
qvist & Allebeck, 1990). The first cohort study to demonstrate
an 8-fold increase in homicide by men and
The second study compared the rate of the quantitative risk of violent behaviour
a 6.5-fold increase by women.
criminal convictions among 538 incident for specific psychotic categories followed
Wallace et al (1998), in a study of indi-
cases of schizophrenia with that of non- an unselected birth cohort of 12 058
viduals convicted of serious offences in
psychotic psychiatric controls matched for individuals prospectively for 26 years
Victoria County, Australia, searched for
age and gender (Wessely et al,al, 1994). Male (Tiihonen et al,
al, 1997). The risk of violent
evidence of a psychiatric contact on the
patients with schizophrenia were twice as offences among males with schizophrenia
county psychiatric register. Those with
likely as men with other mental disorders was 7-fold higher than controls without
schizophrenia were found to be over four
to have a violent conviction. This was mental disorder.
times more likely to be convicted of inter-
despite the control group containing a sub- Brennan et al (2000) traced all arrests
personal violence and ten times more likely
stantial minority of individuals with for violence and hospitalisations for mental
to be convicted of homicide than the
psychiatric disorders with an established illness in a birth cohort followed to age 44
general population.
association with crime. Women with years. Schizophrenia was the only major
schizophrenia were also significantly more mental disorder associated with increased
likely to be convicted of violent crime than risk of violent crime in both males and
controls. females, adjusting for socio-economic Community prevalence studies
In the third study, Mullen et al (2000), status, marital status and substance abuse. The above studies, although valuable in
in Australia, studied two groups of patients Arseneault et al (2000) studied the past- making inferences about the relationship
with schizophrenia first admitted in either year prevalence of violence in 961 young between violence and schizophrenia, are
1975 (before major deinstitutionalisation) adults who constituted 94% of a total city subject to biases that will be discussed

4 91
WAL SH E T AL

below. Data on unselected samples of the diagnostic breakdown of subjects at all availability of diversion to the mental
people from the open community are (Link et al,
al, 1992). Fewer examine schizo- health systems and the severity of the
needed to augment the findings. Probably phrenia alone (Lindqvist & Allebeck, offence.
the most important study in the violence 1990; Wessely et al,
al, 1994) and those that Records of criminal convictions are a
literature to date is that of Swanson et al do use varying diagnostic techniques. widely used data source across studies.
(1990). Using a sample of 10 059 adult Diagnoses are variously derived from case Most violent individuals are not convicted
residents from Epidemiologic Catchment notes, psychiatric registers, clinical inter- (Elliott et al,
al, 1986). The mentally ill tend
Area (ECA) study sites (Eaton & Kessler, views or research interviews. Case-note to be diverted to the mental health care
1985), the authors examined the relation- diagnoses are dependent on individual system at various stages from apprehen-
ship between violence and psychiatric clinical judgements. Those extracted from sion to conviction. As such, it is likely
disorder. Eight per cent of those with case registers are usually those made at that only the more serious crimes will
schizophrenia alone were violent, discharge and are subject to the same lead to conviction. For this reason, the
compared with 2% of those without limitations. These diagnoses may be more association between schizophrenia and
mental illness. Comorbidity with sub- reliable, however, than those made at a more minor forms of violence is
stance abuse increased this percentage to single clinical interview
interview because they are impossible to estimate from this source.
30%. usually based on a period of observation For more serious offending such as homi-
Two other community epidemiological in hospital, collateral information and cide, individuals are more likely to be
studies, both finding increased risk of previous history, which are likely to brought to trial and convicted, thus justi-
violence among psychiatric patients (Link increase the validity of diagnoses. The use fying the dependence on criminal
et al,
al, 1992) and those with major mental of one agreed diagnostic procedure in registers. Unfortunately, as with all such
disorder (Stueve & Link, 1997), respec- studies would allow comparisons of like registers, they are prone to data errors,
tively, failed to provide data on schizo- with like. are not inclusive of all convictions and
phrenia as a separate diagnostic entity. often relate to one geographical area,
taking no account of crimes committed
Definition and measurement outside that jurisdiction.
METHODOLOGICAL of outcome The more recent use of multiple com-
LIMITATIONS OF VIOLENCE
How violence is defined varies greatly and bined measures for violence has highlighted
STUDIES
reported rates differ, depending on the the limitations of the majority of previous
The majority of studies over the past two levels of violence measured. Unsurprisingly, studies that relied on a single source. Stead-
decades have demonstrated a statistical studies that include threats as well as man et al (1998) used agency records, self-
association between schizophrenia and physical contact record higher rates than report and collateral informants to collect
violence. It can be argued, therefore, that those that include contact alone. It is information on violent acts. The one-year
the accumulated evidence from studies virtually impossible to find violence defined period prevalence for violence was 4.5%
adopting different methodologies supports in the same way in any two studies by using agency records (arrest and rehospita-
a causal relationship, because the con- different researchers. This highlights the lisation records) alone, 23.7% by adding
sistency of findings across studies over- need for the development of a standardised, patient self-reported acts that had not been
shadows the methodological weaknesses validated, reliable and acceptable rating in agency records and 27.5% by adding
of any one. Some have argued against this instrument that could be adopted across collateral informant-reported acts that had
conclusion (Arboleda-Florez et al, al, 1998), studies. not been in either agency records or patient
suggesting that this overlooks the possi- Measurement of violence in studies has self-reports. Thus, the final prevalence was
bility of consistent design flaws, including relied upon different single (self-report, six times higher than it would have been
violence measurement, selection bias, informant, case notes, official records) or if estimated from agency records alone.
confounding and poorly controlled com- combined sources of information. All Mulvey et al (1994a
(1994a) specifically set out
parisons, which may offer rival explana- sources have inherent limitations. Self- to compare the yield of violence when dif-
tions for the current statistical report measures may underreport violence ferent sources were used. A dramatically
associations. It is thus important that the because of the desire for social acceptability different picture emerged, depending on
findings of each study be appraised or fear of adverse consequences of the source. These results support the pre-
critically in the light of the limitations reporting. Additionally, retrospective vious observation that self-report methods
inherent in research of this complexity. designs produce problems with recall of consistently produce a higher frequency of
A brief overview of each of these limita- sometimes distant events. Informants, who violence
violence than official records (Elliott et
tions from an epidemiological viewpoint is are often nominated by patients, may not al,
al, 1986). Thus, to provide accurate
outlined below. be the most suitable people to provide empirical data, it is crucial that it be
information or be aware of incidents. based on self-report in conjunction with
Case notes are of limited usefulness collateral informant and official records.
Definition and measurement because they are often incomplete. With One problem inherent to the use of multiple
of exposure regard to police contacts or arrest records, measures is that judgement must be made
Some studies include schizophrenia as part the proportion of violent acts that leads about what constitutes a single episode of
of a heterogeneous group of psychotic dis- to arrest and prosecution varies as a violence and how the inconsistencies that
orders (Hodgins, 1992; Hodgins et al, al, function of the intensity and quality of may exist between reports should be
1996; Steadman et al,
al, 1998) or do not give policing, behaviour of the suspect, the handled.

492
V I OL E N C E A N D S C H I ZO P H R E NI A

Bias effect of social class on violence (Wallace et of committing violent acts: comorbid
Selection bias can occur whenever the al,
al, 1998). Alternatively, if neighbourhood substance abuse and acute psychotic
identification of individual subjects for controls are chosen, the estimated risk symptoms.
inclusion into a study, on the basis of may not be generalisable to the population It has been demonstrated repeatedly
either exposure or outcome status, at large (Steadman et al,al, 1998). that schizophrenia with comorbid sub-
depends in some way on the other axis Other possible biases include inter- stance abuse increases the risk of violence
of interest. This bias will result in an viewer bias and recall bias. On reading considerably compared with schizophrenia
observed relationship between exposure most violence studies it is unclear whether without comorbidity (Swanson et al, al,
(schizophrenia) and outcome (violence) interviewers were blind to subject status. 1990; Cuffel et al,
al, 1994; Tiihonen et al, al,
that is different among those who are If not, selective probing for symptoms of 1997; Wallace et al,
al, 1998). It is important
entered into the study than among those mental illness and/or violent episodes may to note that because there is an increase in
who would have been eligible but did result in interviewer bias. violence risk in those without comorbidity,
not participate. For example, a psychotic substance abuse merely increases the level
individuals refusal to participate in a of risk rather than causing it (Arsenault et
Confounding
study or follow-up interviews might be al,
al, 2000; Brennan et al,
al, 2000). Hence, the
related to his or her propensity for A confounder is a factor that is associated risk from substance abuse appears to be
violence. If so, the rates of violence for with the exposure (schizophrenia) and, additive.
those included in the samples may be independent of this exposure, is a risk With regard to acute symptomatology,
lower than the true rates for individuals factor for outcome (violence). Additionally, Taylor estimated that 46% of a sample of
with schizophrenia. it should not be on the causal pathway psychotic offenders were definitely or prob-
Location of recruitment is a crucial between exposure and outcome. Statistical ably driven by delusions (Taylor, 1985).
factor in interpreting any such association. relationships observed between schizo- But delusions are an extremely common
Research on violence and mental illness is phrenia and violence in any particular study psychopathological phenomenon in psy-
dominated by data on hospitalised/ will hinge on the investigators understand- chosis and serious violence is not, so other
discharged patients, but most individuals ing and statistical treatment of confounding factors must be operating (Taylor, 1998).
with mental disorder are not hospitalised factors (Arboleda-Florez et al, al, 1998). In a methodologically robust study,
(Robins & Reiger, 1991). Cross-sectional Because of the uncertainty of the causal Link et al (1992) compared arrest rates
prevalence studies in representative samples pathway between schizophrenia and vio- and self-reported violence in a sample of
of community residents with both treated lence, it is unclear what variables should community residents with no history of
and untreated mental disorders largely be considered as confounders. The more psychiatric contact with current and former
overcome the problem of selection bias, robust studies do control for a range of patients with heterogeneous diagnoses from
although not completely. They frequently possible confounding factors, but these are the same area. Former patients invariably
exclude those in jail (Steadman et al, al, by no means uniform. The relationship is were more violent than the never-treated
1998) and, as such, will underestimate even more complex than this, however, community sample and almost all the dif-
any association. with a wide range of personal and situa- ference between the groups could be
It is not unusual to find high refusal tional factors that must be important in accounted for by active symptoms. A
and attrition rates in these studies, also the mediation of violence being impossible further study revealed that specific threat/
leading to selection bias. In one study, only to measure. control override symptoms largely
50% of subjects completed all five follow- explained the relationship. These threat/
up interviews. These compliant subjects PREDICTORS OF VIOLENT control override symptoms represent
were found to be significantly less likely BEHAVIOUR IN experiences of patients feeling that people
to have a history of previous violence a SCHIZOPHRENIA are trying to harm them and experiences
major predictor of future violence than of their minds being dominated by forces
those lost to follow-up (Steadman et al, al, Risk factors for violence that operate in outside their control. These results have
1998). those without mental illness operate in been replicated subsequently (Swanson et
In analytical studies, the risk of violent schizophrenia, with strong predictors al,
al, 1990, 1996, 1997; Link et al, al, 1998).
offending in cases is expressed relative to including a history of previous violence The data in these studies, however, have
the risk in controls. It is thus important that and substance abuse. However, no sizeable been criticised for being retrospective,
the results be interpreted with specific refer- body of evidence clearly indicates the rela- having been gathered for other purposes
ence to the control group chosen. If, for ex- tive strength of schizophrenia or mental ill- and having weak measures of delusions
ample, risk of offending in schizophrenia is ness in general as a risk factor for violence and violence. The MacArthur Violence
estimated relative to non-psychotic psychi- compared with other risk factors (Mulvey Risk Assessment Study has largely over-
atric controls (Wessely et al,al, 1994), the risk et al,
al, 1994b
1994b). Indeed, compared with the come these methodological limitations and
ratio will depend on whether or not that magnitude of risk associated with the com- casts doubt on the importance of threat/
group contains an excess of patients with bination of male gender, young age and control override delusions as mediators
personality disorder and substance abuse lower socio-economic status, the risk of for violence (Appelbaum et al, al, 2000).
disorders, both of which are linked to vio- violence presented by mental disorder is Neither delusions in general nor threat/
lent behaviour. If national or population- modest (Monahan, 1997). control override delusions in particular
based figures are used for comparison, they Two factors appear to discriminate were found to be associated with an
may not take into account the confounding those with schizophrenia at increased risk increased risk of violence in this study.

4 93
WAL SH E T AL

The authors suggest that the reliance on and disease. As we have seen previously, (i.e. multiple measurements of violence and
self-report in previous studies may have for example, comorbidity substantially avoidance of bias).
resulted in the mislabelling of other increases the risk of violence in schizo-
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components of threat/control-override symptoms.
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