Name: Rick Meneses

Age: 16 years old

Diagnosis: Cellulitis

Adverse Reaction/
Name of Drug Mechanism of Action Indication Contraindications Interactions Nursing Responsibilities
Side Effects
Name: Rick Meneses
Age: 16 years old
Diagnosis: Cellulitis
Generic Name: Inhibits bacterial cell wall
Cloxacillin synthesis by binding to one
or more of the penicillin-
Trade Name: binding proteins (PBPs)
Pannox which in turn inhibits the
final transpeptidation step
of peptidoglycan synthesis
Prescribed Dose: in bacterial cell walls, thus
500 m IVP q 6h inhibiting cell wall
biosynthesis. Bacteria
eventually lyse due to
ongoing activity of cell wall
autolytic enzymes
(autolysins and murein
hydrolases) while cell wall
assembly is arrested.
Therapeutic Effects:
Bactericidal action
Cloxacillin is limited to Allergy to penicillin Probenecid Hypersensitivity: Before:
the infections due to and other -lactams. enhances cloxacillin Urticaria, Determine history
staphylococci Methi S, Subconjunctival plasma eosinophilia, fever, of hypersensitivity reactons to
particularly in the injections. concentrations if neutropenia and cephalosporin, penicillins, and
following infections: given skin rashes. If skin history of allergies, particularly
Skin and soft tissue concomitantly. rashes occurs, to drugs, before therapy is
infections, bone and treatment should be initiated.
joint infections, Incompatibilities: Cl discontinued.
urinary and oxacillin whether Perform skin test to determine
genitourinary injected through IV Gastrointestinal if patient is allergic to drug
infections, respiratory or IM route is Effects: Nausea, before initiation of therapy.
and ENT infections, incompatible with diarrhea.
neuromeningeal amino acids During:
infections, septicemic solutions, lipidic Hematological Inspect IM and IV injection
infections including solutions, blood for Effects: sites frequently for signs of
endocarditis. transfusion. Agranulocytosis, phlebitis.
In some surgical anemia,
operations, with high thrombocytopenia. Monitor for manifestations
staphylococcus risk, Transient rise in of hypersensitivity.
cloxacillin can be used transaminases and
as short-term alkaline Discontinue drug and report
prevention treatment. phosphatases. their appearance promptly.
Monitor for S&S of
anaphylactoid reaction (see
Appendix G) or other signs or
symptoms of hypersensitivity
reaction (see Appendix F) as
with other penicillins.
Name: Rick Meneses
Age: 16 years old
Diagnosis: Cellulitis