http://www.ncbi.nlm.nih.

gov/pubmed/21753771

Hypertens Res. 2011 Jul 14. doi: 10.1038/hr.2011.89. [Epub ahead of print]

The effect of body mass index and fasting glucose on the relationship
between blood pressure and incident diabetes mellitus: a 5-year follow-
up study.

Lee WY, Kwon CH, Rhee EJ, Park JB, Kim YK, Woo SY, Kim S, Sung KC.

Source

Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of

Medicine, Seoul, Republic of Korea.

Abstract

There is no consensus on the relationship between high blood pressure (BP) and incident diabetes mellitus (DM).

Therefore, the aim of the current study was to investigate the independent association between BP and incident DM

and identify the metabolic components that influence incident DM in Korean subjects. The current study included

14054 non-diabetic subjects (mean age of 41 years) at the start of the study who were followed for an average of 5

years. We measured the risk for incident DM according to the subjects' baseline BP. Subjects were separated into

three groups as follows: normotensive (<120/80mmHg), pre-hypertensive (120/80mmHg BP <140/90mmHg) and

hypertensive ( 140/90mmHg). The overall incidence of DM was 1.8% (246 subjects), comprising 0.9% of the

normotensive group, 1.9% of the pre-hypertensive group and 4.0% of the hypertensive group (P<0.01). Within the

hypertensive group, subjects with high body mass index (BMI) and high fasting-glucose levels were 40 times more

likely to develop DM compared with those with low BMI and low glucose levels (0.3 vs. 13.2%, P=0.001). The risk for

incident DM was significantly higher in the hypertensive group compared with that in the normotensive group (OR

3.41 vs. 1.00, P<0.0001). However, the significance disappeared after making adjustments for the baseline BMI and

fasting glucose levels (OR 1.18 vs. 1.00, P=0.83). We found that the significance of high BP in predicting incident

DM was influenced by the baseline BMI and fasting glucose levels of the subjects.Hypertension Research advance

online publication, 14 July 2011; doi:10.1038/hr.2011.89.

PMID: 21753771 [PubMed - as supplied by publisher]

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arti :
Tidak ada konsensus pada hubungan antara tekanan darah tinggi (BP) dan insiden
diabetes melitus (DM). Oleh karena itu, tujuan dari penelitian ini adalah untuk
menyelidiki asosiasi independen antara BP dan kejadian DM dan mengidentifikasi
komponen metabolik yang mempengaruhi kejadian DM pada mata pelajaran Korea.
Penelitian ini melibatkan 14 054 non-diabetes subyek (usia rata-rata 41 tahun) pada
awal penelitian yang diikuti selama rata-rata 5 tahun. Kami mengukur risiko insiden DM
menurut BP baseline subyek '. Subjek dipisahkan menjadi tiga kelompok sebagai
berikut: normotensif (<120/80 mmHg), pra-hipertensi (120/80 mm Hg BP <140/90
mmHg) dan hipertensi ( 140/90 mm Hg). Insiden keseluruhan DM adalah 1,8% (246
orang), terdiri dari 0,9% dari kelompok normotensif, 1,9% dari kelompok pra-hipertensi
dan 4,0% dari kelompok hipertensi (P <0,01). Dalam kelompok hipertensi, subjek
dengan indeks massa tubuh tinggi (BMI) dan tinggi tingkat glukosa puasa adalah 40 kali
lebih mungkin untuk mengembangkan DM dibandingkan dengan mereka dengan
rendah BMI dan kadar glukosa yang rendah (0,3 vs 13,2%, P = 0,001). Risiko atas
insiden DM secara signifikan lebih tinggi pada kelompok hipertensi dibandingkan
dengan pada kelompok normotensif (OR 3,41 vs 1,00, P <0,0001). Namun, makna
menghilang setelah membuat penyesuaian untuk BMI dasar dan kadar glukosa puasa
(1,18 vs 1,00 OR, P = 0,83). Kami menemukan bahwa pentingnya BP tinggi dalam
memprediksi insiden DM dipengaruhi oleh BMI dasar dan kadar glukosa puasa
publikasi online kemajuan subjects.Hypertension Penelitian, 14 Juli 2011; DOI:
10.1038/hr.2011.89.