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Olga N. Fedotovskaya
Stockholm University
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OlgaN.Fedotovskaya d
a
Sport Technology Research Center, Volga Region State Academy of Physical Culture, Sport and Tourism,
and b Laboratory of Molecular Genetics, Kazan State Medical University, Kazan, and c Department of Molecular
Biology and Genetics, Research Institute for Physical-Chemical Medicine, Moscow, Russia; d Department of
Abstract
Humans vary in their ability to achieve success in sports, and this variability mostly depends on ge-
netic factors. The main goal of this work was to review the current progress in the understanding of
genetic determinism of athlete status and to describe some novel and important DNA polymor-
phisms that may underlie differences in the potential to be an elite athlete. In the past 19 years, at
least 155 genetic markers (located within almost all chromosomes and mtDNA) were found to be
linked to elite athlete status (93 endurance-related genetic markers and 62 power/strength-related
genetic markers). Importantly, 41 markers were identified within the last 2 years by performing ge-
nome-wide association studies (GWASs) of African-American, Jamaican, Japanese, and Russian ath-
letes, indicating that GWASs represent a promising and productive way to study sports-related phe-
notypes. Of note, 31 genetic markers have shown positive associations with athlete status in at least
2 studies and 12 of them in 3 or more studies. Conversely, the significance of 29 markers was not
replicated in at least 1 study, raising the possibility that several findings might be false-positive. Fu-
ture research, including multicentre GWASs and whole-genome sequencing in large cohorts of ath-
letes with further validation and replication, will substantially contribute to the discovery of large
numbers of the causal genetic variants (mutations and DNA polymorphisms) that would partly ex-
plain the heritability of athlete status and related phenotypes. 2016 S. Karger AG, Basel
Genetic factors are considered to play a key role in athletic performance and related
phenotypes such as power, strength, aerobic capacity, flexibility, coordination, and
temperament. Despite a relatively high heritability of athlete status (up to 70% de-
pending on sport discipline) [1] and intermediate phenotypes [2, 3], the search for
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ticular sport-related genetic marker is based on several criteria, such as type of the
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160
120
100
80 155
60
40 79
20 36
Fig. 1. Growth in the number 8
1
of sports-related DNA poly- 0
1998 2005 2009 2012 2015
morphisms discovered from
1998 to 2015.
growing interest in the field of sports genomics and progress in DNA technologies.
Univ. of California Santa Barbara
proach.
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A literature search revealed at least 93 markers are associated with endurance athlete
status, and 19 of them were discovered by the use of microchip technology (table1).
Initially, Ahmetov et al. [7] examined the association between 1,140,419 SNPs and the
relative maximal oxygen consumption rate (VO2max) in 80 international-level Russian
endurance athletes (46 males and 34 females), and identified 6 suggestive endurance
alleles (with p< 105 to 108) which were replicated both in female and male sub-
groups. To validate the obtained results, the authors further performed case-control
studies by comparing the frequencies of 6 SNPs between 218 endurance athletes (or
100 elite endurance athletes) and opposite cohorts (192 Russian controls, 1,367
128.111.121.42 - 6/12/2016 10:07:06 PM
European controls, and 230 Russian power athletes). It was assumed that the
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(with p values from 0.001 to 1.34 105) and replicated in all 3 subgroups of power
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Conclusion
The current review provides evidence that at least 155 genetic markers are linked to
elite athlete status. However, it should be emphasized that most (80%) of the case-
control and association studies have not yet been replicated in independent samples.
Based on that, we strongly believe that much more research is needed before these
findings can be extended to practice in sport. On the other hand, since sport-related
DNA polymorphisms do not fully explain the heritability of athlete status, other forms
of variation, such as rare mutations and epigenetic markers (i.e. stable and heritable
changes in gene expression), must be considered. The issues with respect to appropri-
ate study designs, sample size, population stratification, and quality of the genotype/
phenotype measurement are also of great importance. Future research should also be
focused on identifying genetic markers associated with other sport-related pheno-
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E-Mail genoterra@mail.ru
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