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Social Science & Medicine 66 (2008) 1699e1708

www.elsevier.com/locate/socscimed

Economic development as a determinant of injury


mortality e A longitudinal approach
Syed Moniruzzaman*, Ragnar Andersson
Division of Public Health Sciences, Department of Health and Environmental Sciences, Karlstad University, 651 88 Karlstad, Sweden
Available online 4 March 2008

Abstract

Cross-sectional studies have produced clear inverted U-shaped curves between injury mortality and economic development; yet,
this does not mean that single countries will necessarily follow similar curves as they grow richer over time. This study was con-
ducted to examine whether previous cross-sectional findings can be verified using a longitudinal approach. Data for both injury
mortality and gross domestic product (GDP) per capita were obtained from an official health database for the member countries
of the Organization for Economic Cooperation and Development (OECD) for the period of 1960e1999. Regression models
were then used to examine the longitudinal relationship between these two variables. Substantial improvements in injury mortality
were observed in all income categories in the selected countries. For higher and middle high-income countries, injury mortality
rates (all causes) increased until 1972, peaking in 1972 and then declining. For industrialized countries with relatively low
GDP, injury mortality rates increased until 1977 and then declined. Using cubic regression lines for injury mortality rates, for
all income categories, injury mortality rates increased up to a GDP per capita of $3000e$4000, then decreased significantly.
The rising trends of suicide and homicide rates were observed until countries attained a GDP per capita of around $13,000e
$14,000 for all income categories. It is noteworthy that compared to the intentional injury categories, mortality due to road traffic
accidents and injuries from falls declined earlier on in the economic development process. Longitudinal analysis among high-
income countries confirms earlier cross-sectional findings; that is, most injury categories seem to follow inverted U-shaped trend
lines, with declining trends after peaking at various stages of temporal and economical development. A comparison between time
and economy suggests that differences in peaking time between countries for the same injury category is partly a reflection of
temporal differences in economic development.
2007 Elsevier Ltd. All rights reserved.

Keywords: Economic development; Injury; Suicide; Homicide; Mortality; Organization for Economic Cooperation & Development (OECD);
Longitudinal

Introduction

Economic development has long been considered an


important determinant of changing patterns of disease,
* Corresponding author. Tel.: 46 547002535; fax: 46 54 7002
220.
disability, and mortality in populations (McKeowan,
E-mail addresses: syed.moniruzzaman@kau.se (S. Moniruzzaman), Record, & Turner, 1975; Preston, 1975, 1978; Rogers
ragnar.andersson@kau.se (R. Andersson). & Wofford, 1989). Throughout the last century,

0277-9536/$ - see front matter 2007 Elsevier Ltd. All rights reserved.
doi:10.1016/j.socscimed.2007.12.020
1700 S. Moniruzzaman, R. Andersson / Social Science & Medicine 66 (2008) 1699e1708

important epidemiological changes accompanied eco- 1999). In parallel cross-sectional studies on intentional
nomic development in most countries, especially those injury mortality (suicide and homicide), similar in-
known today as high-income countries (HICs). Further, verted U-shaped patterns are also found in association
both mortality and fertility rates declined enormously. with GNP per capita (Moniruzzaman & Andersson,
Rising standards of living in a population make a major 2004, 2005b).
contribution to the shift in main causes of death, from The main problem in previous cross-sectional stud-
infectious and communicable diseases such as malaria, ies where the association between injury mortality and
diarrhea, and tuberculosis to non-communicable and economic development was examined is that even if
man-made conditions such as cancers, cardiovascular cross-sectional studies produce clear inverted U-shaped
diseases, and injuries resulting from road traffic curves for mortality from low to high-income countries
accidents (van Beeck, Looman, & Machenbach, 1998; at a specific point of time, this does not necessarily
Murray & Chen, 1993; Murray & Lopez, 1997; Oppe, mean that specific countries follow similar curves as
1991; Thom, Epstein, Feldman, & Leaverton, 1985). they grow richer over time. This is why further analysis
These major changes in disease patterns led to the for- is required to examine whether previous cross-sectional
mulation of a theory called the health (epidemiologic) findings can be verified using a longitudinal approach.
transition theory (Omran, 1971). This health transi- Since high-income countries have generally ad-
tion may have been completed in all high-income vanced through most stages of epidemiological transi-
countries, whereas in developing countries it is still tion, as far is known today, this paper aims to explore
underway (Omran, 1971, 1983). the longitudinal relationship between injury mortality
In high-income countries, the rising trends in cardio- and economic development in high-income countries
vascular diseases of the 1950s and 1960s were later over a long time span.
reversed in spite of growing economic development
(Uemura & Pisa, 1988). In the 1970s, such observations Method
inspired the graphic modeling of the health transition
process in the form of waves of health problems Data sources and inclusion criteria
replacing each other through the course of historical de-
velopment: first a declining wave of communicable dis- Mortality and GDP per capita e US$ adjusted with
eases (diseases of poverty), to be followed by a wave of purchasing power parity (PPP) data e were derived
non-communicable diseases (diseases of civilization or from the official health database for the member coun-
well-being), and thirdly (and tentatively) an upswing in tries of the Organization for Economic Cooperation and
psycho-social health problems (Hjort, 1994). Development (OECD) for the period of 1960e1999
Discerning secular trends and understanding health (OECD, 2006). PPP-adjusted values are the rates of cur-
transition processes are essential for the adoption of rency conversion that equalize the purchasing power of
adequate health policies and health planning in all different currencies. Thus, PPP-adjusted values elimi-
countries. The relationship between socio-economic nate differences in price levels between countries.
development and injury as a cause of mortality and mor- Data for all OECD countries reporting to the mortality
bidity needs further clarification (Beaglehole & Bonita, database were reviewed. Age standardized mortality
2004). In an attempt to examine the relationship data for 21 OECD countries were available for each
between economic development and injury mortality, year from 1960 to 1999, except 1999 for which data
cross-sectional studies have produced diverging results. were missing from Belgium, Canada, Denmark, and
Early studies on road traffic injury in a global perspec- New Zealand. Some countries were also excluded due
tive showed increasing injury mortality rates with to small population size (<1 million) in order to reduce
growing national economies (Soderlund & Zwi, 1995; sampling variability. Data were acquired on cause-
Wintemute, 1985). However, more recent and compre- specific mortality rates (per 100,000 in the population)
hensive studies on unintentional injury mortality of UIM, fall injury, RTA, suicide, and homicide.
(UIM) in the span from low to high-income countries The 21 countries are grouped into three categories by
have yielded more complex findings. These analyses level of income in GDP per capita, US$ (PPP), based on
have consistently shown an inverted U-shaped pattern the number of countries in each category and significant
in relation to economic development (Ahmed & Ander- income differences between the categories: high-
sson, 2000, 2002; Moniruzzaman & Andersson, 2005a; income countries with high levels of GDP per capita
Plitponkarnpim, Andersson, Jansson, & Svanstrom, (higher high-income countries) ranging from $25,501
1999; Plitponkarnpim, Andersson, Horte, & Svanstrom, to $33,016: Australia, Austria, Ireland, Netherlands,
S. Moniruzzaman, R. Andersson / Social Science & Medicine 66 (2008) 1699e1708 1701

Canada, Denmark, Switzerland, Norway, and the  Self-inflicted, in other words, suicide (E950eE959
United States (category 1); high-income countries for ICD-9, X60eX84, Y870 for ICD-10).
with medium levels of GDP per capita (middle high-  Interpersonal violence, in other words, homicide
income countries) ranging from $20,501 to $25,500: (E960eE969 for ICD-9, X85eY09, Y871 for
Finland, UK, France, Italy, Sweden, Germany, Bel- ICD-10).
gium, and Japan (category 2); and the lower income
level among high-income countries with GDP per cap- No corrections for inconsistencies between the two
ita (lower high-income countries) from $9386 to versions are made. However, potential impacts from
$20,500: Greece, Portugal, Spain, and New Zealand such inconsistencies are commented under the
(category 3) (Fig. 1). Discussion.
Intentional and unintentional injuries are defined by
a series of codes for external cause of death (WHO, Statistical methods
2001). Unintentional injuries are subdivided into road
traffic injuries, poisoning, falls, fires, drowning, and Means of age standardized mortality rates for injury
other unintentional injuries. Intentional injuries are sub- (all causes) and the four major causes of injury, that is,
divided into self-inflicted injuries (suicide), interper- RTA, falls, suicide and homicide, were calculated for
sonal violence (homicide), war-related injuries, and each income category of countries and year. In stratified
other intentional injuries. analyses, carried out for each of the three income
The International Classification of Disease (ICD), groups of countries, least squared regression lines
9th and 10th editions, was used to define specific causes were fitted to examine the longitudinal relationship
of injury mortality that are referred to in this study. between the cubed value of GDP per capita and injury
mortality. The cubic regression models provided an ad-
 All injuries (E800eE999 for ICD-9, V01eY90 for equate fit, which was better than alternatives using
ICD-10). lower order transformations of the GDP per capita vari-
 Road traffic injuries (E810eE819, E826eE829, able (van Beeck, Borsboom, & Mackenbach, 2000; Lee
E929 for ICD-9, V01eV89, V99, Y850 for ICD- & Shaddick, 2007). The regression lines are presented
10). below in graphs which illustrate the cubic relationship
 Falls (E880eE888 for ICD-9, W00eW19 for ICD- between mortality and GDP per capita predicted by
10). the models. Therefore, the data were best described
by an asymmetric curve. The longitudinal relationship
Country by income per capita between GDP per capita and injury mortality variables
United States 33016
was established for the three income categories. This
Norway 29876 helped to identify income-related differences in injury
Switzerland 28775 mortality by time and economic development. Two sta-
Denmark 27542
Category 1: tistics are presented: adjusted R2, and the associated p
Canada 26601
Netherlands 26581 $25 501 or more value. The adjusted R2 shows the extent to which the
Ireland 25981 two variables are related, and the p value indicates the
Austria 25644 significance of the regression model. The statistical sig-
Australia 25550
nificance levels were set at p < 0.01 and p < 0.05.
Japan 24801
Belgium 24776 Results
Germany 24592
Sweden 24342 Category 2:
Italy 24026 $20 501-$25 500
Injury mortality (all causes) and cause-specific in-
France 23831 jury mortality (i.e., RTA, fall injury, suicide, and homi-
United Kingdom 23741 cide) rates over time, for the three income categories of
Finland 23224
countries, are shown in Fig. 2. In recent decades,
New Zealand 19258
substantial improvements in injury mortality have
Spain 19018 Category 3: been observed in all income categories. More specifi-
Portugal 16854 $20 500 or less cally, for income categories 1 and 2, injury mortality
Greece 15753
rates (all causes) first increased up until 1972, with rates
Fig. 1. Country categories by GDP per capita, US$ (PPP), 1999 of mortality peaking in 1972 e at 73 per 100,000 pop-
(Source: Data from OECD health database). ulation e then declined. For income category 3, the
1702 S. Moniruzzaman, R. Andersson / Social Science & Medicine 66 (2008) 1699e1708

Injury (all causes)


80

70

Rates/100 000
60

50

40

Cat 1
30 Cat 2
Cat 3
20
60

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00
19

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Year

RTA Fall Injury


30 18
16
25
14
Rates/100 000

Rates/100 000
20 12
10
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8
10 6
Cat 1 4 Cat 1
5 Cat 2 Cat 2
Cat 3 2 Cat 3
0 0
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Year Year

Suicide Homicide
18 3
Cat 1
16
Cat 2
2.5
14 Cat 3
Rates/100 000

Rates/100 000

12 2
10
1.5
8
6 1
4 Cat 1
Cat 2 0.5
2 Cat 3
0 0
0

85

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95

0
6

0
19

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Year Year

Fig. 2. Trends lines in age standardized injury mortality rates (per 100,000) by country category among high-income countries, 1960e1999
(Source: Data from OECD health database).

lower income countries, injury mortality rates increased countries. For categories 1 and 2, mortality rates due
until 1977 and then declined. to RTA increased until 1972, followed by a general de-
Similar inverted U-shaped trends in mortality due to cline in rates. For category 3, RTA mortality rates in-
road traffic accidents (RTA) and fall injuries were ob- creased until 1977, then leveled off until 1990, and
served for all income categories of the selected declined from 1990 onwards. Reversal trends were
S. Moniruzzaman, R. Andersson / Social Science & Medicine 66 (2008) 1699e1708 1703

also observed for fall injury mortality rates in all in- were observed up to levels of GDP per capita around
come categories, resulting in an earlier rise and then $13,000e$14,000 for all income categories. It is note-
a downward trend in categories 1 and 2, and a late worthy that compared to the intentional injury cate-
downward trend in category 3. gories, RTA and fall injury mortality declined earlier
The trends in mortality due to intentional injuries in the economic development process. However, all of
such as suicide and homicide were more uncertain. In our injury categories exhibited increasing and then
general, suicide rates increased slightly until 1984 for decreasing levels of mortality rates, as GDP per capita
income categories 1 and 2, with the highest rates of increased over time, suggesting an inverted U-
suicide at 17 per 100,000 in category 2 in 1984; for cat- relationship.
egory 3, no significant change in suicide rates was Table 1 shows the coefficient of determination (r2) of
observed. the regression model for each income category of
Homicide trends were also more inconsistent over countries and their significance levels indicating the
time for all income categories with a slow upswing, extent to which the two variables (GDP per capita and
a leveling off, and then a decrease in mortality rates injury mortality) are related.
from the early 1990s onwards. However, homicide
rates were generally higher throughout the time period Discussion
for category 1, followed by category 2 and then
category 3. Data from 21 member countries of the OECD were
Fig. 3 shows the cubic regression lines for injury analyzed in this study. These countries are referred to
mortality by cause over time from 1960 to 1999. The as the established market economies (Murray & Lo-
cubic regression lines of injury mortality formed clear pez, 1997) or the industrialized countries (Soderlund
and consistent inverted U-shaped curves over the study & Zwi, 1995). There were two major shifts of coun-
period. Two major findings were observed in Fig. 3: tries between the income categories since 1960;
first, an earlier peaking time is observed for higher in- New Zealands GDP per capita was similar to that
come categories compared to lower income categories of Australia, Canada, and Denmark (category 1) in
for all injury types, and secondly, peaking was seen to 1960 and Irelands GDP per capita was close to the
occur earlier in RTA (except for income category 3) average for category 3 (Greece, Portugal, Spain, and
and fall injury (unintentional injury) mortality com- New Zealand) in 1970e1990. However, in our analy-
pared to suicide and homicide (intentional injury). sis all countries remained within their income-based
Fig. 4 shows regression lines of injury mortality (all categories as they were defined by 1999. The influ-
causes) and cause-specific injury mortality rates by eco- ence from these shifts on our overall results is consid-
nomic development, measured as GDP per capita, US$ ered to be limited. The current study provides
(PPP adjusted). Using cubic regression lines for injury longitudinal evidence on the national income (GDP
mortality rates for all income categories, injury mortal- per capita) e injury relationship among high-income
ity rates increased until reaching a GDP per capita of countries. Inverted U-shaped curves for injury mortal-
$3000e$4000, and then decreased significantly from ity over time and over GDP per capita have been
the GDP level per capita of $4000. For RTA, for cate- found, as predicted in earlier cross-sectional studies
gories 1 and 2, the changes in mortality rate by GDP (Ahmed & Andersson, 2000, 2002; Moniruzzaman
per capita were similar to that for all causes of injury, & Andersson, 2004, 2005a, 2005b; Plitponkarnpim,
which increased up to GDP per capita $3000e$4000 Andersson, Horte, et al., 1999; Plitponkarnpim, An-
followed by a significant decline above this level of dersson, Jansson, et al., 1999). Our results show that
GDP per capita ($). For category 3, RTA rates increased in most countries, economic development has been ac-
up to the GDP per capita of $8800, followed by a signif- companied by safety improvements since the early
icant decrease when GDP per capita rose to more than 1980s, but by increased injury risks in earlier years
$9000. Similar reversal trends of mortality were found of the study period. We also find variation in peaking
for fall injury mortality and for injury mortality (all time and levels between income strata and injury cat-
causes) with an exception of the higher income category egories, as well as the corresponding variation by eco-
(category 1); mortality due to fall injury increased up to nomic development. The comparison of injury
a GDP per capita of $3000e$4000 trailed by a decline mortality over time versus by economic development
for categories 2 and 3, while mortality was more line- suggests that differences in peaking time seem in
arly related with GDP per capita for category 1. The part to be a matter of temporal differences in eco-
rise of trends in mortality of suicide and homicide rates nomic development.
1704 S. Moniruzzaman, R. Andersson / Social Science & Medicine 66 (2008) 1699e1708

80 Injury (all causes)

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RTA Fall Injury
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Rates/100 000
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Cat 1 4 Cat 1
5 Cat 2 Cat 2
Cat 3 2 Cat 3
0 0
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18
Suicide Homicide
3
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2.5
14
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Rates/100 000

12 2
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6 1
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Cat 2 0.5 Cat 2
2 Cat 3 Cat 3
0 0
0

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Fig. 3. Cubic regression lines of cause-specific injury mortality rates (per 100,000) by country category among high-income countries, 1960e1999.

The underlying causes of these reversal trends of in- Andersson, Horte, et al., 1999), but rather separate ex-
jury mortality are little known or discussed. Differences planations for each category of injury. Unintentional in-
in peaking time (or economic levels) among different in- jury mortality among children starts to decline already at
jury categories and age/sex groups suggest that there is lower levels of economic development, which may be
no universal explanation (Ahmed & Andersson, 2000; explained by a combination of social changes (fewer
Moniruzzaman & Andersson, 2005a; Plitponkarnpim, children per family, increased school attendance, etc.),
S. Moniruzzaman, R. Andersson / Social Science & Medicine 66 (2008) 1699e1708 1705

Fig. 4. Cubic regression analysis between mortality rates of cause-specific injury and economic development, measured GDP per capita, in three
income categories, 1960e1999.
1706 S. Moniruzzaman, R. Andersson / Social Science & Medicine 66 (2008) 1699e1708

Table 1 weight is given to environmental concerns, causing


Coefficient of determination (r2) and associated p value of cubic pollution to rise alongside industrialization (Smith &
regression of injury mortality rates and level of GDP per capita by
country category among high-income countries, 1960e1999
Ezzati, 2005). After a certain threshold, when basic
physical needs are met, interest in a clean environment
Cause of mortality Category 1 Category 2 Category 3
rises, reversing the trend.
HIC (high) HIC (medium) HIC (low) The incomeeinjury curves have some importance
Injury 0.98** 0.98** 0.94** from a national and global health policy perspective.
Unintentional Up to a certain national income level, increasing
RTA 0.97** 0.94** 0.93** wealth may give rise to more injury deaths. Globally,
Falls 0.98** 0.97** 0.95** a limited number of countries have reached this level,
Intentional meaning that on a global scale, a considerable increase
Suicide 0.95** 0.91** 0.26ns in public health damage due to injuries could still be
Homicide 0.89** 0.71** 0.82** expected in low-income and lower middle-income
**p < 0.01; ns, not significance. countries, as has been reported previously (Murray &
Lopez, 1997). In richer countries, the secular trend
exposure changes (urbanization, shift from unprotected seems to be clearly declining. However, segments
to protected modes of traveling, decline in child labor, of emerging injury risks may still appear as a conse-
etc.), and child safety programs (Bergman & Rivara, quence of social changes, for example, aging popula-
1991; Plitponkarnpim, Andersson, Jansson, et al., tions or socio-political and economic crises (Kaasik,
1999). Among adults, where peaking occurs somewhat Andersson, & Horte, 1998).
later in the developmental process and where traffic Since this study is based on existing data sources,
and occupational injuries play a larger part, structural findings of this type should be interpreted with caution.
changes in these environments such as shifts in vehicle Possible registration bias caused by differences in cod-
fleets from two-wheelers to four-wheelers, improved ing of mortality between countries and over time must
road infrastructure, shift from mechanized to automated be taken into account. It is increasingly recognized
industrial production, transfer of dangerous jobs to low- that classification of death due to fall injury varies
wage countries may account for the reversal trends in over time and between countries (Janssen & Kunt,
this group (van Beeck et al., 2000; Berger & Mohan, 2004; Jansson, 2005). Moreover, in the case of inten-
1996). Other factors include successful traffic and occu- tional injuries, policies and/or practices involving
pational safety programs. Finally, among the elderly, recording a death as suicide vary between countries
where unintentional injury is strongly dominated by despite the use of a standard classification system
falls, for which many countries still experience increas- (Morrison, Stone, & EURORISC Working Group,
ing rates, changes in life style (physical inactivity, etc.) 2000). For example, in Luxembourg, a suicide note is
and improvements in health care and nursing, leading required to register a death as suicide, whereas in other
to larger proportions of frail seniors with multiple illness countries (e.g., the UK, Ireland) a decision on intent is
surviving into advanced ages, might be of key impor- made by a coroner. Social and cultural norms may also
tance (Deeg, Potrait, & Lindeboom, 2002; Saari, Heikki- be influential determinants for whether a death will be
nen, Sakari-Rantala, & Rantanen, 2007). identified and registered as suicide.
Inverted U-shaped curves are also observed in the re- Another problem is the limited sample size for in-
lationship between economic development and changes come category and the category distribution, especially
in environmental health risks. Considerable literature for category 3. Three out of four countries in category 3,
has dealt with the question of whether environmental are southern European countries which have consis-
health risks tend first to rise and then fall with economic tently lower mortality rates due to suicide than those
development, as described for income inequality by No- in northern European countries. Southern European
bel economist Simon Kuznets in the 1950s (Barbier, countries are predominantly Catholic, and religious
1997). The empirical literature (Grossman & Krueger, affiliation has long been regarded as an important factor
1995; Selden & Song, 1994; Stern & Common, 2001) in suicide behavior and classification (Farberow, 1975;
refers to inverted U-shape curves between environmen- WHO, 2002). Moreover, some single countries have
tal health risk factors and economic development; for demonstrated deviating trends from the general patterns
example, pollutant levels rise and then fall with increas- of inverted U-shaped curves; for example, no reversal
ing national income (Smith & Ezzati, 2005). In the be- trend was found in mortality due to homicide in the
ginning of economic development, however, little United States regardless of the economic progress
S. Moniruzzaman, R. Andersson / Social Science & Medicine 66 (2008) 1699e1708 1707

achieved during the study period. Therefore, the study needed to fully understand the dynamics of the relation-
design is also susceptible to aggregation bias; this ship between economic development and injury
means that associations observed for pooled countries mortality.
do not necessarily apply to individual societies.
Aggregating data from countries of various sizes, Acknowledgements
and calculating means, is the subject of another contro-
versy. However, since official data are normally com- We wish to thank Karen Leander for English check-
piled and presented at national levels, and since ing and the Swedish Rescue Services Agency, for their
nations to some degree represent separate sets of legal, financial support.
political and economic conditions, we assert that coun-
tries are relevant units to study and to compare regard- References
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