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Datasheet of Ochratoxin A(OTA)

Description:.
Ochratoxin A is a mycotoxin isolated from the Aspergillus ochraceus mold, a common fungal presence
on moldy food. Ochratoxin A demonstrates nephrotoxicity and teratogenesis in animals, and shows
inhibition of bacterial, yeast, and liver FARSL (phenylalanyl-tRNA synthetases) competitive with
phenylalanine. As these activities are partially attenuated by phenylalanine, Ochratoxin A is suggested
to produce its effects through interacting with proteins that recognize phenylalanine as a substrate, and
has been demonstrated to inhibit PAH (phenylalanine hydroxylase). Derivatives of Ochratoxin A with
other amino acid moieties substituted for the phenylalanine-mimic portion of the molecule demonstrate
inhibition of the aminoacyl tRNA synthetases respective to those amino acids. Ochratoxin A is
described to enhance lipid peroxidation and also present DNA single strand breaks, both suggesting
oxidative damage as a partial mediator of Ochratoxin A cellular effects, and EPR spectroscopy with a
spin trap agent identified the production of hydroxyl radicals by Ochratoxin A in the presence of
NADPH. The nephrotoxic effects of Ochratoxin A are shown to be prevented by SOD (superoxide
dismutase) and catalase, further indicating oxidative damage as the mediator of Ochratoxin A toxicity.
Ochratoxin A is also demonstrated to increase ATP-dependent Ca2+ pump activity in renal cortex
endoplasmic reticulum.

Chemical Information

Catalog DC10144

Purity of current batch: >98%

Molecular Weight (MW) 403.81

Molecular Formula C20H18ClNO6

CAS No. 303-47-9

 Solubility (25C) DMSO

Storage Store at -20C (desiccating conditions).

Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in
advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable
for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room
temperature for at least 1 hour.