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Datasheet of Relebactam

Description:.
Relebactam is a diazabicycloctane inhibitor with activity against a wide spectrum of -lactamases,
including class A (extended-spectrum -lactamases [ESBLs] and KPC) and class C (AmpC) enzymes.
Target: beta-lactamase Imipenem with Relebactam is active against Escherichia coli, Klebsiella
pneumoniae, and Enterobacter spp., including K. pneumoniae carbapenemase (KPC)-producing isolates.
The combination of Imipenem with Relebactam demonstrated activity against KPC-producing
Enterobacteriaceae and multidrug-resistant P. aeruginosa. The imipenem MIC50 and MIC90 values for
the ESBL-producing isolates were 0.25 and 0.5 g/ml, respectively; with the addition of Relebactam, the
corresponding values were 0.25 and 0.25 g/ml. Five isolates harbored blaKPC. For these 5 isolates, the
imipenem MICs ranged from 0.5 to >32 g/ml. With the addition of Relebactam, the MICs decreased to
0.12 to 0.5 g/ml.Relebactam inhibits most class A and class C -lactamases, with selected inhibition of
class D enzymes by avibactam. -Lactamase inhibitors (BLIs) have played an important role in
combatting -lactam resistance in Gram-negative bacteria, but their effectiveness has diminished with
the evolution of diverse and deleterious varieties of -lactamases.
Chemical Information
Catalog DC10441

Purity of current batch: >98%

Molecular Weight (MW) 348.38

Molecular Formula C12H20N4O6S

CAS No. 1174018-99-5

Solubility (25C) DMSO

Storage Store at -20C (desiccating conditions).

Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in
advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable
for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room
temperature for at least 1 hour.