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Datasheet of TM5275 sodium salt

Description:.
"Selective, orally active inhibitor of plasminogen activator inhibitor-1 (PAI-1; IC50 value 6.95 M in tissue plasminoge
n activator-dependent peptide hydrolysis essay) with antithrombotic benefits devoid of bleeding effect in rodents and no
nhuman primates, and with impressive bioavailability.TM 5275 prolongs tPA retention and enhances plasmin generation
on the vascular endothelial cell (VEC) surface as a result of PAI-1 inhibition.

Additionally, TM 5275 represents a novel class of anti-inflammatory agents targeting macrophage migration by the inhi
bition of the interaction of PAI-1 with low-density lipoprotein receptorrelated protein (IC50 values 3.13 M and 3.02
M for LRP1 protein Cl II and Cl IV, respectively)."

Chemical Information
Catalog DC10149

Purity of current batch: >98%

Molecular Weight (MW) 543.97

Molecular Formula C28H27ClN3NaO5

CAS No. 1103926-82-4

Solubility (25C) DMSO

Storage Store at -20C (desiccating conditions).

Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in
advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable
for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room
temperature for at least 1 hour.