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-] ‘A20.year-old ican American fea presets io hor primary care physician with a thee. day history of sun, urgency an equet urination ‘Se repos that she has never ness symptoms efor She does ot smoke, ernie 21 ganas of wares ané Goes nota hc args She sexually sce end hs ad four pares nthe past two years. Her unas ad gram stan show ‘ves Cloudy (Cleseton) ‘Spee rant 1014 (1.001 1035), om 5145-2) 5 Prato + (nop — ace) i ‘Gucoce nogabre (negate) a Ketone, negative (oegatve) Birubin rogaine (nena) 2 Bod negate (negative) . iets nego (rege) 5 es regio (negate) = Roce S(02HPF) at Weos: $2(02HR) 2 RBC casts D(oINPr) 2 ‘Gram Sin ram poste coe! clusters iz in o to fotowing organisms i kay obo caste? = © (A) Entorcoccus faecalis z © (8) Eschoreeia cot = (C)Kibsita pneumena a © () Pseuomonas aeruginosa CE) Stapylococus spropnvicus aaa a USMLE-Step 1 a zi |A24. year-old woman presents or her annus griecologic exam. She sats she has recent noted a change n ex vaginal schrae. She has bad ‘several new sexual ares in the st ew mans sis sad she may have a sexily ransrited disease, even tough se sys tht she als Uses condoms. Dung exam thin, whe, Nomogenous decharge s noted. Adding KOH othe wel meu produces sy oo, ad the sae ‘mount shows enti cls peppered wi many sma dots whn vowod und tho meroscope. ‘ie of to fotowing san appropri Weatment fortis conason? Jattronyen . iprotoxacin 2 Fluconazole £ Matoidazole 2 “Teeethoprin-sulmatnoxazo 2 ‘Show / Hide Explanation 2 20 USMLE-Step 1 a = ‘818 yoar-od female presets to her physansofe wth jaundice and a hisry of cocky abdominal pan. Laboratory tudes eves anemia anda ponpheral smear shows be press of sphorcyes, The patos rod bleed cols domonaraieesmteFagify hon Placed mfypotot sane. A ‘Sagnoss of heresy sohorecyoss% made an the patente scheduled for speectomy, itch of he folowing vaceinatons does tis patent need porto surge? © (A) Boreas persis (8) Clostiaum oan ©(C). Connabacteium aphienae (0) Hecmophiusntuoncoe ©(E) Human poitoma wus Stow / Hide Explanation 1B ie (sm fe « 2 2 ERE rer |A.35. year-old presents wih problems with ving. He says he nermaly can erive dung the day buthas been unable ive dung the night He is ‘table to soo ary oter cart igh On revew cf systams, he descrbs haung loose soos a he pas yoa but he says hats noma rh His ‘oni/medicaton& a day mativtamin. The olewing labs ae awn: 004 cell count 190 cell HV wal ioad 100,000 copes (Normal < 50 coptesinL) ‘Stoo anaes Cysts and eoeytes ae presont in of foto ste most key undorhng caso fora is synpems? © (A) Candida esophagits © (8) Cryesporau (C) tarogenic © (0) Salreneta ©(E) MtaminAdotconcy Show/Hide Explanation « RES ERE rer ‘Act yea-ol males inthe hospital on post parabve dey folowing 2 lange ume debulking for metastatic ase in is abdomen, Hes yt fo be ‘exubate foloung his surgery On moming rou, the nurse epats thal Re has Ban fbi ever he past vee now's chest xy Shows 8 new rato inthe ight lower cee Fleble ronchescopy reosls mucous and pus in te over onc onthe ng side. Gam tain he sputum ‘shows Gram postive coca in csters Amethelinsessirt Stpyococeus aureus (MRSA) nasa Saabs postive He's sled on ovenous vancomyen ‘ie of to folowing goes oncades to prem responsi fr to retin resistance extbod by MRSA? (A) Bla (8) Baz. 2(C) Fema ©(D) Feme ©(E) Moc ‘Show / Mio Explanaton a a] 5.0. year-old wth a history of HV presenis wth progressively worsening shrines of brea over the last weck He fgets is medication every couple days. He denis ovr of cls Physical exam of he ungs shows no abaereaites An ater lod gas reves 90, =80 mmHg ‘Aa cterence = 20 me Hg as A ora) 18) 2 ec) 2 210) a ) rer ‘chest ay shows otuse pathy bist apace, 'Botow wich oft flown CDA eels necessary or prophylactic teatro ofthe onanism causing tos patents disease? sO cals 10 casut. 200 cele 200 cots 400 ces Show/Hide Explanation rer |A20 yea. female resis othe cnc fer evaluation cf rumercus sal papules in he back extncig to her butlocks. Closer sxaminaton of ‘ne papules reveal contal pustules She doesnot have any mgr liessas and ders having evr used inravencus rugs. She mentions have ‘econ taken her ehleren tthe home park and enjoyed he waterside there Har cniden also have sar ashes in te same ecaten but har ‘diatrcian formed hr tat he ash no vananibie by parson person conta nats vinden actor uses by the most kel organs thes response ons patent's sro? © (A) Edema fact that an adit cyclase ©(8} Biloxi tat inactvates eongaton fcr 2 ©(C)_ Exetexin hat nacvates 605 ribosomes ©(0) Betoxin mat osyates ADP ©(E) TSST superantigen that binds smullansousy to MHI and Tel receptor ‘Sow / Hilo Exlanaton rer ‘A 16 year-old highschool reser iss is primary care plyscian inthe cdc because of arash on is leg The ash developed win the pat fw Gays Ii pain whon fouched, ul he dd rot fal twas saris enough fo go he emergency department fr vestment Or physical xarinaton, hehas an enéhematus, sight raised rsh on hs right eg, which si center ins raatost mension. The bots are panty coined. The ‘1a swarm, andthe every Skin appears shiny The patent eps tel ther mambers of his team have sir rashes, and thoy were tl ha they havea Staph econ * ‘ie oo fotowng poten s most reponse fr to vas of host imure defenses by Staphyfocooeus arous? (A) Entertain (8) Hauoniase ©(C) Novel pci ining protin (0) Pencitinaso ©(E), Protein ‘Show /Hio Explanation « 2 2 rer ‘Afourh.year medical student raves o Vitam for a lbal health rotation. Whi thre he sees a patent wih massive let ag. He has ughytough sn with hyperigmentaton and aonpting edems, Which a ho fatowing ste most kay causative goat? (A) Eehinococeusganvians ©(8} Eotamoeba histolytica (6) Entorbiusvomacuas (0) Naogona town ©(E) Wuenereria banca ‘Sow / io Explanation USMLE-Step 1 = zi ‘An anicus moter bins er 6 onto infant to the pedi because of recent changes in behavior. She ays tat he hasbeen roong much more in he past eek and has 3d ver ile oak. In aoaton nes no Toner abet ld Ms Need up. She has been breastfeeding him nd Tas not el iftoduced any Sls oars exter for honey since ne was bmn Teint nas most ikey ingest a substance thal acts at whch ofthe Fotowing ocatons? (A) Mote ceriax (8) Myooyos * 2(C), Sehwanm ele : (0) Spina cord fe CE) Synapse 2 ‘Show/Hide Explanation 2 2 USMLE-Step 1 a zi ‘N90: year-old woman with no siitcant media histor presents for sn evluston with ow aade fever patos and dfouy breathing during ‘xeron Her phys examination fom gst yee was noma Du fe crentexamn, 3 new hlasyichc mum esta the apex oF the Near. ‘Abiopsy o he endomyecaraian shows sunfeant mononuclear cet nian, Wats ho most kay organism causing ho pation symptoms (A) Double sanded, cra, envloped ONA vs ©(8) Gramposte, catalase posive,coagulso-negatve ccs 1©(C) Gram poste, catalase postive, cnaquase pose coccus ©(D)_Singl-standed, nar, non-ameloped RNA vs ©(E) Shnge-strended, segmented, ciculer RNA wis . Sow / Hi Explanation 1B ie (sm fe USMLE-Step 1 a zi ‘Aone: yeaa boy brought tothe eneraency room with fever up o 102 3°F (98°) fortwo days’ duran Hs pent ope tht over has ‘worsened despite gwen ther boy tea wth Raney te emergency room, he has 8 dy, non producive cough. Prasical exsmnaton aso reveals Diateacoqunctalineton. The patents parents po a tey do not Deeve ln nmuzeen of Medications and preter hoe nar approach tok cigs oafcare. Ts foto coud Nave boon prevetod by a ve afenvatod vaccmNo. ‘ie emo most aly cause ote his curent condor? (A) Intenze t (8) oes 2 ce) thos t (0) ote fi ce) Rta ae se ta 2 a USMLE-Step 1 'A25-yoar-ld armor rom Tennesse presents his primary caro physician complaining el malaise, anoreia, productive cough andthe presence of = - ‘denraing stn sions Physcal examination events necrbe ulcers wh indurated borders present on ho pation fac and erm Biopsy of ‘ke cer cuts a broas-base0bukting yeast at 37°C ‘Question # of 2 inthis set Which of he folowing ste most kay diagnosis? 2 (A) Aspergnosts . © (8) Blastomyeose B (6) Coccimycasis : (0) Histoplasmosis 2 © CE) Zygomyensis 2 ‘Sow / eo Explanation 2 20 USMLE-Step 1 A yoar-of farmer rom Tennessee present his primary care physician complaining of male, anreia produce cough andthe presence of = - ‘ening shin tesions Physical examination reas necrobe ulcers wih ndraled borers present on tho patios face and extemats Biopsy of sho ulcer eutuves a 008-Dased budding yeast at 37°. ‘Question 2 of 2 inthis set “Te pation ave is iagnesed wth lastomycoss, «systemic ungalinfcton ‘ie oe fotowing ste best veatment option? # OCA} Amphotericn B f 218) Aatronen i 2c) Fhcenarae » (0) Nomen sn inaconstmng 2 ©(E) Paina a Stow Hie Explanation 2 2 USMLE-Step 1 a zi ‘previously heathy chilis baught the ofice with diab era fever ovr the st 48 hows. Theres no history of recon ravel or sick contacts “The pit econ purchased pl ure. Psa examinaton i netable for deayed capa el and decreased skin tgor. Asoo sample ‘hows eleveled IBCs end Wace Dood. Cul on selectve mata giows nonsecosefermening, mote HS produc, wa negate ros, ihe of e fotowng ste comet mechanssm of pahogeness in ths pint? © (A) _itoctimvason of eotonic mucosa via protease and phosplipasaerzymeslaading to ulceration (8) Invasion of testinal N-cets vsbscteial meses endocytosis ©(C)_ Sectoton of exioxn leaing ocolur necrosis, inlamstion, and fornton of pseudomentrane © (0) _Secroton of xetoen which spl proton syihess by atoraton f tho ribosomal OOS subunit © (E) Secretion of nest stable exctoxn which causes eccuatenofinteceler CGMP Show / Ho Explanation 1B ee USMLE-Step 1 a zi ‘A4-month.od infants ven a soon of honey in ex boted mikby a babysit. Twelve days itr the infant becomes corpse and Droaressively wesko Het movements and posture appear opoy 1s deermned tat Me noney wes conannsted wih spores, wich germinated ‘nd eleased an exon “This tox works by whir mechanism a action? (A) Aetaon of AMP (8) Aetation or cae ‘ ©(C) Indice acta pests i ©(D) nis pron sytoss 2 OE) Prevents reese otacercotne 2 SH Eonar 2 2 USMLE-Step 1 5 a zi 'A3S-yea-ol mans backpackh tough ind and ios o sample the lol caine. 72 hows ater he has acu onset of prose, wate, rnon-body episodes of ven every Nou and dec ogo to he local ER. While sgressvel resus, soo cute obtsned and tows grange curved fos. “Te causatve organism socttes a toxn thal works by What mecransm of actor? (A) Aetwaton of cAMP (8) Aetwatin or cae ©(C) Induces intestinal partis ©(D) ibis protein synthoss ©(E) Prevents release of Ach at persnerat synsses ‘Sow / Hite Explanation . 2 20 USMLE-Step 1 a =| ‘Amesical students wrkna in bsctrlogy sb in which hes expermenting wih ug resistance in bate. Hence that under certin ‘ondons a partculer gene ite tact Cromosome ca mave to aierent pas of he chvomosore. “This proces soe o as which oft folowng? FCA) Conjupaon ©(8) Teansducton ©(C) Teanstermaton . 2 (©(D) Transposon . CE) Vewtence iz, ‘Sow / Hie Explanation 2 2 20 USMLE-Step 1 a zi 'A92.yea-ol mans rused othe emergency room by ambulance because is wif our him ying onthe couch unresponsive, pale, and ses Fis aft puses ae bare palosbe. and ie has eccymoses on hs fogs Hes ny been ate nop! once Deore, ae he sured Dnt domi! ums paying fos wi tends one mah ago, necesstang aslenecomy Blood cules ae poste ‘at moasure cous have preveied ts tom happening? (A) Aniccaguaten wih wartarn 1© (8) Proohacc amet against Clostdum pomingens ©(C) Regular adminisrsten of ttans oxo ©(D)_ Voccination using conjugated polysaccharides ©(E)Yeconstion using We, tenuate microorgsnisms . Stow / Hi Explanation 1B ie (fe USMLE-Step 1 5 a zi ‘N98. year-old fers resents othe emergency room wit afd of history of sovee headache, fever, and hee episodes of omiing. Further ‘vestoning reveals a hisoryof ravenous dug Use and mpl sexual pares. Meng s suspected and Gvebrospna fads dean: ufure and anayss. Cute on Seboursuts ape gions an encapsusted organs, ‘iin stan ould bo uso in ontMing the cavsatve agent of is plots symptoms? eA) Gemsa (8) niaink ‘ © (6). PerdiAct eit 2 810) Siver i CE) eeesen 2 Sow Hie Expanton = > Wich of tho folowing isthe modiations woud have been th best pephylns? (A) Pattern ©(B) teaconazcl ©(C) Penictin a8 ©(D) Pentamitine OE) Trmetnoprmsutametnoxazoie 2. 2 B 2 as = 2 USMLE-Step 1 = =| ‘ASA year-old maleintrevenous crag user presents to he emergency depariment wth jaundice and sins of alae. fer bood selogy retus, ‘onic neeats Bs confmed. Which of Me folowing Serokgy sets wed mah this patents resus, gssuring the ofOwing show wich enibodes ‘and anigens come up postive n be patents ood? ‘Ani HBsAg = antibody to Hepa 8 sutace angen ‘Ani HB0Ag = body to Hepa B envelope angen ‘An HBA = antibody te Hopalits 8 cor antigen z x VEGA ats cow een a natoirg AeeHBakg AanHchg HOOAY HEaAg Hckp 2 we ‘ ¢ 2 3 z sos iE e : : : RA Be : ot 2 : - it 2 F yt aH ouay a 7 218) 8 ‘a ec) c U 2 210) 0 2 owe Fe ee) F USMLE-Step 1 a zi ‘AS: yea-olf male ust tuned fom hunting ip in Eastern Aca. He report that as wok he was bien by a smal insect. dhe has since ‘eyeloped 45 cn ndraed,enytremsious, snd rubbery swing ons eg. Ths accompaniod by Myles. atvahjss, id nee ever a His lod sneer shows ng. slender, Nageted protozoa wi xelplests| mie ‘ie of to fotowng ste most kel organism esponstie? i (A) Leshmania donovens 2 ©(8) Leshmania topica = ©(C) Plasmedum vivax = ©(D) Typancsema brucei 2 ©(E), Typenosoma cruzt a Show / Hid Explanaton Be mem i os USMLE-Step 1 a =| ‘N€0-yea-olf HIV Vietnamese immigrant as ben nthe United States fo the past 10 year. He bas nay been abe to sft heath insurance ‘ad presents is pmary care pysican for tenes evluaten_ He reports tate sues rom vague gastromtestnalsyptons on dy bess a Meco wpe ebm pn er nesta oe cre note, mes, en vonoN, asiuon, no iho toed Ton Senda Fi sated ayanoton reas onns bales. Hs enneby oamnaion sho Fe wo 12000 ces? 2 ‘a. tieout 2 ve we 28 Piatelets: 200,000 cestsimm? z onoonis: ON 2 ‘ie to bung ek agnose? f (A) tambon 2 (8) seieosone 2 (0) Stones sacs 2 0() Teniasotum = 2(€). wnerapancow x Show Hexion 2 a USMLE-Step 1 = zi ‘An BB-year- ol female is rough fo the emergency department her dauer The daughter reports that ner mer hed been recovering fom 8 "econ Dou of neumona ard es been staying wih Ne while ste recovered. Tis morning te dau fepors ate other west and a {ommsed: nf emegey depart he pots ae b'4 SCOT SF) Pyseal examagten Poste orm! 0, Kaba 2 once peromod = _Whic of the following is most lkaly seen on Gram siain of this patient's corabral spinal Mid? aie (A) Gram nope batt x ©(8) Giamnegene docs = OC) Gram postive baci: 2 (0) am pont concn 2 CE). Giamsosto tncet stad coc 5 Show / Hide Exlanaton = o USMLE-Step 1 AST. year-old woman with pooty managed ip | dabotes mls posers wth hoadache, gt sided fail pain, and bury isin in th ight eye. = =I Pystal examination is nolabl fo propess tho igh oye aswel a blak nasal charge. View th ss biopsy Kom the nese vowod wth ‘uorescetanteodysaring by icin ho Alachmons ib ad vowing Exhibit ‘Question 4 of 2 nthe sot ‘ie o te fotowing organs esponsbie ors patents condition? (A) Aspergiisfams (8) Blstomyees dematnas (C) Paracocctoies brasiionsis (0) Rhizopus anmaus ©(E) Sport schenck ‘Stow / Heo Explanaton USMLE-Step 1 7 |AST-yoar-old woman with pooty managed tps | lables melius posers wt hoadache, gt sided fail pain and bury isin in th iat eye Pystal examination is nolable fo props of ho igh oye aswell as lok nasal charge. Viaw th sum biopsy Kom tha nes vowed wih ‘uorescotant2ody sang by ccking ho Mlachmons ib ad vowing Exhibit ‘Question 2 of 2 inthis sot ‘ie of me folowing site eects most commonly seen wt he leatment of choice for his condor? (A) Aplastic aneria ©(8) Hemoyic anemia ©(C) Nephron ©(0) Paneroats ©(E)_ Stevensohnson syndrome ‘Show / Hilo Explanaton USMLE-Step 1 a zi ‘N90. yea-ol Caucsion male presents othe emergency room wi sere cocky sbdominal psn uses and vomitna. Physica examinations nab fr severe ft ide costovetebal ange tenderness. The abn’ tempera is 378°C (88 TF), ps6 74 Dats, respons ae 1 Deathsnn, nd blood pressures 11977 mm fg. Uinahss eveas an skaine fda postive for ities and teukooye esterase and shows 2+ hnomatula Forder quostonng reveals tha th patent tas had mi dysura or aprosmatey two months. Aornal tay rvoas age sono ‘Moot ronal pes. Ar suseal removal, te slone analyzod and sound to be comesod of anonken magnesium prosphai, ‘ich infection most ely precpatod the farmation of ts sone? (A) Condit sbicans (8) Enlorococcus foes ©(C) Escher cot (0) Preeus mais ©(E) Staphylococcus saprophyious ‘Sow / Hie Explanation USMLE-Step 1 a zi Ahomeess man presen othe emergency department wih persistent eve, cough. and unintenional wei ss of 15 pounds over he est hee Ions. Hs temperature 983° (11°F) Exarnnstion of spuum reves a0e-as baci a 2 ‘nat he mage of ansmission fois ines? = Ota) Aitere transmission © (8), Drectcontattansmisson ©(C) Droplet tarsmisson ©(D)_ Fecst-ra transmission ©(E), Vedtrtome tersmssion ‘Sow / Hite Explanation 15 0 0 USMLE-Step 1 a zi ‘AG-yea-old boy s brought the emergency department by hs father because of espatony dess, He does nt have ny cron heats ‘ober. For the pss vo day Nes ad 8 sre tos and hss Deen anebl to ea. Hs her Deleves he geting worse Hs ser Nad an 2 a bteton last wee, bute ch dens ay ear an. On ex, he 8 welnouTshed male n obvious dress signs nce ever fo 101 SF 2 and espratons of 28 boatsimn. He nas stro on ascutabon. His oopharyixs Com fed and edomatous, and No doo on chin ontnyousy Tho os of he exam nor-contbtey Wich of tho fotowing organisms isthe most kay cause ofthis inass? © (A) Hacmophius tuonza, ype 8 Fy iz ©(8) Mycoplasma preumoniag 2 (6) Stapyiococous aureus 2 ©(D) Steptococaus pneumoniae ne ©(E) Stoptococes pyogones = ‘Sow / Hie Explanation 2 ry USMLE-Step 1 a zi ‘Aconcsned mother bring her 8-year on fo he doctor fr penal scratching The patents each has complained abou thi increasingly ‘concerning behave in Gass, The child's Oerwise Hedy, hasan unitrrkble t siory wth hag and wenn progtessng ne Et a fercome’ Pps exam sows pearl excontena bu oewse nena Te says Ne Khng's nose tn and ne ey a romeo = ‘eh psnagen may bo easing he pater sso? 2 Dipyobtum in s Eenacocsu ranaoase 2 Enterobius vermicuans | 2 ebate ra ‘Wuchereria bancrom 7 Stow ie Eaton Be mem i os USMLE-Step 1 a zi |A28 year-old Afican-American feral present o he primary cae physician wth 3-day history of dour, urgency and fequertwination. She ‘reports ta se nas neve nad sla symptoms bef‘. She doesnot smoke, ditks 23 glsses of wine per week. ed des Not Use Hot ros. a ‘So's sesey aed hs ha pees ne peste yas a ee stews en eae os 2 ‘in te owna sonny nd nam rete acs el wa fz Ota) Fi 2 ©(8) Uptpoysacante = 8(C) Pepnayean : (0) Tech ec iz Seow Hie Ente Be mem i os USMLE-Step 1 a zi ‘Awoman wt no krown tubercuosis (7B) exposure being hed as a use. Before she can be hie the hosp equtes her tobe screened er "TB. She nas nove’ bad aPPD sk est bear, so wo-step PPO testing is permed n (de to estblsh et baseine PPO resut 48 Nous are a SIP poement ee 3pm inden second PPD sn es peomed wn wees th 7mm croton Aces Shows mo fz ‘Somat = What is the most ikely explanation for these findings? = (A). Conkmaton feet TB s (8) Fate posto tat nw aap hypaieny recon 2 OCC) Negative PPD test 2 (0) Pamaty TB non ne wo ook inna woo sts fa ©(E) TBrescraon i Stow Hie Eaton = o ‘ATB-yea1-old mele with @ Nistory of COPD and HIV dies suddenly. A complete autopsy Is done to determine the cause of death. The heart is sightly ‘raged win concent hyportopry Te kn tas mutipio paolo Dutone mportnt dng (show by te arow) sido fom to ung show ew tho fotewing fhe mos! hel agnosis? of USMLE-Step 1 a zi ‘8 18ye9-01 clog freshman reports the student clinic witha two day history of dysuria and wet charge. He has neve had simi ‘yobs before. He des not smoxe but hes Deen cing at partes onthe weekends. In ation, be Nas rece became sexu Ste wih a ‘vee paroessin te last mon Gram sisn of his schatbe shows Gram-negative delactco, eS ‘ie of to folowing ea for cut of to gars fom to wrote arp? = (A) Blood agar 2 (© (8) Buerod charcoal yeas ager = ©(C) Chocelate agar = ©(D) MacConkoy agar far ©(E) Thayer marin ons a Show / Hide Explanaton Be ae i i os USMLE-Step 1 a = ‘AZ year-old Caucasian mates brought oho emergency room by his paonls ar thoy saw bood in is uring and par Parents report hal about ‘sack ag hood sme ifaton ane ednoss ns oye Urnajes ad ure clue fveald no Bacena. A poyrerace cha each othe thine was portomea. ‘hich of he folowing sa charatestic ofthe fective agent? (A) Greer ©(8} Doub standoa ©(C) Envelope (© (D) Replicate inthe cytoplasn CE) RNAgenome ‘Show / Hite Explanation USMLE-Step 1 a zi ‘N20: yea-of man resents othe emergency foom wa a sore test Physical examination revess young manin signa des, with mule Datu skin cers, swoon ph gles and named eyes A presume Gagnoss of UseiaIs made ad he patie prompt Heated wih Tetecycine E ‘ie statement bow s cnet about he arganis casing tularemia? © (A) Dogs and cats are the most mpertant reservar er is organs 1©(8) ean o tensmitod by inalaion ands a potontal iowoapon| 1©(C)_tishighty contagious, patats wit aera need tobe quarantined ©(D) iste same organism that causes he plague ©(E) Musvaty occur outside oe Untea States cI) ‘Sow / Hite Explanation Be em i os USMLE-Step 1 = zi |ASt-yea-ol male wih histo of intravenous drug abuse brought ino the emergency dparivent wih fever of 988°C (1097°F) The ptt ‘reports a one monn istry of night seas, shortness of bres, ada cough roductve of purulent sputum. The patent also sites te Nas a Scevsrg catenin toes eincese meter) om vane hs tse vetans Te pas CDs co 2 -cellsimm?. Sputum culture is notable for the growth of acid fast baci that lack photochromogenscity. A nc cpm rst pak cca era? = (AY Coppin wan a (8) meswrtet z © (C). Mycobacterium avium complex © (0) Myesbactenum kansas ©(E) Noctis strids Show Heo Explanation + Be em i os USMLE-Step 1 a = ‘A2 day itis brought the hosp wth poor esing and thar. Sho was born oa 10 yar olémathr who di nol fll up wih doctors ‘Sonngpregraney. The mothrbaloves that sho was progra fr 38 30 wooks ate tno of slvary CS roveal gram postive rods wih ‘umbing my Wich of he folowing isnot 2 component ofthe intacingerganism? 1A) Catalase (8), Ogalecose resdues 1©(C) Endotoxin tke substance ©(0) Brox ©(E) Spore fomaton ‘ow / ie Exlencton USMLE-Step 1 a zi ‘A27-yea-o fers preseis wih shortness of beth ever, and dahon ts hs proaressivey worsened over the past igh days. Achest xray ‘shows eres of preumonia nthe lung bases, She has @ snicant story of ogee Ue since he age of 14 and cureny smokes 2 ack pe Cay. 2 Herpnsican suspects atypical peumona caused by Legonets pneumonia eS ‘en amino ac sould be ea toe cutie med in oder o support grown of is organism? i (A) Alanine = (8) cystono Fy (6) oeasine = (cy = 21D) Tyrosine far O(E) Vote 2 ‘Show/Hide Explanation Be em i os USMLE-Step 1 s = |) Ase nse nt os mete ho oman enen esta ondaingot youre sks ms os atom froeomt vest ne tay artnet aes he tow hapa nse: rhc ams fon brea i, +a (ese det uot aan teste vee ee Cox ements atm en Pe extn eens : ‘Grenomnas oes seers cenang ton tne oes, repo aim dean uae a att nos ton ae 9 S07 (A) Acdtast baci 1©(B) Amasigotes present witin macrophages ©(C) Broad based budding yast at 7 dearees Celsiss ©(D) Cipar-shapedyoast at 97 degrees Casi ©CE) Gramnogatvo roos 23 ‘Show Hid Explanaton USMLE-Step 1 a = |A2B:yoar-old mechani resets lo tho emergency foam wh age laceraton onthe ft oearm, Tho patent states tha soveral days per to pesertaien no cut mse ona poce of shoot metal nhs workshep The words exemay eryhematous ocr and warm fo euch Tare ras upon papain and stg odor Cutie of he wound Ste reveals an oganem wh & Baul zo or hemtss ib ie Wich tne flowing wndonce factors ia eepansibe fortis patents canton? (A) Abphatoxin (8) dora tactor (0) Preain a (0) Toxin ce) Tssr4 23 ‘Show / Hide Explanation USMLE-Step 1 a zi /A95.year-old mle retuned am tipo the deserts of conta nti months apo. lth pon, he epost his rey care physician wit ‘comps of fever, geneaized maeise, and 15 pound waht ss, Ses hs symptoms ben, hs skin Nas become doer Physi xa Suc or massive splenomeay aon vith hepsfomegay. Gemsa stan o splenic aspiration shows macrophages wit) 3-5 micron wise ova otozea at contain a prominent stared oman, a Vnch oe fotowing ho most Hay cagnosts? ©(A) Leistmania donovani ©(B)_Lotsimana major ©(C) Mycobacterium tuberculosis ©(D) Typanoscma cet ©(E) Typanosoma cat 23 ‘Show Hid Explanaton USMLE-Step 1 a zi |A17-yer-l, sex active female comes tothe cn compning offense vepal ching and frothy discharge. Specdum exainton shows the ‘eva oe tamed wit eryemstos,puncato sions surrounding te crv os. Thor © geen achat emited rom the cel os|On wet noun thee are numerous WAC, moti, cvod,Repetaed organs, and absent ce cel. Thee eno sible pseutonyphee on KOM prep, but the ‘wo esis pose a ‘ats te most ney causal exganisn? (A) Candia ticans ©(B) Chaya wachomans ©(C) Gardnerta vaginalis ©(D) Nossa goon CE) TWeromonas vaginas 4 Re 23 ‘Show Hide Explanation USMLE-Step 1 a zi ‘ASO yoa-of4 ith istry of HV present wih intitet headache of 2 days. He took apin bt that id not prove his symptoms. He curenty not comsinant wit is medica. He stated & new Job ane week ago snd is unde ot sess. He denies fever oc. The pint ity Confortiy wang fo be examined, Neu exam shows no abnormates The folowing abs were aw a = D4 lovee 260 ct = ‘Anivtoxoplasma gS Posie “ ‘Aric IGS Nopaine ich of th folowing the most katy agnosis? (A) CMV mening ©(B) Cyplocaceal maningoencophats ©(C) Dissominats nrpes 423 © (0) Tensen hese O(E) Toxopasmosis ‘Show / Hid Explanaton USMLE-Step 1 a =| /AS.year-ld chilis brovhtto the offce comparing of ft ar pin forthe ast two days. His pares sta athe has had eve since yesterday. On furer questonng te parents sy Mat Neha an upee espe wact neon ast week whic esoNed cn sow Inte Oe, Te chids temperature 382°C (10067). On examination the esta ers nomaln appearance end Tere sno lxdees over he mastod bone The "ympanic momorane spony moble and has an named and bulgeg appearance a ‘ch one fotowing omganisms i ha most katy toto agent oh necton? © (A) Haemapiviv inaanzse, te 8 ©(B) Moxos catarmats ©(C)Non-ypable Heemoptits infuerzae ©(D) Stoptococeus preumoniag CE) Stoptococeus pyogenes 23 ‘Show Hide Explanaton USMLE-Step 1 = zi ‘Ane medicaton is develooed fx HIV ta wil have the same mechanism of acon as fewer. The researchers want io overexpress he pre tergoted bythe cup tobe able to peo iro testing. ie ‘nich ore rowing gene tat expresses ho necessary pot? = @fA) ENV “ (6) exe ie (co) NEF ala 21) POL “ ce) we ‘Show Hide Explanation 23 USMLE-Step 1 a zi ‘21-year-old woman presents to her amecolgist complsining of psn during soxalinrcaurse, Se terse is in god hes. She denies any reves, Cis, oF vannal dschaige. On exam Were are mule ough, sey-

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