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Gattefoss USA Technical Series

Lipid School
Oral Bioavailability Enhancement

October 5th, 2017

8:30 a.m - 4:15 p.m
Gattefoss Application Lab | Suite 340
115 West Century Road, Paramus, NJ 07652

This program is designed for scientists facing challenging molecules with solubility
and absorption issues. It focuses on the guiding principles for selecting the right
excipients that alone or in combination, will solubilize the drug in the dose; maintain
lipid formula the drug solubility in vivo while protecting it against rapid precipitation or enzymatic
degradation; and improve drug absorption across the intestinal epithelial cells.

Lipid-based formulations are a widely embraced strategy for enhancing the oral
bioavailability of poorly soluble drugs. Due to the versatility of lipid systems, the
formulation approach is applicable to molecules of all sizes and different solubility
properties, including highly lipophilic grease balls, downright insoluble brick dusts,
and or complex molecules such as peptides.
erratic absorption
Ease of manufacture, scale up, and excellent safety/regulatory profile of lipid-based
formulations can facilitate a seamless drug development process - from early
preclinical to late stage clinical phases, often without significant changes to the
original formulation design. Given the huge potential for saving cost and time in drug
development, the approach is increasingly used in in early solubility screening/drug
candidate selection.
bioavailabilit
enhancement

scale up

shorten
Attendance is free of charge, subject to written confirmation based on seat
availability on a first come, first serve basis.
drug development

improve

GATTEFOSS USA
115 West Century Road - Plaza I - Suite 340 - Paramus, NJ - 07652 - USA
Tel +1 201 265 4800 - Fax +1 201 265 4853 - www.gattefosse.com
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Lipid School
Oral Bioavailability Enhancement
October 5th | 8: 30 a.m - 4:15 p.m | 115 West Century Road, Paramus NJ 07652

8:30 a.m. - 9:00 a.m. Check-in, coffee, tea, light breakfast

9:00 a.m. - 9:30 a.m. Fundamentals of lipid formulation design

Jasmine Musakhanian (Gattefoss USA)

9:30 a.m. - 10:15 a.m. Critical material attributes relevant to solubility /bioavailability enhancement
with lipid formulations
Vincent Jannin (Gattefoss France)

10:15 a.m. - 10:30 a.m Break

10:30 a.m - 11:15 a.m Physiological lipid absorption pathways and lipid formulation design to
increase drug bioavailability and case studies
Vincent Jannin (Gattefoss France)

11:15 a.m - 11:45 a.m. Solubility screening, excipient miscibility, ternary diagram construction,
equilibrium solubility, and saturation in formulation
Jason LePree(Gattefoss USA)

11:45 a.m - 1:00 p.m. Lunch

1:00 p.m - 3:00 p.m Practical/lab session: Solubility & miscibility screening, ternary diagrams,
particle size analysis, lipolysis testing
Jason LePree (Gattefoss USA)

3:00 p.m - 3:15 p.m Break

3:15 p.m. - 3:45 p.m Safety and regulatory considerations

Inayet Ellis (Gattefoss USA)

3:45 p.m. - 4:15 p.m. Early considerations in drug development for saving time and cost
Jason LePree (Gattefoss USA)

Attendance is free of charge, subject to written confirmation based on seat availability

on a first come, first serve basis.